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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Martínez, Paula, Blasco, María A.·2011·Nature Reviews Cancer
DOI 10.1038/nrc3025
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Abstract

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are progressively lost with each round of cell division. Telomere protection requires a minimal length of TTAGGG repeats to allow the binding of shelterin, which prevents the activation of a DNA damage response (DDR) at chromosome ends. Telomere elongation is carried out by telomerase. Telomerase can also act as a transcriptional modulator of the Wnt-β-catenin signalling pathway and has RNA-dependent RNA polymerase activity. Dysfunctional telomeres can lead to either cancer or ageing pathologies depending on the integrity of the DDR. This Review discusses the role of telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as regulating gene expression by binding to non-telomeric sites.

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Metadata

Authors
Martínez, P., & Blasco, M. A.
Venue
Nature Reviews Cancer
Publisher
Springer Science and Business Media LLC
Published
2011-02-24
Volume
11
Issue
3
Pages
161-176
ISSN
  • 1474-175X
  • 1474-1768
DOI
10.1038/nrc3025
Cited by
468
References
59
Language
en
Licence
www.springer.com/tdm (tdm)

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