The impact of the extracellular matrix on inflammation

The Extracellular Matrix: Not Just Pretty Fibrils

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TGF-β signaling and the fibrotic response

Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

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Rapid leukocyte migration by integrin-independent flowing and squeezing

Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

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The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

Schaefer, L., Babelova, A., Kiss, E., Hausser, H.-J., Baliova, M., Krzyzankova, M., Marsche, G., Young, M. F., Mihalik, D., Götte, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23755 · Cited by 850

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

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Glycosaminoglycans and their proteoglycans: host‐associated molecular patterns for initiation and modulation of inflammation

Taylor, K. R., & Gallo, R. L. (2006) · The FASEB Journal · doi:10.1096/fj.05-4682rev · Cited by 639

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., & Sorokin, L. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051342 · Cited by 559

Basement membrane proteoglycans: from cellar to ceiling

Iozzo, R. V. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1702 · Cited by 521

Remodelling the extracellular matrix in development and disease

Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367

The blood-brain barrier

Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437

The extracellular matrix: A dynamic niche in cancer progression

Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

Loh, Q. L., & Choong, C. (2013) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2012.0437 · Cited by 2,668

Crosstalk between cancer‐associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290

Molecular and cellular mechanisms of liver fibrosis and its regression

Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024

Microenvironmental regulation of tumour angiogenesis

De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Liu, T., Han, C., Wang, S., Fang, P., Ma, Z., Xu, L., & Yin, R. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0770-1 · Cited by 860

How leukocytes cross the vascular endothelium

Vestweber, D. (2015) · Nature Reviews Immunology · doi:10.1038/nri3908 · Cited by 858

Tumor-associated macrophages: from basic research to clinical application

Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Han, Y., Yang, J., Fang, J., Zhou, Y., Candi, E., Wang, J., Hua, D., Shao, C., & Shi, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00932-0 · Cited by 720

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Monteran, L., & Erez, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01835 · Cited by 675

Sterile inflammation in the liver

Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666

Pathophysiology of the brain extracellular matrix: a new target for remyelination

Lau, L. W., Cua, R., Keough, M. B., Haylock-Jacobs, S., & Yong, V. W. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3550 · Cited by 549

The extracellular matrix and the immune system: A mutually dependent relationship

Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

Zhang, S., Ermann, J., Succi, M. D., Zhou, A., Hamilton, M. J., Cao, B., Korzenik, J. R., Glickman, J. N., Vemula, P. K., Glimcher, L. H., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa5657 · Cited by 467

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Priego, N., Zhu, L., Monteiro, C., Mulders, M., Wasilewski, D., Bindeman, W., Doglio, L., Martínez, L., Martínez-Saez, E., Ramón y Cajal, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0044-4 · Cited by 452

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

Yamazaki, Y., & Kanekiyo, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091965 · Cited by 451

T cell migration, search strategies and mechanisms

Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01598-8 · Cited by 432

Tissue homeostasis and inflammation

Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053734 · Cited by 364

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

Merline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001868 · Cited by 333

Blood-Brain Barrier Overview: Structural and Functional Correlation

Alahmari, A. (2021) · Neural Plasticity · doi:10.1155/2021/6564585 · Cited by 299

Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation

Sorokin, V., Vickneson, K., Kofidis, T., Woo, C. C., Lin, X. Y., Foo, R., & Shanahan, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599415 · Cited by 292

Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation

Wight, T. N., Kang, I., Evanko, S. P., Harten, I. A., Chang, M. Y., Pearce, O. M. T., Allen, C. E., & Frevert, C. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00512 · Cited by 268

Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation

Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253

Noninvasive Molecular Imaging of Neuroinflammation

Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245

Gene family innovation, conservation and loss on the animal stem lineage

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Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases

Brkic, M., Balusu, S., Libert, C., & Vandenbroucke, R. E. (2015) · Mediators of Inflammation · doi:10.1155/2015/620581 · Cited by 205

Molecular characterization of perivascular drainage pathways in the murine brain

Hannocks, M.-J., Pizzo, M. E., Huppert, J., Deshpande, T., Abbott, N. J., Thorne, R. G., & Sorokin, L. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17749689 · Cited by 201

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Franklin, R. J. M., & Simons, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.023 · Cited by 184

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0538 · Cited by 141

Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier

Gerwien, H., Hermann, S., Zhang, X., Korpos, E., Song, J., Kopka, K., Faust, A., Wenning, C., Gross, C. C., Honold, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8020 · Cited by 113

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G., & Schwartz, M. A. (2016) · Nature Cell Biology · doi:10.1038/ncb3405 · Cited by 96

A local complement response by RPE causes early-stage macular degeneration

Fernandez-Godino, R., Garland, D. L., & Pierce, E. A. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv287 · Cited by 73

Potential Therapeutic Features of Human Amniotic Mesenchymal Stem Cells in Multiple Sclerosis: Immunomodulation, Inflammation Suppression, Angiogenesis Promotion, Oxidative Stress Inhibition, Neurogenesis Induction, MMPs Regulation, and Remyelination Stimulation

Abbasi-Kangevari, M., Ghamari, S.-H., Safaeinejad, F., Bahrami, S., & Niknejad, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00238 · Cited by 79

Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer

Chernov, A. V., & Strongin, A. Y. (2011) · bmc · doi:10.1515/bmc.2011.017 · Cited by 69

Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds

Lv, Y., Wang, H., Li, G., & Zhao, B. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.004 · Cited by 67

Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter

Škuljec, J., Gudi, V., Ulrich, R., Frichert, K., Yildiz, Ö., Pul, R., Voss, E. V., Wissel, K., Baumgärtner, W., & Stangel, M. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182294fad · Cited by 49

Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing

García-García, A., & Martin, I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02256 · Cited by 43

Multifaced Roles of the αvβ3 Integrin in Ehlers–Danlos and Arterial Tortuosity Syndromes’ Dermal Fibroblasts

Zoppi, N., Chiarelli, N., Ritelli, M., & Colombi, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040982 · Cited by 37

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy

Georgiadou, D., Stamatakis, K., Efthimiadou, E. K., Kordas, G., Gantz, D., Chroni, A., & Stratikos, E. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m030965 · Cited by 37

The Matrisome, Inflammation, and Liver Disease

Dolin, C. E., & Arteel, G. E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402516 · Cited by 38

Extracellular Matrix for Myocardial Repair

Dziki, J. L., & Badylak, S. F. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-97421-7_8 · Cited by 25

Lipopolysaccharide-induced neuroinflammation disrupts functional connectivity and community structure in primary cortical microtissues

Atherton, E., Brown, S., Papiez, E., Restrepo, M. I., & Borton, D. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-01616-5 · Cited by 10

An inflammation self-adaptive nanocarrier for highly efficient gene therapy

Jia, H., Yang, Y., Li, M., Li, Y., Han, X., Li, J., Zhang, X., Fan, C., Wu, T., Cui, C., et al. (2020) · Materials Today Chemistry · doi:10.1016/j.mtchem.2020.100287 · Cited by 3