Primate defensins

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809

Defensins. Natural peptide antibiotics of human neutrophils.

Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416

A peptide antibiotic from human skin

Harder, J., Bartels, J., Christophers, E., & Schröder, J.-M. (1997) · Nature · doi:10.1038/43088 · Cited by 1,363

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,311

Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides

Peschel, A., Otto, M., Jack, R. W., Kalbacher, H., Jung, G., & Götz, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8405 · Cited by 994

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

Lehrer, R. I., Lichtenstein, A. K., & Ganz, T. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000541 · Cited by 991

Cathelicidins, multifunctional peptides of the innate immunity

Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

Biragyn, A., Ruffini, P. A., Leifer, C. A., Klyushnenkova, E., Shakhov, A., Chertov, O., Shirakawa, A. K., Farber, J. M., Segal, D. M., Oppenheim, J. J., et al. (2002) · Science · doi:10.1126/science.1075565 · Cited by 902

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

Sørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894

The Pleiotropic Two-Component Regulatory System PhoP-PhoQ

Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887

Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l-Lysine

Peschel, A., Jack, R. W., Otto, M., Collins, L. V., Staubitz, P., Nicholson, G., Kalbacher, H., Nieuwenhuizen, W. F., Jung, G., Tarkowski, A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1067 · Cited by 786

Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes

Nomura, I., Goleva, E., Howell, M. D., Hamid, Q. A., Ong, P. Y., Hall, C. F., Darst, M. A., Gao, B., Boguniewicz, M., Travers, J. B., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3262 · Cited by 731

Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

Valore, E. V., Park, C. H., Quayle, A. J., Wiles, K. R., McCray, P. B., & Ganz, T. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1861 · Cited by 724

Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain

Zanetti, M., Gennaro, R., & Romeo, D. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01050-o · Cited by 713

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

Tang, Y.-Q., Yuan, J., Ösapay, G., Ösapay, K., Tran, D., Miller, C. J., Ouellette, A. J., & Selsted, M. E. (1999) · Science · doi:10.1126/science.286.5439.498 · Cited by 700

Evolution of the lectin–complement pathway and its role in innate immunity

Fujita, T. (2002) · Nature Reviews Immunology · doi:10.1038/nri800 · Cited by 697

Mammalian defensins in immunity: more than just microbicidal

Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696

Defensins of vertebrate animals

Lehrer, R. I., & Ganz, T. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00303-x · Cited by 662

Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

Zhao, C., Wang, I., & Lehrer, R. I. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01123-4 · Cited by 561

hBD‐1: a novel β‐defensin from human plasma

Bensch, K. W., Raida, M., Mägert, H.-J., Schulz-Knappe, P., & Forssmann, W.-G. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00687-5 · Cited by 545

Paneth cells of the human small intestine express an antimicrobial peptide gene

Jones, D. E., & Bevins, C. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50079-x · Cited by 534

Primary structures of three human neutrophil defensins.

Selsted, M. E., Harwig, S. S., Ganz, T., Schilling, J. W., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112121 · Cited by 534

Direct inactivation of viruses by human granulocyte defensins

Daher, K. A., Selsted, M. E., & Lehrer, R. I. (1986) · Journal of Virology · doi:10.1128/jvi.60.3.1068-1074.1986 · Cited by 533

Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.

Nakamura, T., Furunaka, H., Miyata, T., Tokunaga, F., Muta, T., Iwanaga, S., Niwa, M., Takao, T., & Shimonishi, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37448-9 · Cited by 531

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

Kokryakov, V. N., Harwig, S. S. L., Panyutich, E. A., Shevchenko, A. A., Aleshina, G. M., Shamova, O. V., Korneva, H. A., & Lehrer, R. I. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80175-t · Cited by 518

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

Diamond, G., Zasloff, M., Eck, H., Brasseur, M., Maloy, W. L., & Bevins, C. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3952 · Cited by 507

Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization

Hill, C. P., Yee, J., Selsted, M. E., & Eisenberg, D. (1991) · Science · doi:10.1126/science.2006422 · Cited by 507

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501

Monocyte-chemotactic activity of defensins from human neutrophils.

Territo, M. C., Ganz, T., Selsted, M. E., & Lehrer, R. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114394 · Cited by 489

Discovery of five conserved β-defensin gene clusters using a computational search strategy

Schutte, B. C., Mitros, J. P., Bartlett, J. A., Walters, J. D., Jia, H. P., Welsh, M. J., Casavant, T. L., & McCray, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042692699 · Cited by 488

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

García, J.-R. C., Krause, A., Schulz, S., Rodríguez-Jiménez, F.-J., Klüver, E., Adermann, K., Forssmann, U., Frimpong-Boateng, A., Bals, R., & Forssmann, W.-G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0865fje · Cited by 470

Many chemokines including CCL20/MIP-3α display antimicrobial activity

Yang, D., Chen, Q., Hoover, D. M., Staley, P., Tucker, K. D., Lubkowski, J., & Oppenheim, J. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103024 · Cited by 464

Human beta-defensin-2

Schröder, J.-M., & Harder, J. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00013-8 · Cited by 453

Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.

Selsted, M. E., Tang, Y. Q., Morris, W. L., McGuire, P. A., Novotny, M. J., Smith, W., Henschen, A. H., & Cullor, J. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53298-1 · Cited by 443

Cathelicidins - a family of multifunctional antimicrobial peptides

Bals, R., & Wilson, J. M. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-2186-9 · Cited by 427

The multifaceted Paneth cell

Porter, E. M., Bevins, C. L., Ghosh, D., & Ganz, T. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8412-z · Cited by 423

Identification of CRAMP, a Cathelin-related Antimicrobial Peptide Expressed in the Embryonic and Adult Mouse

Gallo, R. L., Kim, K. J., Bernfield, M., Kozak, C. A., Zanetti, M., Merluzzi, L., & Gennaro, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13088 · Cited by 419

Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity

García, J.-R., Jaumann, F., Schulz, S., Krause, A., Rodríguez-Jiménez, J., Forssmann, U., Adermann, K., Klüver, E., Vogelmeier, C., Becker, D., et al. (2001) · Cell and Tissue Research · doi:10.1007/s004410100433 · Cited by 410

PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance

Gunn, J. S., & Miller, S. I. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.23.6857-6864.1996 · Cited by 409

Roles of antimicrobial peptides such as defensins in innate and adaptive immunity

Oppenheim, J. J., Biragyn, A., Kwak, L. W., & Yang, D. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.suppl_2.ii17 · Cited by 407

Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide

Di Nardo, A., Vitiello, A., & Gallo, R. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2274 · Cited by 405

Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family

Shafer, W. M., Qu, X.-D., Waring, A. J., & Lehrer, R. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1829 · Cited by 391

Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity

Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L., & Strieter, R. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.623 · Cited by 382

Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors

Sørensen, O. E., Cowland, J. B., Theilgaard-Mönch, K., Liu, L., Ganz, T., & Borregaard, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5583 · Cited by 370

The Human Antibacterial Cathelicidin, hCAP-18, Is Synthesized in Myelocytes and Metamyelocytes and Localized to Specific Granules in Neutrophils

Sørensen, O., Arnljots, K., Cowland, J. B., Bainton, D. F., & Borregaard, N. (1997) · Blood · doi:10.1182/blood.v90.7.2796 · Cited by 365

Extensive Normal Copy Number Variation of a β-Defensin Antimicrobial-Gene Cluster

Hollox, E. J., Armour, J. A. L., & Barber, J. C. K. (2003) · The American Journal of Human Genetics · doi:10.1086/378157 · Cited by 356

The Solution Structures of the Human β-Defensins Lead to a Better Understanding of the Potent Bactericidal Activity of HBD3 against Staphylococcus aureus

Schibli, D. J., Hunter, H. N., Aseyev, V., Starner, T. D., Wiencek, J. M., McCray, P. B., Tack, B. F., & Vogel, H. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108830200 · Cited by 347

Evaluation of the effects of peptide antibiotics human β‐defensins‐1/‐2 and LL‐37 on histamine release and prostaglandin D2production from mast cells

Niyonsaba, F., Someya, A., Hirata, M., Ogawa, H., & Nagaoka, I. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200104)31:4<1066::aid-immu1066>3.0.co;2-# · Cited by 347

Antimicrobial peptides from Amaranthus caudatus seeds with sequence homology to the cysteine/glycine-rich domain of chitin-binding proteins

Broekaert, W. F., Marien, W., Terras, F. R. G., De Bolle, M. F. C., Proost, P., Van Damme, J., Dillen, L., Claeys, M., & Rees, S. B. (1992) · Biochemistry · doi:10.1021/bi00132a023 · Cited by 345

Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

Jones, D. E., & Bevins, C. L. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81160-2 · Cited by 341

DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS

Hirsch, J. G., & Cohn, Z. A. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.112.6.1005 · Cited by 332

PHAGOCYTIN: A BACTERICIDAL SUBSTANCE FROM POLYMORPHONUCLEAR LEUCOCYTES

Hirsch, J. G. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.103.5.589 · Cited by 325

Mast cell tryptase: a review of its physiology and clinical significance

Payne, V., & Kam, P. C. A. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2004.03757.x · Cited by 320

Enteric defensins: antibiotic peptide components of intestinal host defense.

Selsted, M. E., Miller, S. I., Henschen, A. H., & Ouellette, A. J. (1992) · The Journal of cell biology · doi:10.1083/jcb.118.4.929 · Cited by 309

Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1

Cole, A. M., Hong, T., Boo, L. M., Nguyen, T., Zhao, C., Bristol, G., Zack, J. A., Waring, A. J., Yang, O. O., & Lehrer, R. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706399 · Cited by 298

Human neutrophil granules and secretory vesicles

Borregaard, N., Lollike, K., Kjeldsen, L., Sengeløv, H., Bastholm, L., Nielsen, M. H., & Bainton, D. F. (1993) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1993.tb00629.x · Cited by 295

Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens

Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., & Kwak, L. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6644 · Cited by 286

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

Groisman, E. A., Parra-Lopez, C., Salcedo, M., Lipps, C. J., & Heffron, F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11939 · Cited by 265

Human β‐defensin‐2 functions as a chemotactic agent for tumour necrosis factor‐α‐treated human neutrophils

Niyonsaba, F., Ogawa, H., & Nagaoka, I. (2004) · Immunology · doi:10.1111/j.0019-2805.2004.01816.x · Cited by 265

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes

Lichtenstein, A., Ganz, T., Selsted, M., & Lehrer, R. (1986) · Blood · doi:10.1182/blood.v68.6.1407.1407 · Cited by 263

θ Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry

Yasin, B., Wang, W., Pang, M., Cheshenko, N., Hong, T., Waring, A. J., Herold, B. C., Wagar, E. A., & Lehrer, R. I. (2004) · Journal of Virology · doi:10.1128/jvi.78.10.5147-5156.2004 · Cited by 254

Discovery of new human β-defensins using a genomics-based approach

Peng Jia, H., Schutte, B. C., Schudy, A., Linzmeier, R., Guthmiller, J. M., Johnson, G. K., Tack, B. F., Mitros, J. P., Rosenthal, A., Ganz, T., et al. (2001) · Gene · doi:10.1016/s0378-1119(00)00569-2 · Cited by 251

An epididymis-specific β-defensin is important for the initiation of sperm maturation

Zhou, C. X., Zhang, Y.-L., Xiao, L., Zheng, M., Leung, K. M., Chan, M. Y., Lo, P. S., Tsang, L. L., Wong, H. Y., Ho, L. S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1127 · Cited by 250

An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats

Li, P., Chan, H. C., He, B., So, S. C., Chung, Y. W., Shang, Q., Zhang, Y.-D., & Zhang, Y.-L. (2001) · Science · doi:10.1126/science.1056545 · Cited by 242

Epithelial cell‐derived human β‐defensin‐2 acts as a chemotaxin for mast cells through a pertussis toxin‐sensitive and phospholipase C‐dependent pathway

Niyonsaba, F., Iwabuchi, K., Matsuda, H., Ogawa, H., & Nagaoka, I. (2002) · International Immunology · doi:10.1093/intimm/14.4.421 · Cited by 241

The Structure of Human Macrophage Inflammatory Protein-3α/CCL20

Hoover, D. M., Boulègue, C., Yang, D., Oppenheim, J. J., Tucker, K., Lu, W., & Lubkowski, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203907200 · Cited by 234

Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

Selsted, M. E., Brown, D. M., DeLange, R. J., Harwig, S. S., & Lehrer, R. I. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89110-4 · Cited by 231

Identification of Multiple Novel Epididymis-Specific β-Defensin Isoforms in Humans and Mice

Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., & Ouchi, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2516 · Cited by 228

Defensin-rich dense granules of human neutrophils

Rice, W., Ganz, T., Kinkade, J. J., Selsted, M., Lehrer, R., & Parmley, R. (1987) · Blood · doi:10.1182/blood.v70.3.757.757 · Cited by 227

Mouse neutrophils lack defensins

Eisenhauer, P. B., & Lehrer, R. I. (1992) · Infection and Immunity · doi:10.1128/iai.60.8.3446-3447.1992 · Cited by 226

Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans1

Com, E., Bourgeon, F., Evrard, B., Ganz, T., Colleu, D., Jégou, B., & Pineau, C. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.005389 · Cited by 217

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms

Ouellette, A. J., Hsieh, M. M., Nosek, M. T., Cano-Gauci, D. F., Huttner, K. M., Buick, R. N., & Selsted, M. E. (1994) · Infection and Immunity · doi:10.1128/iai.62.11.5040-5047.1994 · Cited by 213

The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry

Liu, L., Zhao, C., Heng, H. H. Q., & Ganz, T. (1997) · Genomics · doi:10.1006/geno.1997.4801 · Cited by 213

Investigating antibody-catalyzed ozone generation by human neutrophils

Babior, B. M., Takeuchi, C., Ruedi, J., Gutierrez, A., & Wentworth, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530251100 · Cited by 211

Neutrophil Defensins Induce Histamine Secretion from Mast Cells: Mechanisms of Action

Befus, A. D., Mowat, C., Gilchrist, M., Hu, J., Solomon, S., & Bateman, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.947 · Cited by 203

Effect of defensins on interleukin-8 synthesis in airway epithelial cells

Van Wetering, S., Mannesse-Lazeroms, S. P., Van Sterkenburg, M. A., Daha, M. R., Dijkman, J. H., & Hiemstra, P. S. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.5.l888 · Cited by 201

Induction of a Selective and Persistent Extravasation of Neutrophils into the Peritoneal Cavity by Tryptase Mouse Mast Cell Protease 6

Huang, C., Friend, D. S., Qiu, W.-T., Wong, G. W., Morales, G., Hunt, J., & Stevens, R. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1910 · Cited by 200

Homodimeric θ-Defensins from Rhesus macaqueLeukocytes

Tran, D., Tran, P. A., Tang, Y.-Q., Yuan, J., Cole, T., & Selsted, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109117200 · Cited by 198

Defensins are mitogenic for epithelial cells and fibroblasts

Murphy, C. J., Foster, B. A., Mannis, M. J., Selsted, M. E., & Reid, T. W. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041550223 · Cited by 195

Activity of α- and θ-Defensins against Primary Isolates of HIV-1

Wang, W., Owen, S. M., Rudolph, D. L., Cole, A. M., Hong, T., Waring, A. J., Lal, R. B., & Lehrer, R. I. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.515 · Cited by 194

Retrocyclin, an Antiretroviral θ-Defensin, Is a Lectin

Wang, W., Cole, A. M., Hong, T., Waring, A. J., & Lehrer, R. I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4708 · Cited by 194

Innate immune defences in the human endometrium

King, A. E., Critchley, H. O., & Kelly, R. W. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-116 · Cited by 192

Posttranslational processing of defensins in immature human myeloid cells

Valore, E., & Ganz, T. (1992) · Blood · doi:10.1182/blood.v79.6.1538.1538 · Cited by 190

Defensin Expression by the Cornea: Multiple Signalling Pathways Mediate IL-1β Stimulation of hBD-2 Expression by Human Corneal Epithelial Cells

McDermott, A. M., Redfern, R. L., Zhang, B., Pei, Y., Huang, L., & Proske, R. J. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-0787 · Cited by 187

A Novel Big Defensin Identified in Horseshoe Crab Hemocytes: Isolation, Amino Acid Sequence, and Antibacterial Activity1

Saito, T., Kawabata, S.-I., Shigenaga, T., Takayenoki, Y., Cho, J., Nakajima, H., Hirata, M., & Iwanaga, S. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124818 · Cited by 186

Cryptdins: antimicrobial defensins of the murine small intestine

Eisenhauer, P. B., Harwig, S. S., & Lehrer, R. I. (1992) · Infection and Immunity · doi:10.1128/iai.60.9.3556-3565.1992 · Cited by 184

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes

Lehrer, R. I., Daher, K., Ganz, T., & Selsted, M. E. (1985) · Journal of Virology · doi:10.1128/jvi.54.2.467-472.1985 · Cited by 182

Evolution of primate θ-defensins: a serpentine path to a sweet tooth

Nguyen, T. X., Cole, A. M., & Lehrer, R. I. (2003) · Peptides · doi:10.1016/j.peptides.2003.07.023 · Cited by 178

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