Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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2. TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant
   Thornton, Peter, Sevalle, Jean, Deery, Michael J, Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H, Dodd, Roger B, Qamar, Seema, Gomez Perez‐Nievas, Beatriz et al. · 2017 · EMBO Molecular Medicine
3. Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study
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4. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
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5. Insights into TREM2 biology by network analysis of human brain gene expression data
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6. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice
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7. Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
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8. TREM2 dependent and independent functions of microglia in Alzheimer’s disease
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9. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
   Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian · 2016 · EMBO Molecular Medicine
10. Targeting microglia for the treatment of Alzheimer’s Disease
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11. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data
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12. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
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13. Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls
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14. Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
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15. TREM2 in CNS homeostasis and neurodegenerative disease
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16. Variant TREM2 as Risk Factor for Alzheimer's Disease
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17. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
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18. Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
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19. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
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20. Association between genetic traits for immune-mediated diseases and Alzheimer disease
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21. Young microglia restore amyloid plaque clearance of aged microglia
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23. A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons
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24. Directed evolution of adeno-associated virus for efficient gene delivery to microglia
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25. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
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26. Nuclear Receptors License Phagocytosis by Trem2+Myeloid Cells in Mouse Models of Alzheimer's Disease
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27. Progress and promise in understanding the genetic basis of common diseases
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28. The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
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29. APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
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30. Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
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31. Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
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32. Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain
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33. TREM2 is associated with the risk of Alzheimer's disease in Spanish population
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34. YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies
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35. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
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36. Genetics ignite focus on microglial inflammation in Alzheimer’s disease
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37. Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
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38. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models
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39. Microglial TYROBP/DAP12 in Alzheimer's Disease: Transduction of Physiological and Pathological Signals Across TREM2
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40. A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
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41. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
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42. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
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44. TREM 2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices
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50. Molecular basis for the loss-of-function effects of the Alzheimer’s disease-associated R47H variant of the immune receptor TREM2
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51. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
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55. If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
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56. Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease
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62. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation
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63. Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential Link between Alzheimer's disease and systemic inflammation
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65. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia
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66. GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP
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67. DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response
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68. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
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69. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer’s Disease: Evidence From Optical Imaging
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74. The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
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