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Computed Tomography — An Increasing Source of Radiation Exposure
Abstract
The number of computed tomographic (CT) studies performed is increasing rapidly. Because CT scans involve much higher doses of radiation than plain films, we are seeing a marked increase in radiation exposure in the general population. Epidemiologic studies indicate that the radiation dose from even two or three CT scans results in a detectable increase in the risk of cancer, especially in children. This article summarizes the facts about this form of radiation exposure and the implications for public health.
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Cites
Estimated Risks of Radiation-Induced Fatal Cancer from Pediatric CT
Brenner, D. J., Elliston, C. D., Hall, E. J., & Berdon, W. E. (2001) · American Journal of Roentgenology · doi:10.2214/ajr.176.2.1760289 · Cited by 3,222
Self-citationRisk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries
de González, A. B., & Darby, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15433-0 · Cited by 1,718
Preston, D. L., Shimizu, Y., Pierce, D. A., Suyama, A., & Mabuchi, K. (2003) · Radiation Research · doi:10.1667/rr3049 · Cited by 1,172
Cited by
Pearce, M. S., Salotti, J. A., Little, M. P., McHugh, K., Lee, C., Kim, K. P., Howe, N. L., Ronckers, C. M., Rajaraman, P., Craft, A. W., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60815-0 · Cited by 3,735
2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu283 · Cited by 3,128
Moderate and severe traumatic brain injury in adults
Maas, A. I., Stocchetti, N., & Bullock, R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70164-9 · Cited by 2,123
Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001106 · Cited by 2,082
Mathews, J. D., Forsythe, A. V., Brady, Z., Butler, M. W., Goergen, S. K., Byrnes, G. B., Giles, G. G., Wallace, A. B., Anderson, P. R., Guiver, T. A., et al. (2013) · BMJ · doi:10.1136/bmj.f2360 · Cited by 2,029
Yang, Q., Yan, P., Zhang, Y., Yu, H., Shi, Y., Mou, X., Kalra, M. K., Zhang, Y., Sun, L., & Wang, G. (2018) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2018.2827462 · Cited by 1,630
Stout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000603 · Cited by 1,602
Lin, J. S., Bowles, E. J. A., Williams, S. B., & Morrison, C. C. (2017) · JAMA · doi:10.1001/jama.2017.0562 · Cited by 1,082
Smith-Bindman, R., Miglioretti, D. L., Johnson, E., Lee, C., Feigelson, H. S., Flynn, M., Greenlee, R. T., Kruger, R. L., Hornbrook, M. C., Roblin, D., et al. (2012) · JAMA · doi:10.1001/jama.2012.5960 · Cited by 898
Strategies for Reducing Radiation Dose in CT
McCollough, C. H., Primak, A. N., Braun, N., Kofler, J., Yu, L., & Christner, J. (2009) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2008.10.006 · Cited by 842
White, M. C., Holman, D. M., Boehm, J. E., Peipins, L. A., Grossman, M., & Jane Henley, S. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.10.029 · Cited by 762
aLow-dose CT via convolutional neural network
Chen, H., Zhang, Y., Zhang, W., Liao, P., Li, K., Zhou, J., & Wang, G. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.000679 · Cited by 755
Bazarian, J. J., Biberthaler, P., Welch, R. D., Lewis, L. M., Barzo, P., Bogner-Flatz, V., Gunnar Brolinson, P., Büki, A., Chen, J. Y., Christenson, R. H., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30231-x · Cited by 617
McDonald, R. J., Schwartz, K. M., Eckel, L. J., Diehn, F. E., Hunt, C. H., Bartholmai, B. J., Erickson, B. J., & Kallmes, D. F. (2015) · Academic Radiology · doi:10.1016/j.acra.2015.05.007 · Cited by 460
Clinical Practice Guideline: Hoarseness (Dysphonia) (Update)
Stachler, R. J., Francis, D. O., Schwartz, S. R., Damask, C. C., Digoy, G. P., Krouse, H. J., McCoy, S. J., Ouellette, D. R., Patel, R. R., Reavis, C. (. W., et al. (2018) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599817751030 · Cited by 368
Bosch de Basea, M., Thierry-Chef, I., Harbron, R., Hauptmann, M., Byrnes, G., Bernier, M.-O., Le Cornet, L., Dabin, J., Ferro, G., Istad, T. S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02620-0 · Cited by 349
Papa, L., Lewis, L. M., Falk, J. L., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G. M., Demery, J. A., Dixit, N. K., Ferguson, I., et al. (2012) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.08.021 · Cited by 332
Menke, J. (2010) · Radiology · doi:10.1148/radiol.10091938 · Cited by 319
Cawood, T. J., Hunt, P. J., O'Shea, D., Cole, D., & Soule, S. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0234 · Cited by 300
Vincent, C., & Amalberti, R. (2016) · doi:10.1007/978-3-319-25559-0 · Cited by 278
Molecular imaging of the tumor microenvironment
Zhou, Z., & Lu, Z.-R. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.012 · Cited by 253
Sport-Related Concussion in Children and Adolescents
Halstead, M. E., Walter, K. D., Moffatt, K., COUNCIL ON SPORTS MEDICINE AND FITNESS, LaBella, C. R., Brooks, M. A., Canty, G., Diamond, A. B., Hennrikus, W., Logan, K., et al. (2018) · Pediatrics · doi:10.1542/peds.2018-3074 · Cited by 247
Budoff, M. J., Nasir, K., Kinney, G. L., Hokanson, J. E., Barr, R. G., Steiner, R., Nath, H., Lopez-Garcia, C., Black-Shinn, J., & Casaburi, R. (2011) · Journal of Cardiovascular Computed Tomography · doi:10.1016/j.jcct.2010.11.002 · Cited by 228
Body composition in clinical practice
Andreoli, A., Garaci, F., Cafarelli, F. P., & Guglielmi, G. (2016) · European Journal of Radiology · doi:10.1016/j.ejrad.2016.02.005 · Cited by 216
Journy, N., Rehel, J.-L., Ducou Le Pointe, H., Lee, C., Brisse, H., Chateil, J.-F., Caer-Lorho, S., Laurier, D., & Bernier, M.-O. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.526 · Cited by 202
Kang, S. M., Yoon, J. W., Ahn, H. Y., Kim, S. Y., Lee, K. H., Shin, H., Choi, S. H., Park, K. S., Jang, H. C., & Lim, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027694 · Cited by 197
Valsangiacomo Buechel, E. R., Grosse-Wortmann, L., Fratz, S., Eichhorn, J., Sarikouch, S., Greil, G. F., Beerbaum, P., Bucciarelli-Ducci, C., Bonello, B., Sieverding, L., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeu129 · Cited by 168
Amatya, Y., Rupp, J., Russell, F. M., Saunders, J., Bales, B., & House, D. R. (2018) · International Journal of Emergency Medicine · doi:10.1186/s12245-018-0170-2 · Cited by 137
“While the latter has the highest sensitivity, it is associated with high costs and higher doses of radiation [3, 4].”
BackgroundRisk of Brain Tumor Induction from Pediatric Head CT Procedures: A Systematic Literature Review
Sheppard, J. P., Nguyen, T., Alkhalid, Y., Beckett, J. S., Salamon, N., & Yang, I. (2018) · Brain Tumor Research and Treatment · doi:10.14791/btrt.2018.6.e4 · Cited by 90
Clinical Care and Health Disparities
Starfield, B., Gérvas, J., & Mangin, D. (2012) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031811-124528 · Cited by 76
Ekpo, E. U., Adejoh, T., Akwo, J. D., Emeka, O. C., Modu, A. A., Abba, M., Adesina, K. A., Omiyi, D. O., & Chiegwu, U. H. (2018) · Journal of Radiological Protection · doi:10.1088/1361-6498/aaaaf8 · Cited by 61
NATIONAL DIAGNOSTIC REFERENCE LEVEL INITIATIVE FOR COMPUTED TOMOGRAPHY EXAMINATIONS IN KENYA
Korir, G. K., Wambani, J. S., Korir, I. K., Tries, M. A., & Boen, P. K. (2015) · Radiation Protection Dosimetry · doi:10.1093/rpd/ncv020 · Cited by 52
Noise correlation in CBCT projection data and its application for noise reduction in low‐dose CBCT
Zhang, H., Ouyang, L., Ma, J., Huang, J., Chen, W., & Wang, J. (2014) · Medical Physics · doi:10.1118/1.4865782 · Cited by 47
Genetic variation in radiation-induced cell death
Smirnov, D. A., Brady, L., Halasa, K., Morley, M., Solomon, S., & Cheung, V. G. (2012) · Genome Research · doi:10.1101/gr.122044.111 · Cited by 46
Secondary malignant neoplasms in testicular cancer survivors
Curreri, S. A., Fung, C., & Beard, C. J. (2015) · Urologic Oncology: Seminars and Original Investigations · doi:10.1016/j.urolonc.2015.05.002 · Cited by 44
Franck, C., Vandevoorde, C., Goethals, I., Smeets, P., Achten, E., Verstraete, K., Thierens, H., & Bacher, K. (2016) · European Radiology · doi:10.1007/s00330-015-4091-7 · Cited by 43
Cranial ultrasound is a reliable first step imaging in children with suspected craniosynostosis
Pogliani, L., Zuccotti, G. V., Furlanetto, M., Giudici, V., Erbetta, A., Chiapparini, L., & Valentini, L. (2017) · Child's Nervous System · doi:10.1007/s00381-017-3449-3 · Cited by 39
Shan, A., Baumann, G., & Gholamrezanezhad, A. (2021) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2020.12.016 · Cited by 32
Dose Estimation for the European Epidemiological Study on Pediatric Computed Tomography (EPI-CT)
Thierry-Chef, I., Ferro, G., Le Cornet, L., Dabin, J., Istad, T. S., Jahnen, A., Lee, C., Maccia, C., Malchair, F., Olerud, H. M., et al. (2021) · Radiation Research · doi:10.1667/rade-20-00231.1 · Cited by 31
Rhinitis in children less than 6 years of age: current knowledge and challenges
Hardjojo, A., Shek, L. P., van Bever, H. P., & Lee, B. W. (2011) · Asia Pacific Allergy · doi:10.5415/apallergy.2011.1.3.115 · Cited by 28
Sokolov, M., & Neumann, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15010588 · Cited by 23
Smith-Bindman, R., Chu, P., Wang, Y., Chung, R., Lopez-Solano, N., Einstein, A. J., Solberg, L., Cervantes, L. F., Nelson, T. R., Boswell, W., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.0064 · Cited by 23
Diagnostic features of prematurely fused cranial sutures on plain skull X-rays
Schweitzer, T., Kunz, F., Meyer-Marcotty, P., Müller-Richter, U. D. A., Böhm, H., Wirth, C., Ernestus, R.-I., & Linz, C. (2015) · Child's Nervous System · doi:10.1007/s00381-015-2890-4 · Cited by 17
Clerkin, C., Brennan, S., & Mullaney, L. M. (2018) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2018.07.012 · Cited by 14
Riederer, I., Zimmer, C., Pfeiffer, D., Wunderlich, S., Poppert, H., Rummeny, E. J., & Huber, A. (2018) · Clinical Imaging · doi:10.1016/j.clinimag.2018.03.021 · Cited by 12
Ravindra, V. M., Awad, A.-W., Baker, C. M., Lee, A., Anderson, R. C. E., Gociman, B., Patel, K. B., Smyth, M. D., Birgfeld, C., Pollack, I. F., et al. (2021) · Journal of Neurosurgery: Pediatrics · doi:10.3171/2021.2.peds2113 · Cited by 12
Varghese, B., Kandanga, I., Puthussery, P., Vijayan, D., Babu, S. P. H., Aneesh, M. K., Noufal, M., Binu, E. V., Babu, A. C., James, S. M., et al. (2018) · Indian Journal of Radiology and Imaging · doi:10.4103/ijri.ijri_394_17 · Cited by 12
Optimization of CT radiation dose: Insight into DLP and CTDI
Arfat, M., Haq, A., Beg, T., & Jaleel, G. (2024) · Future Health · doi:10.25259/fh_45_2024 · Cited by 10
Redefining Radiation Metrics: Evaluating Actual Doses in Computed Tomography Scans
Sabiniewicz-Ziajka, D., Szarmach, A., Grzywińska, M., Gać, P., & Piskunowicz, M. (2024) · Biomedicines · doi:10.3390/biomedicines12030600 · Cited by 8
Optimization and image quality in CT studies: application of DRLs based on clinical indication
Picone, C., Porto, A., Fusco, R., Granata, C., Brunese, M. C., Granata, V., Ottaiano, A., Barretta, M., Caranci, F., Pecori, B., et al. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07125-8 · Cited by 3
Alenazi, K., Alahmad, H., Algamdi, S., Alhailiy, A., Alkhybari, E., Alhulail, A., Fisal, N., & Albeshan, S. (2024) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2024.111690 · Cited by 3
Oglat, A., Shdaifat, S., Sayah, M., Abukonna, A., & Khogali, W. (2026) · Drug, Healthcare and Patient Safety · doi:10.2147/dhps.s595721
Metadata
- Authors
- Brenner, D. J., & Hall, E. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-11-29
- Volume
- 357
- Issue
- 22
- Pages
- 2277-2284
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2171697262
- Cited by
- 8,748
- References
- 3
- FWCI
- 295.27
- Type
- journal article
- Language
- en
- Open access
- closed
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