Cited by 231Digital Mental Health InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Clinician-Assisted Internet-Based Treatment is Effective for Depression: Randomized Controlled Trial

Perini, Sarah, Titov, Nickolai, Andrews, Gavin·2009·Australian & New Zealand Journal of Psychiatry

DOI 10.1080/00048670902873722

Open this paper in CoChat — free account

Abstract

Objective The aim of the present study was to determine the efficacy of an Internet-based clinician-assisted computerized cognitive behavioural treatment (CaCCBT) programme for depression. Method Forty-five individuals meeting diagnostic criteria for depression were randomly assigned to the Sadness programme or to a waitlist control group. In the clinician-assisted Sadness programme, participants complete six online lessons, weekly homework assignments, receive weekly email contact from a clinical psychologist, and contribute to a moderated online discussion forum with other participants. An intention-to-treat model was used for data analyses. Results A total of 20 (74%) treatment group participants completed all lessons within the 8 week programme, and post-treatment data were collected from 18/27 treatment group and 17/18 waitlist group participants. Treatment group participants reported significantly reduced symptoms of depression as measured by the Beck Depression Inventory-second edition and the Patient Health Questionnaire-Nine Item. Treatment group participants each received an average of eight email contacts (111 min of therapist time]. Mean within- and between-group effect sizes (Cohen's d) across the two measures of depressive symptoms were 0.98 and 0.75, respectively. Participants found the treatment programme acceptable and satisfactory. Conclusions These results replicate those from the pilot trial reported by Perini et al. and are consistent with literature indi…

Integrity signals

Registry

Crossref · 10.1080/00048670902873722

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
Short screening scales to monitor population prevalences and trends in non-specific psychological distress
KESSLER, R. C., ANDREWS, G., COLPE, L. J., HIRIPI, E., MROCZEK, D. K., NORMAND, S.-L. T., WALTERS, E. E., & ZASLAVSKY, A. M. (2002) · Psychological Medicine · doi:10.1017/s0033291702006074 · Cited by 10,327
Self-citation
Internet-based cognitive behaviour therapy for symptoms of depression and anxiety: A meta-analysis
SPEK, V., CUIJPERS, P., NYKLÍČEK, I., RIPER, H., KEYZER, J., & POP, V. (2007) · Psychological Medicine · doi:10.1017/s0033291706008944 · Cited by 1,586
Monitoring Depression Treatment Outcomes With the Patient Health Questionnaire-9
L??we, B., Un??tzer, J., Callahan, C. M., Perkins, A. J., & Kroenke, K. (2004) · Medical Care · doi:10.1097/00005650-200412000-00006 · Cited by 1,354
Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): A diagnostic meta-analysis
Gilbody, S., Richards, D., Brealey, S., & Hewitt, C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0333-y · Cited by 1,290
Prevalence, comorbidity, disability and service utilisation: Overview of the Australian National Mental Health Survey
Andrews, G., Henderson, S., & Hall, W. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.178.2.145 · Cited by 933
Self-citation
Delivering interventions for depression by using the internet: randomised controlled trial
Christensen, H. (2004) · BMJ · doi:10.1136/bmj.37945.566632.ee · Cited by 928
Internet-based self-help for depression: randomised controlled trial
Andersson, G., Bergström, J., Holländare, F., Carlbring, P., Kaldo, V., & Ekselius, L. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.5.456 · Cited by 529 · cited 2×
“Research indicates that Internet-based CaCCBT programmes with email or telephone contact can result in clinically significant improvements in patients with depression [10,15], social phobia [Titov N et al: unpublished data, 2009; 16 21] and panic disorder [22 26], at a level similar to that provided by face-to-face cl…”
BackgroundResult
Computerized, interactive, multimedia cognitive-behavioural program for anxiety and depression in general practice
PROUDFOOT, J., GOLDBERG, D., MANN, A., EVERITT, B., MARKS, I., & GRAY, J. A. (2003) · Psychological Medicine · doi:10.1017/s0033291702007225 · Cited by 389

Show all 22 references

Research works printed but not linked: 22

10.1080/j.1440-1614.2006.01903.x · DOI
10.1016/S0140-6736(07)61393-2 · DOI
10.1016/S0165-0327(03)00134-4 · DOI
10.1002/jclp.10261 · DOI
10.1016/j.neubiorev.2004.03.008 · DOI
Perini S, 2008, E-J Appl Psychol [Online], 4, 2
Lovibond PF, 1995, Manual for the Depression Anxiety Stress Scales (DASS)
10.1080/j.1440-1614.2006.01736.x · DOI
10.1080/00048670802119762 · DOI · Paper page
10.1192/bjp.bp.105.020107 · DOI
Wims E, 2008, E-J Appl Psychol [Online], 4, 2
10.1001/jama.285.15.1987 · DOI · Paper page
Sheehan DV, 1998, J Clin Psychiatry, 59, 22
Beck AT, 1996, Beck Depression Inventory II manual2nd edn
10.1037/0022-3514.54.6.1063 · DOI · Paper page
Sheehan DV, 1983, The anxiety disease
10.1037/1040-3590.19.1.4 · DOI
10.1186/1471-2288-5-35 · DOI
10.1097/01.psy.0000172624.52957.a8 · DOI
Kaltenthaler E, 2008, Psychol Med, 21, 1
10.1192/bjp.bp.106.032078 · DOI
Klien B, 2008, E-J Appl Psychol [Online], 4, 2

Sorted by citations

Computer-based psychological treatments for depression: A systematic review and meta-analysis
Richards, D., & Richardson, T. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.004 · Cited by 1,442
“…their objective was to establish the ef-ﬁ cacy of a computer-based, clinician-assisted, intervention for depression (Andersson et al., 2005; Perini, Titov, & Andrews, 2009; Ruwaard et al., 2009), others examined the ef ﬁ cacy of unsupported computer-based interventions (Clarke et al.,…”
Background
Computer Therapy for the Anxiety and Depressive Disorders Is Effective, Acceptable and Practical Health Care: A Meta-Analysis
Andrews, G., Cuijpers, P., Craske, M. G., McEvoy, P., & Titov, N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013196 · Cited by 1,311
“In the first [24] 70% had sought prior help and 51% were currently taking medication for their depression.”
BackgroundSelf-citation
Persuasive System Design Does Matter: a Systematic Review of Adherence to Web-based Interventions
Kelders, S. M., Kok, R. N., Ossebaard, H. C., & Van Gemert-Pijnen, J. E. (2012) · Journal of Medical Internet Research · doi:10.2196/jmir.2104 · Cited by 1,308
Advantages and limitations of Internet-based interventions for common mental disorders
Andersson, G., & Titov, N. (2014) · World Psychiatry · doi:10.1002/wps.20083 · Cited by 1,160
Self-citation
Computer therapy for the anxiety and depression disorders is effective, acceptable and practical health care: An updated meta-analysis
Andrews, G., Basu, A., Cuijpers, P., Craske, M. G., McEvoy, P., English, C. L., & Newby, J. M. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.01.001 · Cited by 922
Self-citation
Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis
Karyotaki, E., Efthimiou, O., Miguel, C., Maas genannt Bermpohl, F., Furukawa, T. A., Cuijpers, P., Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration, Riper, H., Patel, V., Mira, A., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.4364 · Cited by 866
Self-citation
Cognitive behavior therapy via the Internet: a systematic review of applications, clinical efficacy and cost–effectiveness
Hedman, E., Ljótsson, B., & Lindefors, N. (2012) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/erp.12.67 · Cited by 672
Internet-Delivered Psychological Treatments
Andersson, G. (2016) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-021815-093006 · Cited by 595
How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta-analytic update of the evidence
Cuijpers, P., Cristea, I. A., Karyotaki, E., Reijnders, M., & Huibers, M. J. H. (2016) · World Psychiatry · doi:10.1002/wps.20346 · Cited by 572
Internet-based psychological treatments for depression
Johansson, R., & Andersson, G. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.63 · Cited by 509
Digital interventions for the treatment of depression: a meta-analytic review
Moshe, I., Terhorst, Y., Philippi, P., Domhardt, M., Cuijpers, P., Cristea, I., Pulkki-Råback, L., Baumeister, H., & Sander, L. B. (2021) · Psychological Bulletin · doi:10.1037/bul0000334 · Cited by 390
E-Mental Health: A Rapid Review of the Literature
Lal, S., & Adair, C. E. (2014) · Psychiatric Services · doi:10.1176/appi.ps.201300009 · Cited by 417
Adherence to Internet-Based and Face-to-Face Cognitive Behavioural Therapy for Depression: A Meta-Analysis
van Ballegooijen, W., Cuijpers, P., van Straten, A., Karyotaki, E., Andersson, G., Smit, J. H., & Riper, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100674 · Cited by 409
Internet Treatment for Depression: A Randomized Controlled Trial Comparing Clinician vs. Technician Assistance
Titov, N., Andrews, G., Davies, M., McIntyre, K., Robinson, E., & Solley, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010939 · Cited by 406
“The present CONSORT-Revised compliant randomized controlled trial (RCT) [30] examined the clinical efficacy and acceptability of clinician- and technician-assisted iCBT using the Sadness program [12,13] for people with a DSM-IV [31] diagnosis of depression.”
MethodSelf-citation
Internet-Based Treatment of Depression: A Randomized Controlled Trial Comparing Guided with Unguided Self-Help
Berger, T., Hämmerli, K., Gubser, N., Andersson, G., & Caspar, F. (2011) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2011.616531 · Cited by 383
“The findings for the guided selfhelp group replicate other studies on guided internet-based treatments for depression in which large within- and medium-to-large between-group effect sizes on depression measures are typical (Andersson et al., 2005; Perini et al., 2009; Titov et al., 2010; Vernmark et al., 2010).”
BackgroundResult
Internet- and mobile-based depression interventions for people with diagnosed depression: A systematic review and meta-analysis
Josephine, K., Josefine, L., Philipp, D., David, E., & Harald, B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.021 · Cited by 341
Internet-Delivered Psychological Treatments for Mood and Anxiety Disorders: A Systematic Review of Their Efficacy, Safety, and Cost-Effectiveness
Arnberg, F. K., Linton, S. J., Hultcrantz, M., Heintz, E., & Jonsson, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098118 · Cited by 330
Psychometric Comparison of the PHQ-9 and BDI-II for Measuring Response during Treatment of Depression
Titov, N., Dear, B. F., McMillan, D., Anderson, T., Zou, J., & Sunderland, M. (2011) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2010.550059 · Cited by 342
“These RCTs employed the same recruitment process, inclusion criteria, and treatment materials and are described in detail elsewhere (Perini et al., 2009; Titov et al., 2010).”
MethodSelf-citation
CBT for depression: a pilot RCT comparing mobile phone vs. computer
Watts, S., Mackenzie, A., Thomas, C., Griskaitis, A., Mewton, L., Williams, A., & Andrews, G. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-49 · Cited by 329
Self-citation
Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis
Karyotaki, E., Ebert, D. D., Donkin, L., Riper, H., Twisk, J., Burger, S., Rozental, A., Lange, A., Williams, A. D., Zarski, A. C., et al. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.06.007 · Cited by 303
Self-citation
The efficacy of internet interventions for depression and anxiety disorders: a review of randomised controlled trials
Griffiths, K. M., Farrer, L., & Christensen, H. (2010) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb03685.x · Cited by 303
Transdiagnostic internet treatment for anxiety and depression: a randomised controlled trial
Titov, N., Dear, B. F., Schwencke, G., Andrews, G., Johnston, L., Craske, M. G., & McEvoy, P. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.03.007 · Cited by 285
Self-citation
Clinician-Assisted Internet-Based Treatment is Effective for Panic: A Randomized Controlled Trial
Wims, E., Titov, N., Andrews, G., & Choi, I. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048671003614171 · Cited by 290
Self-citation
Internet Treatment for Generalized Anxiety Disorder: A Randomized Controlled Trial Comparing Clinician vs. Technician Assistance
Robinson, E., Titov, N., Andrews, G., McIntyre, K., Schwencke, G., & Solley, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010942 · Cited by 277
Self-citation
Blending online therapy into regular face-to-face therapy for depression: content, ratio and preconditions according to patients and therapists using a Delphi study
van der Vaart, R., Witting, M., Riper, H., Kooistra, L., Bohlmeijer, E. T., & van Gemert-Pijnen, L. J. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0355-z · Cited by 273
Attitudes towards digital treatment for depression: A European stakeholder survey
Topooco, N., Riper, H., Araya, R., Berking, M., Brunn, M., Chevreul, K., Cieslak, R., Ebert, D. D., Etchmendy, E., Herrero, R., et al. (2017) · Internet Interventions · doi:10.1016/j.invent.2017.01.001 · Cited by 262
Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care
Hedman, E., Ljótsson, B., Kaldo, V., Hesser, H., El Alaoui, S., Kraepelien, M., Andersson, E., Rück, C., Svanborg, C., Andersson, G., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.023 · Cited by 224
There is an app for that! The current state of mobile applications (apps) for DSM-5 obsessive-compulsive disorder, posttraumatic stress disorder, anxiety and mood disorders: VAN AMERINGEN et al.
Van Ameringen, M., Turna, J., Khalesi, Z., Pullia, K., & Patterson, B. (2017) · Depression and Anxiety · doi:10.1002/da.22657 · Cited by 234
Internet administered guided self-help versus individualized e-mail therapy: A randomized trial of two versions of CBT for major depression
Vernmark, K., Lenndin, J., Bjärehed, J., Carlsson, M., Karlsson, J., Öberg, J., Carlbring, P., Eriksson, T., & Andersson, G. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.01.005 · Cited by 226
Efficacy of a web-based, crowdsourced peer-to-peer cognitive reappraisal platform for depression: Randomized controlled trial
Morris, R. R., Schueller, S. M., & Picard, R. W. (2015) · Journal of Medical Internet Research · doi:10.2196/jmir.4167 · Cited by 206
“The primary therapeutic approach behind Panoply draws from CBT.”
Influential
Netmums: a phase II randomized controlled trial of a guided Internet behavioural activation treatment for postpartum depression
O'Mahen, H. A., Richards, D. A., Woodford, J., Wilkinson, E., McGinley, J., Taylor, R. S., & Warren, F. C. (2014) · Psychological Medicine · doi:10.1017/s0033291713002092 · Cited by 201
“Online cognitive behavioural therapy (CBT) for depression has been demonstrated in a number of randomized controlled trials (e.g. Christensen et al. 2004; Warmerdam et al. 2008; Meyer et al. 2009; Perini et al. 2009) and systematic reviews (e.”
Method
Computer-Assisted Cognitive-Behavior Therapy for Depression: A Systematic Review and Meta-Analysis
Wright, J. H., Owen, J. J., Richards, D., Eells, T. D., Richardson, T., Brown, G. K., Barrett, M., Rasku, M. A., Polser, G., & Thase, M. E. (2019) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18r12188 · Cited by 200
“…0.020 −0.009 0.543 1.894 .058 Warmerdam et al 2008 0.543 0.153 0.024 0.243 0.844 3.545 .000 Clarke et al 2009 0.228 0.171 0.029 −0.107 0.562 1.333 .183 Perini et al 2009 0.614 0.311 0.097 0.004 1.223 1.974 .048 Ruwaard et al 2009 0.831 0.296 0.087 0.252 1.410 2.812 .005 Titov et al 2010a 1.262…”
Influential
Transdiagnostic Internet treatment for anxiety disorders: A randomized controlled trial
Titov, N., Andrews, G., Johnston, L., Robinson, E., & Spence, J. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.05.014 · Cited by 196
Self-citation
Adherence as a determinant of effectiveness of internet cognitive behavioural therapy for anxiety and depressive disorders
Hilvert-Bruce, Z., Rossouw, P. J., Wong, N., Sunderland, M., & Andrews, G. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.04.001 · Cited by 193
Self-citation
Psychotherapy for subclinical depression: meta-analysis
Cuijpers, P., Koole, S. L., van Dijke, A., Roca, M., Li, J., & Reynolds, C. F. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.138784 · Cited by 193
Internet Treatment Addressing either Insomnia or Depression, for Patients with both Diagnoses: A Randomized Trial
Blom, K., Jernelöv, S., Kraepelien, M., Bergdahl, M. O., Jungmarker, K., Ankartjärn, L., Lindefors, N., & Kaldo, V. (2015) · SLEEP · doi:10.5665/sleep.4412 · Cited by 197
Internet cognitive behavioural therapy for mixed anxiety and depression: a randomized controlled trial and evidence of effectiveness in primary care
Newby, J. M., Mackenzie, A., Williams, A. D., McIntyre, K., Watts, S., Wong, N., & Andrews, G. (2013) · Psychological Medicine · doi:10.1017/s0033291713000111 · Cited by 181
“2011), and for the primary disorders (Perini et al. 2009).”
Self-citation
Culturally attuned Internet treatment for depression amongst Chinese Australians: A randomised controlled trial
Choi, I., Zou, J., Titov, N., Dear, B. F., Li, S., Johnston, L., Andrews, G., & Hunt, C. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.11.003 · Cited by 180
“05, which was the minimum expected based on similar studies (Perini et al., 2009; Titov et al., 2010a).”
BackgroundMethodResultInfluentialSelf-citation
Cultural adaptation of internet- and mobile-based interventions for mental disorders: a systematic review
Spanhel, K., Balci, S., Feldhahn, F., Bengel, J., Baumeister, H., & Sander, L. B. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00498-1 · Cited by 178
Clinical pathway for the screening, assessment and management of anxiety and depression in adult cancer patients: Australian guidelines
Butow, P., Price, M., Shaw, J., Turner, J., Clayton, J., Grimison, P., Rankin, N., & Kirsten, L. (2015) · Psycho-Oncology · doi:10.1002/pon.3920 · Cited by 178
“As effective as face-to-face care for mild to moderate anxiety and depression [73,74].”
BackgroundInfluential
Combining imagination and reason in the treatment of depression: A randomized controlled trial of internet-based cognitive-bias modification and internet-CBT for depression.
Williams, A. D., Blackwell, S. E., Mackenzie, A., Holmes, E. A., & Andrews, G. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0033247 · Cited by 206
Self-citation
Evaluating the effectiveness and efficacy of unguided internet-based self-help intervention for the prevention of depression: A randomized controlled trial.
Lintvedt, O. K., Griffiths, K. M., Sørensen, K., Østvik, A. R., Wang, C. E. A., Eisemann, M., & Waterloo, K. (2013) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.770 · Cited by 157
Internet-delivered psychotherapy for depression in adults
Titov, N. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32833ed18f · Cited by 158
Self-citation
Providing Human Support for the Use of Digital Mental Health Interventions: Systematic Meta-review
Werntz, A., Amado, S., Jasman, M., Ervin, A., & Rhodes, J. E. (2023) · Journal of Medical Internet Research · doi:10.2196/42864 · Cited by 158
“The most common solution to attrition and low engagement is to provide users with personalized feedback [19] and human support designed to personalize DMHIs through supportive text messages, phone calls, personalized feedback, monitoring, and troubleshooting [34-37].”
A Randomized Controlled Trial Evaluating a Manualized TeleCoaching Protocol for Improving Adherence to a Web-Based Intervention for the Treatment of Depression
Mohr, D. C., Duffecy, J., Ho, J., Kwasny, M., Cai, X., Burns, M. N., & Begale, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070086 · Cited by 158
“three of these trials did not include clinical counseling, while many trials examining coached web-based interactions do include clinical coaching [10,30].”
Background
Does Internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials
Ebert, D. D., Donkin, L., Andersson, G., Andrews, G., Berger, T., Carlbring, P., Rozenthal, A., Choi, I., Laferton, J. A. C., Johansson, R., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716001562 · Cited by 154
“…identified from the database search, primary data was obtained from 14 (Andersson et al. 2005; van Straten et al. 2008; Warmerdam et al. 2008; Perini et al. 2009; Ruwaard et al. 2009; Vernmark et al. 2010; Titov et al. 2010; Berger et al. 2011; van Bastelaar et al. 2011; Choi et al. 2012;…”
BackgroundMethodSelf-citation
The Clinical Effectiveness of Web-Based Cognitive Behavioral Therapy With Face-to-Face Therapist Support for Depressed Primary Care Patients: Randomized Controlled Trial
Høifødt, R. S., Lillevoll, K. R., Griffiths, K. M., Wilsgaard, T., Eisemann, M., Waterloo, K., & Kolstrup, N. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2714 · Cited by 154
“The adherence rate in the present study is comparable to that observed in other online guided interventions, in which adherence varied between 55% and 75% [13,14,23,30,99].”
BackgroundResult
Expressive writing and positive writing for participants with mood disorders: an online randomized controlled trial
Baikie, K. A., Geerligs, L., & Wilhelm, K. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.11.032 · Cited by 150
A RCT of a transdiagnostic internet-delivered treatment for three anxiety disorders: Examination of support roles and disorder-specific outcomes
Johnston, L., Titov, N., Andrews, G., Spence, J., & Dear, B. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028079 · Cited by 150
Self-citation
The Effectiveness of Internet Cognitive Behavioural Therapy (iCBT) for Depression in Primary Care: A Quality Assurance Study
Williams, A. D., & Andrews, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057447 · Cited by 154
Self-citation
Clinician-Assisted Internet-Based Treatment is Effective for Generalized Anxiety Disorder: Randomized Controlled Trial
Titov, N., Andrews, G., Robinson, E., Schwencke, G., Johnston, L., Solley, K., & Choi, I. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903179269 · Cited by 147
“We have demonstrated the clinical efficacy of clinician-assisted (CaCCBT) programmes in randomized controlled trials (RCTs) or open studies in patients with depression [16,17], social phobia [18 25], and in a recent trial in patients with panic disorder [26].”
MethodSelf-citation
Internet-Based CBT for Depression with and without Telephone Tracking in a National Helpline: Randomised Controlled Trial
Farrer, L., Christensen, H., Griffiths, K. M., & Mackinnon, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028099 · Cited by 140
“Effects were also larger than any previous reported effect sizes across 11 RCTs comparing Internet interventions to waitlist, treatment as usual or placebo control conditions for depression [6,15,17,38,39, 40,41,42,43,44,45].”
Result
PSYCHOLOGICAL TREATMENT OF DEPRESSION IN COLLEGE STUDENTS: A METAANALYSIS: Review: Treatment of Depression in Students
Cuijpers, P., Cristea, I. A., Ebert, D. D., Koot, H. M., Auerbach, R. P., Bruffaerts, R., & Kessler, R. C. (2016) · Depression and Anxiety · doi:10.1002/da.22461 · Cited by 137
Efficacy of cognitive behavioural therapy delivered over the Internet for depressive symptoms: A systematic review and meta-analysis
Sztein, D. M., Koransky, C. E., Fegan, L., & Himelhoch, S. (2018) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x17717402 · Cited by 135
Online interventions for depression and anxiety – a systematic review
Saddichha, S., Al-Desouki, M., Lamia, A., Linden, I. A., & Krausz, M. (2014) · Health Psychology and Behavioral Medicine · doi:10.1080/21642850.2014.945934 · Cited by 133
“…analysis, and subsequent applications of components commonly used in CBT for depression including behavior activation and cognitive restructuring Perini et al. (2009) Forty-five individuals with DSM IV depressive disorder were randomized into either the treatment group (Sadness Program) or…”
BackgroundMethodInfluential
Is computerised CBT really helpful for adult depression?-A meta-analytic re-evaluation of CCBT for adult depression in terms of clinical implementation and methodological validity
So, M., Yamaguchi, S., Hashimoto, S., Sado, M., Furukawa, T. A., & McCrone, P. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-113 · Cited by 129
“Perini (2009) [42] community guided iCBT, 8 45 PHQ-9, BDI-ii SDS WL 8 weeks 27% replaced by pretreatment scores Australia”
Background
MomMoodBooster Web-Based Intervention for Postpartum Depression: Feasibility Trial Results
Danaher, B. G., Milgrom, J., Seeley, J. R., Stuart, S., Schembri, C., Tyler, M. S., Ericksen, J., Lester, W., Gemmill, A. W., Kosty, D. B., et al. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2876 · Cited by 124
Randomized Controlled Trial of Web-Based Treatment of Social Phobia Without Clinician Guidance
Titov, N., Andrews, G., Choi, I., Schwencke, G., & Johnston, L. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903179160 · Cited by 122
Self-citation
Relational Agents in Clinical Psychiatry
Bickmore, T., & Gruber, A. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673221003707538 · Cited by 112
Guided internet-based CBT for common mental disorders
Andersson, G., Carlbring, P., Ljótsson, B., & Hedman, E. (2013) · Journal of Contemporary Psychotherapy · doi:10.1007/s10879-013-9237-9 · Cited by 119
“Controlled trials have been conducted in for example Australia (Perini et al. 2009; Titov et al. 2010), The Netherlands (Ruwaard et al.”
BackgroundMethod
An RCT Comparing Effect of Two Types of Support on Severity of Symptoms for People Completing Internet-Based Cognitive Behaviour Therapy for Social Phobia
Titov, N., Andrews, G., Schwencke, G., Solley, K., Johnston, L., & Robinson, E. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903179228 · Cited by 112
“The clinical efficacy or effectiveness of clinicianassisted CCBT programmes has been consistently demonstrated in randomized controlled trials (RCTs) in patients with depression [3,4], panic disorder [5 9], and social phobia [10 12].”
BackgroundSelf-citation
Web-Based Intervention Programs for Depression: A Scoping Review and Evaluation
Renton, T., Tang, H., Ennis, N., Cusimano, M. D., Bhalerao, S., Schweizer, T. A., & Topolovec-Vranic, J. (2014) · Journal of Medical Internet Research · doi:10.2196/jmir.3147 · Cited by 116
“Examining the existing literature, completion rates in RCTs of Web-delivered treatments for depression have primarily ranged from 55%-67% [49-54] with rates as low as 20% [55].”
Randomized trial of Internet-based relapse prevention for partially remitted depression: Preventing relapse in MDD via the Internet
Holländare, F., Johnsson, S., Randestad, M., Tillfors, M., Carlbring, P., Andersson, G., & Engström, I. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01698.x · Cited by 111
The association between adherence and outcome in an Internet intervention for depression
Fuhr, K., Schröder, J., Berger, T., Moritz, S., Meyer, B., Lutz, W., Hohagen, F., Hautzinger, M., & Klein, J. P. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.028 · Cited by 97
Step-by-Step: a new WHO digital mental health intervention for depression
Carswell, K., Harper-Shehadeh, M., Watts, S., van’t Hof, E., Abi Ramia, J., Heim, E., Wenger, A., & van Ommeren, M. (2018) · mHealth · doi:10.21037/mhealth.2018.08.01 · Cited by 104
The effect of psychotherapeutic interventions on positive and negative affect in depression: A systematic review and meta-analysis
Boumparis, N., Karyotaki, E., Kleiboer, A., Hofmann, S. G., & Cuijpers, P. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.019 · Cited by 105
An open trial of a brief transdiagnostic internet treatment for anxiety and depression
Dear, B. F., Titov, N., Schwencke, G., Andrews, G., Johnston, L., Craske, M. G., & McEvoy, P. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.09.007 · Cited by 107
Self-citation
The Use of New Digital Information and Communication Technologies in Psychological Counseling during the COVID-19 Pandemic
Dores, A. R., Geraldo, A., Carvalho, I. P., & Barbosa, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207663 · Cited by 106
Web-Based Cognitive Behavior Therapy for Depression in People With Diabetes Mellitus: A Randomized Controlled Trial
Newby, J. M., Robins, L., Wilhelm, K. A., Smith, J. S., Fletcher, T., Gillis, I., Ma, T., Finch, A. W., Campbell, L. V., & Andrews, G. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.7274 · Cited by 127
“Benchmarked against previous studies of iCBT for depressive and anxiety disorders in the general population, these effect sizes are larger than those seen in patients who do not have chronic physical diseases [43].”
ResultSelf-citation
Effectiveness of Web-based Psychological Interventions for Depression: A Meta-analysis
Cowpertwait, L., & Clarke, D. (2013) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-012-9416-z · Cited by 101
The relationship between persuasive technology principles, adherence and effect of web-Based interventions for mental health: A meta-analysis
Wildeboer, G., Kelders, S. M., & van Gemert-Pijnen, J. E. W. C. (2016) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2016.04.005 · Cited by 98
Characteristics of Adults with Anxiety or Depression Treated at an Internet Clinic: Comparison with a National Survey and an Outpatient Clinic
Titov, N., Andrews, G., Kemp, A., & Robinson, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010885 · Cited by 97
Self-citation
Computer-Assisted Cognitive-Behavior Therapy and Mobile Apps for Depression and Anxiety
Wright, J. H., Mishkind, M., Eells, T. D., & Chan, S. R. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1031-2 · Cited by 93
Assessing Patient Adherence to and Engagement With Digital Interventions for Depression in Clinical Trials: Systematic Literature Review
Forbes, A., Keleher, M. R., Venditto, M., & DiBiasi, F. (2023) · Journal of Medical Internet Research · doi:10.2196/43727 · Cited by 102
“Many studies provided coach feedback to participants after each lesson [72,75,77,99,106,108,111,122,124,130,135,141,144,145,154,155,157,158].”
Using Participatory Design Methodologies to Co-Design and Culturally Adapt the Spanish Version of the Mental Health eClinic: Qualitative Study
Ospina‐Pinillos, L., Davenport, T. A., Diaz, A. M., Navarro-Mancilla, Á. A., Scott, E. M., & Hickie, I. B. (2019) · Journal of Medical Internet Research · doi:10.2196/14127 · Cited by 112
“Although positive results are seen from the use of self-directed electronic health interventions, increased effectiveness has been reported if they are used as part of a stepped-care model [28], with the support of a trained health professional [29] or as an adjunct to face-to-face treatment [30].”
User Acceptance of Computerized Cognitive Behavioral Therapy for Depression: Systematic Review
Rost, T., Stein, J., Löbner, M., Kersting, A., Luck-Sikorski, C., & Riedel-Heller, S. G. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.7662 · Cited by 91
“%) reported a very high level of acceptance [23,26,36,43,45,47-49], 17 studies (59”
Background
Internet cognitive behavioural treatment for obsessive compulsive disorder: A randomised controlled trial
Mahoney, A., Mackenzie, A., Williams, A. D., Smith, J. S., & Andrews, G. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.09.012 · Cited by 95
Self-citation
Challenges and opportunities in internet-mediated telemental health.
Yuen, E. K., Goetter, E. M., Herbert, J. D., & Forman, E. M. (2012) · Professional Psychology: Research and Practice · doi:10.1037/a0025524 · Cited by 89
Mental health related Internet use among psychiatric patients: a cross-sectional analysis
Kalckreuth, S., Trefflich, F., & Rummel-Kluge, C. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0368-7 · Cited by 86
“So far, promising results have been shown for the effective web-based treatment of many common psychiatric disorders [10,11] particularly for depression [12-21] and anxiety disorders [22-24].”
Background
Investigating trajectories of change in psychological distress amongst patients with depression and generalised anxiety disorder treated with internet cognitive behavioural therapy
Sunderland, M., Wong, N., Hilvert-Bruce, Z., & Andrews, G. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.03.005 · Cited by 84
Mechanisms underpinning effective peer support: a qualitative analysis of interactions between expert peers and patients newly-diagnosed with bipolar disorder
Proudfoot, J. G., Jayawant, A., Whitton, A. E., Parker, G. B., Manicavasagar, V. L., Smith, M., & Nicholas, J. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-196 · Cited by 96
“Such interventions are typically offered as stand-alone programs or with support from mental health professionals, with evidence indicating superior outcomes, greater compliance and decreased rates of attrition in supported, compared to unsupported programs [36-38].”
Background
The effect of psychotherapy for depression on improvements in social functioning: a meta-analysis
Renner, F., Cuijpers, P., & Huibers, M. J. H. (2014) · Psychological Medicine · doi:10.1017/s0033291713003152 · Cited by 82
“Thirty-one studies met our inclusion criteria, reported social functioning at post-test, and were included in the meta-analyses comparing the effects of psychotherapy (versus control group) on social functioning.”
Background
Combining computerized home-based treatments for generalized anxiety disorder: an attention modification program and cognitive behavioral therapy
Amir, N., & Taylor, C. T. (2012) · Behavior Therapy · doi:10.1016/j.beth.2010.12.008 · Cited by 76
Blended care-cognitive behavioral therapy for depression and anxiety in real-world settings: Pragmatic retrospective study
Lungu, A., Jun, J. J., Azarmanesh, O., Leykin, Y., & Chen, C. E.-J. (2020) · Journal of Medical Internet Research · doi:10.2196/18723 · Cited by 75
Up-scaling clinician assisted internet cognitive behavioural therapy (iCBT) for depression: A model for dissemination into primary care
Andrews, G., & Williams, A. D. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.05.006 · Cited by 75
“In Table 3 we present their schema and responses in respect to one of the exemplar course, the www.thiswayup.org.au/clinic course for depression (Perini et al., 2008; 2009, Titov et al., 2010) and present a case example for the scalability of iCBT.”
BackgroundSelf-citation
Support from the Internet for Individuals with Mental Disorders: Advantages and Disadvantages of e-Mental Health Service Delivery
Moock, J. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00065 · Cited by 82
The impact of psychological distress tolerance in the treatment of depression
Williams, A. D., Thompson, J., & Andrews, G. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2013.05.005 · Cited by 77
Self-citation
Transdiagnostic versus disorder-specific internet-delivered cognitive behaviour therapy for anxiety and depression in primary care
Newby, J. M., Mewton, L., & Andrews, G. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.06.002 · Cited by 75
“However, these adherence rates are much lower than the rates we find in RCTs of the same programs (between 70 and 89%) (Newby et al., 2013; Perini et al., 2009; Robinson et al., 2010), which is not surprising given that adherence to iCBT is reduced when programs are completed with little to no guidance from clinicians.”
BackgroundResultSelf-citation
Integrating human support into behavioral intervention technologies: The efficiency model of support.
Schueller, S. M., Tomasino, K. N., & Mohr, D. C. (2017) · Clinical Psychology: Science and Practice · doi:10.1037/h0101740 · Cited by 70
A qualitative exploration of Internet-based treatment for comorbid depression and alcohol misuse
Darvell, M. J., Kavanagh, D. J., & Connolly, J. M. (2015) · Internet Interventions · doi:10.1016/j.invent.2015.03.003 · Cited by 69
“Web-based cognitive-behavioural therapy programs have been found efficacious in treating sub-threshold (Perini et al., 2009; Spek et al., 2007, 2008) and moderate (Andersson et al.”
Background
Ethical and legal considerations for internet-based psychotherapy
Dever Fitzgerald, T., Hunter, P. V., Hadjistavropoulos, T., & Koocher, G. P. (2010) · Cognitive Behaviour Therapy · doi:10.1080/16506071003636046 · Cited by 69
Internet and Face-to-face Cognitive Behavioral Therapy for Postnatal Depression Compared With Treatment as Usual: Randomized Controlled Trial of MumMoodBooster
Milgrom, J., Danaher, B., Seeley, J., Holt, C. J., Holt, C., Ericksen, J., Tyler, M. S., Gau, J. M., & Gemmill, A. W. (2020) · Journal of Medical Internet Research · doi:10.2196/17185 · Cited by 69
“For depression and anxiety in particular, the efficacy of internet-based treatment has been demonstrated relative to control conditions in populations with elevated symptoms and increasingly in clinically diagnosed groups [25,29-34].”
Clinical efficacy and economic evaluation of online cognitive behavioral therapy for major depressive disorder: a systematic review and meta-analysis
Ahern, E., Kinsella, S., & Semkovska, M. (2017) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2018.1407245 · Cited by 75
Web-based Intervention for Postpartum Depression: Formative Research and Design of the MomMoodBooster Program
Danaher, B. G., Milgrom, J., Seeley, J. R., Stuart, S., Schembri, C., Tyler, M. S., Ericksen, J., Lester, W., Gemmill, A. W., & Lewinsohn, P. (2012) · JMIR Research Protocols · doi:10.2196/resprot.2329 · Cited by 67
“Guided human support (ranging from a technician-level coach to a more highly skilled therapist) has been shown to increase adherence to online mental health treatments [57,58] and a number of Web-based mental health interventions have used telephones or other mediums to deliver this [20,37,59,60].”
Effectiveness of a Web-Based Guided Self-help Intervention for Outpatients With a Depressive Disorder: Short-term Results From a Randomized Controlled Trial
Kenter, R., Cuijpers, P., Beekman, A., & van Straten, A. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.4861 · Cited by 66
“The low adherence to this intervention is a cause for concern because it is far lower than generally found in Internet-based interventions for depression [12,34-36].”
Electronic Symptom Reporting Between Patient and Provider for Improved Health Care Service Quality: A Systematic Review of Randomized Controlled Trials. Part 1: State of the Art
Johansen, M. A., Henriksen, E. K. K., Horsch, A., Schuster, T., & Berntsen, G. (2012) · Journal of Medical Internet Research · doi:10.2196/jmir.2214 · Cited by 54
“We suggest not focusing so much on symptom and its synonyms as search words, since they were lacking in many of these studies, but to include specific search strings such as Interapy [85,86], Internet-based therapy [86,87], Internet-based treatment [86,88-91], and online therapeutic relationship [86].”
Background
Current perspectives on Internet delivered cognitive behavioral therapy for adults with anxiety and related disorders
Mewton, L., Smith, J., Rossouw, P., & Andrews, G. (2014) · Psychology Research and Behavior Management · doi:10.2147/prbm.s40879 · Cited by 57
Self-citation
An Online Recovery Plan Program: Can Peer Coaching Increase Participation?
Simon, G. E., Ludman, E. J., Goodale, L. C., Dykstra, D. M., Stone, E., Cutsogeorge, D., Operskalski, B., Savarino, J., & Pabiniak, C. (2011) · Psychiatric Services · doi:10.1176/ps.62.6.pss6206_0666 · Cited by 62
Internet‐based cognitive behavior therapy for major depressive disorder: A randomized controlled trial
Rosso, I. M., Killgore, W. D. S., Olson, E. A., Webb, C. A., Fukunaga, R., Auerbach, R. P., Gogel, H., Buchholz, J. L., & Rauch, S. L. (2016) · Depression and Anxiety · doi:10.1002/da.22590 · Cited by 65
“This study used a modified version of the Sadness Program, a technician-assisted iCBT program developed at the UNSW (Perini et al., 2009; Titov et al., 2010).”
BackgroundMethod
Intentional music use to reduce psychological distress in adolescents accessing primary mental health care
Mcferran, K., Hense, C., Koike, A., & Rickwood, D. (2018) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104518767231 · Cited by 59

Authors: Perini, S., Titov, N., & Andrews, G.
Affiliations: St Vincent's Hospital Sydney (AU)
UNSW Sydney (AU)
Corresponding author: Titov, Nickolai
ORCID: Titov, Nickolai
Andrews, Gavin
Venue: Australian & New Zealand Journal of Psychiatry
Publisher: SAGE Publications
Published: 2009-01-01
Volume: 43
Issue: 6
Pages: 571-578
ISSN: 0004-8674 (ISSN-L)
1440-1614
DOI: 10.1080/00048670902873722
OpenAlex: W4239050078
Cited by: 231
References: 36
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 18 · 2016: 20 · 2015: 17 · 2014: 24 · 2013: 26 · 2012: 19
FWCI: 24.30
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Australian & New Zealand Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: University of New South Wales
Topics: Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: depression, online therapy, online forums, treatment acceptability, common mental disorders, treatment efficacy
MeSH terms: Major Depressive Disorder, Female, Humans, Male, Middle Aged, Motivation, Professional-Patient Relations, Surveys and Questionnaires, Cognitive Behavioral Therapy, Patient Satisfaction, Internet, Professional Role, Diagnostic and Statistical Manual of Mental Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinician-Assisted Internet-Based Treatment is Effective for Depression: Randomized Controlled Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks