Mechanism of peripheral nerve modulation and recent applications
Open accessAbstract
Neuromodulation is a multi-interdisciplinary field of neuroscience, neural engineering, and medicine in a complex, but a way of understanding. Recently, the interest and researches in this field have been attracted due to its promising applications such as bionic limbs and bioelectronic medicine. For easier entry into this field, in this review, we approach the basic mechanism, methods, and applications of peripheral neuromodulation sequentially. Firstly, the overall structure and functions of the human nervous system are introduced, especially in the peripheral nervous system (PNS). Specifically, the fundamental neurophysiology regarding action potentials and neural signals is introduced to understand the communication between the neurons. Thereafter, two main methods for peripheral neuromodulation, which are electrical and optogenetic approaches, are introduced with the principles of the state-of-art devices. Finally, advanced applications of neuromodulation combined with the sensor, stimulator, and controller, called a closed-loop system are introduced with an example of bionic limbs.
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Normal functions of the heart and blood vessels, recovery progress of injured tissue, and abnormality of central nervous signal require devices to be implanted inside the body for long-term status monitoring.
“For example, the normal functions of the heart and blood vessels (Ouyang et al. 2021), the recovery progress of the injured tissue (Zhang et al. 2021), and the abnormality of the central nervous signal (Shin et al. 2021), etc., all of which require devices to be implanted inside the body for a long-term status monitoring (Jiang et al. 2020).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Shin et al. 2021
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Wang, C., He, T., Zhou, H., Zhang, Z., & Lee, C. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00118-1 · Cited by 295 · see citing works
- Authors
- Shin, H., Kang, M., & Lee, S.
- Affiliations
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Corresponding author
- Lee, Sanghoon
- Venue
- International Journal of Optomechatronics
- Publisher
- Informa UK Limited
- Published
- 2021-01-01
- Volume
- 15
- Issue
- 1
- Pages
- 182-198
- ISSN
- 1559-9612 (ISSN-L)
- 1559-9620
- OpenAlex
- W3215820245
- Semantic Scholar
- 6b1f6f9d01740f0dae6a6f6bff4916636b3b1602
- Cited by
- 9
- References
- 82
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 5
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Optomechatronics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- DGIST R&D Program of the Ministry of Science and ICT (2021010028)
- National Research Foundation of Korea
- the Korea government (NRF-2019R1C1C1008344)
- Korea Medical Device Development Fund
- Korea government
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- peripheral neuromodulation, peripheral nervous system, action potential, neuronal signaling, electrical stimulation, optogenetics, closed-loop neuromodulation, bionic limbs, bioelectronic medicine, neural engineering
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