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Cited by 561

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Open access
Booth, Amy M., Fang, Yi, Fallon, Jonathan K., Yang, Jr-Ming, Hildreth, James E.K., Gould, Stephen J.·2006·The Journal of Cell Biology
DOI 10.1083/jcb.200508014
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Abstract

Exosomes are secreted, single membrane organelles of ∼100 nm diameter. Their biogenesis is typically thought to occur in a two-step process involving (1) outward vesicle budding at limiting membranes of endosomes (outward = away from the cytoplasm), which generates intralumenal vesicles, followed by (2) endosome–plasma membrane fusion, which releases these internal vesicles into the extracellular milieu as exosomes. In this study, we present evidence that certain cells, including Jurkat T cells, possess discrete domains of plasma membrane that are enriched for exosomal and endosomal proteins, retain the endosomal property of outward vesicle budding, and serve as sites of immediate exosome biogenesis. It has been hypothesized that retroviruses utilize the exosome biogenesis pathway for the formation of infectious particles. In support of this, we find that Jurkat T cells direct the key budding factor of HIV, HIV Gag, to these endosome-like domains of plasma membrane and secrete HIV Gag from the cell in exosomes.

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Metadata

Authors
Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2006-03-13
Volume
172
Issue
6
Pages
923-935
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.200508014
OpenAlex
W2099491642
Cited by
561
References
3
FWCI
8.72
Type
journal article
Language
en
Open access
green

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