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Influenza Virus: Dealing with a Drifting and Shifting Pathogen

Kim, Hyunsuh, Webster, Robert G., Webby, Richard J.·2018·Viral Immunology

DOI 10.1089/vim.2017.0141

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Abstract

Numerous modern technological and scientific advances have changed the vaccine industry. However, nearly 70 years of influenza vaccine usage have passed without substantial changes in the underlying principles of the vaccine. The challenge of vaccinating against influenza lies in the constantly changing nature of the virus itself. Influenza viruses undergo antigenic evolution through antigenic drift and shift in their surface glycoproteins. This has forced frequent updates of vaccine antigens to ensure that the somewhat narrowly focused vaccine-induced immune responses defend against circulating strains. Few vaccine production systems have been developed that can entertain such constant changes. Although influenza virus infection induces long-lived immunologic memory to the same or similar strains, most people do not encounter the same strain repeatedly in their lifespan, suggesting that enhancement of natural immunity is required to improve influenza vaccines. It is clear that transformative change of influenza vaccines requires a rethink of how we immunize. In this study, we review the problems associated with the changing nature of the virus, and highlight some of the approaches being employed to improve influenza vaccines.

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Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Garten, R. J., Davis, C. T., Russell, C. A., Shu, B., Lindstrom, S., Balish, A., Sessions, W. M., Xu, X., Skepner, E., Deyde, V., et al. (2009) · Science · doi:10.1126/science.1176225 · Cited by 2,499
Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
Ulmer, J. B., Donnelly, J. J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. J., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318
Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic.
Johnson, N. P. A. S., & Mueller, J. (2002) · Bulletin of the History of Medicine · doi:10.1353/bhm.2002.0022 · Cited by 1,980
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
Wiley, D. C., Wilson, I. A., & Skehel, J. J. (1981) · Nature · doi:10.1038/289373a0 · Cited by 1,615
Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness
Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C., Huang, J., et al. (1998) · Science · doi:10.1126/science.279.5349.393 · Cited by 1,362
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Ekiert, D. C., Bhabha, G., Elsliger, M.-A., Friesen, R. H. E., Jongeneelen, M., Throsby, M., Goudsmit, J., & Wilson, I. A. (2009) · Science · doi:10.1126/science.1171491 · Cited by 1,326
Generation of influenza A viruses entirely from cloned cDNAs
Neumann, G., Watanabe, T., Ito, H., Watanabe, S., Goto, H., Gao, P., Hughes, M., Perez, D. R., Donis, R., Hoffmann, E., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9345 · Cited by 1,278
A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins
Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
Sui, J., Hwang, W. C., Perez, S., Wei, G., Aird, D., Chen, L.-M., Santelli, E., Stec, B., Cadwell, G., Ali, M., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1566 · Cited by 1,130
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064
Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus
Yuen, K., Chan, P., Peiris, M., Tsang, D., Que, T., Shortridge, K., Cheung, P., To, W., Ho, E., Sung, R., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,052
The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)
Caton, A. J., Brownlee, G. G., Yewdell, J. W., & Gerhard, W. (1982) · Cell · doi:10.1016/0092-8674(82)90135-0 · Cited by 1,034
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Wilkinson, T. M., Li, C. K. F., Chui, C. S. C., Huang, A. K. Y., Perkins, M., Liebner, J. C., Lambkin-Williams, R., Gilbert, A., Oxford, J., Nicholas, B., et al. (2012) · Nature Medicine · doi:10.1038/nm.2612 · Cited by 974
Highly Conserved Protective Epitopes on Influenza B Viruses
Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., et al. (2012) · Science · doi:10.1126/science.1222908 · Cited by 866
Cellular immune correlates of protection against symptomatic pandemic influenza
Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J. J., & Lalvani, A. (2013) · Nature Medicine · doi:10.1038/nm.3350 · Cited by 862
Global Epidemiology of Influenza: Past and Present
Cox, N. J., & Subbarao, K. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.407 · Cited by 840
A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses
Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 822
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics
Kawaoka, Y., Krauss, S., & Webster, R. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4603-4608.1989 · Cited by 805
Self-citation
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
Wrammert, J., Koutsonanos, D., Li, G.-M., Edupuganti, S., Sui, J., Morrissey, M., McCausland, M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777
Rescue of Influenza A Virus from Recombinant DNA
Fodor, E., Devenish, L., Engelhardt, O. G., Palese, P., Brownlee, G. G., & García-Sastre, A. (1999) · Journal of Virology · doi:10.1128/jvi.73.11.9679-9682.1999 · Cited by 775
Ecological and immunological determinants of influenza evolution.
Ferguson, N. M., Galvani, A. P., & Bush, R. M. (2003) · Nature · doi:10.1038/nature01509 · Cited by 746
Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells
Throsby, M., van den Brink, E., Jongeneelen, M., Poon, L. L. M., Alard, P., Cornelissen, L., Bakker, A., Cox, F., van Deventer, E., Guan, Y., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003942 · Cited by 737
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
Yassine, H. M., Boyington, J. C., McTamney, P. M., Wei, C.-J., Kanekiyo, M., Kong, W.-P., Gallagher, J. R., Wang, L., Zhang, Y., Joyce, M. G., et al. (2015) · Nature Medicine · doi:10.1038/nm.3927 · Cited by 699
Influenza
Nicholson, K. G., Wood, J. M., & Zambon, M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14854-4 · Cited by 691
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
Impagliazzo, A., Milder, F., Kuipers, H., Wagner, M. V., Zhu, X., Hoffman, R. M. B., van Meersbergen, R., Huizingh, J., Wanningen, P., Verspuij, J., et al. (2015) · Science · doi:10.1126/science.aac7263 · Cited by 600
Structural Basis Of Immune Recognition Of Influenza Virus Hemagglutinin
Wilson, I. (1990) · Annual Review of Immunology · doi:10.1146/annurev.immunol.8.1.737 · Cited by 579
Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983
Rota, P. A., Wallis, T. R., Harmon, M. W., Rota, J. S., Kendal, A. P., & Nerome, K. (1990) · Virology · doi:10.1016/0042-6822(90)90186-u · Cited by 539 · cited 1×
“While inﬂuenza B viruses are not further categorized into subtypes, two genetically and antigenically distinct lineages of virus, B/Victoria/ 2/87-like and B/Yamagata/16/88-like viruses, are also found in humans (81).”
Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
Steel, J., Lowen, A. C., Wang, T. T., Yondola, M., Gao, Q., Haye, K., García-Sastre, A., & Palese, P. (2010) · mBio · doi:10.1128/mbio.00018-10 · Cited by 533
Epochal Evolution Shapes the Phylodynamics of Interpandemic Influenza A (H3N2) in Humans
Koelle, K., Cobey, S., Grenfell, B., & Pascual, M. (2006) · Science · doi:10.1126/science.1132745 · Cited by 530
Molecular mechanisms of variation in influenza viruses
Webster, R. G., Laver, W. G., Air, G. M., & Schild, G. C. (1982) · Nature · doi:10.1038/296115a0 · Cited by 505
Self-citation
A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
Okuno, Y., Isegawa, Y., Sasao, F., & Ueda, S. (1993) · Journal of Virology · doi:10.1128/jvi.67.5.2552-2558.1993 · Cited by 489
Cross-neutralization of influenza A viruses mediated by a single antibody loop
Ekiert, D. C., Kashyap, A. K., Steel, J., Rubrum, A., Bhabha, G., Khayat, R., Lee, J. H., Dillon, M. A., O’Neil, R. E., Faynboym, A. M., et al. (2012) · Nature · doi:10.1038/nature11414 · Cited by 481
Self-citation
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin
Whittle, J. R. R., Zhang, R., Khurana, S., King, L. R., Manischewitz, J., Golding, H., Dormitzer, P. R., Haynes, B. F., Walter, E. B., Moody, M. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111497108 · Cited by 439
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
Kallewaard, N. L., Corti, D., Collins, P. J., Neu, U., McAuliffe, J. M., Benjamin, E., Wachter-Rosati, L., Palmer-Hill, F. J., Yuan, A. Q., Walker, P. A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.073 · Cited by 426
Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses
Skowronski, D. M., Janjua, N. Z., De Serres, G., Sabaiduc, S., Eshaghi, A., Dickinson, J. A., Fonseca, K., Winter, A.-L., Gubbay, J. B., Krajden, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092153 · Cited by 416
Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase
Steinhauer, D. A., Domingo, E., & Holland, J. J. (1992) · Gene · doi:10.1016/0378-1119(92)90216-c · Cited by 415
Influenza B Virus in Seals
Osterhaus, A. D. M. E., Rimmelzwaan, G. F., Martina, B. E. E., Bestebroer, T. M., & Fouchier, R. A. M. (2000) · Science · doi:10.1126/science.288.5468.1051 · Cited by 415
Long term trends in the evolution of H(3) HA1 human influenza type A.
Fitch, W. M., Bush, R. M., Bender, C. A., & Cox, N. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7712 · Cited by 394
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells
Li, G.-M., Chiu, C., Wrammert, J., McCausland, M., Andrews, S. F., Zheng, N.-Y., Lee, J.-H., Huang, M., Qu, X., Edupuganti, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118979109 · Cited by 393
Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model
Memoli, M. J., Shaw, P. A., Han, A., Czajkowski, L., Reed, S., Athota, R., Bristol, T., Fargis, S., Risos, K., Powers, J. H., et al. (2016) · mBio · doi:10.1128/mbio.00417-16 · Cited by 374
Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection
Monto, A. S., Petrie, J. G., Cross, R. T., Johnson, E., Liu, M., Zhong, W., Levine, M., Katz, J. M., & Ohmit, S. E. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv195 · Cited by 369
Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses
Hause, B. M., Ducatez, M., Collin, E. A., Ran, Z., Liu, R., Sheng, Z., Armien, A., Kaplan, B., Chakravarty, S., Hoppe, A. D., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003176 · Cited by 363
Self-citation
Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950
Nakajima, K., Desselberger, U., & Palese, P. (1978) · Nature · doi:10.1038/274334a0 · Cited by 348
Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites
Both, G. W., Sleigh, M. J., Cox, N. J., & Kendal, A. P. (1983) · Journal of Virology · doi:10.1128/jvi.48.1.52-60.1983 · Cited by 327
Positive Darwinian evolution in human influenza A viruses.
Fitch, W. M., Leiter, J. M., Li, X. Q., & Palese, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4270 · Cited by 320
Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults
Turley, C. B., Rupp, R. E., Johnson, C., Taylor, D. N., Wolfson, J., Tussey, L., Kavita, U., Stanberry, L., & Shaw, A. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.05.041 · Cited by 294
Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older
Dunkle, L. M., Izikson, R., Patriarca, P., Goldenthal, K. L., Muse, D., Callahan, J., & Cox, M. M. J. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1608862 · Cited by 291
A New Type of Virus from Epidemic Influenza
Francis, T. (1940) · Science · doi:10.1126/science.92.2392.405 · Cited by 272
Influenza Vaccine — Outmaneuvering Antigenic Shift and Drift
Treanor, J. (2004) · New England Journal of Medicine · doi:10.1056/nejmp038238 · Cited by 259
Emergence of influenza A viruses
Webby, R. J., & Webster, R. G. (2001) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2001.0997 · Cited by 258
Self-citation
Influenza Vaccine Effectiveness in Preventing Hospitalizations and Deaths in Persons 65 Years or Older in Minnesota, New York, and Oregon: Data from 3 Health Plans
Nordin, J., Mullooly, J., Poblete, S., Strikas, R., Petrucci, R., Wei, F., Rush, B., Safirstein, B., Wheeler, D., & Nichol, K. L. (2001) · The Journal of Infectious Diseases · doi:10.1086/323085 · Cited by 251
A “universal” human influenza A vaccine
Fiers, W., De Filette, M., Birkett, A., Neirynck, S., & Min Jou, W. (2004) · Virus Research · doi:10.1016/j.virusres.2004.02.030 · Cited by 225
Prevention and early treatment of influenza in healthy adults
Demicheli, V (2000) · Vaccine · doi:10.1016/s0264-410x(99)00332-1 · Cited by 211
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms
Kuroda, E., Ishii, K. J., Uematsu, S., Ohata, K., Coban, C., Akira, S., Aritake, K., Urade, Y., & Morimoto, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.019 · Cited by 207
A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin
Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Basler, C. F., & Crowe, J. E. (2011) · Journal of Virology · doi:10.1128/jvi.00700-11 · Cited by 204
Effects of Adjuvants on the Safety and Immunogenicity of an Avian Influenza H5N1 Vaccine in Adults
Bernstein, D. I., Edwards, K. M., Dekker, C. L., Belshe, R., Talbot, H. K. B., Graham, I. L., Noah, D. L., He, F., & Hill, H. (2008) · The Journal of Infectious Diseases · doi:10.1086/527489 · Cited by 195
Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments
Schotsaert, M., De Filette, M., Fiers, W., & Saelens, X. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.6 · Cited by 195
Reassortment and Insertion-Deletion Are Strategies for the Evolution of Influenza B Viruses in Nature
McCullers, J. A., Wang, G. C., He, S., & Webster, R. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7343-7348.1999 · Cited by 180
Self-citation
Host cell-mediated variation in H3N2 influenza viruses
Katz, J. M., Naeve, C. W., & Webster, R. G. (1987) · Virology · doi:10.1016/0042-6822(87)90418-1 · Cited by 166
Self-citation
ISCOMTM‐based vaccines: The second decade
Sanders, M. T., Brown, L. E., Deliyannis, G., & Pearse, M. J. (2005) · Immunology & Cell Biology · doi:10.1111/j.1440-1711.2005.01319.x · Cited by 166
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin
Fang, R., Min Jou, W., Huylebroeck, D., Devos, R., & Fiers, W. (1981) · Cell · doi:10.1016/0092-8674(81)90049-0 · Cited by 163
A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
Wu, Y., Cho, M., Shore, D. A., Song, M., Choi, J.-A., Jiang, T., Deng, Y., Bourgeois, M. A., Almli, L. M., Yang, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8708 · Cited by 152
Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence
Li, C., Hatta, M., Nidom, C. A., Muramoto, Y., Watanabe, S., Neumann, G., & Kawaoka, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912807107 · Cited by 144
An Antibody That Prevents the Hemagglutinin Low pH Fusogenic Transition
Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L. J., Wharton, S. A., Skehel, J. J., & Knossow, M. (2002) · Virology · doi:10.1006/viro.2001.1320 · Cited by 143
The Putative Polymerase Sequence of Infectious Salmon Anemia Virus Suggests a New Genus within the Orthomyxoviridae
Krossøy, B., Hordvik, I., Nilsen, F., Nylund, A., & Endresen, C. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2136-2142.1999 · Cited by 132
Influenza Virus: a Master of Metamorphosis
de Jong, J. C., Rimmelzwaan, G. F., Fouchier, R. A. M., & Osterhaus, A. D. M. E. (2000) · Journal of Infection · doi:10.1053/jinf.2000.0652 · Cited by 131
Evolutionary characteristics of influenza B virus since its first isolation in 1940: dynamic circulation of deletion and insertion mechanism
Nerome, R., Hiromoto, Y., Sugita, S., Tanabe, N., Ishida, M., Matsumoto, M., Lindstrom, S., Takahashi, T., & Nerome, K. (1998) · Archives of Virology · doi:10.1007/s007050050399 · Cited by 128
A short description of the Myxovirus group (influenza and related viruses)
Andrewes, C. H., Bang, F. B., & Burnet, F. M. (1955) · Virology · doi:10.1016/0042-6822(55)90014-3 · Cited by 114
Dose‐Related Safety and Immunogenicity of a Trivalent Baculovirus‐Expressed Influenza‐Virus Hemagglutinin Vaccine in Elderly Adults
Treanor, J. J., Schiff, G. M., Couch, R. B., Cate, T. R., Brady, R. C., Hay, C. M., Wolff, M., She, D., & Cox, M. M. J. (2006) · The Journal of Infectious Diseases · doi:10.1086/503050 · Cited by 114
Research and development of universal influenza vaccines
Du, L., Zhou, Y., & Jiang, S. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.01.001 · Cited by 111
Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants
Wong, T. M., Allen, J. D., Bebin-Blackwell, A.-G., Carter, D. M., Alefantis, T. G., DiNapoli, J. M., Kleanthous, H., & Ross, T. M. (2017) · Journal of Virology · doi:10.1128/jvi.01581-17 · Cited by 106
Compatibility among Polymerase Subunit Proteins Is a Restricting Factor in Reassortment between Equine H7N7 and Human H3N2 Influenza Viruses
Li, C., Hatta, M., Watanabe, S., Neumann, G., & Kawaoka, Y. (2008) · Journal of Virology · doi:10.1128/jvi.01445-08 · Cited by 102
An influenza A virus containing influenza B virus 5' and 3' noncoding regions on the neuraminidase gene is attenuated in mice.
Muster, T., Subbarao, K., Enami, M., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5177 · Cited by 96
Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret
Rao, S. S., Kong, W., Wei, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009812 · Cited by 88
Correlates of protection: Novel generations of influenza vaccines
Rimmelzwaan, G. F., & McElhaney, J. E. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.07.043 · Cited by 79
Universal Influenza B Vaccine Based on the Maturational Cleavage Site of the Hemagglutinin Precursor
Bianchi, E., Liang, X., Ingallinella, P., Finotto, M., Chastain, M. A., Fan, J., Fu, T., Song, H. C., Horton, M. S., Freed, D. C., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7380-7388.2005 · Cited by 77
Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1
Lambe, T., Carey, J. B., Li, Y., Spencer, A. J., van Laarhoven, A., Mullarkey, C. E., Vrdoljak, A., Moore, A., & Gilbert, S. C. (2013) · Scientific Reports · doi:10.1038/srep01443 · Cited by 76
Identification of Another Epidemic Respiratory Disease
Francis, T., Quilligan, J. J., & Minuse, E. (1950) · Science · doi:10.1126/science.112.2913.495 · Cited by 76
Transmission Characteristics of the 2009 H1N1 Influenza Pandemic: Comparison of 8 Southern Hemisphere Countries
Opatowski, L., Fraser, C., Griffin, J. T., de Silva, E., Kerkhove, M. D. V., Lyons, E., Cauchemez, S., & Ferguson, N. M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002225 · Cited by 69
The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response
Chen, Y., Zhou, H., & Jin, H. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.03.078 · Cited by 68
Vaccinia Virus-Based Multivalent H5N1 Avian Influenza Vaccines Adjuvanted with IL-15 Confer Sterile Cross-Clade Protection in Mice
Poon, L. L. M., Leung, C. Y. H., Nicholls, J. M., Perera, P., Lichy, J. H., Yamamoto, M., Waldmann, T. A., Peiris, M. J. S., & Perera, L. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803467 · Cited by 61
Immunodominant CD4+T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein
Chen, L., Zanker, D. J., Xiao, K., Wu, C., Zou, Q., & Chen, W. (2014) · Journal of Virology · doi:10.1128/jvi.01631-14 · Cited by 55
Genetic diversity of influenza B virus: The frequent reassortment and cocirculation of the genetically distinct reassortant viruses in a community
Matsuzaki, Y., Sugawara, K., Takashita, E., Muraki, Y., Hongo, S., Katsushima, N., Mizuta, K., & Nishimura, H. (2004) · Journal of Medical Virology · doi:10.1002/jmv.20156 · Cited by 46
A nasal Proteosome™ influenza vaccine containing baculovirus-derived hemagglutinin induces protective mucosal and systemic immunity
Jones, T., Allard, F., Cyr, S. L., et al. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00387-6 · Cited by 42
Chimeric Influenza A Viruses with a Functional Influenza B Virus Neuraminidase or Hemagglutinin
Flandorfer, A., García‐Sastre, A., Basler, C. F., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9116-9123.2003 · Cited by 36
Mechanism of attenuation of a chimeric influenza A/B transfectant virus
Luo, G., Bergmann, M. M., García‐Sastre, A., et al. (1992) · Journal of Virology · doi:10.1128/jvi.66.8.4679-4685.1992 · Cited by 35
Recombinant hemagglutinin influenza vaccine provides broader spectrum protection
Dunkle, L. M., & Izikson, R. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1203261 · Cited by 29
Extensive Mammalian Ancestry of Pandemic (H1N1) 2009 Virus
Ilyushina, N. A., Kim, J.-K., Negovetich, N. J., Choi, Y. K., Lang, V., Bovin, N. V., Forrest, H. L., Song, M., Pascua, P. N. Q., Kim, C., et al. (2010) · Emerging infectious diseases · doi:10.3201/eid1602.091141 · Cited by 17
Self-citation
Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses
Kim, H., Velkov, T., Camuglia, S., Rockman, S. P., & Tannock, G. A. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.09.038 · Cited by 3
Self-citation

Aging in COVID-19: Vulnerability, immunity and intervention
Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007
A brief review of influenza virus infection
Javanian, M., Barary, M., Ghebrehewet, S., Koppolu, V., Vasigala, V., & Ebrahimpour, S. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26990 · Cited by 458
Learning the language of viral evolution and escape
Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science · doi:10.1126/science.abd7331 · Cited by 361
NIH funding for vaccine readiness before the COVID-19 pandemic
Kiszewski, A. E., Cleary, E. G., Jackson, M. J., & Ledley, F. D. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.03.022 · Cited by 38

See all 419

Authors: Kim, H., Webster, R. G., & Webby, R. J.
Venue: Viral Immunology
Publisher: SAGE Publications
Published: 2018-03
Volume: 31
Issue: 2
Pages: 174-183
ISSN: 0882-8245 (ISSN-L)
1557-8976
DOI: 10.1089/vim.2017.0141
OpenAlex: W2786042132
Cited by: 419
References: 89
FWCI: 24.55
Type: journal article
Language: en
Open access: closed

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Influenza Virus: Dealing with a Drifting and Shifting Pathogen

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