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GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia
Open accessAbstract
Synchronization of neuronal activity in the neocortex may underlie the coordination of neural representations and thus is critical for optimal cognitive function. Because cognitive deficits are the major determinant of functional outcome in schizophrenia, identifying their neural basis is important for the development of new therapeutic interventions. Here we review the data suggesting that phasic synaptic inhibition mediated by specific subtypes of cortical gamma-aminobutyric acid (GABA) neurons is essential for the production of synchronized network oscillations. We also discuss evidence indicating that GABA neurotransmission is altered in schizophrenia and propose mechanisms by which such alterations can decrease the strength of inhibitory connections in a cell-type-specific manner. We suggest that some alterations observed in the neocortex of schizophrenia subjects may be compensatory responses that partially restore inhibitory synaptic efficacy. The findings of altered neural synchrony and impaired cognitive function in schizophrenia suggest that such compensatory responses are insufficient and that interventions aimed at augmenting the efficacy of GABA neurotransmission might be of therapeutic value.
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Cites
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
Buzsáki, G. (2006) · doi:10.1093/acprof:oso/9780195301069.001.0001 · Cited by 4,873
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Self-citationVariations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070
Whittington, M. A., Traub, R. D., & Jefferys, J. G. R. (1995) · Nature · doi:10.1038/373612a0 · Cited by 1,613
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498
Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
Klausberger, T., Magill, P. J., Márton, L. F., Roberts, J. D. B., Cobden, P. M., Buzsáki, G., & Somogyi, P. (2003) · Nature · doi:10.1038/nature01374 · Cited by 1,345
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Lewis, D. A., Curley, A. A., Glausier, J. R., & Volk, D. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.004 · Cited by 1,071
Self-citationUhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn062 · Cited by 629
Common circuit defect of excitatory-inhibitory balance in mouse models of autism
Gogolla, N., LeBlanc, J. J., Quast, K. B., Südhof, T. C., Fagiolini, M., & Hensch, T. K. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9023-x · Cited by 610
Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594
Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase
Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., & Dugan, L. L. (2007) · Science · doi:10.1126/science.1148045 · Cited by 585
An Integrative Model of the Maturation of Cognitive Control
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034054 · Cited by 550
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
“Synchronization of cortical and hippocampal neural networks at gamma frequencies (30–80) Hz is important for proper cognition, memory, and learning [108], but are perturbed in schizophrenic patients [58, 109, 110].”
BackgroundInfluentialThe Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516
Gonzalez-Burgos, G., & Lewis, D. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs010 · Cited by 478
Self-citationSerotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462
“…gamma oscillations and synchrony have also been reported in schizophrenia patients as well, suggesting the existence of network alterations (Spencer et al., 2003; Cho et al., 2006; Uhlhaas and Singer, 2006; Basar and Güntekin, 2008; Gonzalez-Burgos and Lewis, 2008; Gonzalez-Burgos et al., 2010).”
BackgroundLinking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.004 · Cited by 337
Hashemi, E., Ariza, J., Rogers, H., Noctor, S. C., & Martínez-Cerdeño, V. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw021 · Cited by 322
Mao, X. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1519 · Cited by 296
Curley, A. A., Arion, D., Volk, D. W., Asafu-Adjei, J. K., Sampson, A. R., Fish, K. N., & Lewis, D. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11010052 · Cited by 283
Self-citationPrefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans
Chini, M., & Hanganu-Opatz, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.017 · Cited by 253
Hong, L. E., Summerfelt, A., Buchanan, R. W., O'Donnell, P., Thaker, G. K., Weiler, M. A., & Lahti, A. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.168 · Cited by 274
Mellios, N., Huang, H.-S., Baker, S. P., Galdzicka, M., Ginns, E., & Akbarian, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.019 · Cited by 266
Alterations of cortical GABA neurons and network oscillations in schizophrenia
Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0124-8 · Cited by 260
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255
Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
Spencer, K. M., Niznikiewicz, M. A., Nestor, P. G., Shenton, M. E., & McCarley, R. W. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-85 · Cited by 253
Minzenberg, M. J., Firl, A. J., Yoon, J. H., Gomes, G. C., Reinking, C., & Carter, C. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.150 · Cited by 247
Smucny, J., Dienel, S. J., Lewis, D. A., & Carter, C. S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01089-0 · Cited by 231
Self-citationInhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
Lewis, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.003 · Cited by 217
Self-citationDevelopment of the GABAergic System from Birth to Adolescence
Kilb, W. (2012) · The Neuroscientist · doi:10.1177/1073858411422114 · Cited by 190
Enomoto, T., Tse, M. T., & Floresco, S. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.038 · Cited by 179
Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
Berridge, M. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1806-z · Cited by 181
Translating Glutamate: From Pathophysiology to Treatment
Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002804 · Cited by 168
Powell, S. B., Sejnowski, T. J., & Behrens, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.049 · Cited by 164
Imaging of Thalamocortical Dysrhythmia in Neuropsychiatry
Schulman, J. J., Cancro, R., Lowe, S., Lu, F., Walton, K. D., & Llinás, R. R. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00069 · Cited by 167
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165
Llado-Pelfort, L., Santana, N., Ghisi, V., Artigas, F., & Celada, P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr220 · Cited by 156
Rotaru, D. C., Yoshino, H., Lewis, D. A., Ermentrout, G. B., & Gonzalez-Burgos, G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1970-10.2011 · Cited by 151
Self-citationCrowley, T., Cryan, J. F., Downer, E. J., & O’Leary, O. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.001 · Cited by 150
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148
Barr, M. S., Farzan, F., Rajji, T. K., Voineskos, A. N., Blumberger, D. M., Arenovich, T., Fitzgerald, P. B., & Daskalakis, Z. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.020 · Cited by 144
Cortical basket cell dysfunction in schizophrenia
Curley, A. A., & Lewis, D. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224659 · Cited by 136
Self-citationSimpson, H. B., Shungu, D. C., Bender, J., Mao, X., Xu, X., Slifstein, M., & Kegeles, L. S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.132 · Cited by 138
Towards a cognitive neuroscience of self-awareness
Lou, H. C., Changeux, J. P., & Rosenstand, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.004 · Cited by 131
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
Guidotti, A., Dong, E., Kundakovic, M., Satta, R., Grayson, D. R., & Costa, E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.010 · Cited by 130
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
Penzes, P., Buonanno, A., Passafaro, M., Sala, C., & Sweet, R. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12261 · Cited by 125
Mechanisms of Working Memory Impairment in Schizophrenia
Van Snellenberg, J. X., Girgis, R. R., Horga, G., van de Giessen, E., Slifstein, M., Ojeil, N., Weinstein, J. J., Moore, H., Lieberman, J. A., Shohamy, D., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.017 · Cited by 123
Hippocampal Interneurons in Bipolar Disorder
Konradi, C., Zimmerman, E. I., Yang, C. K., Lohmann, K. M., Gresch, P., Pantazopoulos, H., Berretta, S., & Heckers, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.175 · Cited by 115
Gamma oscillation deficits and the onset and early progression of schizophrenia
Woo, T.-U. W., Spencer, K., & McCarley, R. W. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673221003747609 · Cited by 96
The early auditory gamma-band response is heritable and a putative endophenotype of schizophrenia
Hall, M.-H., Taylor, G., Sham, P., Schulze, K., Rijsdijk, F., Picchioni, M., Toulopoulou, T., Ettinger, U., Bramon, E., Murray, R. M., et al. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp134 · Cited by 95
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95
Carmeli, C., Knyazeva, M. G., Cuénod, M., & Do, K. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029341 · Cited by 81
Structural organization of long-range GABAergic projection system of the hippocampus
Jinno, S. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.013.2009 · Cited by 75
Ferguson, B. R., & Gao, W.-J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.01027 · Cited by 75
Pozzi, L., Dorocic, I. P., Wang, X., Carlén, M., & Meletis, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083879 · Cited by 74
A New Role for Endophenotypes in the GWAS Era: Functional Characterization of Risk Variants
Hall, M.-H. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523532 · Cited by 66
Georgiev, D., Arion, D., Enwright, J. F., Kikuchi, M., Minabe, Y., Corradi, J. P., Lewis, D. A., & Hashimoto, T. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13040468 · Cited by 61
Self-citationShaw, A. D., Knight, L., Freeman, T. C. A., Williams, G. M., Moran, R. J., Friston, K. J., Walters, J. T. R., & Singh, K. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz066 · Cited by 54
McNally, J. M., McCarley, R. W., & Brown, R. E. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-012-0346-z · Cited by 47
Egerton, A., Fusar-Poli, P., & M. Stone, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316244 · Cited by 36
Bouamrane, L., Scheyer, A. F., Lassalle, O., Iafrati, J., Thomazeau, A., & Chavis, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00308 · Cited by 34
Neural and neuronal discoordination in schizophrenia: from ensembles through networks to symptoms
Krajcovic, B., Fajnerova, I., Horacek, J., Kelemen, E., Kubik, S., Svoboda, J., & Stuchlik, A. (2019) · Acta Physiologica · doi:10.1111/apha.13282 · Cited by 29
Brain circuit pathology in Down syndrome: from neurons to neural networks
Bartesaghi, R. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0067 · Cited by 25
Association of intracortical myelin and cognitive function in bipolar I disorder
Sehmbi, M., Rowley, C. D., Minuzzi, L., Kapczinski, F., Steiner, M., Sassi, R. B., Bock, N. A., & Frey, B. N. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12875 · Cited by 17
Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice
Li, H., Lin, L.-Y., Zhang, Y., Lim, Y., Rahman, M., Beck, A., Al-Hawwas, M., Feng, S., Bobrovskaya, L., & Zhou, X.-F. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.007 · Cited by 16
Berndt, L. C. S., Singh, K. D., & Shaw, A. D. (2026) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf149 · Cited by 3
Metadata
- Authors
- Gonzalez-Burgos, G., & Lewis, D. A.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-21
- Volume
- 34
- Issue
- 5
- Pages
- 944-961
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2171907536
- Cited by
- 577
- References
- 49
- FWCI
- 24.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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