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Cell Signaling and Stress Responses

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Hotamisligil, Gökhan S., Davis, Roger J.·2016·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a006072
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Abstract

Stress-signaling pathways are evolutionarily conserved and play an important role in the maintenance of homeostasis. These pathways are also critical for adaptation to new cellular environments. The endoplasmic reticulum (ER) unfolded protein response (UPR) is activated by biosynthetic stress and leads to a compensatory increase in ER function. The JNK and p38 MAPK signaling pathways control adaptive responses to intracellular and extracellular stresses, including environmental changes such as UV light, heat, and hyperosmotic conditions, and exposure to inflammatory cytokines. Metabolic stress caused by a high-fat diet represents an example of a stimulus that coordinately activates both the UPR and JNK/p38 signaling pathways. Chronic activation of these stress-response pathways ultimately causes metabolic changes associated with obesity and altered insulin sensitivity. Stress-signaling pathways, therefore, represent potential targets for therapeutic intervention in the metabolic stress response and other disease processes.

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Metadata

Authors
Hotamisligil, G. S., & Davis, R. J.
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2016-10
Volume
8
Issue
10
Pages
a006072
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a006072
OpenAlex
W2528851536
Cited by
493
References
31
Type
posted content
Language
en
Open access
bronze

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Hotamisligil, G. S., & Davis, R. J. (2016). Cell Signaling and Stress Responses. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a006072

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