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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

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Severe Sepsis and Septic Shock

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VEGF receptor signalling ? in control of vascular function

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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A randomized trial of protocol-based care for early septic shock.

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Exosomes – vesicular carriers for intercellular communication

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

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Nonresolving Inflammation

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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

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Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

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Disease Tolerance as a Defense Strategy

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Association between mitochondrial dysfunction and severity and outcome of septic shock

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Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

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HMGB1 is a therapeutic target for sterile inflammation and infection

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Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

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Drotrecogin Alfa (Activated) in Adults with Septic Shock

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Thrombotic Microangiopathies

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A genomic storm in critically injured humans

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Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

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Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

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The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

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The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

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VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

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Inflammation and coagulation

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Bacteria activate sensory neurons that modulate pain and inflammation

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Thrombosis: tangled up in NETs

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Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

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Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

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Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

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Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

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Sepsis definitions: time for change

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Sepsis: Current Dogma and New Perspectives

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Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation

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Inflammation, endothelium, and coagulation in sepsis

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The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

Singer, M. (2014) · Virulence · doi:10.4161/viru.26907 · Cited by 617

Microcirculatory Alterations in Patients With Severe Sepsis: Impact of Time of Assessment and Relationship With Outcome*

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The inflammatory response in sepsis

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Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

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Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

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Sepsis and Endothelial Permeability

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Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1–phosphate receptor-1 crossactivation

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Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

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Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding

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Cell-derived microparticles in haemostasis and vascular medicine

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Reactivation of Multiple Viruses in Patients with Sepsis

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Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

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Neural reflexes in inflammation and immunity

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Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide.

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Immunotherapy for Sepsis — A New Approach against an Ancient Foe

Hotchkiss, R. S., & Opal, S. (2010) · New England Journal of Medicine · doi:10.1056/nejmcibr1004371 · Cited by 367

Nutrition in the acute phase of critical illness

Casaer, M. P., & Van den Berghe, G. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1304623 · Cited by 335

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

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Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

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Broken Barriers: A New Take on Sepsis Pathogenesis

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A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

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Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

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Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia

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Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

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The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

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Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation

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Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

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Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock*

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Biomarkers of endothelial activation/dysfunction in infectious diseases

Page, A. V., & Liles, W. C. (2013) · Virulence · doi:10.4161/viru.24530 · Cited by 270

Prolonged Lymphopenia, Lymphoid Depletion, and Hypoprolactinemia in Children with Nosocomial Sepsis and Multiple Organ Failure

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The Search for Effective Therapy for Sepsis: Back to the Drawing Board?

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Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia

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The role of platelets in sepsis

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage

Kaneider, N. C., Leger, A. J., Agarwal, A., Nguyen, N., Perides, G., Derian, C., Covic, L., & Kuliopulos, A. (2007) · Nature Immunology · doi:10.1038/ni1525 · Cited by 233

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

Eigenbrod, T., Park, J.-H., Harder, J., Iwakura, Y., & Núñez, G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8194 · Cited by 228

How Metabolism Generates Signals during Innate Immunity and Inflammation

McGettrick, A. F., & O'Neill, L. A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.486464 · Cited by 225

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

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Red blood cell rheology in sepsis

Piagnerelli, M., Boudjeltia, K. Z., Vanhaeverbeek, M., & Vincent, J.-L. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1783-2 · Cited by 210

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

Haneklaus, M., O’Neill, L. A., & Coll, R. C. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.004 · Cited by 204

Engagement of Glycoprotein IIb/IIIa (α IIb β 3 ) on Platelets Upregulates CD40L and Triggers CD40L-Dependent Matrix Degradation by Endothelial Cells

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HMGB1 Mediates Cognitive Impairment in Sepsis Survivors

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HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption

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Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

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Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

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How Point-of-Care Testing Could Drive Innovation in Global Health

Jani, I. V., & Peter, T. F. (2013) · New England Journal of Medicine · doi:10.1056/nejmsb1214197 · Cited by 193

Matrix metalloproteases and PAR1 activation

Austin, K. M., Covic, L., & Kuliopulos, A. (2013) · Blood · doi:10.1182/blood-2012-09-355958 · Cited by 192

The Next Generation of Sepsis Clinical Trial Designs: What Is Next After the Demise of Recombinant Human Activated Protein C?*

Opal, S. M., Dellinger, R. P., Vincent, J.-L., Masur, H., & Angus, D. C. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000325 · Cited by 191

The fibrin-derived peptide Bβ15–42 protects the myocardium against ischemia-reperfusion injury

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Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

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The Antiinflammatory Endothelial Tyrosine Kinase Tie2 Interacts With a Novel Nuclear Factor-κB Inhibitor ABIN-2

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Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

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Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant.

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Regulation of vascular permeability by sphingosine 1-phosphate

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Effect of Intravenous FX06 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction

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Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients

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The Harmful Role of C5a on Innate Immunity in Sepsis

Ward, P. A. (2010) · Journal of Innate Immunity · doi:10.1159/000317194 · Cited by 159

Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis

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The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

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