Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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Rota, Paul A., Oberste, M. Steven, Monroe, Stephan S., Nix, W. Allan, Campagnoli, Ray, Icenogle, Joseph P., Peñaranda, Silvia, Bankamp, Bettina, Maher, Kaija, Chen, Min-hsin, Tong, Suxiong, Tamin, Azaibi, Lowe, Luis, Frace, Michael, DeRisi, Joseph L., Chen, Qi, Wang, David, Erdman, Dean D., Peret, Teresa C. T., Burns, Cara, Ksiazek, Thomas G., Rollin, Pierre E., Sanchez, Anthony, Liffick, Stephanie, Holloway, Brian, Limor, Josef, McCaustland, Karen, Olsen-Rasmussen, Melissa, Fouchier, Ron, Günther, Stephan, Osterhaus, Albert D. M. E., Drosten, Christian, Pallansch, Mark A., Anderson, Larry J., Bellini, William J.·2003·Science

DOI 10.1126/science.1085952

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Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to anyof the previouslycharacterized coronaviruses.

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Authors: Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M.-H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J. L., Chen, Q., Wang, D., Erdman, D. D., Peret, T. C. T., Burns, C., Ksiazek, T. G., Rollin, P. E., Sanchez, A., Liffick, S., Holloway, B., Limor, J., McCaustland, K., Olsen-Rasmussen, M., Fouchier, R., Günther, S., Osterhaus, A. D. M. E., Drosten, C., Pallansch, M. A., Anderson, L. J., & Bellini, W. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-05-30
Volume: 300
Issue: 5624
Pages: 1394-1399
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1085952
OpenAlex: W2116586125
Cited by: 2,474
References: 0
FWCI: 191.22
Type: journal article
Language: en
Open access: green

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Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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