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Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials
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Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.
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“Both intrinsic and extrinsic factors have been shown to influence myelination. For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
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In the citing paper
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
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“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Wake et al., 2011
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Metadata
- Authors
- Wake, H., Lee, P. R., & Fields, R. D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fields, R. Douglas
- Venue
- Science
- Published
- 2011-09-16
- Volume
- 333
- Issue
- 6049
- Pages
- 1647-1651
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3482340
- OpenAlex
- W2167904957
- Cited by
- 636
- References
- 24
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 25 · 2023: 28 · 2022: 31 · 2021: 49 · 2020: 38 · 2019: 51 · 2018: 48 · 2017: 63 · 2016: 56 · 2015: 59 · 2014: 50 · 2013: 50 · 2012: 29
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- myelination, action potential, oligodendrocytes, dorsal root ganglion neurons, myelin basic protein, local protein synthesis, glutamate release, synaptic vesicles, Fyn, activity-dependent myelination, neural development
- MeSH terms
- Action Potentials, Adenosine Triphosphate, Animals, Axons, Calcium, Cell Differentiation, Cells, Cultured, Electric Stimulation, Myelin Basic Protein, Ganglia, Spinal, Myelin Sheath, Synaptic Transmission, Oligodendroglia, Receptors, Transferrin, Synaptic Vesicles, Signal Transduction, Glutamic Acid, Calcium Signaling, Proto-Oncogene Proteins c-fyn, Mice, Neural Stem Cells
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