Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, Mihael H., Lavedan, Christian, Leroy, Elisabeth, Ide, Susan E., Dehejia, Anindya, Dutra, Amalia, Pike, Brian, Root, Holly +12 more·1997·Science
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- Is synaptic loss a unique hallmark of Alzheimer’s disease?Scheff, Stephen W., Neltner, Janna H., Nelson, Peter T. · 2014 · Biochemical Pharmacology
- T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s diseaseSubbarayan, Meena S., Hudson, Charles, Moss, Lauren D., Nash, Kevin R., Bickford, Paula C. · 2020 · Journal of Neuroinflammation
- Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in VivoLou, Haiyan, Montoya, Susana E., Alerte, Tshianda N.M., Wang, Jian, Wu, Jianjun, Peng, Xiangmin, Hong, Chang-Sook, Friedrich, Emily E., Mader, Samantha A., Pedersen, Courtney J. et al. · 2010 · Journal of Biological Chemistry
- RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analysesGustavsson, Emil K, Follett, Jordan, Trinh, Joanne, Barodia, Sandeep K, Real, Raquel, Liu, Zhiyong, Grant-Peters, Melissa, Fox, Jesse D, Appel-Cresswell, Silke, Stoessl, A Jon et al. · 2024 · The Lancet Neurology
- Disease model organism for Parkinson disease: <i>Drosophila melanogaster</i>Aryal, Binod, Lee, Youngseok · 2019 · BMB Reports
- Pathogenic Mechanisms of Neurodegeneration in Parkinson DiseaseMullin, Stephen, Schapira, Anthony H.V. · 2015 · Neurologic Clinics
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- Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse modelKohl, Zacharias, Winner, Beate, Ubhi, Kiren, Rockenstein, Edward, Mante, Michael, Münch, Martina, Barlow, Carolee, Carter, Todd, Masliah, Eliezer, Winkler, Jürgen · 2012 · European Journal of Neuroscience
- Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodiesNelson, P. T., Kryscio, R. J., Jicha, G. A., Abner, E. L., Schmitt, F. A., Xu, L. O., Cooper, G., Smith, C. D., Markesbery, W. R. · 2009 · Neurology
- Parkinsons Disease and other α-SynucleinopathiesGoedert, Michel · 2001 · Clinical Chemistry and Laboratory Medicine
- Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein AggregationVieira, Bruno Di Marco, Radford, Rowan A., Chung, Roger S., Guillemin, Gilles J., Pountney, Dean L. · 2015 · Frontiers in Cellular Neuroscience
- Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblastsBraidy, Nady, Gai, Wei-Ping, Xu, Ying Hua, Sachdev, Perminder, Guillemin, Gilles J, Jiang, Xing-Mai, Ballard, J William O, Horan, Martin P, Fang, Zhi Ming, Chong, Beng H et al. · 2013 · Translational Neurodegeneration
- Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative DiseasesStanga, Serena, Caretto, Anna, Boido, Marina, Vercelli, Alessandro · 2020 · International Journal of Molecular Sciences
- A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson's DiseasePabon, Mibel M., Jernberg, Jennifer N., Morganti, Josh, Contreras, Jessika, Hudson, Charles E., Klein, Ronald L., Bickford, Paula C. · 2012 · PLoS ONE
- Striatal glutamatergic hyperactivity in Parkinson's diseaseCampanelli, F., Natale, G., Marino, G., Ghiglieri, V., Calabresi, P. · 2022 · Neurobiology of Disease
- Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's diseaseKumaran, Ravindran, Cookson, Mark R. · 2015 · Human Molecular Genetics
- Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndromeCharlett, A., Dobbs, R. J., Dobbs, S. M., Weller, C., Brady, P., Peterson, D.W. · 2009 · Acta Neurologica Scandinavica
- Extreme cerebrospinal fluid amyloid β levels identify family with late‐onset Alzheimer's disease presenilin 1 mutationKauwe, John S. K., Jacquart, Sarah, Chakraverty, Sumi, Wang, Jun, Mayo, Kevin, Fagan, Anne M., Holtzman, David M., Morris, John C., Goate, Alison M. · 2007 · Annals of Neurology
- C-terminal α-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disordersTakeda, A., Hashimoto, M., Mallory, M., Sundsumo, M., Hansen, L., Masliah, E. · 2000 · Acta Neuropathologica
- Preserving Lysosomal Function in the Aging Brain: Insights from NeurodegenerationPeng, Wesley, Minakaki, Georgia, Nguyen, Maria, Krainc, Dimitri · 2019 · Neurotherapeutics
- Quantitative neurohistological features of frontotemporal degenerationArnold, Steven E., Han, Li-Ying, Clark, Christopher M., Grossman, Murray, Trojanowski, John Q. · 2000 · Neurobiology of Aging
- O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein ProteinopathiesPermanne, Bruno, Sand, Astrid, Ousson, Solenne, Nény, Maud, Hantson, Jennifer, Schubert, Ryan, Wiessner, Christoph, Quattropani, Anna, Beher, Dirk · 2022 · ACS Chemical Neuroscience
- Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy BodiesHashimoto, Makoto, Masliah, Eliezer · 2003 · Neurochemical Research
- Basal lamina changes in neurodegenerative disordersNguyen, Benjamin, Bix, Gregory, Yao, Yao · 2021 · Molecular Neurodegeneration
- Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagyLiu, Jia, Wang, Xue, Lu, Yongquan, Duan, Chunli, Gao, Ge, Lu, Lingling, Yang, Hui · 2017 · Cell Death & Disease
- Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson diseaseNoureddine, Maher A., Qin, Xue-Jun, Oliveira, Sofia A., Skelly, Tara J., van der Walt, Joelle, Hauser, Michael A., Pericak-Vance, Margaret A., Vance, Jeffery M., Li, Yi-Ju · 2005 · Human Genetics
- Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive DystoniaKawahata, Ichiro, Fukunaga, Kohji · 2020 · International Journal of Molecular Sciences
- α‐Synuclein promotes clathrin‐mediated NMDA receptor endocytosis and attenuates NMDA‐induced dopaminergic cell deathCheng, Furong, Li, Xin, Li, Yaohua, Wang, Chaodong, Wang, Tao, Liu, Guangwei, Baskys, Andrius, Uéda, Kenji, Chan, Piu, Yu, Shun · 2011 · Journal of Neurochemistry
- Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein ProteinWongkongkathep, Piriya, Han, Jong Yoon, Choi, Tae Su, Yin, Sheng, Kim, Hugh I., Loo, Joseph A. · 2018 · Journal of the American Society for Mass Spectrometry
- Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s diseaseGonzález-Hernández, Tomás · 2010 · Frontiers in Neuroanatomy
- Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive declineSegatto, Marco, Leboffe, Loris, Trapani, Laura, Pallottini, Valentina · 2014 · Current Medicinal Chemistry
- Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?Cebrián, Carolina, Loike, John D., Sulzer, David · 2014 · Current Topics in Behavioral Neurosciences
- Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s diseaseEteleeb, Abdallah M., Novotny, Brenna C., Tarraga, Carolina Soriano, Sohn, Christopher, Dhungel, Eliza, Brase, Logan, Nallapu, Aasritha, Buss, Jared, Farias, Fabiana, Bergmann, Kristy et al. · 2024 · PLOS Biology
- Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse BrainYabuki, Yasushi, Matsuo, Kazuya, Kawahata, Ichiro, Fukui, Naoya, Mizobata, Tomohiro, Kawata, Yasushi, Owada, Yuji, Shioda, Norifumi, Fukunaga, Kohji · 2020 · International Journal of Molecular Sciences
- Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic miceBencsik, Anna, Muselli, Letizia, Leboidre, Mikael, Lakhdar, Latifa, Baron, Thierry · 2014 · Journal of Neuropathology & Experimental Neurology
- Rifampicin Attenuates the MPTP-Induced Neurotoxicity in Mouse BrainOida, Y., Kitaichi, K., Nakayama, H., Ito, Y., Fujimoto, Y., Shimazawa, M., Nagai, H., Hara, H. · 2006 · Brain Research
- Relevance of chronic stress and the two faces of microglia in Parkinson's diseaseHerrera, Antonio J., Espinosa-Oliva, Ana M., Carrillo-Jiménez, Alejandro, Oliva-Martín, María J., García-Revilla, Juan, García-Quintanilla, Alberto, de Pablos, Rocío M., Venero, José L. · 2015 · Frontiers in Cellular Neuroscience
- C/EBPβ/δ-secretase signaling mediates Parkinson’s disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOBWu, Zhourui, Xia, Yiyuan, Wang, Zhihao, Su Kang, Seong, Lei, Kecheng, Liu, Xia, Jin, Lingjing, Wang, Xiaochuan, Cheng, Liming, Ye, Keqiang · 2021 · Molecular Psychiatry
- Dose- and time-dependent α-synuclein aggregation induced by ferric iron in SK-N-SH cellsLi, Wen-Jing, Jiang, Hong, Song, Ning, Xie, Jun-Xia · 2010 · Neuroscience Bulletin
- Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson’s diseaseAndersen, Julie K. · 2003 · Neurotoxicity Research
- Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.Bortolozzi, Analia, Manashirov, Sharon, Chen, Alon, Artigas, Francesc · 2021 · Pharmacology & Therapeutics
- Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson’s Disease: Current Understanding and Knowledge GapsHuntington, Taylor E, Srinivasan, Rahul · 2021 · Aging and disease
- ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s DiseaseSiokas, Vasileios, Aloizou, Athina-Maria, Tsouris, Zisis, Liampas, Ioannis, Liakos, Panagiotis, Calina, Daniela, Docea, Anca Oana, Tsatsakis, Aristidis, Bogdanos, Dimitrios P., Hadjigeorgiou, Georgios M. et al. · 2021 · Journal of Clinical Medicine
- Exploring the connection between the gut microbiome and parkinson's disease symptom progression and pathology: implications for supplementary treatment optionsChan, Dennis G., Ventura, Katelyn, Villeneuve, Ally, Du Bois, Paul, Holahan, Matthew R. · 2022 · Journal of Parkinson's Disease
- Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson's disease miceJiao, Lingling, Du, Xixun, Jia, Fengju, Li, Yong, Zhu, Dexiao, Tang, Tinging, Jiao, Qian, Jiang, Hong · 2021 · Neurobiology of Aging
- Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosomeIqbal, Anila, Baldrighi, Marta, Murdoch, Jennifer N., Fleming, Angeleen, Wilkinson, Christopher J. · 2020 · Biology Open
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- Neuropathology of dementiaKim, Eun-Joo, Vatsavayai, Sarat, Seeley, William W. · 2016 · The Behavioral Neurology of Dementia
- Human iPSC Models in Drug Discovery: Opportunities and ChallengesSilva, M.C., Cross, A., Brandon, N.J., Haggarty, S.J. · 2017 · Comprehensive Medicinal Chemistry III
- The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseasesLane-Donovan, Courtney, Paredes, Mercedes, Kao, Aimee W. · 2025 · Progress in Neurobiology