The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Abstract
Deletion of the promoter and the first exon of the DNA polymerase β gene (pol β) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Self-citation
Cited by
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Self-citationConditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Self-citationMitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280
Krokan, H. E., & Bjoras, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012583 · Cited by 1,322
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Self-citationTie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Huh, C.-G., Factor, V. M., Sánchez, A., Uchida, K., Conner, E. A., & Thorgeirsson, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306068101 · Cited by 750
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform
Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P., & Conneely, O. M. (2000) · Science · doi:10.1126/science.289.5485.1751 · Cited by 704
Lange, S. S., Takata, K.-I., & Wood, R. D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2998 · Cited by 615
Genomic views of distant-acting enhancers
Visel, A., Rubin, E. M., & Pennacchio, L. A. (2009) · Nature · doi:10.1038/nature08451 · Cited by 610
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570
The transcriptional control of hematopoiesis [see comments]
Shivdasani, R., & Orkin, S. (1996) · Blood · doi:10.1182/blood.v87.10.4025.bloodjournal87104025 · Cited by 560
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
Gu, Y., Filippi, M.-D., Cancelas, J. A., Siefring, J. E., Williams, E. P., Jasti, A. C., Harris, C. E., Lee, A. W., Prabhakar, R., Atkinson, S. J., et al. (2003) · Science · doi:10.1126/science.1088485 · Cited by 510
Mikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y., & Orkin, S. H. (2003) · Nature · doi:10.1038/nature01345 · Cited by 371
Rajewsky, K., Gu, H., Kühn, R., Betz, U. A., Müller, W., Roes, J., & Schwenk, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118828 · Cited by 361
Self-citationReardon, J. T., Bessho, T., Kung, H. C., Bolton, P. H., & Sancar, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9463 · Cited by 366
DNA methylation represses transcription in vivo
Siegfried, Z., Eden, S., Mendelsohn, M., Feng, X., Tsuberi, B.-Z., & Cedar, H. (1999) · Nature Genetics · doi:10.1038/9727 · Cited by 354
Base excision repair and cancer
Wallace, S. S., Murphy, D. L., & Sweasy, J. B. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.038 · Cited by 329
Alonzi, T., Maritano, D., Gorgoni, B., Rizzuto, G., Libert, C., & Poli, V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1621-1632.2001 · Cited by 329
FORTINI, P., & DOGLIOTTI, E. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.10.008 · Cited by 318
Kimura, Y., Okamura, Y., & Higashijima, S.-I. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4993-05.2006 · Cited by 302
“To obtain isolated labeling in transgenic fish for morphological analysis, we used the Cre/loxP recombination system (Gu et al., 1994).”
MethodChen, C., & Tonegawa, S. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.157 · Cited by 300
Molecular Mechanisms of DNA Damage and Repair: Progress in Plants
Tuteja, N., Singh, M. B., Misra, M. K., Bhalla, P. L., & Tuteja, R. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074219 · Cited by 272
Bebenek, K., & Kunkel, T. A. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69005-x · Cited by 258
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B., Förster, I., Habenicht, A. J. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28034 · Cited by 252
Somatic mutations and aging: a re-evaluation
Vijg, J. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00202-x · Cited by 243
Txnip balances metabolic and growth signaling via PTEN disulfide reduction
Hui, S. T. Y., Andres, A. M., Miller, A. K., Spann, N. J., Potter, D. W., Post, N. M., Chen, A. Z., Sachithanantham, S., Jung, D. Y., Kim, J. K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800293105 · Cited by 214
Historical origins of transdifferentiation and reprogramming
Graf, T. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.012 · Cited by 194
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport
Morris, S. M., Tallquist, M. D., Rock, C. O., & Cooper, J. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1555 · Cited by 186
Thiel, M., Caldwell, C. C., Kreth, S., Kuboki, S., Chen, P., Smith, P., Ohta, A., Lentsch, A. B., Lukashev, D., & Sitkovsky, M. V. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000853 · Cited by 175
Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172
Cre‐lox P‐Mediated Recombination: General Principles and Experimental Considerations
McLellan, M. A., Rosenthal, N. A., & Pinto, A. R. (2017) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.22 · Cited by 172
E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
Young, P., Boussadia, O., Halfter, H., Grose, R., Berger, P., Leone, D. P., Robenek, H., Charnay, P., Kemler, R., & Suter, U. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg560 · Cited by 156
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases
Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S., & Szczesny, B. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.01.005 · Cited by 141
DNA Oxidation and Excision Repair Pathways
Lee, T.-H., & Kang, T.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236092 · Cited by 116
Site-Specific Recombinases for Manipulation of the Mouse Genome
Birling, M.-C., Gofflot, F., & Warot, X. (2009) · Methods in Molecular Biology · doi:10.1007/978-1-60327-019-9_16 · Cited by 106
DNA polymerases and human diseases
Sweasy, J. B., Lauper, J. M., & Eckert, K. A. (2006) · Radiation Research · doi:10.1667/rr0706.1 · Cited by 93
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance
Humble, M. M., Young, M. J., Foley, J. F., Pandiri, A. R., Travlos, G. S., & Copeland, W. C. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds506 · Cited by 78
Whole-rat conditional gene knockout via genome editing
Brown, A. J., Fisher, D. A., Kouranova, E., McCoy, A., Forbes, K., Wu, Y., Henry, R., Ji, D., Chambers, A., Warren, J., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2516 · Cited by 77
Nelson, R. J., & Chiavegatto, S. (2000) · ILAR Journal · doi:10.1093/ilar.41.3.153 · Cited by 46
Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish
Shin, M., Yin, H.-M., Shih, Y.-H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.07.022 · Cited by 28
CYTOCHROME P450 KNOCKOUT MICE: NEW TOXICOLOGICAL MODELS
McKinnon, R. A., & Nebert, D. W. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02153.x · Cited by 22
Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia
Mroue-Ruiz, F. H., Desai, B., Garvin, M. M., Shehu, J. H., Kamau, F., Kar, U., & Bolton, J. L. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153657 · Cited by 3
Metadata
- Authors
- Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K.
- Venue
- Science
- Published
- 1994-07
- Volume
- 265
- Issue
- 5168
- Pages
- 103-106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048139403
- Cited by
- 1,397
- References
- 1
- FWCI
- 28.43
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
