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Explosion in the complexity of membrane protein recycling
Abstract
For decades, recycling of membrane proteins has been represented in figures by arrows between the “endosome” and the plasma membrane, but recently there has been an explosion in the understanding of the mechanisms and protein complexes required to facilitate protein recycling. Here, some key discoveries will be introduced, including assigning function to a number of recently recognized protein complexes and linking their function to protein recycling. Furthermore, the importance of lipid interactions and links to diseases and epithelial polarity will be summarized.
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Recycling of internalized membrane proteins back to the cell surface is achieved by at least two distinct pathways, the SNX27-Retromer and SNX17-Retriever pathways.
“In recent years, it has become clear that recycling of internalized membrane proteins back to the cell surface is achieved by at least 2 distinct pathways – the SNX27-Retromer and SNX17-Retriever pathways (McNally et al., 2017; Chen et al., 2019; McDonald, 2020).”
From Dual endomembrane recycling pathways function in parallel to support synapse maintenance and plasticity (2025) · cites this paper as McDonald, 2020
Disruptions in protein recycling impair synaptic plasticity and have been linked to neurodevelopmental and neurodegenerative disorders.
“Disruptions in protein recycling impair synaptic plasticity and have been linked to neurodevelopmental and neurodegenerative disorders”
From Dual endomembrane recycling pathways function in parallel to support synapse maintenance and plasticity (2025) · cites this paper as McDonald, 2020
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Metadata
- Authors
- McDonald, F. J.
- Affiliations
- Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
- ORCID
- McDonald, Fiona J.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2021-04-01
- Volume
- 320
- Issue
- 4
- Pages
- C483-C494
- ISSN
- 0363-6143
- 1522-1563
- Cited by
- 13
- References
- 12
- Language
- en
- Funders
- Lottery Health New Zealand (LHR-2016-26783)
- University of Otago Research Grant (2015, 2013)
- Department of Physiology, University of Otago
- Royal Society of New Zealand | Marsden Fund (U00-04-01, 02_UOA_128)
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