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Cited by 264

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Invited Review: Intracellular signaling in contracting skeletal muscle

Sakamoto, Kei, Goodyear, Laurie J.·2002·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00167.2002
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Abstract

Physical exercise is a significant stimulus for the regulation of multiple metabolic and transcriptional processes in skeletal muscle. For example, exercise increases skeletal muscle glucose uptake, and, after exercise, there are increases in the rates of both glucose uptake and glycogen synthesis. A single bout of exercise can also induce transient changes in skeletal muscle gene transcription and can alter rates of protein metabolism, both of which may be mechanisms for chronic adaptations to repeated bouts of exercise. A central issue in exercise biology is to elucidate the underlying molecular signaling mechanisms that regulate these important metabolic and transcriptional events in skeletal muscle. In this review, we summarize research from the past several years that has demonstrated that physical exercise can regulate multiple intracellular signaling cascades in skeletal muscle. It is now well established that physical exercise or muscle contractile activity can activate three of the mitogen-activated protein kinase signaling pathways, including the extracellular signal-regulated kinase 1 and 2, the c-Jun NH 2-terminal kinase, and the p38. Exercise can also robustly increase activity of the AMP-activated protein kinase, as well as several additional molecules, including glycogen synthase kinase 3, Akt, and the p70 S6 kinase. A fundamental goal of signaling research is to determine the biological consequences of exercise-induced signaling through these molecules, and this review also provides an update of progress in this area.

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Metadata

Authors
Sakamoto, K., & Goodyear, L. J.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2002-07-01
Volume
93
Issue
1
Pages
369-383
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00167.2002
OpenAlex
W2157054897
Cited by
264
References
157
FWCI
6.16
Type
journal article
Language
en
Open access
closed

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