Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508

The Pathobiology of Diabetic Complications

Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525

Dynamics of fat cell turnover in humans

Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

PPARγ signaling and metabolism: the good, the bad and the future

Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016

Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · cited 1×

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

Inoguchi, T., Li, P., Umeda, F., Yu, H. Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1939 · Cited by 1,577

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484

Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482

Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406

Obesity and Systemic Oxidative Stress: Clinical Correlates of Oxidative Stress in The Framingham Study

Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1×

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253

Reactive oxygen species in cancer cells: Live by the sword, die by the sword

Schumacker, P. T. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.015 · Cited by 1,242

The FoxO code

Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170

Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Ishii, H., Jirousek, M. R., Koya, D., Takagi, C., Xia, P., Clermont, A. C., Bursell, S., Kern, T. S., Ballas, L. M., Heath, W. F., et al. (1996) · Science · doi:10.1126/science.272.5262.728 · Cited by 1,103

Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training

Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.001 · Cited by 1,020

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

Geraldes, P., & King, G. L. (2010) · Circulation Research · doi:10.1161/circresaha.110.217117 · Cited by 1,019

Novel insights of dietary polyphenols and obesity

Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 925

Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907

Oxidative stress and metabolic syndrome

Roberts, C. K., & Sindhu, K. K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.026 · Cited by 883

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

Du, X., Matsumura, T., Edelstein, D., Rossetti, L., Zsengellér, Z. K., Szabó, C., & Brownlee, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18127 · Cited by 843

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 816

Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint

Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 797

Cross talk between mitochondria and NADPH oxidases

Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 770

The phagocytes: neutrophils and monocytes

Dale, D. C., Boxer, L. A., & Liles, W. C. (2008) · Blood · doi:10.1182/blood-2007-12-077917 · Cited by 769

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Vincent, H. K., & Taylor, A. G. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803177 · Cited by 752

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 745

Extending life span by increasing oxidative stress

Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 737

Adipocytokines in Obesity and Metabolic Disease

Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692

T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692

Influence of body fat distribution on free fatty acid metabolism in obesity.

Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683

Leptin induces oxidative stress in human endothelial cells

Bouloumié, A., Marumo, T., Lafontan, M., & Busse, R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1231 · Cited by 679

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

Tormos, K. V., Ansó, E., Hamanaka, R. B., Eisenbart, J. D., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 676

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 622

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · cited 1×

Omega-3 Fatty Acids and Cardiovascular Disease

Kris‐Etherton, P. M., Harris, W. S., & Appel, L. J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057393.97337.ae · Cited by 597

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100966 · Cited by 585

Reactive oxygen species enhance insulin sensitivity

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581

Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins

González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 567

AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept

Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 554

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 550

Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State

Savini, I., Catani, M. V., Evangelista, D., Gasperi, V., & Avigliano, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510497 · Cited by 527

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

Dray, C., Knauf, C., Daviaud, D., Waget, A., Boucher, J., Buléon, M., Cani, P. D., Attané, C., Guigné, C., Carpéné, C., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.003 · Cited by 522

Redox signaling in macrophages

Forman, H. J. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00010-3 · Cited by 521

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., & Goldstein, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1844-1854.2004 · Cited by 520

The Hyperglycemia-induced Inflammatory Response in Adipocytes

Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K. T., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411863200 · Cited by 507

Periadventitial fat releases a vascular relaxing factor

Löhn, M., Dubrovska, G., Lauterbach, B., Luft, F. C., Gollasch, M., & Sharma, A. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0024com · Cited by 474

Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats

Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M. (2008) · Obesity · doi:10.1038/oby.2008.315 · Cited by 473

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459

Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress

Tao, L., Gao, E., Jiao, X., Yuan, Y., Li, S., Christopher, T. A., Lopez, B. L., Koch, W. J., Chan, L., Goldstein, B. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.666941 · Cited by 452

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433

Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion

Lee, H., Lee, Y. J., Choi, H., Ko, E. H., & Kim, J. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808742200 · Cited by 428

The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome?

Engeli, S., Schling, P., Gorzelniak, K., Boschmann, M., Janke, J., Ailhaud, G. P., Teboul, M., Massiéra, F., & Sharma, A. M. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00311-4 · Cited by 416

Vascular NADPH oxidases: molecular mechanisms of activation

Brandes, R. P., & Kreuzer, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.007 · Cited by 411

Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

Gabbay, K. H., MEROLA, L. O., & Field, R. A. (1966) · Science · doi:10.1126/science.151.3707.209 · Cited by 400

The Suppressive Effect of Dietary Restriction and Weight Loss in the Obese on the Generation of Reactive Oxygen Species by Leukocytes, Lipid Peroxidation, and Protein Carbonylation

Dandona, P., Mohanty, P., Ghanim, H., Aljada, A., Browne, R. W., Hamouda, W., Prabhala, A., Afzal, A., & Garg, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7150 · Cited by 397

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391

Vitamin D3 in fat tissue

Blum, M., Dolnikowski, G. G., Seyoum, E., Harris, S. S., Booth, S. L., Peterson, J., Saltzman, E. J., & Dawson‐Hughes, B. (2008) · Endocrine · doi:10.1007/s12020-008-9051-4 · Cited by 366

Effect of fatty acids on energy coupling processes in mitochondria

Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363

Effects of Exercise Training on Glucose Homeostasis

Boulé, N. G., Weisnagel, S. J., Lakka, T. A., Tremblay, A., Bergman, R. N., Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.108 · Cited by 356

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., Agrawal, R., Zheng, L., Leeper, N. J., Pearl, N., Patterson, A. J., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34871 · Cited by 332

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329

Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.

Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., & Kelley, D. E. (2007) · Diabetes · doi:10.2337/db07-0141 · Cited by 321

Mitochondria and Reactive Oxygen Species

Addabbo, F., Montagnani, M., & Goligorsky, M. S. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130054 · Cited by 302

Hydrogen Peroxide Generated during Cellular Insulin Stimulation Is Integral to Activation of the Distal Insulin Signaling Cascade in 3T3-L1 Adipocytes

Mahadev, K., Wu, X., Zilbering, A., Zhu, L., Lawrence, J. T. R., & Goldstein, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105061200 · Cited by 298

Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome

Fujita, K., Nishizawa, H., Funahashi, T., Shimomura, I., & Shimabukuro, M. (2006) · Circulation Journal · doi:10.1253/circj.70.1437 · Cited by 291

Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’

Lundgren, M., Svensson, M. K. E., Lindmark, S., Renström, F., Ruge, T., & Eriksson, J. W. (2007) · Diabetologia · doi:10.1007/s00125-006-0572-1 · Cited by 283

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 278

Carotenoids in Human Blood and Tissues

Parker, R. S. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.101 · Cited by 276

Physical Activity and Insulin Sensitivity

Balkau, B., Mhamdi, L., Oppert, J., Nolan, J. J., Golay, A., Porcellati, F., Laakso, M., Ferrannini, E., & on behalf of the EGIR-RISC Study Group (2008) · Diabetes · doi:10.2337/db07-1605 · Cited by 276

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

Schröder, K., Wandzioch, K., Helmcke, I., & Brandes, R. P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.174219 · Cited by 264

Adiponectin, driver or passenger on the road to insulin sensitivity?

Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251

Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes

Han, C. Y., Kargi, A. Y., Omer, M., Chan, C. K., Wabitsch, M., O’Brien, K. D., Wight, T. N., & Chait, A. (2009) · Diabetes · doi:10.2337/db09-0925 · Cited by 250

Carbonylation of Adipose Proteins in Obesity and Insulin Resistance

Grimsrud, P. A., Picklo, M. J., Griffin, T. J., & Bernlohr, D. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600120-mcp200 · Cited by 249

Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells

May, J. M., & de Haën, C. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30209-0 · Cited by 231

Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells

Kanda, Y., Hinata, T., Kang, S. W., & Watanabe, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.06.007 · Cited by 231

Differentiation of Human Adipose-Derived Stem Cells into Fat Involves Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of Antioxidant Enzymes

Higuchi, M., Dusting, G. J., Peshavariya, H., Jiang, F., Hsiao, S. T.-F., Chan, E. C., & Liu, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0306 · Cited by 231

Mitochondrial Reactive Oxygen Species Control the Transcription Factor CHOP-10/GADD153 and Adipocyte Differentiation

Carrière, A., Carmona, M.-C., Fernandez, Y., Rigoulet, M., Wenger, R. H., Pénicaud, L., & Casteilla, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407258200 · Cited by 230

Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation

Cordeiro, R. M. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.09.016 · Cited by 228

Molecular mechanisms of the cardiovascular protective effects of polyphenols

Andriantsitohaina, R., Auger, C., Chataigneau, T., Étienne-Selloum, N., Li, H., Martínez, M. C., Schini‐Kerth, V. B., & Laher, I. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003406 · Cited by 224

Local adipose tissue renin-angiotensin system

Cassis, L. A., Police, S. B., Yiannikouris, F. B., & Thatcher, S. E. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0019-9 · Cited by 224

Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells.

Kôno, T., Robinson, F. W., Blevins, T. L., & Ezaki, O. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33914-0 · Cited by 215

Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

Curtis, J., Grimsrud, P. A., Hahn, W. S., Xu, X. M., Foncea, R. E., Graham, D. W., Brestoff, J. R., Wiczer, B. M., Ilkayeva, O., Cianflone, K., et al. (2010) · Diabetes · doi:10.2337/db09-1105 · Cited by 211

Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice

Ketonen, J., Jin, S., Martonen, E., & Mervaala, E. M. A. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0661 · Cited by 209

Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes

Gao, C., Zhu, C., Zhao, Y., Chen, X.-H., Ji, C., Zhang, C., Zhu, J., Xia, Z., Tong, M., & Guo, X. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.039 · Cited by 209

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

Czech, M., Lawrence, J. C., & Lynn, W. S. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.10.4173 · Cited by 208

Reactive oxygen species are downstream products of TRAF-mediated signal transduction

Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103074200 · Cited by 203

Gut metabotypes govern health effects of dietary polyphenols

Bolca, S., de Wiele, T. V., & Possemiers, S. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.09.009 · Cited by 201

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

Du, X., Matsumura, T., Edelstein, D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318127 · Cited by 200

The implication of obesity on total antioxidant capacity in apparently healthy men and women: The ATTICA study

Chrysohoou, C., Panagiotakos, D. B., Pitsavos, C., Skoumas, I., Papademetriou, L., Economou, M., & Stefanadis, C. (2007) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.007 · Cited by 199

Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes

Soares, A. F., Guichardant, M., Cozzone, D., Bernoud‐Hubac, N., Bouzaïdi-Tiali, N., Lagarde, M., & Géloën, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.010 · Cited by 198

Comparison of serum concentrations of α-tocopherol and β-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)

Strauss, R. S. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70409-9 · Cited by 198

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

Fischer-Posovszky, P., Kukulus, V., Tews, D., Unterkircher, T., Debatin, K.-M., Fulda, S., & Wabitsch, M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28435 · Cited by 195

alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.

Konrad, T., Vicini, P., Kusterer, K., Höflich, A., Assadkhani, A., Böhles, H. J., Sewell, A., Tritschler, H., Cobelli, C., & Usadel, K. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.280 · Cited by 189

Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes

Rudich, A., Kozlovsky, N., Potashnik, R., & Bashan, N. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.5.e935 · Cited by 188

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

Han, C. Y., Umemoto, T., Omer, M., Den Hartigh, L. J., Chiba, T., LeBoeuf, R., Buller, C. L., Sweet, I. R., Pennathur, S., Abel, E. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304998 · Cited by 187

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

Spencer, M. L., Finlin, B. S., Ünal, R., Zhu, B., Morris, A. J., Shipp, L. R., Lee, J. D., Walton, R. G., Adu, A. K., Erfani, R. A., et al. (2013) · Diabetes · doi:10.2337/db12-1042 · Cited by 186

Signaling Pathways Involved in Human Vascular Smooth Muscle Cell Proliferation and Matrix Metalloproteinase-2 Expression Induced by Leptin

Li, L., Mamputu, J., Wiernsperger, N. F., & Renier, G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2227 · Cited by 185

Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue

Koenen, T. B., Stienstra, R., van Tits, L. J., Graaf, J. D., Stalenhoef, A. F. H., Joosten, L. A. B., Tack, C. J., & Netea, M. G. (2011) · Diabetes · doi:10.2337/db10-0266 · Cited by 175

Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms

Yue, P., Jin, H. H., Xu, S., Aillaud, M., Deng, A. C., Azuma, J., Kundu, R. K., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2010) · Endocrinology · doi:10.1210/en.2010-0576 · Cited by 171

Necrosis of the Anterior Pituitary and Zona Glomerulosa of the Adrenal

Bradley, R. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90874-8 · Cited by 170

Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity

Li, R., Wang, W., Zhang, H., Yang, X., Fan, Q., Christopher, T. A., Lopez, B. L., Tao, L., Goldstein, B. J., Gao, F., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00462.2007 · Cited by 169

Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia

Bełtowski, J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00236-3 · Cited by 168

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166

Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation

Kurata, A., Nishizawa, H., Kihara, S., Maeda, N., Sonoda, M., Okada, T., Ohashi, K., Hibuse, T., Fujita, K., Yasui, A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001810 · Cited by 166

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

Wang, C., Wang, C., Huang, H., & Wei, Y. (2013) · The FEBS Journal · doi:10.1111/febs.12096 · Cited by 165

Serum Concentrations of Retinol, α-Tocopherol and the Carotenoids Are Influenced by Diet, Race and Obesity in a Sample of Healthy Adolescents

Neuhouser, M. L., Rock, C. L., Eldridge, A. L., Kristal, A. R., Patterson, R. E., Cooper, D. A., Neumark‐Sztainer, D., Cheskin, L. J., & Thornquist, M. D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2184 · Cited by 164

Plasma free fatty acid turnover rate in obesity

Björntorp, P., Bergman, H., & Varnauskas, E. (1969) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1969.tb07347.x · Cited by 161

The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress

Pillon, N. J., Croze, M. L., Vella, R., Soulère, L., Lagarde, M., & Soulage, C. O. (2012) · Endocrinology · doi:10.1210/en.2011-1957 · Cited by 157

Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons

Zeng, X. J., Yu, S. P., Zhang, L., & Wei, L. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.005 · Cited by 156

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

Hayes, G. R., & Lockwood, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.8115 · Cited by 155

Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2

Krieger‐Brauer, H. I., Medda, P. K., & KATHER, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10135 · Cited by 152

Activation of catalase by apelin prevents oxidative stress‐linked cardiac hypertrophy

Foussal, C., Lairez, O., Calise, D., Pathak, A., Guilbeau‐Frugier, C., Valet, P., Parini, A., & Kunduzova, O. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.025 · Cited by 151

Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans

Elizalde, M., Rydén, M., van Harmelen, V., Eneroth, P. H. E., Gyllenhammar, H., Holm, C., Ramel, S., Ölund, A., Arner, P., & Andersson, K. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33432-5 · Cited by 150

Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo

Uchiyama, S., Taniguchi, Y., Saka, A., Yoshida, A., & Yajima, H. (2010) · Nutrition · doi:10.1016/j.nut.2010.01.019 · Cited by 148

The Metabolism of Tritiated Glucose by Rat Adipose Tissue

Katz, J. J., & Rognstad, R. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99873-x · Cited by 140

Relationship of oxidative stress with obesity and its role in obesity induced metabolic syndrome.

Sankhla, M., Sharma, T. K., Mathur, K., Rathor, J. S., Butolia, V., Gadhok, A. K., Vardey, S. K., Sinha, M., & Kaushik, G. G. (2012) · PubMed · Cited by 131

Lipophilic Micronutrients and Adipose Tissue Biology

Landrier, J., Marcotorchino, J., & Tourniaire, F. (2012) · Nutrients · doi:10.3390/nu4111622 · Cited by 129

Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C

Maingrette, F., & Renier, G. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2121 · Cited by 124

Regulation of the nitric oxide system in human adipose tissue

Engeli, S., Janke, J., Gorzelniak, K., Böhnke, J., Ghose, N., Lindschau, C., Luft, F. C., & Sharma, A. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300322-jlr200 · Cited by 123

Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance

Murdolo, G., Piroddi, M., Luchetti, F., Tortoioli, C., Canonico, B., Zerbinati, C., Galli, F., & Iuliano, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.12.014 · Cited by 122

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

Stern, J., Hollander, N., Batchelor, B., Cohn, C., & Hirsch, J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92474-9 · Cited by 122

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK

Archuleta, T. L., Lemieux, A. M., Saengsirisuwan, V., Teachey, M. K., Lindborg, K. A., Kim, J. S., & Henriksen, E. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.014 · Cited by 122

PKC-δ-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase

Talior, I., Tennenbaum, T., Kuroki, T., & Eldar-Finkelman, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00378.2004 · Cited by 120

Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes

Wang, C., Ching-chū, W., & Wei, Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05625.x · Cited by 120

Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways

Than, A., Cheng, Y., Foh, L.-C., Leow, M. K., Lim, S. C., Chuah, Y. J., Kang, Y., & Chen, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.07.002 · Cited by 120

Differential Expression of Oxidative Stress and Inflammation Related Genes in Peripheral Blood Mononuclear Cells in Response to a Low-Calorie Diet: A Nutrigenomics Study

Crujeiras, A. B., Parra, D., Milagro, F. I., Goyenechea, E., Larrarte, E., Margareto, J., & Martínez, J. A. (2008) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0001 · Cited by 119

Identification and pharmacological properties of E339–3D6, the first nonpeptidic apelin receptor agonist

Iturrioz, X., Alvear‐Perez, R., Mota, N. D., Franchet, C., Guillier, F., Leroux, V., Dabiré, H., Jouan, M. L., Chabane, H., Gerbier, R., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-140715 · Cited by 112

Red Wine Polyphenols Prevent Metabolic and Cardiovascular Alterations Associated with Obesity in Zucker Fatty Rats (Fa/Fa)

Agouni, A., Lagrue-Lak-Hal, A.-H., Mostefai, H. A., Tesse, A., Mulder, P. G. H., Rouet, P., Desmoulin, F., Heymes, C., Martínez, M. C., & Andriantsitohaina, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005557 · Cited by 111

Enhanced Sensitivity of Insulin-resistant Adipocytes to Vanadate Is Associated with Oxidative Stress and Decreased Reduction of Vanadate (+5) to Vanadyl (+4)

Lu, B., Ennis, D., Lai, R., Bogdanovic, E., Nikolov, R., Salamon, L., Fantus, C., Le‐Tien, H., & Fantus, I. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106783200 · Cited by 105

Adipose Tissue Proadipogenic Redox Changes in Obesity

Galinier, A., Carrière, A., Fernandez, Y., Carpéné, C., André, M., Caspar‐Bauguil, S., Thouvenot, J.-P., Périquet, B., Pénicaud, L., & Casteilla, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506949200 · Cited by 104

Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway

Tian, C., Ye, X., Zhang, R., Long, J., Ren, W., Ding, S., Liao, D., Jin, X., Wu, H., Shun-qin, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053796 · Cited by 102

Tocopherol distribution and intracellular localization in human adipose tissue

Traber, M. G., & Kayden, H. J. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.3.488 · Cited by 101

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

Demozay, D., Mas, J.-C., Rocchi, S., & OBBERGHEN, E. V. (2008) · Diabetes · doi:10.2337/db07-0389 · Cited by 101

Meta‐analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma

Bjelaković, G., Nagorni, A. V., Nikolova, D., Simonetti, R. G., Bjelaković, M., & Gluud, C. N. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02970.x · Cited by 100

Health Effects of Mixed Fruit and Vegetable Concentrates: A Systematic Review of the Clinical Interventions

Esfahani, A., Wong, J. M., Truan, J., Villa, C., Mirrahimi, A., Srichaikul, K., & Kendall, C. W. C. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10719971 · Cited by 97

Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics

Paolisso, G., di Maro, G., Pizza, G., D’Amore, A., Sgambato, S., Tesauro, P., Varricchio, M., & D'Onofrio, F. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.3.e435 · Cited by 97

Mammalian Antioxidant Defenses Are Not Inducible by H2O2

Desaint, S., Luriau, S., Aude, J.-C., Rousselet, G., & Tolédano, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401888200 · Cited by 96

Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes

楠知里, Liu, Y., Yoshizaki, T., Nakagawa, F., Ishikado, A., Kondo, M., Morino, K., Sekine, O., Ugi, S., Nishio, Y., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.115 · Cited by 95

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

Du, X. L., Edelstein, D., Dimmeler, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111235 · Cited by 91

Inhibition of Glucose-Induced Insulin Secretion by 4-Hydroxy-2-Nonenal and Other Lipid Peroxidation Products1

Miwa, I., Ichimura, N., Sugiura, M., Hamada, Y., & Taniguchi, S. (2000) · Endocrinology · doi:10.1210/endo.141.8.7614 · Cited by 87

Blood vitamin and lipid levels in overweight and obese women.

de Burgos, A. M., Wartanowicz, M., & Ziemlański, Ś. (1992) · PubMed · Cited by 85

Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation

Zhang, Y., & Chen, X. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2010 · Cited by 84

High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner

Long, E. K., Olson, D. M., & Bernlohr, D. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.030 · Cited by 83

Periadventitial adipose tissue impairs coronary endothelial function via PKC-β-dependent phosphorylation of nitric oxide synthase

Payne, G. A., Bohlen, H. G., Dinçer, Ü. D., Borbouse, L., & Tune, J. D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00116.2009 · Cited by 80

Skeletal Muscle Lipid Peroxidation and Insulin Resistance in Humans

Ingram, K. H., Hill, H. S., Moellering, D. R., Hill, B. G., Lara‐Castro, C., Newcomer, B. R., Brandon, L. J., Ingalls, C. P., Penumetcha, M., Rupp, J. C., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2963 · Cited by 77

The lipid peroxidation end‐product 4‐HNE induces COX‐2 expression through p38MAPK activation in 3T3‐L1 adipose cell

Zarrouki, B., Soares, A. F., Guichardant, M., Lagarde, M., & Géloën, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.048 · Cited by 76

Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin.

Little, S. A., & de Haën, C. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70390-1 · Cited by 74

Evaluation of antioxidant properties of major dietary polyphenols and their protective effect on 3T3-L1 preadipocytes and red blood cells exposed to oxidative stress

Hatia, S., Septembre‐Malaterre, A., Sage, F. L., Badiou, A., Baret, P., Payet, B., d’Hellencourt, C. L., & Gonthier, M. (2014) · Free Radical Research · doi:10.3109/10715762.2013.879985 · Cited by 70

Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells

Volk, T. J., Hensel, M., Schuster, H., & Kox, W. J. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007059616914 · Cited by 69

The in vitro oxidizability of lipoprotein particles in obese and non-obese subjects

Gaal, L. F. V., Vertommen, J., & Leeuw, I. H. D. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00316-x · Cited by 62

Involvement of Oxidative Stress and the JNK Pathway in Glucose Toxicity

Kaneto, H., Nakatani, Y., Kawamori, D., Miyatsuka, T., & Matsuoka, T. (2004) · The Review of Diabetic Studies · doi:10.1900/rds.2004.1.165 · Cited by 61

Modulation of lipid metabolism by polyphenol‐rich grape skin extract improves liver steatosis and adiposity in high fat fed mice

Park, H., Jung, U. J., Lee, M., Cho, S., Jung, H., Hong, J. H., Park, Y. B., Kim, S. R., Shim, S., Jung, J., et al. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200447 · Cited by 61

Glutathionylated Lipid Aldehydes Are Products of Adipocyte Oxidative Stress and Activators of Macrophage Inflammation

Frohnert, B. I., Long, E. K., Hahn, W. S., & Bernlohr, D. A. (2014) · Diabetes · doi:10.2337/db13-0777 · Cited by 60 · cited 1×

Antioxidant Vitamin Levels in Plasma and Low Density Lipoprotein of Obese Girls

Kljno, T., Hozumi, M., Morinobu, T., Murata, T., Mingci, Z., & Tamai, H. (1998) · Free Radical Research · doi:10.3109/10715769809097878 · Cited by 59

Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes

Zhang, X., Wang, Z., Li, J., Gu, D., Li, S., Shen, C., & Song, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070663 · Cited by 58

Adipose tissue expandability, lipotoxicity and the metabolic syndrome

Vidal‐Puig, A. (2013) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(13)70026-3 · Cited by 54

Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased

Frayn, K. N., Langin, D., & Karpe, F. (2008) · Diabetologia · doi:10.1007/s00125-007-0901-z · Cited by 54

Blockade of the Renin-Angiotensin System Ameliorates Apelin Production in 3T3-L1 Adipocytes

Hung, W., Hsieh, T., Lin, T. H., Chou, P.-C., Hsiao, P., Lin, K., & Shin, S. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6274-4 · Cited by 50

n-3 fatty acids modulate adipose tissue inflammation and oxidative stress

Fan, C., Zirpoli, H., & Qi, K. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835c02c8 · Cited by 50

Hormesis in Aging and Neurodegeneration—A Prodigy Awaiting Dissection

Mao, L., & Franke, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140713109 · Cited by 47

Eicosapentaenoic acid up‐regulates apelin secretion and gene expression in 3T3‐L1 adipocytes

Lorente‐Cebrián, S., Bustos, M., Martí, A., Martínez, J. A., & Moreno-Aliaga, M. J. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900522 · Cited by 45

Transcriptome-based identification of antioxidative gene expression after fish oil supplementation in normo- and dyslipidemic men

Schmidt, S., Stahl, F., Mutz, K., Scheper, T., Hahn, A., & Schuchardt, J. (2012) · Nutrition and Metabolism · doi:10.1186/1743-7075-9-45 · Cited by 45

Alteration of Amine Oxidase Activity in the Adipose Tissue of Obese Subjects

Visentin, V., Prévot, D., Front, V. D. D. S., Morin‐Cussac, N., Thalamas, C., Galitzky, J., Valet, P., Zorzano, A., & Carpéné, C. (2004) · Obesity Research · doi:10.1038/oby.2004.62 · Cited by 43

Systems biology of antioxidants

Andriantsitohaina, R., Duluc, L., Rodríguez, J., del Valle, L. G., Guevara-García, M., Simard, G., Soleti, R., Su, D., Velázquez‐Pérez, L., Wilson, J. X., et al. (2012) · Clinical Science · doi:10.1042/cs20110643 · Cited by 42

Site specific changes of redox metabolism in adipose tissue of obese Zucker rats

Galinier, A., Carrière, A., Fernandez, Y., Caspar‐Bauguil, S., Périquet, B., Périquet, A., Pénicaud, L., & Casteilla, L. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.052 · Cited by 39

Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes

Tang, S., Le‐Tien, H., Goldstein, B. J., Shin, P., Lai, R., & Fantus, I. G. (2001) · Diabetes · doi:10.2337/diabetes.50.1.83 · Cited by 38

Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells

Perrot, V., & Rechler, M. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212750200 · Cited by 28

Diffusion of hydrogen peroxide across DPPC large unilamellar liposomes

Abuin, E., Lissi, E. A., & Ahumada, M. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.07.001 · Cited by 27

Inhibition of Glucose-Induced Insulin Secretion by 4-Hydroxy-2-Nonenal and Other Lipid Peroxidation Products

Miwa, I. (2000) · Endocrinology · doi:10.1210/en.141.8.2767 · Cited by 26

Nishikawa T, Du Edelstein DXL & Yamagishi S et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature404: 787-790

Nishikawa, T., Edelstein, D., Du, X., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D. A., Oates, P. J., Hammes, H., et al. (2000) · Cited by 23

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1

Demozay, A., Más, J. A. S., Rocchi, S., & OBBERGHEN, E. V. (2008) · Cited by 3

Oxidative stress, inflammation and treatment response in major depression

Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473

Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J. I., & Sodhi, K. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.13800 · Cited by 458

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Pérez-Torres, I., Castrejón-Téllez, V., Soto, M. E., Rubio-Ruiz, M. E., Manzano-Pech, L., & Guarner‐Lans, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041786 · Cited by 437

Nutrients and Oxidative Stress: Friend or Foe?

Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 455

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 416

Review Article Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View

Lay, S. L., Simard, G., Martínez, M. C., & Andriantsitohaina, R. (2016)

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

Matsuda, M., & Shimomura, I. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.05.004 · Cited by 651

Oxidative stress in adipose tissue as a primary link in pathogenesis of insulin resistance

Kuzmenko, D. I., Удинцев, С. Н., Klimenteva, T. K., & Serebrov, V. Y. (2016) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750816030100 · Cited by 5

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508

Oxidative stress and obesity

Malenica, M., & Meseldžić, N. (2022) · Arhiv za farmaciju · doi:10.5937/arhfarm72-36123 · Cited by 4