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Cited by 328

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women: The Women’s Health and Aging Study

Volpato, Stefano, Guralnik, Jack M., Ferrucci, Luigi, Balfour, Jennifer, Chaves, Paulo, Fried, Linda P., Harris, Tamara B.·2001·Circulation
DOI 10.1161/01.cir.103.7.947
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Abstract

Background —Systemic chronic inflammation has been found to be related to all-cause mortality risk in older persons. We investigated whether specific chronic conditions, particularly cardiovascular disease (CVD), affect the association between high interleukin (IL)-6 level and mortality in a sample of disabled older women. Methods and Results —IL-6 serum level was measured at baseline in 620 women ≥65 years old. The presence and severity of medical conditions was ascertained by standard criteria that used multiple sources of information. The sample was surveyed over the 3-year follow-up. After adjustment for potential confounders, compared with those in the lowest tertile, women in the highest IL-6 tertile were at higher risk of all-cause mortality. The presence of CVD, however, strongly affected the risk of mortality associated with high IL-6. Among women with prevalent CVD, those with high IL-6 levels had >4-fold risk of death (RR 4.6; 95% CI 2.0 to 10.5) compared with women in the lowest tertile, whereas the relative risk associated with high IL-6 among those without CVD was much lower and not significant (RR 1.8; 95% CI 0.7 to 4.2). Adjustment for all chronic diseases and disease severity measures, including ankle-brachial index, forced expiratory volume, and exercise tolerance, did not change the results. Conclusions —IL-6 level is helpful in identifying a subgroup of older CVD patients with high risk of death over a period of 3 years. Systemic inflammation, as measured by IL-6, may be related to the clinical evolution of older patients with CVD.

Overview

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Crossref · 10.1161/01.cir.103.7.947

Cites

5 of 5 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 5 references

Research works printed but not linked: 24

  1. 10.1161/circ.94.5.874 · DOI
  2. 10.1056/NEJM199408183310701 · DOI
  3. 10.1056/NEJM199704033361401 · DOI · Paper page
  4. 10.1016/S0002-9343(99)00066-2 · DOI · Paper page
  5. 10.1161/atvb.19.12.3071 · DOI
  6. 10.1161/atvb.20.4.1047 · DOI
  7. 10.2165/00002512-199405050-00005 · DOI
  8. 10.1161/circ.100.8.793 · DOI
  9. 10.1016/S0735-1097(99)00432-5 · DOI
  10. 10.1161/circ.99.16.2079 · DOI
  11. 10.1016/S0002-9149(98)00872-8 · DOI
  12. Guralnik JM Fried LP Simonsick EM et al eds. The Women’s Health and Aging Study. Health and Social Characteristics of Older Women with Disability. Bethesda MD: National Institute on Aging; 1995: NIH publication No. 95-4009. · DOI
  13. 10.1161/circ.88.3.8353913 · DOI
  14. 10.1161/circ.64.6.7296795 · DOI
  15. 10.1093/ajcn/53.4.839 · DOI
  16. 10.1016/S0065-2776(08)60379-X · DOI
  17. 10.1182/blood.V82.2.513.513 · DOI
  18. 10.1161/01.CIR.89.1.36 · DOI
  19. 10.1161/circ.99.24.3103 · DOI
  20. 10.1016/S0735-1097(97)00494-4 · DOI
  21. 10.1126/science.1631560 · DOI
  22. 10.1016/S0002-8703(98)70080-8 · DOI
  23. 10.1093/oxfordjournals.aje.a008963 · DOI
  24. 10.1161/atvb.17.10.2167 · DOI

Cited by

Metadata

Authors
Volpato, S., Guralnik, J. M., Ferrucci, L., Balfour, J., Chaves, P., Fried, L. P., & Harris, T. B.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-02-20
Volume
103
Issue
7
Pages
947-953
ISSN
  • 0009-7322
  • 1524-4539
DOI
10.1161/01.cir.103.7.947
Cited by
328
References
5
Language
en

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