Cited by 455Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

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Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk

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Chia, Chee W., Egan, Josephine M., Ferrucci, Luigi·2018·Circulation Research

DOI 10.1161/circresaha.118.312806PMC PMC6205735

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Abstract

Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in life expectancy with a simultaneous increase in the prevalence of diabetes mellitus in the older population. This large number of older individuals with diabetes mellitus is problematic given that CVD risk associated with aging and diabetes mellitus. In this review, we summarize epidemiological data relating to diabetes mellitus and CVD, with an emphasis on the aging population. We then present data on hyperglycemia as a risk factor for CVD and review the current knowledge of age-related changes in glucose metabolism. Next, we review the role of obesity in the pathogenesis of age-related glucose dysregulation, followed by a summary of the results from major randomized controlled trials that focus on cardiovascular risk reduction through glycemic control, with a special emphasis on older adults. We then conclude with our proposed model of aging that body composition changes and insulin resistance link possible dysregulation of physiological pathways leading to obesity and diabetes mellitus—both forms of accelerated aging—and risks for CVD.

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Effects of 3 Months of Continuous Subcutaneous Administration of Glucagon-Like Peptide 1 in Elderly Patients With Type 2 Diabetes
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Dietary Linoleic Acid Elevates the Endocannabinoids 2‐AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet
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The Enteric Enhancement of Glucose-stimulated Insulin Release: The Role of GIP in Aging, Obesity, and Non-insulin-dependent Diabetes Mellitus
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“comparable between young and old individuals, indicating that β-cell sensitivity to GIP is reduced in advancing age.(94)”
Result
Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals
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Aging, Depot Origin, and Preadipocyte Gene Expression
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Respiration in Adipocytes is Inhibited by Reactive Oxygen Species
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INFLUENCE OF AGE ON INTRAVENOUS GLUCOSE TOLERANCE AND SERUM IMMUNOREACTIVE INSULIN
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Increased TNFα and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis
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Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans
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Effect of Age on Glucose Tolerance and Glucose Uptake in Healthy Individuals
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Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE)
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Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VIII. Evaluation of insulin therapy: final report.
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Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging
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Effect of Aging and Diabetes on the Enteroinsular Axis
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Authors: Chia, C. W., Egan, J. M., & Ferrucci, L.
Affiliations: National Institutes of Health (US)
Corresponding author: Ferrucci, Luigi
ORCID: Chia, Chee W.
Egan, Josephine M.
Ferrucci, Luigi
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-09-14
Volume: 123
Issue: 7
Pages: 886-904
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.118.312806
PMC: PMC6205735
OpenAlex: W2891409258
Semantic Scholar: 5a8e379d2aa3e6281c5204edc4fa23822ef37775
Cited by: 454
References: 208
Citations by year: 2026: 61 · 2025: 71 · 2024: 72 · 2023: 82 · 2022: 70 · 2021: 38 · 2020: 42 · 2019: 15 · 2018: 1
FWCI: 3.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (Z01AG000015)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: aging, glucose metabolism, hyperglycemia, cardiovascular risk, diabetes mellitus, older adults, obesity, insulin resistance, glycemic control, body composition, accelerated aging, cardiovascular disease
MeSH terms: Adipose Tissue, Age Factors, Aging, Animals, Blood Glucose, Cardiovascular Diseases, Health Status, Humans, Hyperglycemia, Insulin, Insulin Resistance, Models, Biological, Obesity, Prognosis, Risk Factors, Biomarkers, Prevalence, Risk Assessment, Adiposity

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Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk

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