The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index; none of the 118 sources its claims cite is checked for support yet.
Causes, consequences, and reversal of immune system aging
Open accessAbstract
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 of 118 cited sources checked · 0 supported · 0 flagged
In the paper
“Despite the increase in their number, myeloid-biased stem cells are not as robust as their young counterparts (24)”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [24] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1)”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites [1] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“As a result, elderly individuals do not respond to immune challenge as robustly as the young.”
- Also stated in: § Introduction · hedged
“While elderly individuals are by no means immunodeficient, they often do not respond efficiently to novel or previously encountered antigens.”
- Also stated in: § Introduction · plain
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1), a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
- Not checked yetcites [1] source
- Not checked yetcites (2)(3)(4)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Introduction · hedged
None of the sources cited for this claim have been checked yet.
In the paper
“which in turn could underlie the numerous age-related deficiencies observed in mature myeloid cells such as neutrophils and macrophages (25,26).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11,17).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (8)(9)(10)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“The causes of this age-related reduction in lymphocyte development are multifactorial and include changes in HSCs and progenitor cells (11,12) as well as the local tissue and systemic environments (13,14).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“The age-related increase in expression of myeloid lineage genes in the studies noted above (11,17) likely resulted from the accumulation of myeloid-biased HSCs, as these analyses were performed on unseparated pools of HSCs.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites (2)(3)(4)
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“this has led to the conclusion that age-related changes in the endocrine system contribute to declines in lymphopoiesis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 28
- Probably not a substantial claim. 3
None of the sources cited for this claim have been checked yet.
In the paper
“From an immunologic perspective, the most profound effect of stem cell aging in both mice (11,18) and humans (17) is a decreased capacity to produce lymphocytes and an increase in myeloid potential.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“it is now appreciated that the number of lymphoid-biased stem cells declines with age concomitant with an increase in myeloid-biased HSCs (19).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [19] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues.”
- Also stated in: § Effects of aging on immune system development · plain
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
- Also stated in: § Effects of aging on immune system development · plain
“the number of B cell (28)(29)(30)(31) and T cell (32,33) progenitors in bone marrow and thymus is markedly reduced with age.”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Effects of aging on immune system development · plain
None of the sources cited for this claim have been checked yet.
In the paper
“HSCs exhibit multiple age-related changes that include impaired adherence to stromal cells and, in some strains of mice (15,16) and elderly humans (17), an increase in number.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The effects of aging on the immune system are widespread and affect the rate at which naive B and T cells are produced as well as the composition and quality of the mature lymphocyte pool.”
- Also stated in: § Aging and the decline of immune function · boosted
“The answer is that the composition and quality of the mature lymphocyte pool is profoundly altered by aging.”
§ Causes, consequences, and reversal of immune system aging > Introduction
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Aging and the decline of immune function · boosted
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, chronic stimulation with persistent viral infections such as CMV can exhaust the naive pool of cells and result in an oligoclonal memory cell expansion.”
§ Causes, consequences, and reversal of immune system aging > Aging and the decline of immune function
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“This decline is likely due to decreased numbers of IgM + memory and switched memory B cells, because the total number of naive B cells remains unchanged by aging (51,52).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Regardless of how the shift occurs from a salutary to an inflammatory milieu, the end result may be a negative effect on the ability of naive lymphocytes from the bone marrow or thymus to lodge in an organ such as the spleen as well as the function of mature lymphocytes already resident in that tissue.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Similar to B cell progenitors, ETPs and DN cells from old mice also exhibit age-related defects in proliferation and high rates of apoptosis (ref.32 and Figure 1).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (ref.32)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These oligoclonal expanded CD8 + memory T cells are further distinguished in humans by loss of expression of the CD28 co-stimulatory molecule (47,48) and impaired immune function.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The accumulation of CD8 + CD28 -T cells and CMV seropositivity are components of the immune risk profile, which has been proposed as a predictor of mortality in individuals 65 and older (49)”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [49] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Lymphoid-biased HSCs in old mice also appear to accumulate deficiencies that, as discussed below, may compromise their selfrenewal potential and contribute to the decline of this population (27).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Age-relat-ed microenvironmental changes also have a major impact in the thymus, where T cell development is dependent upon an intact thymic milieu composed of fibroblasts, macrophages, dendritic cells, and thymic epithelial cells.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“B cell number in mice is unchanged by aging, but in human peripheral blood their absolute number is reduced (51).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [51] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“It is clear that the number of thymic epithelial cells declines over time and that they are not replaced, as a result of impaired proliferation (38).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [38] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“For example, common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice do not proliferate as extensively as do young cells, and they exhibit significantly higher rates of apoptosis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Levels of ROS in cells may also be regulated by ataxia telangiectasia mutated (ATM) kinase, and age-related declines in expression of ATM can result in an increase in ROS in cells (77,78).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“CD4 + T cells exhibit reduced T cell receptor signaling intensity and altered production of various cytokines following antigen binding (70,71).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [70] Maue, 2009, Curr Opin Immunol.
- Not checked yetcites [71] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Thus, repeated cell division may result in progressive telomere shortening that in turn results in DNA damage that can no longer be repaired efficiently due to agerelated defects in DNA repair mechanisms (75).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [75] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“GH and IGF-1 bind to receptors expressed on thymocytes (101) and thymic epithelial cells (102)”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“mice with hypomorphic expression of DNMT1 exhibit relatively normal myeloerythroid potential but show a significant block in lymphoid development (92).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [92] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In this regard, loss of DNMT3a impairs differentiation of HSCs while their number increases in the bone marrow (91)”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [91] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Wang and colleagues demonstrated that BATF levels increased in HSCs in response to DNA damage and that this resulted in the differentiation of lymphoid-biased HSCs at the expense of their self-renewal (27).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“recent studies have shown that both Ink4a and Arf expression increases in pro-B cells from old mice and that inhibiting their expression can partially reverse the effects of aging (81).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [81] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“GH treatment resulted in increased thymic mass, increased thymic output as measured by T cell receptor rearrangement excision circles in circulating T cells, and increased numbers of naive CD4 + T cells.”
- Also stated in: § Rejuvenating the aging immune system · plain
“It is important to note that the effects of GH were not thymus specific, as the subjects also had expanded numbers of naive peripheral CD4 + T cells (105).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [105] Napolitano, 2008, J Clin Invest.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Rejuvenating the aging immune system · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and suggest that such interventions could be administered to a large cohort of individuals.”
§ Causes, consequences, and reversal of immune system aging > Caveats in immune system rejuvenation
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“it is not unreasonable to expect that this information will continue to be translated into therapies to rejuvenate the aging immune system.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“As predicted, levels of Ink4a expression in ETPs and DN cells harvested from FGF7-treated mice were downregulated, and these cells exhibited enhanced proliferation (82).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [82] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a tremendous amount is now known regarding the cellular changes that occur in the aging immune system and the molecular events that underlie them.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“beneficial effects were observed when it commenced in adults but were not evident when initiated in prepubertal or aged non-human primates (112).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [112] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“FGF7 is particularly remarkable because its administration to old mice results in a renewal of the thymic microenvironment, increased numbers of ETPs, and a restoration of thymus cellularity to levels observed in the young (106, 107).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
The thymic effects of GH, IGF-1, and FGF7 are short-lived, and the thymus returns to its previous size after treatment ends.
“because their effects are transient and the thymus reverts to its former size following the cessation of treatment.”
The paper relies on this without support.
Aging affects the immune system differently across individuals.
“It is likely that the effects of aging on the immune system will not be uniform between individuals.”
The paper relies on this without support.
GH, IGF-1, and FGF7 act throughout the body because their receptors are present on cells in many tissues.
“factors such as GH, IGF-1, and FGF7 have widespread systemic effects due to the expression of their receptors on cells in multiple tissues.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence of waning adaptive immunity is already apparent in mid adulthood, as early as at the age of 50 years, with increasing clinical relevance in the 7th–10th decade of life”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Montecino-Rodriguez et al., 2013
In the citing paper
“most older people over the age of 60–65 years (although not all) experience some immune dysregulation that makes them less able to respond to immune challenges [33,34].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [34]
Citations
Cites
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Insulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
Self-citationRegulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175
Flagged first, then by citations
Research works printed but not linked: 3
- Weng, 2009, Trends Genet., 30, 306
- Maue, 2009, Curr Opin Immunol., 30, 301
- Napolitano, 2008, J Clin Invest., 118, 1085
Cited by
Sorted by citations
Items 501–600 of 797
Outcome of acute pancreatitis in octogenarians: A retrospective study
Mauro, D. D., Wijesurendere, C., Attanasio, A., Fulgenzi, C. A. M., Elkhuffash, I., Ricciardi, E., Wajed, S., & Manzelli, A. (2019) · JGH Open · doi:10.1002/jgh3.12279 · Cited by 4
An, J. H., Shin, J. U., Kim, H. J., Lee, H. J., Yoon, M. S., & Kim, D. H. (2020) · Annals of Dermatology · doi:10.5021/ad.2020.32.1.47 · Cited by 4
Akazawa, H., Hagiya, H., Koyama, T., & Otsuka, F. (2024) · Mycopathologia · doi:10.1007/s11046-023-00814-1 · Cited by 4
“Apart from the physiological decline in immune function [19], a higher prevalence of various comorbidities such as malignancies [20], diabetes [21], and chronic organ diseases [22] provides an explanatory link to the increasing susceptibility of older individuals to cryptococcosis.”
BackgroundProteomic studies of putative molecular signatures for biological effects by Korean Red Ginseng
Lee, Y. Y., Seo, H. W., Kyung, J.-S., Hyun, S. H., Han, B. C., Park, S., So, S. H., Lee, S. H., & Yi, E. C. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.05.001 · Cited by 4
Use of Immune Modulator Interferon-Gamma to Support Combating COVID-19 Pandemic
Özçelik, F., Tanoğlu, A., Çıracı, M. Z., & Ozçelik, I. K. (2020) · International Journal of Coronaviruses · doi:10.14302/issn.2692-1537.ijcv-20-3345 · Cited by 4
Review on druggable targets of key age‐associated properties regulated by therapeutic agents
Unni, A. P., Sajitha Lulu, S., & Pillai, G. G. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13759 · Cited by 4
Fuentes, A. P., Serrano‐Conde, E., Roldán, C., Benito, R., Mejías, G., Sampedro, A., March-Roselló, G. A., Fernández-Natal, I., Esperalba, J., Rodríguez-Domínguez, M., et al. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-04139-5 · Cited by 4
“Some authors have suggested a relationship between this delayed response in elderly individuals, with less favorable disease evolution in this population group [28].”
BackgroundAskmyr, D., Abolhalaj, M., Jimenez, D. G., Greiff, L., Lindstedt, M., & Lundberg, K. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.08.007 · Cited by 5
Pseudo‐spectral method for controlling the drug dosage in cancer
Nazari, M., Nazari, M., & Skandari, M. H. N. (2020) · IET Systems Biology · doi:10.1049/iet-syb.2020.0054 · Cited by 4
Zhang, H., Li, D., Lai, Z., Zhou, J., Zhang, J., & Li, Z. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.06.009 · Cited by 4
Mouse Aging Cell Atlas Analysis Reveals Global and Cell Type Specific Aging Signatures Revision 1Preprint
Zhang, M. J., Pisco, A. O., Darmanis, S., & Zou, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.23.887604 · Cited by 4
Causal Inference with Selectively Deconfounded DataPreprint
Gan, K., Li, A., Lipton, Z. C., & Tayur, S. R. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3940523 · Cited by 4
Lemaître, P., Tareen, S. H. K., Pasciuto, E., Mascali, L. G., Martirosyan, A., Callaerts‐Vegh, Z., Dooley, J., Holt, M. G., Yshii, L., & Liston, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.01.482519 · Cited by 4
An inflammatory and quiescent HSC subpopulation expands with age in humans
Safina, K. R., Salik, B., Kotliar, D., Curtis, M. L., Good, J., Weng, C., David, S., Raychaudhuri, S., Kreso, A., Trowbridge, J. J., et al. (2026) · Genome biology · doi:10.1186/s13059-026-03936-z · Cited by 4
Yao, J., Wang, Y., & Zhang, Y. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.018 · Cited by 3
“A major limitation of the aged immune system is the impaired generation and function of T and B lymphocytes 50 .”
Jonczyk, R., Stanislawski, N., Seiler, L. K., Ahani, S., Bueltemeier, A., Stahl, F., Beutel, S., Blume, H., Hauß, C., Melk, A., et al. (2022) · Journal of Clinical Virology · doi:10.1016/j.jcv.2022.105322 · Cited by 3
Azeez, T. A., & Adeagbo, A. I. (2023) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-023-03939-3 · Cited by 3
“Additionally, old age is associated with depressed immunity (making them more prone to infections) [77, 78] and due to economic and socio-cultural reasons, elderly people have poor access to qualitative healthcare in Africa [79, 80].”
BackgroundImmunological features of ESRD patients undergoing hemodialysis of various ages
Chen, X., Xiang, F., Cao, X., Lv, W., Shen, B., Zou, J., & Ding, X. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03683-1 · Cited by 3
“One of the hallmarks of aging is the gradual deterioration of the immune system [5, 6].”
Pneumonia in Geriatric Patients: Focus on Etiology, Clinical Features, Diagnosis, and Prevention
Tomys-Składowska, J., Lamch, M., Jabłońska, M., Błasik, N., Janiszewska, M., Nieciecka, A., Husejko, J., & Kędziora–Kornatowska, K. (2023) · Journal of Health Study and Medicine · doi:10.2478/jhsm-2023-0017 · Cited by 6
Impact of Respiratory Bacterial Findings on Patients with Chronic Pulmonary Aspergillosis
Cho, H. K., Moon, S. M., Kim, H., & Shin, B. (2024) · International Journal of Microbiology · doi:10.1155/2024/1329884 · Cited by 3
“CPA patients with bacteria have characteristics such as older age, diabetes, and a previous history of extrathoracic malignancy, suggesting that these factors can infuence host defense and immunity and can contribute to disease progression and mortality [26–28].”
Characterization of a natural model of adult mice with different rate of aging
Félix, J., Cerro, E. D., Garrido, A., & la Fuente, M. D. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111991 · Cited by 3
Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age
Taher, N. A. B., Isaza-Correa, J. M., Melo, A. M., Kelly, L. A., Al-Harbi, A. I., O’Dea, M. I., Zareen, Z., Ryan, E., Omer, M., Townsend, L., et al. (2024) · Immuno · doi:10.3390/immuno4040023 · Cited by 4
Ma, X., Li, X., Che, L., & Dong, J. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1463348 · Cited by 3
The Genomics of Aging at the Single-Cell Scale
Zhou, W. Y., & Cao, J. (2025) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-120523-024422 · Cited by 4
Yzet, C., Tse, S., Kayal, M., Hirten, R. P., & Colombel, J. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190308102021 · Cited by 3
Ghezeldasht, S. A., Hedayati‐Moghaddam, M. R., Mosavat, A., & Akbarin, M. M. (2019) · Modern Care Journal · doi:10.5812/modernc.93956 · Cited by 3
“On the other hand, in the present study, HDV seropositivity was more prevalent among older patients, which could be attributed to the reduced immunity, particularly compromised immune system in the elderly (26).”
BackgroundRadenković, D., Zhavoronkov, A. A., & Bischof, E. Y. (2021) · Springer eBooks · doi:10.1007/978-3-030-58080-3_248-1 · Cited by 4
Lived Experiences of Older Adults in the COVID-19 Pandemic in a Teaching Hospital in Ghana
Aboh, I. K., Arthur, A. L., & Woolley, P. (2022) · Gerontology and Geriatric Medicine · doi:10.1177/23337214221094195 · Cited by 3
Age-Related Dysfunction in the Innate Immune Response to Lung Infections
Boe, D. M., Chen, M. M., & Kovacs, E. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_91 · Cited by 3
Rastegar-Kashkouli, A., Jafari, M., & Yousefi, P. (2022) · Journal of Renal Endocrinology · doi:10.34172/jre.2022.25064 · Cited by 3
Zhu, W., Wu, L., Xie, W., Zhang, G., Gu, Y., Hou, Y., & He, Y. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03897-3 · Cited by 3
Jalaleddini, K., Bermel, R. A., Talente, B., Weinstein, D., Qureshi, F., Rasmussen, M., Menon, S., Amarapala, M., Jordan, K., Ghoreyshi, A., et al. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241227372 · Cited by 3
Kodali, N., Bhattaru, A., Blanchard, I., Sharma, Y., & Lipner, S. R. (2024) · Melanoma Research · doi:10.1097/cmr.0000000000000968 · Cited by 3
“Aging decreases immune function and surveillance [38], potentially causing unregulated tumor growth and the inability to defend against reactive oxygen species, which could explain the increased mortality in older patients with BRAF and NRAS mutations.”
Frailty: An Underappreciated Risk Factor for IBD Complications
Venkatesh, A., Susheela, A., & Kochar, B. D. (2024) · Current Gastroenterology Reports · doi:10.1007/s11894-024-00945-5 · Cited by 3
“However, inflammation is associated with frailty [23], further supporting the importance of understanding the impact of frailty in older adults with IBD who may have more than one reason for chronic inflammation.”
Wang, J., Li, Q., Kong, Y., Zhou, F., Li, J., Li, W., Wang, K., Wu, T., Guan, Y., Xie, J., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00393 · Cited by 3
“As people become older, their immune systems become weaker and antibody responses are slow (Montecino-Rodriguez et al., 2013), which induces many dysfunctions (Weigle, 1989).”
BackgroundParida, B. P., Misra, B. B., & Misra, A. N. (2018) · 4open · doi:10.1051/fopen/2018004 · Cited by 3
Parameter identification of a model for prostate cancer treated by intermittent therapy
Draghi, C., Denis, F., Tolédano, A., & Christophe Letellier, A. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.10.004 · Cited by 3
Impact of the Second Epidemic Wave of SARS-CoV-2: Increased Exposure of Young People
Capai, L., Masse, S., Fourié, T., Decarreaux, D., Canarelli, J., Simeoni, M.-H., Amroun, A., Ali, S. M., Villarroel, P. M. S., de Lamballerie, X. N., et al. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.715192 · Cited by 3
“Another reason is the reduced efficacy of the immune response that could account for antibody fading (22, 23).”
BackgroundAlmulhem, M., Thayakaran, R., Hanif, S., Gooden, T. E., Thomas, G. N., Hazlehurst, J., Tahrani, A. A., Hanif, W., & Nirantharakumar, K. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262530 · Cited by 3
“The effects of diabetes [35] and age [36] on the immune system are well-established, including increased susceptibility to infection, especially severe infection.”
BackgroundSingh, B., & Rai, A. K. (2022) · Human Immunology · doi:10.1016/j.humimm.2022.10.002 · Cited by 3
Type 2 Diabetes Mellitus Associated with Premature Aging
Bilici, M., Arpacı, D., İlikhan, S. U., ÇORAKÇI, B. D., Bayraktaroğlu, T., Araslı, M., & Tekin, İ. Ö. (2017) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.14024 · Cited by 3
“It is proposed that the ratio of naive T-cells to memory T-cells declines, an increase in the number of memory T-cells is now a particularly well-recognized feature of aging (10, 28-31).”
BackgroundInfectious Dose and an Aging Population: Susceptibility of the Aged to Foodborne Pathogens
Smith, J. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-56836-2_16 · Cited by 3
Brainstem cytokine changes in healthy ageing and Motor Neurone Disease
Tennakoon, A., Katharesan, V., & Johnson, I. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.08.013 · Cited by 3
Dorshkind, K. A., & Rawlings, D. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00020-2 · Cited by 3
Self-citationInfluence of age on the clinical efficacy of tigecycline in severely ill patients
Bassetti, M., Guirao, X., Montravers, P., Rossolini, G. M., García, M. S., Sganga, G., & Eckmann, C. (2019) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2019.03.018 · Cited by 3
New onset of Bell’s palsy in a patient with West Nile Encephalitis
Vaysman, T., Melkonyan, A., & Liu, A. K. (2020) · Clinical Case Reports · doi:10.1002/ccr3.3009 · Cited by 3
Glenton, C., Winje, B. A., Carlsen, B., Eilers, R., Wennekes, M. D., & Lewin, S. A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013706 · Cited by 3
Fokoua-Maxime, C. D., Ndjabo, M. A., Ankobil, A., Momah, K. V., Metomb, S. F., & Choukem, S. P. (2020) · medRxiv · doi:10.1101/2020.07.06.20147124 · Cited by 3
SARS-CoV-2 air and surface contamination on a COVID-19 ward and at homePreprint
Oksanen, L., Virtanen, J. M. E., Sanmark, E., Rantanen, N., Venkat, V., Sofieva, S., Aaltonen, K., Kivistö, I., Svirskaitė, J., Pérez, A., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1002547/v1 · Cited by 4
Age-dependent roles of cardiac remodeling in sepsis defense and pathogenesisPreprint
Sanchez, K. K., McCarville, J. L., Stengel, S. J., Snyder, J. M., Williams, A. E., & Ayres, J. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.14.532695 · Cited by 3
Reisser, Y., Hornung, F., Häder, A., Lauf, T., Nietzsche, S., Löffler, B., & Deinhardt‐Emmer, S. (2024) · eLife · doi:10.7554/elife.100433 · Cited by 3
Menkiti, F. E., Okani, C. O., Onyiaorah, I. V., Ukah, C. O., Menkiti, I. O., Ihekwoaba, E. C., Okoye, O. A., Ofiaeli, O. C., & Akpuaka, F. C. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03862-7 · Cited by 2
“Similarly, ageing is associated with factors that may affect PD-L1 regulation and expression, including decline in immune function [71, 72], increased risk of accumulating genetic and epigenetic alterations that lead to genomic instability [73, 74], increased co-morbidities and medication that can…”
Isolation and Ex Vivo Testing of CD8+ T-Cell Division and Activation Using Mouse Splenocytes
Dolan, M., Shi, Y., McKenery, A., Tzetzo, S. L., Chida, K., Takabe, K., Abrams, S. I., & Ebos, J. M. L. (2025) · BIO-PROTOCOL · doi:10.21769/bioprotoc.5423 · Cited by 2
Luan, C., Tsai, Y.-T., Chen, K.-Y., & Yap, W. (2025) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2025.111123 · Cited by 2
Jevtić, B., Lazarević, M. N., Miljković, Đ., & Nikolich, J. Ž. (2026) · European Journal of Immunology · doi:10.1002/eji.70163 · Cited by 3
Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6
Stahl, S., Widmaier, H., Sakk, V., Nalapareddy, K., Kissmann, A., Rosenau, F., Mulaw, M. A., Haslam, D. B., & Geiger, H. (2026) · Microbiome · doi:10.1186/s40168-026-02428-3 · Cited by 2
“2C)—consistent with the well-documented myeloid bias during aging [52–54]—their relative abundance within ileal LPLs remained unchanged (Suppl.”
Lin, Y.-S., Alonso, V., Singh, A., Liu, Y., Tang, Y., Mehta, A., King, J. K., Paing, M., Salomonis, N., Grimes, H. L., et al. (2026) · Cell Press Blue · doi:10.1016/j.cpblue.2026.100051 · Cited by 2
Multinutrient Approach to Slow Down Brain Aging and Related Neurodegenerative Disorders
Singh, A. K., Singh, S., Garg, G., & Rizvi, S. I. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00005-5 · Cited by 2
Evaluation of Efficacy and Safety of Nivolumab and Pembrolizumab in Elderly Cancer Patients
Kim, H. S., Jeong, H., & Shim, M. K. (2020) · Korean Journal of Clinical Pharmacy · doi:10.24304/kjcp.2020.30.1.11 · Cited by 2
Rachdi, R., Hannachi, S., Zribi, S., Ayed, O. B., Abid, R., Moatemri, Z., Mhamdi, S., DABBOUSSI, S., Gharsallah, H., Sellami, W., et al. (2022) · Médecine tropicale et santé internationale · doi:10.48327/mtsi.v2i3.2022.207 · Cited by 2
“Ceci s’expliquait par le processus de vieillissement et le déclin du système immunitaire, surtout la fonction des lymphocytes T et B, et la production excessive de cytokines de type 2 [10,19].”
BackgroundAging and Changes in White Blood Cells Count and Immunity: A Systematic Review
Abukanna, A. M. A., Alanazi, F. M., AlAnazi, Z. M., ALANAZI, F. A. L., Alanazi, A. H. O., & Alanazi, R. M. L. (2022) · Clinical Cancer Investigation Journal · doi:10.51847/kcawdh6o97 · Cited by 2
“B cell lineage aging has been linked to changes in the bone marrow microenvironment, presumably as a result of stromal cells secreting less IL-7.([2])”
BackgroundSharkawy, D. A. E., Nada, H. R., & Al-Kubati, S. R. (2023) · Dermatologic Surgery · doi:10.1097/dss.0000000000003846 · Cited by 2
“This may be explained by the natural weakening of the immune system response by the advancing age.(15) Regarding the laser group, similar results were reported in the literature.”
ResultPertiwi, D., Aulia, A. P., & Rahayu, R. (2022) · MEDICA ARTERIANA (Med-Art) · doi:10.26714/medart.4.1.2022.32-38 · Cited by 2
Larina, V. N., & Сергеевна, Щ. Е. (2024) · Cardiosomatics · doi:10.17816/cs632927 · Cited by 2
Lepore, G., Succu, S., Cappai, M. G., Frau, A., Senes, A., Zedda, M., Farina, V., & Gadau, S. D. (2024) · Animals · doi:10.3390/ani14192900 · Cited by 3
Damtie, S., Legese, B., Fentie, A., Solomon, Y., Erkihun, M., Molla, T., Almaw, A., Kiros, T., Wondmagegn, M., & Berhan, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-90441-1 · Cited by 2
Nguyen, J. D. K., Yohannes, K., Setiady, I., Phillips, E. C., Hays, R. A., Behm, B. W., Warren, C. A., & Shin, J. H. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251334517 · Cited by 2
“22,24,25 However, even when controlling for comorbidities, age was an independent risk factor for FMT failure, a finding that has been corroborated in other studies.”
Zhang, X., Shi, H., & Ross, T. M. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00539-3 · Cited by 2
“Thus, the aged immune system needs additional stimulation to enhance both innate and adaptive immune responses to fight newly emerged influenza virus variants or other respiratory pathogens [2, 11].”
InfluentialTurning VDR Off to Turn Immunity On: Metadichol Derepresses VDBP in Human Monocytes
Raghavan, P. R. (2026) · Medical Research Archives · doi:10.18103/mra.2026.0394 · Cited by 4
Therapeutic Implications of Angiogenesis in Cancer
Makhoul, I., Atrash, S., Arnaoutakis, K., Safar, M., Pennisi, A., Huffman, L. B., & Griffin, R. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-61115-0_9 · Cited by 2
The relationship between ageing and changes in the human blood and brain methylomes
Bryant, P., & Elofsson, A. (2022) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqac001 · Cited by 2
Thude, H., Kramer, K., Koch, M., Peine, S., Sterneck, M. R., & Nashan, B. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.09.024 · Cited by 2
Gut Microbiota Pattern of Centenarians
Wu, L. H., Zinellu, A., Milanesi, L., Rubino, S., Kelvin, D. J., & Carru, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_9 · Cited by 2
İmmunosenescence and The İmportance of İnfluenza and Pneumococcal Vaccine in Elderly?
Erdoğdu, H. İ., & Öner, C. (2019) · Turkish Journal of Family Medicine & Primary Care · doi:10.21763/tjfmpc.653275 · Cited by 2
Merza, A. M. (2020) · The Journal of The University of Duhok · doi:10.26682/sjuod.2020.23.2.1 · Cited by 2
Nicolò, A. D., Avataneo, V., Cusato, J., Palermiti, A., Mula, J., Vivo, E. D. D., Antonucci, M., Bonora, S., Calcagno, A., Perri, G. D., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11050869 · Cited by 2
“Several reports have showed similar or even higher IgG titers in elderly people [28,29]; therefore, the difference in severity could be related to the timing (more than quantity) of the humoral immune response [24,26].”
BackgroundAssessment of COVID-19 vaccination effectiveness
Stoczyńska-Fidelus, E., & Rieske, P. (2022) · Alergologia Polska - Polish Journal of Allergology · doi:10.5114/pja.2022.114393 · Cited by 2
Tuberculous Meningitis: an Update on the Pathogenesis and Neuroimmunology
Hokeness, S., Lanni, F., Glycenfer, J., Obregón‐Henao, A., & Henao-Tamayo, M. I. (2024) · Current Tropical Medicine Reports · doi:10.1007/s40475-023-00310-y · Cited by 2
“In the immune system, aging is associated with impaired homeostasis of the extracellular milieu leading to a progressive dysregulation of immune responses resulting in impaired wound healing, diminished adaptive immunity, and an accumulation of senescence [39, 40].”
Tribin, F. E., Williams, E., Testamarck, V., Carreño, J. M., Bielak, D. A., Yellin, T., Krammer, F., Hoffer, M. E., Pallikkuth, S., & Pahwa, S. G. (2024) · PLoS ONE · doi:10.1371/journal.pone.0292566 · Cited by 3
COMPARATIVE EXPERIMENTAL STUDIES ON THE SPLEEN OF YOUNG AND AGED BALB/C AND CD-1 MICE
Al-Zahaby, A. S., Salem, M. L., Abdul-Aziz, K. K., & Serageldeen, H. M. (2017) · International Journal of Advanced Research in Biological Sciences (IJARBS) · doi:10.22192/ijarbs.2017.04.12.024 · Cited by 2
“Montecino-Rodriguez et al.(2013) stated that, the most recognized consequences of aging is a decline in immune function.”
BackgroundInfluentialWhen wrinkles appear on the immune system can it be reversed?
Sibaii, H., El-Zayat, S. R., & Khalil, M. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0441 · Cited by 4
“By time, repeated exposure to antigens increases the number of protective memory T cells [84] memory T cells of seniors are often senescent, and dysfunctional as they lose the ability to proliferate and divide [83]; and secrete high levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha and IL-6 [57,…”
BackgroundInfluentialContribution of the Microbiota to Healthy Aging
Forssten, S. D., & Ouwehand, A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00059-0 · Cited by 2
Pendock, L. F. (2018) · doi:10.51415/10321/3157 · Cited by 2
Network topology and evolution of the gene co-expression of T-cells during immuno-senescencePreprint
Mair, M. L., Tchitcheck, N., Witten, T. M., & Thomas‐Vaslin, V. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.01.458500 · Cited by 2
The cGAS-STING pathway is an in vivo modifier of genomic instability syndromesPreprint
Bergman, M., Goshtchevsky, U., Atlan, T., Astre, G., Halabi, R., El, H., Moses, E., Lemus, A. J. J., Benayoun, B. A., Tzfati, Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.16.618655 · Cited by 2
“Inflammaging can also exacerbate other age-related pathologies 16,69,70 , such as interfering with the clearance of precancerous cells 71 .”
BackgroundDance, Y. W., Amitrano, A., Saffron, A. M., Min, C., Thompson, L. T., Ge, Z., Smith, I. M., Macaluso, N. C., Ezenwanne, C., Milcik, N., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.13.699374 · Cited by 2
Torres, A., Marchioro, S. B., Ribeiro, M. B., de Morais, I. R. B., Freire, S. M., & Nascimento, R. J. M. (2021) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2021039675 · Cited by 2
Paul, A. G., Miller, S. R., Heilbrun, L. K., & Smith, D. W. (2022) · Cureus · doi:10.7759/cureus.30645 · Cited by 1
“Advanced age is also associated with a weaker immune system and thus a higher likelihood of immune evasion by the CC tumor cells from tumor-infiltrating lymphocytes such as cytotoxic T cells and macrophages [23].”
BackgroundSymbiotic association of gut microbiome in health and diseases at ageing
Mane, S. S., Patel, D. A., & Patil, P. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99334-0.00049-9 · Cited by 1
Dahal, C., Adhikari, S., Regmi, R. S., Sapkota, S., Adhikari, N., Sharma, S., Banjara, M. R., Chalise, B. S., Ghimire, P., & Rijal, K. R. (2025) · Infectious Diseases & Immunity · doi:10.1097/id9.0000000000000157 · Cited by 1
“[33] In this study, higher fractions of E. coli were recovered from urine samples (70/86).”
Zhu, X. M., Tedesco, D. J., Gallo, L., Shahrokhi, S., & Jeschke, M. G. (2025) · Journal of Burn Care & Research · doi:10.1093/jbcr/iraf205 · Cited by 1
Wang, J., Han, N., Bai, L., Li, H., Du, L., Liu, H., Zeng, Y., Zhang, H., Chen, X.-B., Yang, J., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70684 · Cited by 1
Age and liver transplantation: a key factor in clinical outcomes? single center study in Argentina
Pazmiño, M. S., Benítez, P. C. A., Fernández, M. F., Yantorno, S. E., Descalzi, V., Tarditti, F. D., Novellis, M. L., Fasolo, J. C., Rumbo, M., Tullius, S. G., et al. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1729048 · Cited by 1
Tuosto, L., Gelibter, A. J., Strigari, L., Asquino, A., Siringo, M., Pace, A., Valentino, F., Capozzi, D., Bianchini, S., Bellati, F., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07719-9 · Cited by 1
“Although others recognized the characteristics observed in the healthy donor group [21], the imbalance between the number of old healthy donors and cancer patients may appear to be a limitation of the study.”
Targeting Age-Associated Immune Senescence via Nanoparticle-Based Metabolic Reprogramming
Nair, P. G., Unnikrishnan, B. S., Vijayan, V. V., Howlett, S. E., Cullis, P. R., & Gujar, S. A. (2026) · ACS Nano · doi:10.1021/acsnano.5c18638 · Cited by 2
Gensheimer, J., LaGosh, J., Moulton, E. R., Sun, V., de Barros, S. C., Montecino‐Rodriguez, E., Yiu, G., Yuan, X., Dorshkind, K. A., & Gm, C. (2026) · Aging Cell · doi:10.1111/acel.70615 · Cited by 1
“…of proinflammatory changes in the aged thymic microenvironment such as the age-related loss of thymic epithelial cells and the gain of adipocytes which may amplify subtle intrinsic defects that only manifest under inflammatory conditions in vivo (Kousa et al. 2024; Montecino-Rodriguez et al. 2013).”
InfluentialSelf-citationGaspar, H. B. (2014) · Blood · doi:10.1182/blood-2013-11-535633 · Cited by 1
Role of the Fyn −93A>G polymorphism (rs706895) in acute rejection after liver transplantation
Thude, H., Kramer, K., Peine, S., Sterneck, M. R., Nashan, B., & Koch, M. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.09.013 · Cited by 1
“It is well known that aging is accompanied by a limited immune function, since both the extent of T-cell and B-cell maturation as well as the function of these cells is down regulated [43,44].”
BackgroundCorrelation Between the Vitamin D Intake with Clinical Symptoms of Patients Pulmonary Tuberculosis
Suharti, N., Faadhila, T., & Sulastri, D. (2017) · Public Health International Conference (PHICo) · doi:10.2991/phico-16.2017.11 · Cited by 1
“In old age, already there is a decrease in the production of B cells and T cells in the bone marrow and thymus, and decreased function of mature lymphocytes in secondary lymphoid tissues [22].”
BackgroundSocial workers can help older adults prepare for and respond to natural and man-made emergencies
Gallo, H. B., Karimi, B. P., Abdulridha, M., Howard, J. L., Kiani, H., Maico, J. R., Peace, M. V., Sicley, B. S., Yoo, J., & Wilber, K. H. (2018) · Journal of Gerontological Social Work · doi:10.1080/01634372.2018.1432737 · Cited by 1
Metadata
- Authors
- Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Dorshkind, Kenneth
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 958-965
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582124
- OpenAlex
- W1978103330
- Semantic Scholar
- 21eeafabbc2cc60c6c46752d238c5688d989e17b
- Cited by
- 793
- References
- 120
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 72 · 2023: 86 · 2022: 96 · 2021: 126 · 2020: 106 · 2019: 64 · 2018: 54 · 2017: 37 · 2016: 21 · 2015: 27 · 2014: 18 · 2013: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG034875, AG034875)
- David Geffen School of Medicine, University of California, Los Angeles
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, B cell aging, T cell senescence, thymus, bone marrow, secondary lymphoid organs, lymphocyte function
- MeSH terms
- Aging, Animals, Hematopoietic Stem Cells, Humans, Immune System, Immunologic Factors, Lymphoid Progenitor Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-06, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-06 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
