The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index; none of the 118 sources its claims cite is checked for support yet.
Causes, consequences, and reversal of immune system aging
Open accessAbstract
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.
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In the paper
“Despite the increase in their number, myeloid-biased stem cells are not as robust as their young counterparts (24)”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [24] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1)”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites [1] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“As a result, elderly individuals do not respond to immune challenge as robustly as the young.”
- Also stated in: § Introduction · hedged
“While elderly individuals are by no means immunodeficient, they often do not respond efficiently to novel or previously encountered antigens.”
- Also stated in: § Introduction · plain
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1), a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
- Not checked yetcites [1] source
- Not checked yetcites (2)(3)(4)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Introduction · hedged
None of the sources cited for this claim have been checked yet.
In the paper
“which in turn could underlie the numerous age-related deficiencies observed in mature myeloid cells such as neutrophils and macrophages (25,26).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11,17).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (8)(9)(10)
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In the paper
“The causes of this age-related reduction in lymphocyte development are multifactorial and include changes in HSCs and progenitor cells (11,12) as well as the local tissue and systemic environments (13,14).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“The age-related increase in expression of myeloid lineage genes in the studies noted above (11,17) likely resulted from the accumulation of myeloid-biased HSCs, as these analyses were performed on unseparated pools of HSCs.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites (2)(3)(4)
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“this has led to the conclusion that age-related changes in the endocrine system contribute to declines in lymphopoiesis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 28
- Probably not a substantial claim. 3
None of the sources cited for this claim have been checked yet.
In the paper
“From an immunologic perspective, the most profound effect of stem cell aging in both mice (11,18) and humans (17) is a decreased capacity to produce lymphocytes and an increase in myeloid potential.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“it is now appreciated that the number of lymphoid-biased stem cells declines with age concomitant with an increase in myeloid-biased HSCs (19).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [19] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues.”
- Also stated in: § Effects of aging on immune system development · plain
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
- Also stated in: § Effects of aging on immune system development · plain
“the number of B cell (28)(29)(30)(31) and T cell (32,33) progenitors in bone marrow and thymus is markedly reduced with age.”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Effects of aging on immune system development · plain
None of the sources cited for this claim have been checked yet.
In the paper
“HSCs exhibit multiple age-related changes that include impaired adherence to stromal cells and, in some strains of mice (15,16) and elderly humans (17), an increase in number.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The effects of aging on the immune system are widespread and affect the rate at which naive B and T cells are produced as well as the composition and quality of the mature lymphocyte pool.”
- Also stated in: § Aging and the decline of immune function · boosted
“The answer is that the composition and quality of the mature lymphocyte pool is profoundly altered by aging.”
§ Causes, consequences, and reversal of immune system aging > Introduction
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Aging and the decline of immune function · boosted
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, chronic stimulation with persistent viral infections such as CMV can exhaust the naive pool of cells and result in an oligoclonal memory cell expansion.”
§ Causes, consequences, and reversal of immune system aging > Aging and the decline of immune function
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“This decline is likely due to decreased numbers of IgM + memory and switched memory B cells, because the total number of naive B cells remains unchanged by aging (51,52).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Regardless of how the shift occurs from a salutary to an inflammatory milieu, the end result may be a negative effect on the ability of naive lymphocytes from the bone marrow or thymus to lodge in an organ such as the spleen as well as the function of mature lymphocytes already resident in that tissue.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Similar to B cell progenitors, ETPs and DN cells from old mice also exhibit age-related defects in proliferation and high rates of apoptosis (ref.32 and Figure 1).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (ref.32)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These oligoclonal expanded CD8 + memory T cells are further distinguished in humans by loss of expression of the CD28 co-stimulatory molecule (47,48) and impaired immune function.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The accumulation of CD8 + CD28 -T cells and CMV seropositivity are components of the immune risk profile, which has been proposed as a predictor of mortality in individuals 65 and older (49)”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [49] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Lymphoid-biased HSCs in old mice also appear to accumulate deficiencies that, as discussed below, may compromise their selfrenewal potential and contribute to the decline of this population (27).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Age-relat-ed microenvironmental changes also have a major impact in the thymus, where T cell development is dependent upon an intact thymic milieu composed of fibroblasts, macrophages, dendritic cells, and thymic epithelial cells.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“B cell number in mice is unchanged by aging, but in human peripheral blood their absolute number is reduced (51).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [51] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“It is clear that the number of thymic epithelial cells declines over time and that they are not replaced, as a result of impaired proliferation (38).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [38] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“For example, common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice do not proliferate as extensively as do young cells, and they exhibit significantly higher rates of apoptosis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Levels of ROS in cells may also be regulated by ataxia telangiectasia mutated (ATM) kinase, and age-related declines in expression of ATM can result in an increase in ROS in cells (77,78).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“CD4 + T cells exhibit reduced T cell receptor signaling intensity and altered production of various cytokines following antigen binding (70,71).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [70] Maue, 2009, Curr Opin Immunol.
- Not checked yetcites [71] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Thus, repeated cell division may result in progressive telomere shortening that in turn results in DNA damage that can no longer be repaired efficiently due to agerelated defects in DNA repair mechanisms (75).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [75] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“GH and IGF-1 bind to receptors expressed on thymocytes (101) and thymic epithelial cells (102)”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“mice with hypomorphic expression of DNMT1 exhibit relatively normal myeloerythroid potential but show a significant block in lymphoid development (92).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [92] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In this regard, loss of DNMT3a impairs differentiation of HSCs while their number increases in the bone marrow (91)”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [91] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Wang and colleagues demonstrated that BATF levels increased in HSCs in response to DNA damage and that this resulted in the differentiation of lymphoid-biased HSCs at the expense of their self-renewal (27).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“recent studies have shown that both Ink4a and Arf expression increases in pro-B cells from old mice and that inhibiting their expression can partially reverse the effects of aging (81).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [81] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“GH treatment resulted in increased thymic mass, increased thymic output as measured by T cell receptor rearrangement excision circles in circulating T cells, and increased numbers of naive CD4 + T cells.”
- Also stated in: § Rejuvenating the aging immune system · plain
“It is important to note that the effects of GH were not thymus specific, as the subjects also had expanded numbers of naive peripheral CD4 + T cells (105).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [105] Napolitano, 2008, J Clin Invest.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Rejuvenating the aging immune system · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and suggest that such interventions could be administered to a large cohort of individuals.”
§ Causes, consequences, and reversal of immune system aging > Caveats in immune system rejuvenation
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“it is not unreasonable to expect that this information will continue to be translated into therapies to rejuvenate the aging immune system.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“As predicted, levels of Ink4a expression in ETPs and DN cells harvested from FGF7-treated mice were downregulated, and these cells exhibited enhanced proliferation (82).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [82] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a tremendous amount is now known regarding the cellular changes that occur in the aging immune system and the molecular events that underlie them.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“beneficial effects were observed when it commenced in adults but were not evident when initiated in prepubertal or aged non-human primates (112).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [112] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“FGF7 is particularly remarkable because its administration to old mice results in a renewal of the thymic microenvironment, increased numbers of ETPs, and a restoration of thymus cellularity to levels observed in the young (106, 107).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
The thymic effects of GH, IGF-1, and FGF7 are short-lived, and the thymus returns to its previous size after treatment ends.
“because their effects are transient and the thymus reverts to its former size following the cessation of treatment.”
The paper relies on this without support.
Aging affects the immune system differently across individuals.
“It is likely that the effects of aging on the immune system will not be uniform between individuals.”
The paper relies on this without support.
GH, IGF-1, and FGF7 act throughout the body because their receptors are present on cells in many tissues.
“factors such as GH, IGF-1, and FGF7 have widespread systemic effects due to the expression of their receptors on cells in multiple tissues.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence of waning adaptive immunity is already apparent in mid adulthood, as early as at the age of 50 years, with increasing clinical relevance in the 7th–10th decade of life”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Montecino-Rodriguez et al., 2013
In the citing paper
“most older people over the age of 60–65 years (although not all) experience some immune dysregulation that makes them less able to respond to immune challenges [33,34].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [34]
Citations
Cites
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Insulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
Self-citationRegulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175
Flagged first, then by citations
Research works printed but not linked: 3
- Weng, 2009, Trends Genet., 30, 306
- Maue, 2009, Curr Opin Immunol., 30, 301
- Napolitano, 2008, J Clin Invest., 118, 1085
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“Advanced age is an established risk factor for immunosenescence [98], which is due in part to the inability of both the innate and adaptive immune systems to generate protective immunity [12, 99].”
BackgroundReprogramming systemic and local immune function to empower immunotherapy against glioblastoma
Zhou, S., Huang, Y., Chen, Y., Liu, Y., Xie, L., You, Y., Tong, S., Xu, J., Jiang, G., Song, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35957-8 · Cited by 74
Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis
Kadowaki, A., Saga, R., Lin, Y., Sato, W., & Yamamura, T. (2019) · Brain · doi:10.1093/brain/awz012 · Cited by 79
Golomb, L., Sagiv, A., Pateras, I. S., Maly, A., Krizhanovsky, V, Gorgoulis, V. G., Oren, M., & Ben-Yehuda, A. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.21 · Cited by 71
“aging than innate immunity, as reflected by the inability of old individuals to mount an effective humoral response.(10) This is partially due to reduced lymphopoiesis, associated with events such as thymic involution(11) and age-dependent skewing of hematopoietic stem cell commitment toward myeloid lineage differenti…”
BackgroundThe aging bone marrow and its impact on immune responses in old age
Pritz, T., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.016 · Cited by 71
Human bone marrow adipocytes display distinct immune regulatory properties
Miggitsch, C., Meryk, A., Naismith, E., Pangrazzi, L., Ejaz, A., Jenewein, B., Wagner, S., Nägele, F., Fenkart, G., Trieb, K., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.023 · Cited by 71
“Aging is associated with an increased susceptibility to opportunistic infections [1], an effect which is at least partially due to the aging of the immune system [2].”
BackgroundRapp, J. L., Lieberman‐Cribbin, W., Tuminello, S., & Taioli, E. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.08.2065 · Cited by 70
“org with increasing age, the adverse outcomes in older patients noted here are not unexpected.(9)”
Aging enhances release of exosomal cytokine mRNAs by Aβ 1‐42 ‐stimulated macrophages
Mitsuhashi, M., Taub, D. D., Kapogiannis, D., Eitan, E., Zukley, L. M., Mattson, M. P., Ferrucci, L., Schwartz, J. B., & Goetzl, E. J. (2013) · The FASEB Journal · doi:10.1096/fj.13-238980 · Cited by 70
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BackgroundBreast Cancer Immunotherapy: An Update
Makhoul, I., Atiq, M. O., Alwbari, A. M., & Kieber‐Emmons, T. (2018) · Breast Cancer Basic and Clinical Research · doi:10.1177/1178223418774802 · Cited by 75
Wood, W. A., Krishnamurthy, J., Mitin, N., Torrice, C., Parker, J. S., Snavely, A. C., Shea, T. C., Serody, J. S., & Sharpless, N. E. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.029 · Cited by 73
“…to color in this figure legend, the reader is referred to the web version of this article.) likely that graft-derived T-cells produced via a dysfunctional thymus exhibit accelerated aging (Min et al., 2005; Montecino-Rodriguez et al., 2013; Dorshkind et al., 2009; Linton and Dorshkind, 2004).”
BackgroundPan-cancer analysis reveals molecular patterns associated with age
Shah, Y., Verma, A., Marderstein, A. R., White, J. B., Bhinder, B., Medina, J. S. G., & Elemento, O. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110100 · Cited by 71
The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop
Budinger, G. R. S., Kohanski, R. A., Gan, W., Kobor, M. S., Amaral, L. A. N., Armanios, M. Y., Kelsey, K. T., Pardo, A., Tuder, R. M., Macián, F., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx090 · Cited by 69
“Hyporesponsiveness of the adaptive immune system might also result from an age-related loss in signals from key stromal populations in the bone marrow, thymus, lymph node, or spleen, which are necessary to maintain the stem cell niche or to preserve the function of differentiated cells (51,52).”
BackgroundThe systemic environment: at the interface of aging and adult neurogenesis
Smith, L. K., White, C., & Villeda, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2715-8 · Cited by 70
“…in decreased production of naïve T cells, and peripheral expansion of senescent memory and effector T cells (Dorshkind et al. 2009) that may promote an inflammatory systemic milieu as a result of their elevated cytokine production (Effros 2007; Huang et al. 2008; Montecino-Rodriguez et al. 2013).”
BackgroundThe emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67
The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients
Gröber, U., & Holick, M. F. (2021) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000693 · Cited by 67
Simnica, D., Akyüz, N., Schliffke, S., Mohme, M., von Wenserski, L., Mährle, T., Fanchi, L. F., Lamszus, K., & Binder, M. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1644110 · Cited by 63
“A decrease in immune function over time is thought to explain increasing rates of infection, autoimmunity and cancer with age .(1) T cells are traditionally connected with this concept, since the thymus that generates the naïve T cell repertoire from bone marrow derived hematopoietic stem cells undergoes a visible dec…”
BackgroundGeller, A. I., Lovegrove, M. C., Shehab, N., Hicks, L. A., Sapiano, M. R. P., & Budnitz, D. S. (2018) · Journal of General Internal Medicine · doi:10.1007/s11606-018-4430-x · Cited by 63
Human lymphocyte repertoires in ageing
Boyd, S. D., Liu, Y., Wang, C., Martin, V., & Dunn‐Walters, D. K. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.007 · Cited by 61
Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
Chen, Z., Yi, W., Morita, Y., Wang, H., Cong, Y., Liu, J., Xiao, Z., Rudolph, K. L., Cheng, T., & Ju, Z. (2015) · Nature Communications · doi:10.1038/ncomms7808 · Cited by 63
Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting
Kumar, V. (2018) · Inflammation · doi:10.1007/s10753-018-0939-8 · Cited by 66
Fiorino, S., Gallo, C. G., Zippi, M., Sabbatani, S., Manfredi, R., Moretti, R., Fogacci, E., Maggioli, C., Loffredo, F. T., Giampieri, E., et al. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01669-y · Cited by 61
Mazzoni, A., Maggi, L., Capone, M., Spinicci, M., Salvati, L., Colao, M. G., Vanni, A., Kiros, S. T., Mencarini, J., Zammarchi, L., et al. (2020) · European Journal of Immunology · doi:10.1002/eji.202048915 · Cited by 61
Ethnicity and survival in bladder cancer: a population-based study based on the SEER database
Fang, W., Yang, Z.-Y., Chen, T., Shen, X., & Zhang, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02308-w · Cited by 60
Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney
Márquez‐Expósito, L., Tejedor-Santamaria, L., Valentijn, F. A., Tejera‐Muñoz, A., Rayego‐Mateos, S., Marchant, V. A., Rodrigues-Díez, R. R., Rubio-Soto, I., Knoppert, S. N., Ortíz, A., et al. (2022) · Antioxidants · doi:10.3390/antiox11020301 · Cited by 60
Sex hormones have pervasive effects on thymic epithelial cells
Dumont-Lagacé, M., St-Pierre, C., & Perreault, C. (2015) · Scientific Reports · doi:10.1038/srep12895 · Cited by 63
Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells
Stervbo, U., Meier, S., Mälzer, J. N., Baron, U., Bozzetti, C., Jürchott, K., Nienen, M., Olek, S., Rachwalik, D., Schulz, A. R., et al. (2015) · AGE · doi:10.1007/s11357-015-9828-3 · Cited by 60
“, older than 65 years) because of increased susceptibility to infections and an impaired response to vaccines (Montecino-Rodriguez et al. 2013).”
BackgroundAging and endothelin: Determinants of disease
Barton, M. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.09.009 · Cited by 63
“…but in fact accessible to numerous (therapeutic) interventions (Ma et al., 2000; Newgard and Sharpless, 2013; Adamczak et al., 2004, 2003; Benigni et al., 2009; Dorshkind and Swain, 2009; Laufs et al., 2004; Montecino-Rodriguez et al., 2013; Ortmann et al., 2004; Werner et al., 2009, 2008).”
BackgroundAhmed, D., Roy, D., & Cassol, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/6238978 · Cited by 62
“Further, aging is associated with dysregulation of the immune system via immune exhaustion (immunosenescence) and chronic inflammation (inflammaging) [109, 110].”
BackgroundThe impact of COVID-19 on health systems, mental health and the potential for nursing
Frawley, T., van Gelderen, F., Somanadhan, S., Coveney, K., Phelan, A. A., Lynam-Loane, P., & Brún, A. D. (2020) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2020.105 · Cited by 58
“…due to senescence, the immune system becomes less effective, and there is a compromised production of T and B lymphocytes which are responsible for generating antibodies in the body as well as the diminished function of mature lymphocytes (Montecino-Rodriguez et al. 2013, Weyend & Goronzy 2016).”
BackgroundRisk factors for hospitalization among persons with COVID-19—Colorado
Vahey, G. M., McDonald, E. G., Marshall, K. E., Martin, S. W., Chun, H., Herlihy, R., Tate, J. E., Kawasaki, B., Midgley, C. M., Alden, N. B., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256917 · Cited by 59
Training vs. Tolerance: The Yin/Yang of the Innate Immune System
Lajqi, T., Köstlin‐Gille, N., Bauer, R., Zarogiannis, S. G., Lajqi, E., Ajeti, V., Dietz, S., Kranig, S. A., Rühle, J., Demaj, A., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11030766 · Cited by 60
Yitbarek, K., Abraham, G., Girma, T., Tilahun, T., & Woldie, M. K. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.08.018 · Cited by 62
Vollmer, B. L., Wolf, A. B., Sillau, S., Corboy, J. R., & Álvarez, E. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.799138 · Cited by 55
“In addition, malignancy and other agent-specific adverse events are reported in some cases (6, 7).”
BackgroundValentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., et al. (2016) · Aging · doi:10.18632/aging.101022 · Cited by 56
“Age-related alteration of the immune system contributes to increased susceptibility to infections, autoimmune diseases and cancer in the elderly [63].”
Allo, V. C. M., Hauk, V. C., Sarbia, N., Pinto, N. A., Croci, D. O., Dalotto‐Moreno, T., Morales, R. M., Gatto, S. G., Cocco, M. N. M., Stupirski, J. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922778117 · Cited by 55
“Studies of immune cell development revealed age-related changes on hematopoietic stem cells, leading to contraction of the lymphoid cell compartment and amplification of myeloid cell programs in both mouse and human (45, 46).”
BackgroundThe Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease
Hage, R. E., Al-Arawe, N., & Hinterseher, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032399 · Cited by 56
“The term “immunoscence” first appeared a few decades ago to refer to impaired or faulty immune responses leading to a decrease in the ability to trigger the immune response and effectively produce antibodies against different pathogens [47,48].”
BackgroundEscalante, J., Artaiz, O., Diwakarla, S., & McQuade, R. M. (2024) · GeroScience · doi:10.1007/s11357-024-01451-2 · Cited by 62
“In parallel, the functionality of mature lymphocytes in secondary lymphoid tissues is impaired, further weakening immune responses to novel antigens [38, 56, 109].”
Teh, B. W., Harrison, S. J., Pellegrini, M., Thursky, K., Worth, L. J., & Slavin, M. A. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.01.004 · Cited by 55
“Impact of increasing age on cell-me In the adaptive immune system, T and B cell phenotypes are changed as a result of a shift from production of lymphoid to myeloid lineage by haematopoietic stem cell precursors and age-related involution of the thymus [30].”
BackgroundPomegranate Juice Enhances Healthy Lifespan in Drosophila melanogaster: An Exploratory Study
Balasubramani, S. P., Jayaram, M., Chatterjee, A., Patnaik, E., Kukkupuni, S. K., Nongthomba, U., & Venkatasubramanian, P. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00245 · Cited by 54
Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective
Darwiche, W., Gubler, B., Marolleau, J., & Ghamlouch, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00683 · Cited by 55
Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging
Ryan, L., Hay, M., Huentelman, M. J., Duarte, A., Rundek, T., Levin, B. E., Soldan, A., Pettigrew, C. A., Mehl, M. R., & Barnes, C. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00128 · Cited by 55
The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53
Human Aging and Cancer: Role of miRNA in Tumor Microenvironment
Sandiford, O. A., Moore, C. A., Du, J., Boulad, M., Gergues, M., Eltouky, H., & Rameshwar, P. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-74470-4_9 · Cited by 54
Tumor-Infiltrating CD8 T Cells Predict Clinical Breast Cancer Outcomes in Young Women
Jin, Y. W., & Hu, P. (2020) · Cancers · doi:10.3390/cancers12051076 · Cited by 52
“Various immune subsets should decline with age in a phenomenon known as immunosenescence [22].”
BackgroundEarly systemic immune biomarkers predict bone regeneration after trauma
Cheng, A., Vantucci, C. E., Krishnan, L., Ruehle, M. A., Kotanchek, T., Wood, L. B., Roy, K., & Guldberg, R. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017889118 · Cited by 53
“In fact, immunosenescence with aging has been well documented (48, 49).”
BackgroundAge-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation
Li, G., Ju, J., Weyand, C. M., & Goronzy, J. J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402389 · Cited by 55
“A better understanding of the age-associated defects in adaptive immunity holds the potential to design age-targeted interventions to improve vaccine responses (3, 18).”
BackgroundZhou, D., Byers, L. A., Sable, B., Smit, M.-A. D., Sadraei, N. H., Dutta, S., & Upreti, V. V. (2023) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2346 · Cited by 52
“46 Interestingly, the patients with PR and SD (with tumor shrinkage and the disappearance of multiple liver metastases) were young (33 and 41 years old, respectively) and female.”
BackgroundTomay, F., Wells, K., Duong, L., Tsu, J. W., Dye, D. E., Radley‐Crabb, H. G., Grounds, M. D., Shavlakadze, T., Metharom, P., Nelson, D. J., et al. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12046 · Cited by 54
“Immunosenescence has been extensively studied in the context of the adaptive immune system, highlighting the declining function of T and B cells.(8) Several studies also indicate that aging impacts on innate immunity.”
BackgroundGuastella, A. R., Michelhaugh, S. K., Klinger, N. V., Fadel, H. A., Kiousis, S., Ali‐Fehmi, R., Kupsky, W. J., Juhász, C., & Mittal, S. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2869-6 · Cited by 54
“Although the underlying mechanisms are not fully understood, it is generally accepted that one consequence of aging is a decline in immune function [47].”
Microbiota–host interactions shape ageing dynamics
Popkes, M., & Valenzano, D. R. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0596 · Cited by 54
“However, immune function is subject to severe alterations during ageing, including improper immune surveillance of damaged and infected cells, chronic inflammatory responses and autoimmunity, leading to extensive tissue damage [87].”
BackgroundBrown, B. N., Haschak, M. J., Lopresti, S. T., & Stahl, E. C. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.001 · Cited by 55
Borgiani, E., Figge, C., Kruck, B., Willie, B. M., Duda, G. N., & Checa, S. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3801 · Cited by 51
Verma, D., Gupta, S., Biswas, J., Joshi, N., Singh, A., Gupta, P., Tiwari, S., Kanumuri, R. S., Chaturvedi, S., Wahajuddin, M., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.014 · Cited by 50
Rahman, M., Islam, M., Shimanto, M. H., Ferdous, J., Rahman, A. A.-N. S., Sagor, P. S., & Chowdhury, T. (2020) · Environment Development and Sustainability · doi:10.1007/s10668-020-01028-x · Cited by 49
Molecular, ecological, and behavioral drivers of the bat-virus relationship
Gonzalez, V., & Banerjee, A. (2022) · iScience · doi:10.1016/j.isci.2022.104779 · Cited by 56
“In humans, aging is related to a deteriorating immune response (Montecino-Rodriguez et al., 2013).”
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice
Xie, Z., Lin, M., Xing, B., Wang, H., Zhang, H., Cai, Z., Mei, X., & Zhu, Z. (2025) · Science Advances · doi:10.1126/sciadv.ads4957 · Cited by 51
“The immune system undergoes a progressive decline as aging ( 22 ).”
Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus
Cepeda, S., & Griffith, A. V. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.022 · Cited by 53
“…(Yang et al., 2009), as well as loss of cortico-medullary junction integrity and cortical thinning (Manley et al., 2011), and decreased complexity of medullary islet morphology (Griffith et al., 2012) (and reviewed in (Manley et al., 2011; Montecino-Rodriguez et al., 2013; Taub and Longo, 2005)).”
BackgroundInfluentialDevelopment of mucosal‐associated invariant T cells
Koay, H., Godfrey, D. I., & Pellicci, D. G. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12039 · Cited by 52
“It is currently unclear how reduced numbers of MAIT cells impacts on the immune system of older individuals, although it is well described that as humans age they become increasingly immunocompromised.(81,82) Thus, one key factor that underpins the variability of MAIT cells in humans appears to be age, with optimal MA…”
BackgroundFaithful preclinical mouse models for better translation to bedside in the field of immuno-oncology
Saito, R., Kobayashi, T., Kashima, S., Matsumoto, K., & Ogawa, O. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01520-z · Cited by 53
“Aged bone marrow shows decreased production of lymphocytes and a relative increase in the myeloid population [71].”
BackgroundGao, Y. M., Yuan, D., Gai, L., Wu, X., Shi, Y., He, Y., Liu, C., Zhang, C., Zhou, G., & Yuan, C. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.08.005 · Cited by 48
“Thereinto, maladjustment of immune system is the main factor causing increased inflammation during the aging process [9,10].”
BackgroundAging hampers neutrophil extracellular traps (NETs) efficacy
Sabbatini, M., Bona, E., Novello, G., Migliario, M., & Renò, F. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02201-0 · Cited by 51
“During aging, the human immune system undergoes a process of decline in its protective function, making our body more susceptible to infections [22, 23].”
BackgroundSingle-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
Zhang, C., Lei, L., Yang, X., Ma, K., Zheng, H., Su, Y., Jiao, A., Wang, X., Liu, H., Zou, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002809 · Cited by 50
Denton, A. E., Dooley, J., Cinti, I., Silva-Cayetano, A., Fra-Bidó, S., Innocentin, S., Hill, D. L., Carr, E. J., McKenzie, A. N. J., Liston, A., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abk0018 · Cited by 61
“Older individuals are at higher risk of infection partly because of decreased functionality of the immune system (1).”
BackgroundRole of macrophage migration inhibitory factor in age-related lung disease
Sauler, M., Bucala, R., & Lee, P. J. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00339.2014 · Cited by 49
“Advanced age is associated with decreased neutrophil function, attenuated innate immune signaling, and a decreased repertoire of adaptive immune responses (39, 101, 127, 128).”
A Cell for the Ages: Human γδ T Cells across the Lifespan
Clark, B. L., & Thomas, P. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238903 · Cited by 50
McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48
“Normal aging is associated with dysregulation of immune response, described as immunosenescence [121], which is associated with low-grade chronic peripheral inflammation, described as inflammaging [105].”
BackgroundGenomic and molecular features distinguish young adult cancer from later-onset cancer
Lee, W., Wang, Z., Saffern, M., Jun, T. W., & Huang, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110005 · Cited by 48
Palmer, S., Cunniffe, N. J., & Donnelly, R. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0982 · Cited by 47
Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes
Márquez‐Expósito, L., Tejedor-Santamaria, L., Santos‐Sanchez, L., Valentijn, F. A., Cantero‐Navarro, E., Rayego‐Mateos, S., Rodrigues-Díez, R. R., Tejera‐Muñoz, A., Marchant, V. A., Sanz, A. B., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662020 · Cited by 46
“Moreover, aging-related dysregulation of several innate and acquired immune responses have been described (Goronzy and Weyand, 2013; Montecino-Rodriguez et al., 2013; Franceschi and Campisi, 2014), and in human kidney transplant patients, aged donor kidneys were observed to attract more infiltrating inflammatory cells…”
BackgroundRahman, M. M., Islam, F., Mim, S. A., Khan, M. S., Islam, M. R., Haque, M. A., Mitra, S., Emran, T. B., & Rauf, A. (2022) · Journal of Nanomaterials · doi:10.1155/2022/4217529 · Cited by 46
RetractedFrailty in inflammatory bowel diseases: an emerging concept
Kochar, B. D., Orkaby, A. R., Ananthakrishnan, A. N., & Ritchie, C. S. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211025474 · Cited by 45
Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections
Mercatelli, D., Pedace, E., Veltri, P., Giorgi, F. M., & Guzzi, P. H. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.002 · Cited by 42
“As investigated in [60], ageing is characterised by the decline of the immune function.”
Jalal, N. A., Al-Ghamdi, A. M., Momenah, A. M., Ashgar, S. S., Bantun, F., Bahwerth, F. S., Hariri, S. H., Johargy, A. K., Barhameen, A. A. A., Al-Said, H. M., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12010164 · Cited by 44
Bezold, V., Rosenstock, P., Scheffler, J., Geyer, H., Horstkorte, R., & Bork, K. (2019) · Aging · doi:10.18632/aging.102123 · Cited by 45
“com 5267 AGING shown by other groups that treatment with AGEmodified proteins led to an upregulation of RAGE expression [43,44].”
BackgroundBanuelos, J., Sabbagh, M. D., Roh, S., Nguyen, M.-D. T., Lemaine, V., Tran, N. V., Jacobson, S. R., Boughey, J. C., Jakub, J. W., Hieken, T. J., et al. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000006202 · Cited by 43
Schwartz, M. D., Emerson, S. G., Punt, J. A., & Goff, W. D. (2020) · Aging and Disease · doi:10.14336/ad.2020.0619 · Cited by 43
“Multiple components of host immunologic response to pathogens are diminished with aging [3].”
BackgroundBowirrat, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111817 · Cited by 46
“Thus, physiological changes with the passage of time are partially responsible for the alteration in the central and peripheral immune responses [56,57].”
BackgroundAmmer‐Herrmenau, C., Kulkarni, U., Andreas, N., Ungelenk, M., Ravens, S., Hübner, C., Kather, A., Kurth, I., Bauer, M. W., & Kamradt, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211716 · Cited by 42
Metabolic reprogramming: a bridge between aging and tumorigenesis
Drapela, S., Ilter, D., & Gomes, A. P. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13261 · Cited by 41
Overlapping evidence of innate immune dysfunction in psychotic and affective disorders
Hughes, H. K., & Ashwood, P. (2020) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2020.100038 · Cited by 39
The multifaceted role of macrophages in homeostatic and injured skeletal muscle
Wang, X., & Zhou, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274816 · Cited by 45
“Aged immune system loses its ability to mount an ef fi cient immune response to infection or injury (167, 168).”
BackgroundPalmisano, F., Boeri, L., Fontana, M., Gallioli, A., LORENZIS, E. D., Zanetti, S. P., Sampogna, G., Spinelli, M. G., Albo, G., Longo, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25069-5 · Cited by 41
Smith, C., Lamba, N., Ou, Z., Vo, Q.-A., Araujo-Lama, L., Lim, S., Joshi, D., Doucette, J. A., Papatheodorou, S., Tafel, I. J., et al. (2019) · Journal of Spine Surgery · doi:10.21037/jss.2019.03.06 · Cited by 41
“While these studies were not intended to be matched cohort studies, the data suggested an increased vulnerability to infections in the elderly population; this observation may be explained by the decline in immune function known to occur with aging (43).”
BackgroundAging of the progenitor cells that initiate prostate cancer
Freeland, J., Crowell, P. D., Giafaglione, J. M., Boutros, P. C., & Goldstein, A. S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.014 · Cited by 43
“Similarly, age-related immune dysfunction may reduce efficiency of immune surveillance[16, 17], enabling the survival and expansion of pre-malignant cells.”
BackgroundRelation of Dietary Factors with Infection and Mortality Rates of COVID-19 Across the World
Abdulah, D. M., & Hassan, A. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1434-0 · Cited by 42
Modeling human immune responses to vaccination in vitro
Morrocchi, E., van Haren, S. D., Palma, P., & Levy, O. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.002 · Cited by 40
Adult Thymic Epithelium Contains Nonsenescent Label-Retaining Cells
Dumont-Lagacé, M., Brochu, S., St-Pierre, C., & Perreault, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302961 · Cited by 41
Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity
Hasiakos, S., Gwack, Y., Kang, M., & Nishimura, I. (2021) · Journal of Dental Research · doi:10.1177/0022034521990652 · Cited by 37
“Elderly populations display distinct reductions in memory B cells and naive T-cell populations and exhibit altered immune responses (Montecino-Rodriguez et al. 2013), culminating in a heterogenic bias toward Th17 phenotypes (Huang et al.”
BackgroundMankowski, R. T., Anton, S. D., Ghita, G. L., Brumback, B., Darden, D. B., Bihorac, A., Leeuwenburgh, C., Moldawer, L. L., Efron, P. A., Brakenridge, S. C., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab080 · Cited by 41
“2) Charlson Comorbidity Index, median (25th, 75th) 0 (0, 0)a 4 (4, 6) 4 (3, 6) 5 (4, 7) Race, n (%) White 67 (89) 133 (91) 71 (95) 54 (89) African American 7 (10) 10 (7) 3 (4) 6 (10) American Indian 1 (1) 0 (0) 0 (0) 0 (0) Asian 0 (0) 1 (1) 1 (1) 0 (0) Unknown 0 (0) 1 (1) 0 (0) 1 (1) Non-Hispanic ethnicity, n (%) 70 (…”
BackgroundTang, X., Deng, B., Zang, A., He, X., Zhou, Y., Wang, D., Li, D., Dai, X., Chen, J., Zhang, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940577 · Cited by 39
Glenton, C., Carlsen, B., Lewin, S. A., Wennekes, M. D., Winje, B. A., & Eilers, R. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013706.pub2 · Cited by 40
“As a person becomes older, their immune system gradually deteriorates and they become more vulnerable to infections (Montecino-Rodriguez 2013).”
BackgroundAging Immune System and Its Correlation With Liability to Severe Lung Complications
Li, Y., Wang, C., & Peng, M. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.735151 · Cited by 40
“When a healthy person breathes, their alveoli are filled with air, but in individuals suffering from pneumonia, the alveoli are filled with fluid and pus which results in breathing difficulty due to a limited amount of oxygen (22, 34).”
BackgroundTelomerase deficiency reflects age-associated changes in CD4+ T cells
Matthe, D. M., Thoma, O., Sperka, T., Neurath, M. F., & Waldner, M. J. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00273-0 · Cited by 41
“Within the adaptive immune system, a relative reduction in B and T cell progenitors and naïve B and T cells have been reported amongst other changes [5].”
Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner
Yi, W., Hu, X., Chen, Z., Liu, L., Tian, Y., Chen, H., Cong, Y., Yang, F., Zhang, L., Rudolph, K. L., et al. (2015) · Blood · doi:10.1182/blood-2015-02-624114 · Cited by 38
Mosquera, M. J., Kim, S., Zhou, H., Jing, T. T., Luna, M., Guss, J. D., Reddy, P. M., Lai, K., Leifer, C. A., Brito, I., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav9788 · Cited by 40
“10 of 13 disease vaccines and vaccination in the populations that manifest metabolic syndrome (43, 44) and predict how metabolic diseases, gut pathologies, and other inflammatory conditions may affect nanovaccine response.”
BackgroundThe Lanostane Triterpenoids in Poria cocos Play Beneficial Roles in Immunoregulatory Activity
Chao, C.-L., Huang, H.-W., Su, M., Lin, H., & Wu, W. (2021) · Life · doi:10.3390/life11020111 · Cited by 38
Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients
Caro, J., Braunstein, M. J., Williams, L. S., Bruno, B., Kaminetzky, D., Siegel, A., Razzo, B. M., Alfandari, S., Morgan, G. J., Davies, F. E., et al. (2022) · Leukemia · doi:10.1038/s41375-021-01506-9 · Cited by 39
“The number of naïve T-cells is decreased, and there is a relative shift towards memory T-cells, which results in decreased T-cell diversity, thereby reducing the ability to respond to new distinct antigens [61, 62].”
BackgroundCellular senescence as a therapeutic target to improve renal transplantation outcome
van Willigenburg, H., de Keizer, P. L. J., & de Bruin, R. W. F. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.02.015 · Cited by 38
Chrono-tailored drug delivery systems: recent advances and future directions
Butler, C. T., Rodgers, A. M., Curtis, A. M., & Donnelly, R. F. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01539-4 · Cited by 42
“Enhancing antibody responses in older adults is particularly important as the efficacy of vaccines deteriorates with age [146, 147].”
Background
Metadata
- Authors
- Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Dorshkind, Kenneth
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 958-965
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582124
- OpenAlex
- W1978103330
- Semantic Scholar
- 21eeafabbc2cc60c6c46752d238c5688d989e17b
- Cited by
- 793
- References
- 120
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 72 · 2023: 86 · 2022: 96 · 2021: 126 · 2020: 106 · 2019: 64 · 2018: 54 · 2017: 37 · 2016: 21 · 2015: 27 · 2014: 18 · 2013: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG034875, AG034875)
- David Geffen School of Medicine, University of California, Los Angeles
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, B cell aging, T cell senescence, thymus, bone marrow, secondary lymphoid organs, lymphocyte function
- MeSH terms
- Aging, Animals, Hematopoietic Stem Cells, Humans, Immune System, Immunologic Factors, Lymphoid Progenitor Cells
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