The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index; none of the 118 sources its claims cite is checked for support yet.
Causes, consequences, and reversal of immune system aging
Open accessAbstract
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.
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In the paper
“Despite the increase in their number, myeloid-biased stem cells are not as robust as their young counterparts (24)”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [24] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1)”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites [1] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“As a result, elderly individuals do not respond to immune challenge as robustly as the young.”
- Also stated in: § Introduction · hedged
“While elderly individuals are by no means immunodeficient, they often do not respond efficiently to novel or previously encountered antigens.”
- Also stated in: § Introduction · plain
“This is illustrated by increased vulnerability of individuals 70 years of age and older to influenza (1), a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
- Not checked yetcites [1] source
- Not checked yetcites (2)(3)(4)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Introduction · hedged
None of the sources cited for this claim have been checked yet.
In the paper
“which in turn could underlie the numerous age-related deficiencies observed in mature myeloid cells such as neutrophils and macrophages (25,26).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11,17).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (8)(9)(10)
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In the paper
“The causes of this age-related reduction in lymphocyte development are multifactorial and include changes in HSCs and progenitor cells (11,12) as well as the local tissue and systemic environments (13,14).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“The age-related increase in expression of myeloid lineage genes in the studies noted above (11,17) likely resulted from the accumulation of myeloid-biased HSCs, as these analyses were performed on unseparated pools of HSCs.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“a situation that is exacerbated by their poor response to vaccination (2)(3)(4).”
§ Causes, consequences, and reversal of immune system aging > Introduction
What the sources say
- Not checked yetcites (2)(3)(4)
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“this has led to the conclusion that age-related changes in the endocrine system contribute to declines in lymphopoiesis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 28
- Probably not a substantial claim. 3
None of the sources cited for this claim have been checked yet.
In the paper
“From an immunologic perspective, the most profound effect of stem cell aging in both mice (11,18) and humans (17) is a decreased capacity to produce lymphocytes and an increase in myeloid potential.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“it is now appreciated that the number of lymphoid-biased stem cells declines with age concomitant with an increase in myeloid-biased HSCs (19).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [19] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues.”
- Also stated in: § Effects of aging on immune system development · plain
“primary lymphopoiesis in the elderly is significantly diminished, as exemplified by involution of the thymus (8)(9)(10).”
- Also stated in: § Effects of aging on immune system development · plain
“the number of B cell (28)(29)(30)(31) and T cell (32,33) progenitors in bone marrow and thymus is markedly reduced with age.”
§ Causes, consequences, and reversal of immune system aging > Abstract
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Effects of aging on immune system development · plain
None of the sources cited for this claim have been checked yet.
In the paper
“HSCs exhibit multiple age-related changes that include impaired adherence to stromal cells and, in some strains of mice (15,16) and elderly humans (17), an increase in number.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The effects of aging on the immune system are widespread and affect the rate at which naive B and T cells are produced as well as the composition and quality of the mature lymphocyte pool.”
- Also stated in: § Aging and the decline of immune function · boosted
“The answer is that the composition and quality of the mature lymphocyte pool is profoundly altered by aging.”
§ Causes, consequences, and reversal of immune system aging > Introduction
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Aging and the decline of immune function · boosted
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, chronic stimulation with persistent viral infections such as CMV can exhaust the naive pool of cells and result in an oligoclonal memory cell expansion.”
§ Causes, consequences, and reversal of immune system aging > Aging and the decline of immune function
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“This decline is likely due to decreased numbers of IgM + memory and switched memory B cells, because the total number of naive B cells remains unchanged by aging (51,52).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Regardless of how the shift occurs from a salutary to an inflammatory milieu, the end result may be a negative effect on the ability of naive lymphocytes from the bone marrow or thymus to lodge in an organ such as the spleen as well as the function of mature lymphocytes already resident in that tissue.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Similar to B cell progenitors, ETPs and DN cells from old mice also exhibit age-related defects in proliferation and high rates of apoptosis (ref.32 and Figure 1).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites (ref.32)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These oligoclonal expanded CD8 + memory T cells are further distinguished in humans by loss of expression of the CD28 co-stimulatory molecule (47,48) and impaired immune function.”
§ Causes, consequences, and reversal of immune system aging > Figure 1
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“The accumulation of CD8 + CD28 -T cells and CMV seropositivity are components of the immune risk profile, which has been proposed as a predictor of mortality in individuals 65 and older (49)”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [49] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Lymphoid-biased HSCs in old mice also appear to accumulate deficiencies that, as discussed below, may compromise their selfrenewal potential and contribute to the decline of this population (27).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Age-relat-ed microenvironmental changes also have a major impact in the thymus, where T cell development is dependent upon an intact thymic milieu composed of fibroblasts, macrophages, dendritic cells, and thymic epithelial cells.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“B cell number in mice is unchanged by aging, but in human peripheral blood their absolute number is reduced (51).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [51] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“It is clear that the number of thymic epithelial cells declines over time and that they are not replaced, as a result of impaired proliferation (38).”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
- Not checked yetcites [38] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“For example, common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice do not proliferate as extensively as do young cells, and they exhibit significantly higher rates of apoptosis.”
§ Causes, consequences, and reversal of immune system aging > Effects of aging on immune system development
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Levels of ROS in cells may also be regulated by ataxia telangiectasia mutated (ATM) kinase, and age-related declines in expression of ATM can result in an increase in ROS in cells (77,78).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“CD4 + T cells exhibit reduced T cell receptor signaling intensity and altered production of various cytokines following antigen binding (70,71).”
§ Causes, consequences, and reversal of immune system aging > Figure 1
What the sources say
- Not checked yetcites [70] Maue, 2009, Curr Opin Immunol.
- Not checked yetcites [71] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Thus, repeated cell division may result in progressive telomere shortening that in turn results in DNA damage that can no longer be repaired efficiently due to agerelated defects in DNA repair mechanisms (75).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [75] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“GH and IGF-1 bind to receptors expressed on thymocytes (101) and thymic epithelial cells (102)”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“mice with hypomorphic expression of DNMT1 exhibit relatively normal myeloerythroid potential but show a significant block in lymphoid development (92).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [92] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“In this regard, loss of DNMT3a impairs differentiation of HSCs while their number increases in the bone marrow (91)”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [91] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Wang and colleagues demonstrated that BATF levels increased in HSCs in response to DNA damage and that this resulted in the differentiation of lymphoid-biased HSCs at the expense of their self-renewal (27).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [27] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“recent studies have shown that both Ink4a and Arf expression increases in pro-B cells from old mice and that inhibiting their expression can partially reverse the effects of aging (81).”
§ Causes, consequences, and reversal of immune system aging > Intracellular changes in developing and mature lymphocytes
What the sources say
- Not checked yetcites [81] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“GH treatment resulted in increased thymic mass, increased thymic output as measured by T cell receptor rearrangement excision circles in circulating T cells, and increased numbers of naive CD4 + T cells.”
- Also stated in: § Rejuvenating the aging immune system · plain
“It is important to note that the effects of GH were not thymus specific, as the subjects also had expanded numbers of naive peripheral CD4 + T cells (105).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [105] Napolitano, 2008, J Clin Invest.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Rejuvenating the aging immune system · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and suggest that such interventions could be administered to a large cohort of individuals.”
§ Causes, consequences, and reversal of immune system aging > Caveats in immune system rejuvenation
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“it is not unreasonable to expect that this information will continue to be translated into therapies to rejuvenate the aging immune system.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“As predicted, levels of Ink4a expression in ETPs and DN cells harvested from FGF7-treated mice were downregulated, and these cells exhibited enhanced proliferation (82).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [82] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a tremendous amount is now known regarding the cellular changes that occur in the aging immune system and the molecular events that underlie them.”
§ Causes, consequences, and reversal of immune system aging > Conclusions and perspectives
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“beneficial effects were observed when it commenced in adults but were not evident when initiated in prepubertal or aged non-human primates (112).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
What the sources say
- Not checked yetcites [112] source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“FGF7 is particularly remarkable because its administration to old mice results in a renewal of the thymic microenvironment, increased numbers of ETPs, and a restoration of thymus cellularity to levels observed in the young (106, 107).”
§ Causes, consequences, and reversal of immune system aging > Rejuvenating the aging immune system
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
The thymic effects of GH, IGF-1, and FGF7 are short-lived, and the thymus returns to its previous size after treatment ends.
“because their effects are transient and the thymus reverts to its former size following the cessation of treatment.”
The paper relies on this without support.
Aging affects the immune system differently across individuals.
“It is likely that the effects of aging on the immune system will not be uniform between individuals.”
The paper relies on this without support.
GH, IGF-1, and FGF7 act throughout the body because their receptors are present on cells in many tissues.
“factors such as GH, IGF-1, and FGF7 have widespread systemic effects due to the expression of their receptors on cells in multiple tissues.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence of waning adaptive immunity is already apparent in mid adulthood, as early as at the age of 50 years, with increasing clinical relevance in the 7th–10th decade of life”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Montecino-Rodriguez et al., 2013
In the citing paper
“most older people over the age of 60–65 years (although not all) experience some immune dysregulation that makes them less able to respond to immune challenges [33,34].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [34]
Citations
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Flagged first, then by citations
Research works printed but not linked: 3
- Weng, 2009, Trends Genet., 30, 306
- Maue, 2009, Curr Opin Immunol., 30, 301
- Napolitano, 2008, J Clin Invest., 118, 1085
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“The response to antigens with aging is reduced, and thus it can possibly affect the immune tumor microenvironment (43,44).”
BackgroundEfficacy of topical treatments for molluscum contagiosum in randomized controlled trials
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“To attempt to reverse the aging of thymus and increase the pool of T cells, antioxidants and blockers of cyclin-dependent kinases are of considerable interest, somatotropin, IGF-1, IL-7 and FGF7 have also been studied in this regard (22).”
BackgroundImmune Cells and Immunosenescence
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“immune system function that characteristically occur during aging.(21) Indeed, such changes have been associated not only with higher cancer incidence(22) but also with slower cancer progression in advanced age.”
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Bone marrow fat and the decline of B lymphopoiesis in rabbits
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“…been widely studied and declining B lymphopoiesis in old mice is now attributed to changes in both hematopoietic progenitors and the BM microenvironment (Cho et al., 2008, Kondo et al., 1997, Labrie et al., 2004a, Miller and Allman, 2003, Miller and Allman, 2005, Montecino-Rodriguez et al., 2013).”
BackgroundGlycation interferes with natural killer cell function
Rosenstock, P., Bezold, V., Bork, K., Scheffler, J., & Horstkorte, R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.006 · Cited by 18
Micronutrients that Affect Immunosenescence
Abiri, B., & Vafa, M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_2 · Cited by 18
Microbial contamination and efficacy of disinfection procedures of companion robots in care homes
Bradwell, H. L., Johnson, C. W., Lee, J., Winnington, R., Thill, S., & Jones, R. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237069 · Cited by 16
“Older adults may be particularly vulnerable to health consequences when exposed to pathogens due to a decline in immune function with ageing [47].”
Shaping immunity: The influence of natural selection on population immune diversity
Randolph, H. E., Aracena, K. A., Lin, Y., Mu, Z., & Barreiro, L. B. (2024) · Immunological Reviews · doi:10.1111/imr.13329 · Cited by 20
“25 Likewise, immunological differences associated with sex have been widely described.”
BackgroundTsai, Y.-M., Gamper, N. L., Huang, T.-W., Lee, S.-C., & Chang, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101612 · Cited by 17
“Immunity is different in older and younger persons, such that elderly individuals do not respond to immune challenge as robustly as the young [13].”
BackgroundFrom conifers to cognition: Microbes, brain and behavior
Lathe, R., & Clair, D. S. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12680 · Cited by 16
Patil, S. V., Dhumal, U., & Acharya, A. (2023) · Adesh University Journal of Medical Sciences & Research · doi:10.25259/aujmsr_35_2022 · Cited by 16
Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders
Pointner, A., Krammer, U. D. B., Tomeva, E., Magnet, U., Hippe, B., Jacob, U., & Haslberger, A. G. (2024) · Life · doi:10.3390/life14030390 · Cited by 18
MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells
Colpani, O., & Spinetti, G. (2019) · Vascular Biology · doi:10.1530/vb-19-0017 · Cited by 16
Lane, L. C., Kuś, A., Bednarczuk, T., Bossowski, A. T., Daroszewski, J., Jurecka‐Lubieniecka, B., Cordell, H. J., Pearce, S. H. S., Cheetham, T. D., & Mitchell, A. L. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa347 · Cited by 16
“The aging immune system may contribute to the phenotypic differences observed between YOGD and LOGD, where involution of the thymus and reduced B- and T-lymphocyte production may alter the mechanisms driving the autoimmune response in the older population (49).”
BackgroundRioux, M. L., Francis, M. E., Swan, C. L., Ge, A., Kroeker, A., & Kelvin, A. A. (2021) · Viruses · doi:10.3390/v13040678 · Cited by 16
Maine, G. N., Krishnan, S. M., Walewski, K., Trueman, J., Sykes, E., & Sun, Q. (2022) · Journal of Immunological Methods · doi:10.1016/j.jim.2022.113243 · Cited by 16
Targets of Immune Regeneration in Rheumatoid Arthritis
Hohensinner, P. J., Goronzy, J. J., & Weyand, C. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.020 · Cited by 17
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients
Rogiers, A., van den Oord, J. J., Garmyn, M., Stas, M., Kenis, C., Wildiers, H. P. M. W., Marine, J., & Wolter, P. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0304-7 · Cited by 16
Brusch, G. A., Christian, K. A., Brown, G. P., Shine, R., & DeNardo, D. F. (2018) · Oecologia · doi:10.1007/s00442-018-4321-1 · Cited by 16
Abbas, S. A., Helou, J. E., Chalah, M. A., Hilal, H., Saliba, G., Abboud, H., & Ayache, S. S. (2019) · Medicina · doi:10.3390/medicina55050201 · Cited by 16
“In this context, it is important to note that older age is associated with decreased cellular immunity which makes such patients only relatively immunocompetent [14].”
BackgroundN’dilimabaka, N., Mounguegui, D. M., Lekana-Douki, S. E., Yattara, M. K., Obame‐Nkoghe, J., Longo-Pendy, N. M., Koumba, I. P. K., Mve-Ella, O. B., Moukouama, S. E. K., Dzembo, C., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.975712 · Cited by 16
Durand, A., Bonilla, N., Level, T., Ginestet, Z., Lombès, A., Guichard, V., Germain, M., Jacques, S., Letourneur, F., Cruzeiro, M. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45984-8 · Cited by 20
“Although aging affects both the innate and adaptive immune systems, these changes are most pronounced in adaptive immune cells 10,11 .”
BackgroundAagingBase: a comprehensive database of anti-aging peptides
Kunjulakshmi, R., Kumar, A., Kumar, K. V., Sengupta, A., Kundal, K., Sharma, S., Pawar, A., Krishna, P. S., Alfatah, M., Ray, S., et al. (2024) · Database · doi:10.1093/database/baae016 · Cited by 16
Chen, Z., Guo, Y., Sun, H., Zhang, W., Hou, S., Guo, Y., Ma, X., & Meng, H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1394738 · Cited by 15
Singhal, G., Morgan, J., Corrigan, F., Toben, C. G., Jawahar, M. C., Jaehne, E. J., Manavis, J., Hannan, A. J., & Baune, B. T. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00862-x · Cited by 14
The 5-Ws of immunotherapy in head and neck cancer
Botticelli, A., Mezi, S., Pomati, G., Cerbelli, B., Rocco, C. D., Amirhassankhani, S., Sirgiovanni, G., Occhipinti, M. A., Napoli, V. M., Emiliani, A., et al. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103041 · Cited by 15
T cell responses in senior patients with community-acquired pneumonia related to disease severity
Bian, L., Bi, Y., Zhou, S., Chen, Z.-D., Wen, J., Jin, S. K., Mao, L., & Wang, L. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.041 · Cited by 15
High‐mobility group box 1 at the time of parturition in women with gestational diabetes mellitus
Hill, A. V., Menon, R., Perez-Patron, M. J., Carrillo, G., Xu, X., & Taylor, B. D. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13175 · Cited by 15
Recent advances in understanding the mechanisms determining longevity
Bayersdorf, R., & Schumacher, B. (2019) · F1000Research · doi:10.12688/f1000research.19610.1 · Cited by 14
COVID-19 fatalities by zip codes and socioeconomic indicators across various U.S. regions
Sen-Crowe, B., Lin, I.-C. F., Alfaro, R., McKenney, M. G., & Elkbuli, A. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102471 · Cited by 13
Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B. K., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., et al. (2022) · Cancers · doi:10.3390/cancers14184346 · Cited by 14
“tion, thus contrasting with previous reports suggesting that peripheral and intra-tumoral immunity were known to decline over time [30,38].”
ResultLiu, J. A., Walton, J. C., Bumgarner, J. R., Walker, W. H., Meléndez‐Fernández, O. H., DeVries, A. C., & Nelson, R. J. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2135442 · Cited by 15
Aging: Epigenetic modifications
Mishra, S., Raval, M., Kachhawaha, A. S., Tiwari, B. S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.002 · Cited by 14
Senescent T Cells in Age-Related Diseases
Yu, P.-J., Zhou, M. L., Liu, Y., & Du, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0219 · Cited by 16
Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme
Rubio, Y. L. B., González-Reymúndez, A., Wu, K.-H., Griguer, C. E., Steibel, J. P., Campos, G. D. L., Doseff, A. I., Gallo, K. A., & Vazquez, A. I. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200391 · Cited by 14
“…that functions as a tumor repressor (Chi et al. 2017),HCN1 (that codes for a proton channel that regulates the normal brain rhythmic activity (Pan et al. 2015), and the fork-head transcription factors FOXD3 (involved in cell pluripotency and reported as tumor suppressor; Li et al. 2017), and…”
BackgroundOlagoke, O., Quigley, B. L., Eiden, M., & Timms, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-48880-0 · Cited by 14
Kanji, J. N., Bailey, A., Fenton, J., Ling, S. H., Rivera, R., Plitt, S. S., Sligl, W., Taylor, S. C., Turnbull, L., Tipples, G. A., et al. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.08.022 · Cited by 13
“Thus the lower titers seen in the mRNA-1273 group could be also attributed to the tendency for elderly patients to mount less of an immune response to vaccines [45].”
Chaos theory for clinical manifestations in multiple sclerosis
Akaishi, T., Takahashi, T., & Nakashima, I. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.04.004 · Cited by 14
Xiang, P., Jing, W., Lin, Y., Liu, Q., Shen, J., Hu, X., Chen, J., Cai, R., Hare, J. M., Zhu, W. M., et al. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30490 · Cited by 14
New Approaches to Profile the Microbiome for Treatment of Neurodegenerative Disease
Elmaleh, D. R., Downey, M. A., Kundakovic, L., Wilkinson, J. E., Neeman, Z., & Segal, E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210198 · Cited by 14
“An aging person’s immune sys-tem typically reacts less robustly to environmental stimuli than a younger person’s does, with altered B and T cell development and differentiation resulting in an overall decrease in functional specific immunity [14].”
Stromal senescence contributes to age-related increases in cancer
Ye, J., Melam, A., & Stewart, S. A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00840-9 · Cited by 16
“obscure, it is thought to be driven by the ongoing accumulation of inflammatory chemokines and cytokines that result in a chronically inflamed state 181 (Fig.”
Camejo, L., Nandeesha, N., Phan, K. H., Chharath, K., Tran, T., Ciesla, D. J., & Velanovich, V. (2022) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-022-02446-3 · Cited by 13
“There is a decrease in the production of new adaptive immune cells such as lymphocytes, as well as an age-associated decline in certain subsets of protective CD4 + T cells and B cells in the thymus gland or bone marrow [20, 21].”
BackgroundFlip a coin: cell senescence at the maternal–fetal interface
Gong, G.-S., Muyayalo, K. P., Zhang, Y., Lin, X., & Liao, A. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad071 · Cited by 13
“Another study has demonstrated that the removal of the proinflammatory SASP environment can lead to a reversal of the senescent phenotype, indicating that the SASP factors might be both the cause and consequence of cell senescence [29].”
BackgroundImmune senescence: A key player in cancer biology
Yang, Y., Fan, L., Li, M., & Wang, Z. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.12.001 · Cited by 15
Janssen, L., Dubbelaar, M. L., Holtman, I. R., de Boer-Bergsma, J. J., Eggen, B. J. L., Boddeke, H. W. G. M., Deyn, P. P. D., & Dam, D. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.014 · Cited by 13
Can Youthful Mesenchymal Stem Cells from Wharton’s Jelly Bring a Breath of Fresh Air for COPD?
Janczewski, A. M., Wojtkiewicz, J., Malinowska, E., & Doboszyńska, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112449 · Cited by 13
“Likewise, younger patients may be more responsive to MSC treatment since elderly individuals do not respond to immune challenge as robustly as the young [107].”
BackgroundShaikh, V. S., Nazeruddin, G. M., Shaikh, Y. I., Bloukh, S. H., Edis, Z., & Pathan, H. M. (2020) · Engineered Science · doi:10.30919/es8d1009 · Cited by 13
Yoo‐Jeong, M., Haardörfer, R., Holstad, M. M., Hepburn, K. W., & Waldrop‐Valverde, D. (2020) · AIDS and Behavior · doi:10.1007/s10461-020-02957-4 · Cited by 13
Shinde, P., Kuhikar, R., Kulkarni, R. S., Khan, N., Limaye, L. S., & Kale, V. P. (2021) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3180 · Cited by 13
Kim, S. H., Choi, H. S., Jin, E. S., Choi, H., Lee, H. J., Lee, S., Lee, C. Y., Lee, M. G., & Kim, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-97121-w · Cited by 13
Xiang, M., Gao, Y., Zhou, Y., Wang, M., & Yao, X. (2023) · BMC Cancer · doi:10.1186/s12885-023-11075-y · Cited by 13
“Since immunity decreases with age [82], EOCRC patients may be more sensitive to immunotherapy than their older counterparts [4].”
BackgroundErdoğdu, H. İ. (2018) · The Turkish Journal of Geriatrics · doi:10.31086/tjgeri.2018.54 · Cited by 13
Teras, J., Kroon, H. M., Miura, J. T., Kenyon-Smith, T., Beasley, G. M., Mullen, D., Farrow, N. E., Mosca, P. J., Lowe, M., Farley, C. R., et al. (2020) · Annals of Surgical Oncology · doi:10.1245/s10434-020-08312-0 · Cited by 14
Cain, D. J., del Arroyo, A. G., & Ackland, G. L. (2014) · Intensive Care Medicine Experimental · doi:10.1186/2197-425x-2-6 · Cited by 14
“Advanced age is associated with progressively impaired innate and adaptive immunity [67].”
Background2.5 Million Person-Years of Life Have Been Lost Due to COVID-19 in the United StatesPreprint
Elledge, S. (2020) · medRxiv · doi:10.1101/2020.10.18.20214783 · Cited by 10
“We and others (Montecino-Rodriguez et al., 2013; Shrock et al, 2020) have previously shown that the immune system decreases in efficiency with age.”
BackgroundDavid Oliver: What the pandemic measures reveal about ageism
Oliver, D. (2020) · BMJ · doi:10.1136/bmj.m1545 · Cited by 12
Role of “Ferritin” in COVID-19 pneumonia
Patil, S. V., Toshniwal, S., Acharya, A., & Narwade, G. (2022) · Muller Journal of Medical Sciences and Research · doi:10.4103/mjmsr.mjmsr_19_22 · Cited by 12
Ananya, A., Holden, K. G., Gu, Z., Nettleton, D. S., Mallapragada, S. K., Wannemuehler, M. J., Kohut, M. L., & Narasimhan, B. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00332-0 · Cited by 14
Adult human neurogenesis: A view from two schools of thought
Alshebib, Y., Hori, T., Goel, A. H., Fauzi, A. A., & Kashiwagi, T. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.07.004 · Cited by 15
Ruiz-Lozano, R., Calvo‐Gallego, J. L., Pivonka, P., McDonald, M. M., & Martínez‐Reina, J. (2024) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-024-01846-2 · Cited by 12
Soontara, C., Uchuwittayakul, A., Kayansamruaj, P., Amparyup, P., Wongpanya, R., & Srisapoome, P. (2024) · Vaccines · doi:10.3390/vaccines12060641 · Cited by 12
“Thus, the use of the WC+CC vaccine holds promise for enhancing disease control measures in aquaculture settings, ultimately contributing to the sustainability and productivity of fish farming operations.”
BackgroundRacioppi, M., Gianfrancesco, L. D., Ragonese, M., Palermo, G., Sacco, E., & Bassi, P. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.03.020 · Cited by 12
Risk Factors of SARS-CoV-2 Infection: Global Epidemiological Study
Barletta, W. A. (2021) · JMIRx Med · doi:10.2196/28843 · Cited by 12
“An alternative explanation is the decrease in immune functions with aging [7].”
BackgroundMethodInfluence of biotic interventions on the immune response to vaccines in young and older adults
Spacova, I., Patusco, R., Lebeer, S., & Jensen, M. G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.001 · Cited by 13
Vaccinations in Older Adults with Gastrointestinal Diseases
Horton, H. A., Kim, H., & MELMED, G. Y. (2013) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2013.10.002 · Cited by 12
Pan-Cancer Analysis of Genomic Sequencing Among the Elderly
Wahl, D. R., Nguyen, P. L., Santiago, M., Yousefi, K., Davicioni, E., Shumway, D. A., Speers, C. W., Mehra, R., Feng, F. Y.-C., Osborne, J. R., et al. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.01.002 · Cited by 12
“Furthermore, the molecular characteristics of cancer in the elderly are likely different from cancer in younger patients due to factors such as increased mutational burden and altered immune resp onses[7,8].”
BackgroundCancer Immunoprevention and Public Health
Singh, S. K., & Dorak, M. T. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00101 · Cited by 13
“Further, a lot of pharmacologic ways to rejuvenate the aging immune system are also present (72, 79), but none is in current routine use yet.”
BackgroundCOVID-19 and the Elderly: Why Does the Immune System Matter?
Chalise, H. N. (2020) · Journal of Infectious Diseases & Travel Medicine · doi:10.23880/jidtm-16000s1-003 · Cited by 12
“In addition, the aging body produces fewer immune cells, including white blood cells, which can slow recovery from injuries, infection, and illness [19].”
BackgroundEffect of Age on Innate and Adaptive Immunity in Hospitalized COVID-19 Patients
Cham, L. B., Pahus, M. H., Grønhøj, K., Olesen, R., Ngo, H. T. T., Monrad, I., Kjølby, M., Tolstrup, M., Gunst, J. D., & Søgaard, O. S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204798 · Cited by 12
Han, Y., Lam, J. C. K., Li, V. O. K., Crowcroft, J., Fu, J., Downey, J., Gozes, I., Zhang, Q., Wang, S., & Gilani, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-02523-5 · Cited by 12
Halalopathy: Stimulation of the Immune System Through Enrichment of Potential Energy
Alzeer, J., & Alzeer, J. (2022) · International Journal of Regenerative Medicine · doi:10.31487/j.rgm.2022.01.02 · Cited by 12
L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management
Sahebnasagh, A., Avan, R., Monajati, M., Hashemi, J., Habtemariam, S., Negintaji, S., & Saghafi, F. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211117092345 · Cited by 12
Guidelines for microbiome studies in renal physiology
Muralitharan, R. R., Snelson, M., Méric, G., Coughlan, M. T., & Marques, F. Z. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00072.2023 · Cited by 11
Rare Yeasts in Latin America: Uncommon Yet Meaningful
Gil, Ó., Hernández-Pabón, J. C., Tabares, B., Lugo-Sánchez, C., & Firacative, C. (2023) · Journal of Fungi · doi:10.3390/jof9070747 · Cited by 11
Vidal-Seguel, N., Cabrera, C., Ferrada, L., Artigas-Arias, M., Alegría-Molina, A., Sanhueza, S. A., Flores, A., Huard, N., SAPUNAR, J., Salazar, L. A., et al. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112280 · Cited by 11
TLR/NLRP3 inflammasome signaling pathways as a main target in frailty, cachexia and sarcopenia
Shahbaz, S. K., Mokhlesi, A., Sadegh, R. K., Rahimi, K., Jamialahmadi, T., Butler, A. E., Kesharwani, P., & Sahebkar, A. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102723 · Cited by 11
Prognostic factors in severe dengue patients: A multi-center retrospective cohort study
Yang, C.-H., Lee, I., Chen, Y.-C., Hsu, J.-C., Hsu, J.-C., Tai, C., Huang, C., Lin, C.-Y., & Chen, Y. (2025) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0012846 · Cited by 11
Adhikari, R. B., Dhakal, M. A., Ale, P. B., Regmi, G. R., & Ghimire, T. R. (2025) · Veterinary Medicine and Science · doi:10.1002/vms3.70310 · Cited by 11
“By nature, ageing downregulates the immune system (Montecino-Rodriguez et al. 2013) which is why parasitic infection, including the infection by opportunistic parasites like Cryptosporidium , Entamoeba and Strongyloides , was predominantly detected in old elephants.”
He, J., Burova, E., Taduriyasas, C., Ni, M., Adler, C., Wei, Y. Z., Negron, N., Xiong, K., Bai, Y., Shavlakadze, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425992122 · Cited by 11
“In a separate study ( 8 ), a single - cell transcriptomic analysis of CD4+ T regulatory (Treg) cells from mice aged 3, 18, and 24 mo revealed distinct clusters of Treg cells, including an increase in proinflammatory cells and a reduction in precursor cells.”
The role of estrogen, immune function and aging in heart transplant outcomes
Morgan, A. E., Dewey, E. N., Mudd, J. O., Gelow, J. M., Davis, J. D., Song, H. K., Tibayan, F. A., & Bhamidipati, C. M. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.07.007 · Cited by 11
The role of Sestrins in the regulation of the aging process
Fan, X., Zeng, Y. Y., Song, W., Li, J., Ai, S., Yang, D., Mao, X., & Yang, M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111251 · Cited by 12
Brauer, L., Krüger, K., Weyh, C., & Alack, K. (2021) · Immuno · doi:10.3390/immuno1030009 · Cited by 11
“Aging affects the immune system globally, for example, the rate of naïve B- and T-cell production as well as the constitution and quality of the mature lymphocyte pool [2].”
BackgroundAragão-Santos, J. C., Vasconcelos, A. B. S., de Resende–Neto, A. G., Rodrigues, L. S., Silva, N. D. L., da Silva, D. N., Schimieguel, D. M., Corrêa, C. B., & Silva‐Grigoletto, M. E. D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111504 · Cited by 14
SARS‐CoV‐2 indoor environment contamination with epidemiological and experimental investigations
Oksanen, L., Virtanen, J. M. E., Sanmark, E., Rantanen, N., Venkat, V., Sofieva, S., Aaltonen, K., Kivistö, I., Svirskaitė, J., Pérez, A. D., et al. (2022) · Indoor Air · doi:10.1111/ina.13118 · Cited by 10
Towards a multidimensional model of inflamed depression
Wijaya, M. T., Jin, R. R., Liu, X., Zhang, R., & Lee, T. M. C. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100564 · Cited by 12
Xiong, W., Jiang, X., He, J., Liu, X., Zhu, Y., Liu, B., & Huang, Y. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200766 · Cited by 11
Risk factors for tuberculosis mortality in a tertiary care center in Oman, 2006–2016
Gaifer, Z. (2017) · International Journal of Mycobacteriology · doi:10.4103/ijmy.ijmy_123_17 · Cited by 11
“[18] We believe that an aging immune system may have contributed to TB-related deaths in this group of elderly patients.[19] Not surprisingly, we found low body weight was associated with TB-related death, which supports findings in other studies.”
ResultAnibijuwon, I., Gbala, I., & Adebisi, O. O. (2018) · Notulae Scientia Biologicae · doi:10.15835/nsb10310300 · Cited by 10
Oh, J., Vukusic, S., Tiel‐Wilck, K., Inshasi, J. S. S., Rog, D. J., Baker, D. P., Pyatkevich, Y., Poole, E. M., & Vermersch, P. (2021) · Journal of Central Nervous System Disease · doi:10.1177/11795735211028781 · Cited by 11
Kristensen, N. K., Lange, J., Frøslev, T., & Pedersen, A. B. (2022) · Acta Orthopaedica · doi:10.2340/17453674.2022.4580 · Cited by 10
Khan, Q. A., Jan, A., Iram, S., Haider, I., Badshah, A., Khan, A., Hidayat, A., Farrukh, A. M., Ain, H. U., & Verma, R. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002402 · Cited by 10
“A clear relationship has been observed between the age of respondents and their physical health condition, indicating that vulnerability to health problems increases with age [35,36] .”
BackgroundSchmieder, H., Leischner, C., Piotrowsky, A., Marongiu, L., Venturelli, S., & Burkard, M. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00501-3 · Cited by 14
“In line with that, hematopoietic stem cells mature and hematopoietic tissue decreases, resulting in a mitigated lymphocyte production [12, 13].”
An evidence-based debate on epigenetics and immunosenescence in COVID-19
Claudio Napoli, A., Coscioni, E., Trama, U., Strozziero, M. G., & Benincasa, G. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100069 · Cited by 10
Metadata
- Authors
- Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Dorshkind, Kenneth
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 958-965
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582124
- OpenAlex
- W1978103330
- Semantic Scholar
- 21eeafabbc2cc60c6c46752d238c5688d989e17b
- Cited by
- 793
- References
- 120
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 72 · 2023: 86 · 2022: 96 · 2021: 126 · 2020: 106 · 2019: 64 · 2018: 54 · 2017: 37 · 2016: 21 · 2015: 27 · 2014: 18 · 2013: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG034875, AG034875)
- David Geffen School of Medicine, University of California, Los Angeles
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, B cell aging, T cell senescence, thymus, bone marrow, secondary lymphoid organs, lymphocyte function
- MeSH terms
- Aging, Animals, Hematopoietic Stem Cells, Humans, Immune System, Immunologic Factors, Lymphoid Progenitor Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-06, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-06 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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