The DOI matches its OpenAlex record; 4 of the 4 references it cites were found in a registry or an index.
Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion
Abstract
Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food intake and GH secretion. We determined plasma ghrelin concentrations in patients with simple obesity, anorexia nervosa, and type 2 diabetes mellitus by RIA. We also studied plasma ghrelin responses to glucose load and meal intake and obtained a 24-h profile of circulating ghrelin in humans. Plasma ghrelin concentrations in patients with simple obesity and anorexia nervosa were lower and higher, respectively, than those of healthy subjects with normal body weight. Among those with type 2 diabetes mellitus, obese patients had lower and lean patients higher fasting plasma ghrelin concentrations than normal-weight patients. Fasting plasma ghrelin concentration was negatively correlated with body mass index in both nondiabetic and diabetic patients. Plasma ghrelin concentrations of normal subjects decreased significantly after oral and iv glucose administration; a similar response was also observed in diabetic patients after a meal tolerance test, reaching a nadir of 69% of the basal level after the meal. Circulating plasma ghrelin showed a diurnal pattern with preprandial increases, postprandial decreases, and a maximum peak at 0200 h. This study demonstrates that nutritional state is a determinant of plasma ghrelin in humans. Ghrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance. These findings suggest the involvement of ghrelin in the regulation of feeding behavior and energy homeostasis.
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Self-citationA role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 1×
“In contrast, an intracerebroventricular administration of anti-ghrelin IgG robustly suppressed feeding (14).”
BackgroundSelf-citationGhrelin Strongly Stimulates Growth Hormone Release in Humans
Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto, A., Harada, M., Mori, K., Komatsu, Y., Usui, T., Shimatsu, A., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7167 · Cited by 864 · cited 1×
“Ghrelin stimulates GH release in humans (7, 8).”
BackgroundSelf-citationHo, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503
Cited by
Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
Self-citationThe role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Self-citationGhrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Obesity and androgens: facts and perspectives
Pasquali, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.054 · Cited by 469
Korner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417
Effects of Maternal Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity
Smith, J., Cianflone, K., Biron, S., Hould, F. S., Lebel, S., Marceau, S., Lescelleur, O., Biertho, L., Simard, S., Kral, J. G., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0709 · Cited by 354
Ghrelin stimulates gastric emptying and hunger in normal-weight humans
Levin, F., Edholm, T., Schmidt, P. T., Grybäck, P., Jacobsson, H., Degerblad, M., Höybye, C., Holst, J. J., Rehfeld, J. F., Hellström, P. M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2638 · Cited by 313
Teff, K. L., Grudziak, J., Townsend, R. R., Dunn, T. N., Grant, R. W., Adams, S. H., Keim, N. L., Cummings, B. P., Stanhope, K. L., & Havel, P. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2192 · Cited by 301
Exercise-induced suppression of acylated ghrelin in humans
Broom, D. R., Stensel, D. J., Bishop, N. C., Burns, S. F., & Miyashita, M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2006 · Cited by 294
Differential Effects of Gastric Bypass and Banding on Circulating Gut Hormone and Leptin Levels
Korner, J., Inabnet, W., Conwell, I. M., Taveras, C., Daud, A., Olivero‐Rivera, L., Restuccia, N. L., & Bessler, M. (2006) · Obesity · doi:10.1038/oby.2006.179 · Cited by 240
Endocrine Effects of Relative Energy Deficiency in Sport
Elliott-Sale, K. J., Tenforde, A. S., Parziale, A. L., Holtzman, B., & Ackerman, K. E. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0127 · Cited by 229
The physiology of gastric emptying
Hellström, P. M., Grybäck, P., & Jacobsson, H. (2006) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2006.02.002 · Cited by 223
Natalucci, G., Riedl, S., Gleiss, A., Zidek, T., & Frisch, H. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01919 · Cited by 182
Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men
Pagotto, U., Gambineri, A., Pelusi, C., Genghini, S., Cacciari, M., Otto, B., Castañeda, T., Tschöp, M., & Pasquali, R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030554 · Cited by 120
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
Camilleri, M., Papathanasopoulos, A., & Odunsi, S. T. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.72 · Cited by 115
Possible entrainment of ghrelin to habitual meal patterns in humans
Frecka, J. M., & Mattes, R. D. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00448.2007 · Cited by 116
Chu, M. C., Cosper, P., Orio, F., Carmina, E., & Lobo, R. A. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.073 · Cited by 113
Weickert, M. O., Spranger, J., Holst, J. J., Otto, B., Koebnick, C., Möhlig, M., & Pfeiffer, A. F. H. (2006) · British Journal of Nutrition · doi:10.1017/bjn20061902 · Cited by 111
Short‐Term Effects of Gastric Bypass Surgery on Circulating Ghrelin Levels
Morínigo, R., Casamitjana, R., Moizé, V., Lacy, A. M., Delgado, S., Gomis, R., & Vidal, J. (2004) · Obesity Research · doi:10.1038/oby.2004.139 · Cited by 108
The role of ghrelin in the regulation of glucose homeostasis
Alamri, B. N., Shin, K., Chappe, V., & Anini, Y. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0018 · Cited by 93
Galhardo, J., Hunt, L. P., Lightman, S. L., Sabin, M. A., Bergh, C., Sodersten, P., & Shield, J. P. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1999 · Cited by 89
Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism
Dimaraki, E. V., & Jaffe, C. A. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9022-0 · Cited by 84
Chu, M. C., Cosper, P., Nakhuda, G. S., & Lobo, R. A. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.04.043 · Cited by 82
Tobore, T. O. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112560 · Cited by 73
Buijs, R. M., Guzmán Ruiz, M. A., Méndez Hernández, R., & Rodríguez Cortés, B. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.02.001 · Cited by 63
From Disordered Eating to Addiction: The “Food Drug” in Bulimia Nervosa
Umberg, E. N., Shader, R. I., Hsu, L. K. G., & Greenblatt, D. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318252464f · Cited by 52
Mager, U., Kolehmainen, M., de Mello, V. D. F., Schwab, U., Laaksonen, D. E., Rauramaa, R., Gylling, H., Atalay, M., Pulkkinen, L., & Uusitupa, M. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0862 · Cited by 49
Thom, G., Dombrowski, S. U., Brosnahan, N., Algindan, Y. Y., Rosario Lopez-Gonzalez, M., Roditi, G., Lean, M. E. J., & Malkova, D. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0568-9 · Cited by 49
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48
Ghrelin in neuroendocrine organs and tumours
Leontiou, C. A., Franchi, G., & Korbonits, M. (2007) · Pituitary · doi:10.1007/s11102-007-0023-0 · Cited by 40
Somogyi, V., Gyorffy, A., Scalise, T. J., Kiss, D. S., Goszleth, G., Bartha, T., Frenyo, V. L., & Zsarnovszky, A. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000035 · Cited by 37
Bowels control brain: gut hormones and obesity
Bewick, G. A. (2012) · Biochemia Medica · doi:10.11613/bm.2012.032 · Cited by 36
Zouhal, H., Sellami, M., Saeidi, A., Slimani, M., Abbassi-Daloii, A., Khodamoradi, A., El Hage, R., Hackney, A. C., & Ben Abderrahman, A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz005 · Cited by 35
Serum ghrelin levels in patients with Hashimoto's thyroiditis
Altinova, A. E., Toruner, F., Karakoc, A., Yetkin, I., Ayvaz, G., Cakir, N., & Arslan, M. (2006) · Thyroid · doi:10.1089/thy.2006.16.1259 · Cited by 33
Rao (2008) · doi:10.1016/j.pnpbp.2008.05.013 · Cited by 32
Endocrine and Metabolic Actions of Ghrelin
Gasco, V., Beccuti, G., Marotta, F., Benso, A., Granata, R., Broglio, F., & Ghigo, E. (2010) · Endocrine Development · doi:10.1159/000262531 · Cited by 30
Total ghrelin levels during acute insulin infusion in patients with polycystic ovary syndrome
Micic, D., Sumarac-Dumanovic, M., Kendereski, A., Cvijovic, G., Zoric, S., Pejkovic, D., Micic, J., Milic, N., Dieguez, C., & Casanueva, F. F. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03349222 · Cited by 28
Jiao, L., Du, X., Jia, F., Li, Y., Zhu, D., Tang, T., Jiao, Q., & Jiang, H. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.011 · Cited by 19
Pinneo, S., O'Mealy, C., Rosas Jr., M., Tsang, M., Liu, C., Kern, M., Hooshmand, S., & Hong, M. Y. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.0063 · Cited by 19
“Sibling” battle or harmony: Crosstalk between nesfatin-1 and ghrelin
Chen, X., Dong, J., Jiao, Q., Du, X., Bi, M., & Jiang, H. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04193-6 · Cited by 17
Metadata
- Authors
- Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M. S., Tanaka, M., Nozoe, S.-I., Hosoda, H., Kangawa, K., & Matsukura, S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- Oxford University Press
- Published
- 2002-01-01
- Volume
- 87
- Issue
- 1
- Pages
- 240-244
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2048194663
- Cited by
- 1,299
- References
- 4
- FWCI
- 31.85
- Type
- journal article
- Language
- en
- Open access
- closed
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