Control of the G2/M Transition

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,071

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

Participation of p53 protein in the cellular response to DNA damage.

Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,021

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

T antigen is bound to a host protein in SY40-transformed cells

LANE, D. P., & CRAWFORD, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,394

p53: puzzle and paradigm.

Ko, L. J., & Prives, C. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,344

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

Cell Cycle Checkpoints: Preventing an Identity Crisis

Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,039

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Genetic Control of the Cell Division Cycle in Yeast: A model to account for the order of cell cycle events is deduced from the phenotypes of yeast mutants.

Hartwell, L. H., Culotti, J., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567

Regulation of the G2/M transition by p53

Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,559

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

Masui, Y., & Markert, C. L. (1971) · Journal of Experimental Zoology · doi:10.1002/jez.1401770202 · Cited by 1,545

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D., & Hunt, T. (1983) · Cell · doi:10.1016/0092-8674(83)90420-8 · Cited by 1,516

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y.-Y., Matsuoka, S., Wakeham, A., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,285

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,258

Is a p53-Regulated Inhibitor of G2/M Progression

Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

Gould, K. L., & Nurse, P. (1989) · Nature · doi:10.1038/342039a0 · Cited by 1,218

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

Srivastava, S., Zou, Z., Pirollo, K., Blattner, W., & Chang, E. H. (1990) · Nature · doi:10.1038/348747a0 · Cited by 1,211

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J., Miki, Y., et al. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,205

DNA damage activates p53 through a phosphorylation–acetylation cascade

Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204

Cyclin synthesis drives the early embryonic cell cycle

Murray, A. W., & Kirschner, M. W. (1989) · Nature · doi:10.1038/339275a0 · Cited by 1,191

Sibling rivalry in the E2F family

Trimarchi, J. M., & Lees, J. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm714 · Cited by 1,158

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

Weinert, T. A., & Hartwell, L. H. (1988) · Science · doi:10.1126/science.3291120 · Cited by 1,156

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

Finlay, C. A., Hinds, P. W., Tan, T. H., Eliyahu, D., Oren, M., & Levine, A. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.531 · Cited by 1,144

E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints

Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.949802 · Cited by 1,125

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

Murray, A. W., Solomon, M. J., & Kirschner, M. W. (1989) · Nature · doi:10.1038/339280a0 · Cited by 1,096

Post‐translational modifications and activation of p53 by genotoxic stresses

Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,079

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

Untitled work

(1999) · PubMed · Cited by 1,030

Inhibition of cyclin-dependent kinases by p21.

Harper, J. W., Elledge, S. J., Keyomarsi, K., Dynlacht, B., Tsai, L. H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., & Swindell, E. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.4.387 · Cited by 1,023

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972

cdc25+ functions as an inducer in the mitotic control of fission yeast

Russell, P., & Nurse, P. (1986) · Cell · doi:10.1016/0092-8674(86)90546-5 · Cited by 970

Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells

Kanda, T., Sullivan, K. F., & Wahl, G. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70156-3 · Cited by 969

Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe

Nurse, P., Thuriaux, P., & Nasmyth, K. (1976) · Molecular and General Genetics MGG · doi:10.1007/bf00268085 · Cited by 910

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

Schultz, L. B., Chehab, N. H., Malikzay, A., & Halazonetis, T. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1381 · Cited by 904

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Nature · doi:10.1038/44188 · Cited by 895

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

Maltzman, W., & Czyzyk, L. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1689 · Cited by 893

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

Gautier, J., Norbury, C., Lohka, M., Nurse, P., & Maller, J. (1988) · Cell · doi:10.1016/0092-8674(88)90206-1 · Cited by 871

Genetic control of cell size at cell division in yeast

Nurse, P. (1975) · Nature · doi:10.1038/256547a0 · Cited by 861

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Agarwal, M. L., Agarwal, A., Taylor, W. R., & Stark, G. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8493 · Cited by 858

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

Pines, J., & Hunter, T. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.1.1 · Cited by 858

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 829

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development · doi:10.1101/gad.11.24.3471 · Cited by 818

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

Dunphy, W. G., Brizuela, L., Beach, D., & Newport, J. (1988) · Cell · doi:10.1016/0092-8674(88)90205-x · Cited by 816

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 777

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

Nurse, P., & Bissett, Y. (1981) · Nature · doi:10.1038/292558a0 · Cited by 730

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

Parada, L. F., Land, H., Weinberg, R. A., Wolf, D., & Rotter, V. (1984) · Nature · doi:10.1038/312649a0 · Cited by 730

Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

Niculescu, A. B., Chen, X., Smeets, M., Hengst, L., Prives, C., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.629 · Cited by 724

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

Eliyahu, D., Raz, A., Gruss, P., Givol, D., & Oren, M. (1984) · Nature · doi:10.1038/312646a0 · Cited by 717

Inactivation of the p34 cdc2 -Cyclin B Complex by the Human WEE1 Tyrosine Kinase

Parker, L. L., & Piwnica-Worms, H. (1992) · Science · doi:10.1126/science.1384126 · Cited by 716

Cyclin is a component of maturation-promoting factor from Xenopus

Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T., & Maller, J. L. (1990) · Cell · doi:10.1016/0092-8674(90)90599-a · Cited by 663

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J., & Beach, D. (1989) · Cell · doi:10.1016/0092-8674(89)90687-9 · Cited by 654

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

Lohka, M. J., Hayes, M. K., & Maller, J. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3009 · Cited by 644

MDM2 — master regulator of the p53 tumor suppressor protein

Momand, J., Wu, H.-H., & Dasgupta, G. (2000) · Gene · doi:10.1016/s0378-1119(99)00487-4 · Cited by 641

GADD45 induction of a G 2 /M cell cycle checkpoint

Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, A. J., & Harris, C. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3706 · Cited by 634

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

Lohka, M. J., & Masui, Y. (1983) · Science · doi:10.1126/science.6601299 · Cited by 623

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

Ishida, S., Huang, E., Zuzan, H., Spang, R., Leone, G., West, M., & Nevins, J. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4684-4699.2001 · Cited by 596

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13777 · Cited by 583

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

Jenkins, J. R., Rudge, K., & Currie, G. A. (1984) · Nature · doi:10.1038/312651a0 · Cited by 552

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

Furnari, B., Rhind, N., & Russell, P. (1997) · Science · doi:10.1126/science.277.5331.1495 · Cited by 539

Cyclins and cyclin-dependent kinases: a biochemical view

Pines, J. (1995) · Biochemical Journal · doi:10.1042/bj3080697 · Cited by 538

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

Cliby, W. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 536

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., & Fornace, A. J. (2001) · Nature · doi:10.1038/35075107 · Cited by 532

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

Swenson, K. I., Farrell, K. M., & Ruderman, J. V. (1986) · Cell · doi:10.1016/0092-8674(86)90801-9 · Cited by 530

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

Arion, D., Meijer, L., Brizuela, L., & Beach, D. (1988) · Cell · doi:10.1016/0092-8674(88)90060-8 · Cited by 528

Rb function in cell-cycle regulation and apoptosis

Harbour, J. W., & Dean, D. C. (2000) · Nature Cell Biology · doi:10.1038/35008695 · Cited by 509

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Maser, R. S., Monsen, K. J., Nelms, B. E., & Petrini, J. H. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6087 · Cited by 499

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

Fan, S., Smith, M. L., Rivet, D. J., Duba, D. E., Zhan, Q., Kohn, K. W., Fornace, A. J., & O'Connor, P. M. (1995) · PubMed · Cited by 490

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L., Harris, C. C., & Fornace, A. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202667 · Cited by 474

Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation

Xu, B., Kim, S.-T., Lim, D.-S., & Kastan, M. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1049-1059.2002 · Cited by 473

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

Walworth, N., Davey, S., & Beach, D. (1993) · Nature · doi:10.1038/363368a0 · Cited by 457

Polo-like kinase-1 is a target of the DNA damage checkpoint

Smits, V. A. J., Klompmaker, R., Arnaud, L., Rijksen, G., Nigg, E. A., & Medema, R. H. (2000) · Nature Cell Biology · doi:10.1038/35023629 · Cited by 440

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

Espinosa, J. M., & Emerson, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00283-0 · Cited by 439

p53 regulates a G 2 checkpoint through cyclin B1

Innocente, S. A., Abrahamson, J. L. A., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 436

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

Bradbury, E. M., Inglis, R. J., & Matthews, H. R. (1974) · Nature · doi:10.1038/247257a0 · Cited by 431

Two cellular proteins that bind to wild-type but not mutant p53.

Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R., & Fields, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6098 · Cited by 431

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Chaturvedi, P., Eng, W. K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan, R. S., Lu, Q., Faucette, L. F., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202925 · Cited by 423

Functionally homologous cell cycle control genes in budding and fission yeast

Beach, D., Durkacz, B., & Nurse, P. (1982) · Nature · doi:10.1038/300706a0 · Cited by 412

The retinoblastoma gene family in differentiation and development

Lipinski, M. M., & Jacks, T. (1999) · Oncogene · doi:10.1038/sj.onc.1203244 · Cited by 405

Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts.

Lohka, M. J., & Maller, J. L. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.2.518 · Cited by 404

rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint

Walworth, N. C., & Bernards, R. (1996) · Science · doi:10.1126/science.271.5247.353 · Cited by 397

Rhabdomyosarcoma in Children: Epidemiologic Study and Identification of a Familial Caneer Syndrome

(1969) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/43.6.1365 · Cited by 397

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

Fesquet, D., Labbé, J. C., Derancourt, J., Capony, J. P., Galas, S., Girard, F., Lorca, T., Shuttleworth, J., Dorée, M., & Cavadore, J. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05980.x · Cited by 389

The G2-phase DNA-damage checkpoint

O’Connell, M. J., Walworth, N. C., & Carr, A. M. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01773-6 · Cited by 384

The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex

Liu, F., Stanton, J. J., Wu, Z., & Piwnica-Worms, H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.571 · Cited by 376

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

Poon, R. Y., Yamashita, K., Adamczewski, J. P., Hunt, T., & Shuttleworth, J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05981.x · Cited by 376

REGULATORY GENES CONTROLLING MITOSIS IN THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE

Nurse, P., & Thuriaux, P. (1980) · Genetics · doi:10.1093/genetics/96.3.627 · Cited by 369

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., & Nishida, E. (2001) · Nature · doi:10.1038/35065617 · Cited by 364

Checking out the G2/M transition

Smits, V. A. J., & Medema, R. H. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00204-4 · Cited by 355

MPF localization is controlled by nuclear export

Hagting, A., Karlsson, C., Clute, P., Jackman, M., & Pines, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4127 · Cited by 334

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

Toyoshima, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.10.2728 · Cited by 328

Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1

Yang, J., Bardes, E. S. G., Moore, J. D., Brennan, J., Powers, M. A., & Kornbluth, S. (1998) · Genes & Development · doi:10.1101/gad.12.14.2131 · Cited by 323

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.

Zwicker, J., Lucibello, F. C., Wolfraim, L. A., Gross, C., Truss, M., Engeland, K., & Müller, R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00130.x · Cited by 322

Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity

Booher, R. N., Holman, P. S., & Fattaey, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22300 · Cited by 313

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

Labbe, J. C., Lee, M. G., Nurse, P., Picard, A., & Doree, M. (1988) · Nature · doi:10.1038/335251a0 · Cited by 308

Evidence for a second cell cycle block at G2/M by p53.

Stewart, N., Hicks, G. G., PARASKEVAS, F., & Mowat, M. R. A. (1995) · PubMed · Cited by 300

Caffeine inhibits the checkpoint kinase ATM

Blasina, A., Price, B. D., Turenne, G. A., & McGowan, C. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80486-2 · Cited by 295

The molecular basis for cell cycle delays following ionizing radiation: a review

Maity, A., McKenna, W. G., & Muschel, R. J. (1994) · Radiotherapy and Oncology · doi:10.1016/0167-8140(94)90408-1 · Cited by 294

Mechanism by which caffeine potentiates lethality of nitrogen mustard.

Lau, C. C., & Pardee, A. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.2942 · Cited by 291

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

Amon, A., Surana, U., Muroff, I., & Nasmyth, K. (1992) · Nature · doi:10.1038/355368a0 · Cited by 290

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

Sorger, P. K., & Murray, A. W. (1992) · Nature · doi:10.1038/355365a0 · Cited by 283

A kinase from fission yeast responsible for blocking mitosis in S phase

Murakami, H., & Okayama, H. (1995) · Nature · doi:10.1038/374817a0 · Cited by 281

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

Kovesdi, I., Reichel, R., & Nevins, J. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2180 · Cited by 278

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

Zhou, B.-B. S., Chaturvedi, P., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R., Mattern, M. R., Winkler, J. D., & Khanna, K. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10342 · Cited by 278

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

Di Stefano, L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg613 · Cited by 274

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

Polager, S., Kalma, Y., Berkovich, E., & Ginsberg, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205102 · Cited by 269

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

Venclovas, C., & Thelen, M. P. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2481 · Cited by 267

Sensing and responding to DNA damage

Lowndes, N. F., & Murguia, J. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00050-7 · Cited by 266

Cooperative effects of genes controlling the G2/M checkpoint

Chan, T. A., Hwang, P. M., Hermeking, H., Kinzler, K. W., & Vogelstein, B. (2000) · Genes & Development · doi:10.1101/gad.14.13.1584 · Cited by 262

Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

Dolganov, G. M., Maser, R. S., Novikov, A., Tosto, L., Chong, S., Bressan, D. A., & Petrini, J. H. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4832 · Cited by 224

Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308105200 · Cited by 221

p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint

Smits, V. A. J., Klompmaker, R., Vallenius, T., Rijksen, G., Mäkelä, T. P., & Medema, R. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005437200 · Cited by 221

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1

Moore, J. D., Yang, J., Truant, R., & Kornbluth, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.2.213 · Cited by 219

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

Lock, R. B., & Ross, W. E. (1990) · PubMed · Cited by 217

Epistatic gene interactions in the control of division in fission yeast

FANTES, P. (1979) · Nature · doi:10.1038/279428a0 · Cited by 210

A novel Rad24 checkpoint protein complex closely related to replication factor C

Green, C. M., Erdjument-Bromage, H., Tempst, P., & Lowndes, N. F. (2000) · Current Biology · doi:10.1016/s0960-9822(99)00263-8 · Cited by 208

Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.

Griffiths, D. J., Barbet, N. C., McCready, S., Lehmann, A. R., & Carr, A. M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00269.x · Cited by 205

The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression

Jin, S., Antinore, M. J., Lung, F.-D. T., Dong, X., Zhao, H., Fan, F., Colchagie, A. B., Blanck, P., Roller, P. P., Fornace, A. J., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000284200 · Cited by 202

Purification and characterization of human DNA damage checkpoint Rad complexes

Lindsey-Boltz, L. A., Bermudez, V. P., Hurwitz, J., & Sancar, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201373498 · Cited by 198

A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

Edwards, R. J., Bentley, N. J., & Carr, A. M. (1999) · Nature Cell Biology · doi:10.1038/15623 · Cited by 197

Mechanisms of G2 Arrest in Response to Overexpression of p53

Taylor, W. R., DePrimo, S. E., Agarwal, A., Agarwal, M. L., Schönthal, A. H., Katula, K. S., & Stark, G. R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3607 · Cited by 195

Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

Maiti, B., Li, J., de Bruin, A., Gordon, F., Timmers, C., Opavsky, R., Patil, K., Tuttle, J., Cleghorn, W., & Leone, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501410200 · Cited by 190

Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629))

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · Cited by 177

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

Bates, S., Ryan, K. M., Phillips, A. C., & Vousden, K. H. (1998) · Oncogene · doi:10.1038/sj.onc.1202104 · Cited by 176

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

Cicirelli, M. F., Pelech, S. L., & Krebs, E. G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77978-2 · Cited by 169

p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

Chang, B.-D., Broude, E. V., Fang, J., Kalinichenko, T. V., Abdryashitov, R., Poole, J. C., & Roninson, I. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203573 · Cited by 168

Inhibition of Polo-like Kinase-1 by DNA Damage Occurs in an ATM- or ATR-dependent Fashion

van Vugt, M. A. T. M., Smits, V. A. J., Klompmaker, R., & Medema, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101831200 · Cited by 164

Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases

Ferguson, A. M., White, L. S., Donovan, P. J., & Piwnica-Worms, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2853-2860.2005 · Cited by 164

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

Tommasi, S., & Pfeifer, G. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6901 · Cited by 163

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

Medema, R. H., Klompmaker, R., Smits, V. A., & Rijksen, G. (1998) · Oncogene · doi:10.1038/sj.onc.1201558 · Cited by 161

p53 Regulation of G 2 Checkpoint Is Retinoblastoma Protein Dependent

Flatt, P. M., Tang, L. J., Scatena, C. D., Szak, S. T., & Pietenpol, J. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4210-4223.2000 · Cited by 161

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells

Jallepalli, P. V., Lengauer, C., Vogelstein, B., & Bunz, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213159200 · Cited by 154

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

Souza, C. P. C. D., Ellem, K. A. O., & Gabrielli, B. G. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4872 · Cited by 154

Cdc25 protein phosphatases in cell proliferation

Draetta, G. F., & Eckstein, J. W. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00049-2 · Cited by 148

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts

Baus, F., Gire, V., Fisher, D., Piette, J., & Dulić, V. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg387 · Cited by 143

The Human G2 Checkpoint Control Protein hRAD9 Is a Nuclear Phosphoprotein That Forms Complexes with hRAD1 and hHUS1

St.Onge, R. P., Udell, C. M., Casselman, R., & Davey, S. K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1985 · Cited by 142

Coupling of Mitosis to the Completion of S Phase Through Cdc34-Mediated Degradation of Wee1

Michael, W. M. (1998) · Science · doi:10.1126/science.282.5395.1886 · Cited by 139

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

Lopez‐Girona, A., Tanaka, K., Chen, X.-B., Baber, B. A., McGowan, C. H., & Russell, P. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191557598 · Cited by 135

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells

Smith, K. A. B., Gorman, P. A., Stark, M. B., Groves, R. P., & Stark, G. R. (1990) · Cell · doi:10.1016/0092-8674(90)90417-d · Cited by 133

Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions

Meijer, L., & Pondaven, P. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90147-4 · Cited by 125

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1

Yuan, J., Eckerdt, F., Bereiter‐Hahn, J., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1206011 · Cited by 122

p130/E2F4 Binds to and Represses the cdc2 Promoter in Response to p53

Taylor, W. R., Schönthal, A. H., Galante, J., & Stark, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005101200 · Cited by 110

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

McGowan, C. H. (2002) · BioEssays · doi:10.1002/bies.10101 · Cited by 109

G2 arrest in response to topoisomerase II inhibitors: the role of p53.

Clifford, B., Beljin, M., Stark, G. R., & Taylor, W. R. (2003) · PubMed · Cited by 109

A Human Homologue of the Schizosaccharomyces pombe rad1+ Checkpoint Gene Encodes an Exonuclease

Parker, A. E., de Weyer, I. V., Laus, M. C., van Oostveen, I., Yon, J. R., Verhasselt, P., & Luyten, W. H. M. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18332 · Cited by 102

Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response

Ahn, J., Urist, M., & Prives, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213185200 · Cited by 99

G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

Dou, Q. P., Zhao, S., Levin, A., Wang, J., Helin, K., & Pardee, A. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42259-9 · Cited by 99

Cell Cycle Regulation of DNA Replication Initiator Factor Dbf4p

Cheng, L., Collyer, T., & Hardy, C. F. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4270 · Cited by 93

p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2

Jackson, M. W., Agarwal, M. K., Yang, J., Bruss, P., Uchiumi, T., Agarwal, M. L., Stark, G. R., & Taylor (2005) · Journal of Cell Science · doi:10.1242/jcs.02307 · Cited by 92

Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2.

Kharbanda, S. M., Saleem, A., Datta, R., et al. (1994) · PubMed · Cited by 86

Ran-independent nuclear import of cyclin B1–Cdc2 by importin β

Takizawa, C. G., Weis, K., & Morgan, D. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7938 · Cited by 85

Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint

Furnari, B. A., Rhind, N., Boddy, M. N., Shanahan, P., Lopez‐Girona, A., & Russell, P. R. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.1 · Cited by 77

E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress

Polager, S., & Ginsberg, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210327200 · Cited by 71

Identification of a Cell-Type-Specific and E2F-Independent Mechanism for Repression of cdc2 Transcription

Sugarman, J. L., Schönthal, A. H., & Glass, C. K. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3282 · Cited by 43

Oncogenic intelligence: Cell immortalization and transformation by the p53 gene

Lane, D. P. (1984) · Nature · doi:10.1038/312596a0 · Cited by 41

FACS-Based Detection of Phosphorylated Histone H3 for the Quantitation of Mitotic Cells

Taylor, W. R. (2004) · Humana Press eBooks · doi:10.1385/1-59259-811-0:293 · Cited by 21

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

Yang, L., Besschetnova, T. Y., Brooks, C. R., Shah, J. V., & Bonventre, J. V. (2010) · Nature Medicine · doi:10.1038/nm.2144 · Cited by 1,333

Aurora‐A Kinase: A Potent Oncogene and Target for Cancer Therapy

Yan, M., Wang, C., He, B., Yang, M., Tong, M., Long, Z., Liu, B., Peng, F., Xu, L., Zhang, Y., et al. (2016) · Medicinal Research Reviews · doi:10.1002/med.21399 · Cited by 293

Proline oxidase functions as a mitochondrial tumor suppressor in human cancers

Liu, Y., Borchert, G. L., Donald, S. P., Diwan, B. A., Anver, M., & Phang, J. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1223 · Cited by 132

Untitled work

(2007) · Cited by 33

p21 WAF1 /Cip1 limits senescence and acinar‐to‐ductal metaplasia formation during pancreatitis

Grabliauskaite, K., Hehl, A. B., Seleznik, G. M., Saponara, E., Schlesinger, K., Zuellig, R. A., Dittmann, A., Bain, M., Reding, T., Sonda, S., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4440 · Cited by 27