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Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation
Open accessAbstract
The extracellular matrix (ECM) of the brain plays crucial roles during the development, maturation, and regeneration of the CNS. In a subpopulation of neurons, the ECM condenses to superstructures called perineuronal nets (PNNs) that surround synapses. Camillo Golgi described PNNs a century ago, yet their biological functions remain elusive. Here, we studied a mouse mutant that lacks four ECM components highly enriched in the developing brain: the glycoproteins tenascin-C and tenascin-R and the chondroitin sulfate proteoglycans brevican and neurocan. Primary embryonic hippocampal neurons and astrocytes were cultivated using a cell insert system that allows for co-culture of distinct cell populations in the absence of direct membrane contacts. The wild-type and knock-out cells were combined in the four possible permutations. Using this approach, neurons cultivated in the presence of mutant astrocytes displayed a transient increase of synapses after 2 weeks. However, after a period of 3 weeks or longer, synapse formation and stabilization were compromised when either neuron or astrocyte cell populations or both were of mutant origin. The development of PNN structures was observed, but their size was substantially reduced on knock-out neurons. The synaptic activity of both wild-type and knock-out neurons was monitored using whole-cell patch clamping. The salient observation was a reduced frequency of IPSCs and EPSCs, whereas the amplitudes were not modified. Remarkably, the knock-out neuron phenotypes could not be rescued by wild-type astrocytes. We conclude that the elimination of four ECM genes compromises neuronal function.
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“In a previous study our laboratory investigated hippocampal neurons of the quadruple knockout mouse in vitro and found diminished PNNs and an altered expression of synaptic proteins that were accompanied by a decreased frequency of mEPSCs and mIPSCs after 14 and 21 DIV29.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
In the citing paper
“This may be due in part to the degradation of the PNNs in which synapses are embedded, as the genetic ablation of one or more PNN structural components and consequent loss of neuronal PNN integrity can induce the loss of synapses [28, 80] and impaired synaptic colocalization/expression of neurotransmitter receptor subunits [29], potentially manifesting as deficits in synaptic plasticity (e.g. LTP)”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [80]
In the citing paper
“PNNs are autonomously constructed by neurons (Miyata et al. , 2005; Geissler et al. , 2013; Fowke et al. , 2017)”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Geissler et al. , 2013
In the citing paper
“The results found for the in vivo PNN formation fit perfectly with the in vitro findings29, both demonstrating a diminished PNN formation in the postnatal quadruple knockout mouse.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
In the citing paper
“The loss of TnC, TnR, brevican and neurocan resulted in a significant increase of synaptic density within 14 DIV that transited to a decremented synapse number after 21 DIV.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
In the citing paper
“Neurons coated with PNNs were characterized by an attenuated synapse number after both 14 and 21 DIV29.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
In the citing paper
“In this model hippocampal neurons lacking neurocan, brevican, TN-R and TN-C display rudimentary PNNs and reduced synapse number, suggesting that PNNs are important for synapse formation/stabilization (Geissler et al., 2013).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Geissler et al., 2013
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Citations
Cites
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Tripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820
Kaech, S., & Banker, G. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.356 · Cited by 1,766
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058528 · Cited by 1,454
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Culturing hippocampal neurons.
Tanaka, H. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.163 · Cited by 1,141
Sommer, I., & Schachner, M. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90477-2 · Cited by 1,136
Perineuronal Nets Protect Fear Memories from Erasure
Gogolla, N., Caroni, P., Lüthi, A., & Herry, C. (2009) · Science · doi:10.1126/science.1174146 · Cited by 760
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
Dityatev, A., Schachner, M., & Sonderegger, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2898 · Cited by 559
Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554
Activity-dependent structural and functional plasticity of astrocyte-neuron interactions
Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00036.2007 · Cited by 531
Local Ca2+ detection and modulation of synaptic release by astrocytes
Di Castro, M. A., Chuquet, J., Liaudet, N., Bhaukaurally, K., Santello, M., Bouvier, D., Tiret, P., & Volterra, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2929 · Cited by 529
Perineuronal nets: past and present
Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482
Dieck, S., Sanmartí-Vila, L., Langnaese, K., Richter, K., Kindler, S., Soyke, A., Wex, H., Smalla, K.-H., Kämpf, U., Fränzer, J.-T., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.2.499 · Cited by 482
Experimental observations on the development of polarity by hippocampal neurons in culture.
Goslin, K., & Banker, G. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1507 · Cited by 416
Extracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395
J1/tenascin is a repulsive substrate for central nervous system neurons
Faissner, A., & Kruse, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90217-4 · Cited by 378
Self-citationRole for glia in synaptogenesis
Ullian, E. M., Christopherson, K. S., & Barres, B. A. (2004) · Glia · doi:10.1002/glia.20082 · Cited by 377
Composition of Perineuronal Net Extracellular Matrix in Rat Brain
Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367
Dityatev, A., Brückner, G., Dityateva, G., Grosche, J., Kleene, R., & Schachner, M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20361 · Cited by 365
Carulli, D., Rhodes, K. E., Brown, D. J., Bonnert, T. P., Pollack, S. J., Oliver, K., Strata, P., & Fawcett, J. W. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20822 · Cited by 341
Development of Excitatory Circuitry in the Hippocampus
Hsia, A. Y., Malenka, R. C., & Nicoll, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2013 · Cited by 279
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dörries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271
Self-citationNeurofascin assembles a specialized extracellular matrix at the axon initial segment
Hedstrom, K. L., Xu, X., Ogawa, Y., Frischknecht, R., Seidenbecher, C. I., Shrager, P., & Rasband, M. N. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705119 · Cited by 268
Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7417-7427.2002 · Cited by 264
Self-citation[Chondroitin sulfate proteoglycans in neural development and regeneration].
Gu, W.-L., & Lu, P. (2007) · PubMed · Cited by 255
Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
Ippolito, D. M., & Eroğlu, Ç. (2010) · Journal of Visualized Experiments · doi:10.3791/2270 · Cited by 254
Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236
Dityatev, A. E., Seidenbecher, C. I., & Schachner, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.08.003 · Cited by 235
Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain
Saghatelyan, A., de Chevigny, A., Schachner, M., & Lledo, P. (2004) · Nature Neuroscience · doi:10.1038/nn1211 · Cited by 229
New roles for astrocytes: Regulation of CNS synaptogenesis
Ślęzak, M., & Pfrieger, F. W. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.005 · Cited by 224
Chondroitin sulfate proteoglycans in neural development and regeneration
Laabs, T. L., Carulli, D., Geller, H. M., & Fawcett, J. W. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.014 · Cited by 218
Kochlamazashvili, G., Henneberger, C., Bukalo, O., Dvoretskova, E., Senkov, O., Lievens, P. M.-J., Westenbroek, R., Engel, A. K., Catterall, W. A., Rusakov, D. A., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.030 · Cited by 215
Wang, D., Ichiyama, R. M., Zhao, R., Andrews, M. R., & Fawcett, J. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0983-11.2011 · Cited by 214
Perineuronal net formation and structure in aggrecan knockout mice
Giamanco, K. A., Morawski, M., & Matthews, R. T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.032 · Cited by 207
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207
Self-citationSaghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207
Modulation of Perineuronal Nets and Parvalbumin with Developmental Song Learning
Balmer, T. S., Carels, V. M., Frisch, J. L., & Nick, T. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2974-09.2009 · Cited by 181
Fuss, B., Wintergerst, E. S., Bartsch, U., & Schachner, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.5.1237 · Cited by 179
Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172
Kwok, J. C. F., Carulli, D., & Fawcett, J. W. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06878.x · Cited by 170
Haas, C. A., Rauch, U., Thon, N., Merten, T., & Deller, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09953.1999 · Cited by 151
Self-citationSeidenbecher, C. I., Richter, K., Rauch, U., Fässler, R., Garner, C. C., & Gundelfinger, E. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27206 · Cited by 149
Self-citationProteomic Analysis of Astrocytic Secretion in the Mouse
Lafon‐Cazal, M., Adjali, O., Galéotti, N., Poncet, J., Jouin, P., Homburger, V., Bockaert, J., & Marin, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211980200 · Cited by 143
Rathjen, F. G., Wolff, M., & Chiquet‐Ehrismann, R. (1991) · Development · doi:10.1242/dev.113.1.151 · Cited by 140
Giamanco, K. A., & Matthews, R. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.055 · Cited by 138
Structural and Functional Aberrations in the Cerebral Cortex of Tenascin-C Deficient Mice
Irintchev, A., Rollenhagen, A., Troncoso, E., Kiss, J. Z., & Schachner, M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh195 · Cited by 137
Aggrecan: Beyond cartilage and into the brain
Morawski, M., Brückner, G., Arendt, T., & Matthews, R. T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.010 · Cited by 136
Converting juvenile into adult plasticity: a role for the brain's extracellular matrix
Gundelfinger, E. D., Frischknecht, R., Choquet, D., & Heine, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07253.x · Cited by 136
Weston, M. C., Nehring, R. B., Wojcik, S. M., & Rosenmund, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.002 · Cited by 134
Pyka, M., Wetzel, C., Aguado, A., Geissler, M., Hatt, H., & Faissner, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07690.x · Cited by 131
Self-citationJohn, N., Krügel, H., Frischknecht, R., Smalla, K.-H., Schultz, C., Kreutz, M. R., Gundelfinger, E. D., & Seidenbecher, C. I. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.011 · Cited by 122 · cited 3×
“1) confirms earlier reports that highlighted the localization at the axon hillock (John et al., 2006; Hedstrom et al., 2007).”
BackgroundResultSaghatelyan, A., Gorissen, S., Albert, M., Hertlein, B., Schachner, M., & Dityatev, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00216.x · Cited by 116
Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan
Lander, C., Zhang, H., & Hockfield, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00174.1998 · Cited by 107
Morellini, F., Sivukhina, E., Stoenica, L., Oulianova, E., Bukalo, O., Jakovcevski, I., Dityatev, A., Irintchev, A., & Schachner, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq017 · Cited by 104
Zhao, R., Muir, E. M., Alves, J. N., Rickman, H. M., Allan, A. Y., Kwok, J. C. F., Roet, K. C. D., Verhaagen, J., Schneider, B. L., Bensadoun, J., et al. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.08.003 · Cited by 95
Artificial Astrocytes Improve Neural Network Performance
Porto-Pazos, A. B., Veiguela, N., Mesejo, P., Navarrete, M., Alvarellos, A., Ibáñez, O., Pazos, A., & Araque, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019109 · Cited by 89
Extracellular matrix alterations in brains lacking four of its components
Rauch, U., Zhou, X.-H., & Roos, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.026 · Cited by 88
Self-citationNeurotrophin signaling among neurons and glia during formation of tripartite synapses
Elmariah, S. B., Hughes, E. G., Oh, E. J., & Balice‐Gordon, R. J. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000189 · Cited by 85
Susarla, B. T. S., Laing, E. D., Yu, P., Katagiri, Y., Geller, H. M., & Symes, A. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07470.x · Cited by 81
Cross-talk between neurons and glia: highlights on soluble factors
Gomes, F. C. A., Spohr, T., Martinez, R., & Moura‐Neto, V. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000500008 · Cited by 81
Hippocampal Metaplasticity Induced by Deficiency in the Extracellular Matrix Glycoprotein Tenascin-R
Bukalo, O., Schachner, M., & Dityatev, A. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1022-07.2007 · Cited by 80
Karus, M., Denecke, B., ffrench‐Constant, C., Wiese, S., & Faissner, A. (2011) · Development · doi:10.1242/dev.067413 · Cited by 80
Self-citationMatsui, F., Nishizuka, M., Yasuda, Y., Aono, S., Watanabe, E., & Oohira, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00009-2 · Cited by 78
Zhang, Y., Anderson, P. N., Campbell, G., Mohajeri, H. M., Schachner, M., & Lieberman, A. R. (1995) · Journal of Neurocytology · doi:10.1007/bf01257374 · Cited by 71
Nikonenko, A., Schmidt, S., Skibo, G., Brückner, G., & Schachner, M. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10537 · Cited by 69
Casting a net on dendritic spines: The extracellular matrix and its receptors
Dansie, L. E., & Ethell, I. M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20963 · Cited by 68
Training and anti-CSPG combination therapy for spinal cord injury
García‐Alías, G., & Fawcett, J. W. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.009 · Cited by 68
Freeing the Brain from the Perineuronal Net
Fox, K. D., & Caterson, B. (2002) · Science · doi:10.1126/science.1079224 · Cited by 57
Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression
Ferhat, L., Chevassus-au-Louis, N., Jorquera, I., Niquet, J., Khrestchatisky, M., Ben‐Ari, Y., & Represa, A. (1996) · Journal of Neurocytology · doi:10.1007/bf02284785 · Cited by 52
Wintergerst, E. S., Faissner, A., & Celio, M. R. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00011-1 · Cited by 46
Self-citationPyka, M., Busse, C., Seidenbecher, C. I., Gundelfinger, E. D., & Faissner, A. (2010) · Synapse · doi:10.1002/syn.20816 · Cited by 41
Self-citationSeizures induce tenascin-C mRNA expression in neurons
Ferhat, L., Chevassus-au-Louis, N., Khrestchatisky, M., Ben‐Ari, Y., & Represa, A. (1996) · Journal of Neurocytology · doi:10.1007/bf02284821 · Cited by 40
Geißler, M., & Faissner, A. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.11.030 · Cited by 36
Self-citationTenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C
Michele, M., & Faissner, A. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.004 · Cited by 28
Self-citationCybulska-Kłosowicz, A., Zakrzewska, R., Pyza, E., Kossut, M. M., & Schachner, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03605.x · Cited by 21
Mahler, M., Ferhat, L., Gillian, A. M., Ben-Ari, Y., & Represa, A. (1996) · Cell Communication & Adhesion · doi:10.3109/15419069609014221 · Cited by 12
Novel conserved oligodendrocyte surface epitope identified by monoclonal antibody 4860
Czopka, T., Hennen, E., von Holst, A., & Faissner, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0868-9 · Cited by 11
Self-citationPostnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
Br�ckner, G., Grosche, J., Schmidt, S., H�rtig, W., Margolis, R. U., Delpech, B., Seidenbecher, C. I., Czaniera, R., & Schachner, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001225)428:4
Meyer-Puttlitz (1996) · doi:10.1002/(sici)1096-9861(19960226)366:1
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Metadata
- Authors
- Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A.
- Affiliations
- Ruhr University Bochum (DE)
- Lund University (SE)
- University of Regensburg (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-05-01
- Volume
- 33
- Issue
- 18
- Pages
- 7742-7755
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618965
- OpenAlex
- W2012448906
- Cited by
- 140
- References
- 86
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 12 · 2021: 15 · 2020: 18 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 3
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- perineuronal nets, extracellular matrix, hippocampal neurons, astrocytes, tenascin-C, tenascin-R, brevican, neurocan, chondroitin sulfate proteoglycans, synaptogenesis, synapse stabilization, inhibitory postsynaptic currents, excitatory postsynaptic currents, co-culture, embryonic neurons
- MeSH terms
- Animals, Astrocytes, Cell Count, Cells, Cultured, Embryo, Mammalian, Female, Hippocampus, Male, Mice, Inbred C57BL, Nerve Net, Neurons, Synapses, Extracellular Matrix Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Tenascin, Excitatory Postsynaptic Potentials, Mice, Inhibitory Postsynaptic Potentials, Neurocan, Brevican
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