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Cited by 369

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

The benefits and risks of testosterone replacement therapy: a review

Open access
Morley, John·2009·Therapeutics and Clinical Risk Management
DOI 10.2147/tcrm.s3025
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Abstract

The benefits and risks of testosterone replacement therapy: a review Nazem Bassil1, Saad Alkaade2, John E Morley1,31Division of Geriatric Medicine; 2Internal Medicine, Saint Louis University Health Sciences Center, St. Louis, Missouri, USA; 3GRECC, VA Medical Center, St. Louis, Missouri, USAAbstract: Increased longevity and population aging will increase the number of men with late onset hypogonadism. It is a common condition, but often underdiagnosed and undertreated. The indication of testosterone-replacement therapy (TRT) treatment requires the presence of low testosterone level, and symptoms and signs of hypogonadism. Although controversy remains regarding indications for testosterone supplementation in aging men due to lack of large-scale, long-term studies assessing the benefits and risks of testosterone-replacement therapy in men, reports indicate that TRT may produce a wide range of benefits for men with hypogonadism that include improvement in libido and sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life and cardiovascular disease. Perhaps the most controversial area is the issue of risk, especially possible stimulation of prostate cancer by testosterone, even though no evidence to support this risk exists. Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening untreated sleep apnea or severe heart failure. Despite this controversy, testosterone supplementation in the United States has increased substantially over the past several years. The physician should discuss with the patient the potential benefits and risks of TRT. The purpose of this review is to discuss what is known and not known regarding the benefits and risks of TRT.Keywords: hypogonadism, testosterone replacement therapy, erectile dysfunction, osteoporosis, cardiovascular disease

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Metadata

Authors
Morley, J.
Venue
Therapeutics and Clinical Risk Management
Publisher
Informa UK Limited
Published
2009-06
Volume
5
Issue
3
Pages
427
ISSN
  • 1176-6336 (ISSN-L)
  • 1178-203X
DOI
10.2147/tcrm.s3025
OpenAlex
W1965482286
Cited by
369
References
57
FWCI
13.27
Type
journal article
Language
en
Open access
gold

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