Cited by 154Physical Activity and HealthDementia and Cognitive Impairment ResearchCardiovascular and exercise physiology

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A review of cardiorespiratory fitness-related neuroplasticity in the aging brain

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Hayes, Scott M., Hayes, Jasmeet P., Cadden, Margaret, Verfaellie, Mieke·2013·Frontiers in Aging Neuroscience

DOI 10.3389/fnagi.2013.00031PMC PMC3709413

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Abstract

The literature examining the relationship between cardiorespiratory fitness and the brain in older adults has increased rapidly, with 30 of 34 studies published since 2008. Here we review cross-sectional and exercise intervention studies in older adults examining the relationship between cardiorespiratory fitness and brain structure and function, typically assessed using Magnetic Resonance Imaging (MRI). Studies of patients with Alzheimer's disease are discussed when available. The structural MRI studies revealed a consistent positive relationship between cardiorespiratory fitness and brain volume in cortical regions including anterior cingulate, lateral prefrontal, and lateral parietal cortex. Support for a positive relationship between cardiorespiratory fitness and medial temporal lobe volume was less consistent, although evident when a region-of-interest approach was implemented. In fMRI studies, cardiorespiratory fitness in older adults was associated with activation in similar regions as those identified in the structural studies, including anterior cingulate, lateral prefrontal, and lateral parietal cortex, despite heterogeneity among the functional tasks implemented. This comprehensive review highlights the overlap in brain regions showing a positive relationship with cardiorespiratory fitness in both structural and functional imaging modalities. The findings suggest that aerobic exercise and cardiorespiratory fitness contribute to healthy brain aging, although additional studies in Alzheimer's disease are needed.

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Authors: Hayes, S. M., Hayes, J. P., Cadden, M., & Verfaellie, M.
Affiliations: Boston University (US)
Corresponding author: Hayes, Scott M.
ORCID: Hayes, Scott M.
Hayes, Jasmeet P.
Verfaellie, Mieke
Venue: Frontiers in Aging Neuroscience
Publisher: Frontiers Media SA
Published: 2013
Volume: 5
Pages: 31-31
ISSN: 1663-4365 (ISSN-L)
DOI: 10.3389/fnagi.2013.00031
PMC: PMC3709413
OpenAlex: W2125682808
Cited by: 154
References: 101
Citations by year: 2026: 3 · 2025: 14 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 11 · 2019: 16 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 16 · 2013: 3
FWCI: 11.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Aging Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
National Institute of Mental Health (K23MH084013)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: cardiorespiratory fitness, neuroplasticity, brain aging, older adults, aerobic exercise, brain structure, brain function, cortical volume, anterior cingulate cortex, prefrontal cortex, parietal cortex, medial temporal lobe, Alzheimer's disease, exercise intervention

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A review of cardiorespiratory fitness-related neuroplasticity in the aging brain

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