Skeletal muscle loss: cachexia, sarcopenia, and inactivity

Epidemiology of Sarcopenia among the Elderly in New Mexico

Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539

Aging of skeletal muscle: a 12-yr longitudinal study

Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443

Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults

Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933

Longitudinal changes in body composition in older men and women: role of body weight change and physical activity

Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804

Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections

Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M. (1983) · Muscle & Nerve · doi:10.1002/mus.880060809 · Cited by 582

Essential Amino Acid and Carbohydrate Supplementation Ameliorates Muscle Protein Loss in Humans during 28 Days Bedrest

Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Sanford, A. P., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032159 · Cited by 338

Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men–the MINOS study

Szulc, P., Beck, T. J., Marchand, F., & Delmas, P. D. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041230 · Cited by 284

EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly

Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.03.009 · Cited by 237

Frailty and sarcopenia: The potential role of an aged immune system

Wilson, D., Jackson, T., Sapey, E., & Lord, J. M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.006 · Cited by 573

The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial

Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0034-6 · Cited by 403

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

Herold, F., Törpel, A., Schega, L., & Müller, N. G. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0217-2 · Cited by 349

Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies

Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-061509-131248 · Cited by 319

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

Han, H. Q., Zhou, X., Mitch, W. E., & Goldberg, A. L. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.019 · Cited by 314

The effect of intramuscular fat on skeletal muscle mechanics: implications for the elderly and obese

Rahemi, H., Nigam, N., & Wakeling, J. M. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0365 · Cited by 253

Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia: Opportunities, Challenges, and Recommendations for Physical Activity Interventions

Billot, M., Calvani, R., Urtamo, A., Sánchez-Sánchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, M. N., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s253535 · Cited by 242

A comparative study of software programmes for cross‐sectional skeletal muscle and adipose tissue measurements on abdominal computed tomography scans of rectal cancer patients

van Vugt, J. L. A., Levolger, S., Gharbharan, A., Koek, M., Niessen, W. J., Burger, J. W. A., Willemsen, S. P., de Bruin, R. W. F., & IJzermans, J. N. M. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12158 · Cited by 217

Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis

Nay, K., Jollet, M., Goustard, B., Baati, N., Vernus, B., Pontones, M., Lefeuvre-Orfila, L., Bendavid, C., Rué, O., Mariadassou, M., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00521.2018 · Cited by 215

Muscle metabolism and atrophy: let’s talk about sex

Rosa-Caldwell, M. E., & Greene, N. P. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0257-3 · Cited by 202

Development and validation of anthropometric prediction equations for lean body mass, fat mass and percent fat in adults using the National Health and Nutrition Examination Survey (NHANES) 1999–2006

Lee, D. H., Keum, N., Hu, F. B., Orav, E. J., Rimm, E. B., Sun, Q., Willett, W. C., & Giovannucci, E. L. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517002665 · Cited by 191

Nutrition and chronic kidney disease

Fouque, D., Pelletier, S., Mafra, D., & Chauveau, P. (2011) · Kidney International · doi:10.1038/ki.2011.118 · Cited by 190

Frailty and muscle metabolism dysregulation in the elderly

Evans, W. J., Paolisso, G., Abbatecola, A. M., Corsonello, A., Bustacchini, S., Strollo, F., & Lattanzio, F. (2010) · Biogerontology · doi:10.1007/s10522-010-9297-0 · Cited by 173

Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)

Crawford, J., Prado, C. M. M., Johnston, M. A., Gralla, R. J., Taylor, R. P., Hancock, M. L., & Dalton, J. T. (2016) · Current Oncology Reports · doi:10.1007/s11912-016-0522-0 · Cited by 178

The effects of vitamin D3 supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study

Close, G. L., Leckey, J., Patterson, M., Bradley, W., Owens, D. J., Fraser, W. D., & Morton, J. P. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091735 · Cited by 155

Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle

Porter, C., Hurren, N. M., Cotter, M. V., Bhattarai, N., Reidy, P. T., Dillon, E. L., Durham, W. J., Tuvdendorj, D., Sheffield-Moore, M., Volpi, E., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00125.2015 · Cited by 134

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

Beharry, A. W., Sandesara, P. B., Roberts, B. M., Ferreira, L. F., Senf, S. M., & Judge, A. R. (2014) · Journal of Cell Science · doi:10.1242/jcs.136390 · Cited by 128

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129

The role of estrogen deficiency in skin ageing and wound healing

Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118

No change in myonuclear number during muscle unloading and reloading

Bruusgaard, J. C., Egner, I. M., Larsen, T. K., Dupre-Aucouturier, S., Desplanches, D., & Gundersen, K. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00436.2012 · Cited by 107

Dietary magnesium Is positively associated with skeletal muscle power and indices of muscle mass and may attenuate the association between circulating C-Reactive Protein and muscle mass in women

Welch, A. A., Kelaiditi, E., Jennings, A., Steves, C. J., Spector, T. D., & MacGregor, A. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2692 · Cited by 100

Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review

Campbell, M., Varley-Campbell, J., Fulford, J., Taylor, B., Mileva, K. N., & Bowtell, J. L. (2019) · Sports Medicine · doi:10.1007/s40279-019-01088-8 · Cited by 94

Self-Reported Sleep Duration and Time in Bed as Predictors of Physical Function Decline: Results from the InCHIANTI Study

Stenholm, S., Kronholm, E., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2011) · Sleep · doi:10.5665/sleep.1402 · Cited by 88

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

Nilsson, M. I., Dobson, J. P., Greene, N. P., Wiggs, M. P., Shimkus, K. L., Wudeck, E. V., Davis, A. R., Laureano, M. L., & Fluckey, J. D. (2013) · The FASEB Journal · doi:10.1096/fj.12-224006 · Cited by 87

IL-15 Promotes Human Myogenesis and Mitigates the Detrimental Effects of TNFα on Myotube Development

O’Leary, M. F., Wallace, G. R., Bennett, A. J., Tsintzas, K., & Jones, S. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-13479-w · Cited by 85

The Association between Daily Calcium Intake and Sarcopenia in Older, Non-Obese Korean Adults: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) 2009

Seo, M. H., Kim, M. K., Park, S. E., Rhee, E. J., Park, C. Y., Lee, W.-Y., Baek, K. H., Song, K.-H., Kang, M. I., & Oh, K. W. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej12-0395 · Cited by 81

The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

Kim, C., & Hwang, J.-K. (2020) · Nutrients · doi:10.3390/nu12041079 · Cited by 80

Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men

Donges, C. E., Duffield, R., Guelfi, K. J., Smith, G. C., Adams, D. R., & Edge, J. A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0443 · Cited by 74

“Nutraceuticals” in relation to human skeletal muscle and exercise

Deane, C. S., Wilkinson, D. J., Phillips, B. E., Smith, K., Etheridge, T., & Atherton, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2016 · Cited by 73

Assessment and definition of lean body mass deficiency in the elderly

Müller, M. J., Geisler, C., Pourhassan, M., Glüer, C.-C., & Bosy-Westphal, A. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.169 · Cited by 63

Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids: Nutrition Reviews©, Vol. ••, No. ••

Pasiakos, S. M., & McClung, J. P. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00420.x · Cited by 53

Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males

Wall, B. T., Dirks, M. L., Snijders, T., Stephens, F. B., Senden, J. M. G., Verscheijden, M.-L., & van Loon, L. J. C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.11.019 · Cited by 52

Soluble Whey Protein Hydrolysate Ameliorates Muscle Atrophy Induced by Immobilization via Regulating the PI3K/Akt Pathway in C57BL/6 Mice

Shin, J. E., Park, S. J., Ahn, S. I., & Choung, S.-Y. (2020) · Nutrients · doi:10.3390/nu12113362 · Cited by 52

Weight Loss Strategies in the Elderly: A Clinical Conundrum

Coker, R. H., & Wolfe, R. R. (2018) · Obesity · doi:10.1002/oby.21961 · Cited by 47

Flavonoids: Nutraceutical Potential for Counteracting Muscle Atrophy

Kim, C., & Hwang, J.-K. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-020-00816-5 · Cited by 45

Influence of body adiposity on structural characteristics of skeletal muscle in men and women

Lafortuna, C. L., Tresoldi, D., & Rizzo, G. (2014) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12062 · Cited by 42

Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model

Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37

Impact of blood flow‐restricted bodyweight exercise on skeletal muscle adaptations

Jakobsgaard, J. E., Christiansen, M., Sieljacks, P., Wang, J., Groennebaek, T., de Paoli, F., & Vissing, K. (2018) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12509 · Cited by 33

Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia

Rosa-Caldwell, M. E., Benson, C. A., Lee, D. E., Brown, J. L., Washington, T. A., Greene, N. P., & Wiggs, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217841 · Cited by 13

Organotypic cultures as aging associated disease models

Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12