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Cited by 106Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Overweight and Obesity as Determinants of Cardiovascular Risk: The Framingham Experience

Wilson, Peter W. F., D'Agostino, Ralph B., Sullivan, Lisa, Parise, Helen, Kannel, William B.·2002·Archives of Internal Medicine
DOI 10.1001/archinte.162.16.1867
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Abstract

Background To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for hypertension, hypercholesterolemia, diabetes mellitus, and cardiovascular sequelae has been reported. Methods Relations between categories of body mass index (BMI), cardiovascular disease risk factors, and vascular disease end points were examined prospectively in Framingham Heart Study participants aged 35 to 75 years, who were followed up to 44 years. The primary outcome was new cardiovascular disease, which included angina pectoris, myocardial infarction, coronary heart disease, or stroke. Analyses compared overweight (BMI [calculated as weight in kilograms divided by the square of height in meters], 25.0-29.9) and obese persons (BMI ≥30) to a referent group of normal-weight persons (BMI, 18.5-24.9). Results The age-adjusted relative risk (RR) for new hypertension was highly associated with overweight status (men: RR, 1.46; women: RR, 1.75). New hypercholesterolemia and diabetes mellitus were less highly associated with excess adiposity. The age-adjusted RR (confidence interval [CI]) for cardiovascular disease was increased among those who were overweight (men: 1.21 [1.05-1.40]; women: 1.20 [1.03-1.41]) and the obese (men: 1.46 [1.20-1.77]; women: 1.64 [1.37-1.98]). High population attributable risks were related to excess weight (BMI ≥25) for the outcomes hypertension (26% men; 28% women), angina pectoris (26% men; 22% women), and coronary heart disease (23% men; 15% women). Conclusions The overweight category is associated with increased relative and population attributable risk for hypertension and cardiovascular sequelae. Interventions to reduce adiposity and avoid excess weight may have large effects on the development of risk factors and cardiovascular disease at an individual and population level.

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Crossref · 10.1001/archinte.162.16.1867

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Metadata

Authors
Wilson, P. W. F., D'Agostino, R. B., Sullivan, L., Parise, H., & Kannel, W. B.
Affiliations
Boston University (US)
ORCID
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2002-09-09
Volume
162
Issue
16
Pages
1867
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.162.16.1867
OpenAlex
W1564433957
Cited by
22
References
36
Citations by year
2022: 3 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
Archives of Internal Medicine (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (N01-HC-38038)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR/AG 41398)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
overweight, obesity, body mass index, cardiovascular risk, hypertension, hypercholesterolemia, diabetes mellitus, coronary artery disease, stroke, angina pectoris, population attributable risk, Framingham Heart Study

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