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Cited by 1,297

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Three-Year Outcomes for Maintenance Therapies in Recurrent Depression

Frank, Ellen·1990·Archives of General Psychiatry
DOI 10.1001/archpsyc.1990.01810240013002
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Abstract

We conducted a randomized 3-year maintenance trial in 128 patients with recurrent depression who had responded to combined short-term and continuation treatment with imipramine hydrochloride and interpersonal psychotherapy. A five-cell design was used to determine whether a maintenance form of interpersonal psychotherapy alone or in combination with medication could play a significant role in the prevention of recurrence. A second question was whether maintaining antidepressant medication at the dosage used to treat the acute episode rather than decreasing to a "maintenance" dosage would provide prophylaxis superior to that observed in earlier trials in which a maintenance dosage strategy was employed. Survival analysis demonstrated a highly significant prophylactic effect for active imipramine hydrochloride maintained at an average dose of 200 mg and a modest prophylactic effect for monthly interpersonal psychotherapy. We conclude that active imipramine hydrochloride maintained at an average dose of 200 mg is an effective means of preventing recurrence and that monthly interpersonal psychotherapy serves to lengthen the time between episodes in patients not receiving active medication.

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Metadata

Authors
Frank, E.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1990-12-01
Volume
47
Issue
12
Pages
1093
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1990.01810240013002
OpenAlex
W2100495048
Cited by
1,297
References
2
FWCI
34.62
Type
journal article
Language
en
Open access
closed

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