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Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Abstract
BACKGROUND: Current investigations suggest that brain white matter may be qualitatively altered in schizophrenia even in the face of normal white matter volume. Diffusion tensor imaging provides a new approach for quantifying the directional coherence and possibly connectivity of white matter fibers in vivo. METHODS: Ten men who were veterans of the US Armed Forces and met the DSM-IV criteria for schizophrenia and 10 healthy, age-matched control men were scanned using magnetic resonance diffusion tensor imaging and magnetic resonance structural imaging. RESULTS: Relative to controls, the patients with schizophrenia exhibited lower anisotropy in white matter, despite absence of a white matter volume deficit. In contrast to the white matter pattern, gray matter anisotropy did not distinguish the groups, even though the patients with schizophrenia had a significant gray matter volume deficit. The abnormal white matter anisotropy in patients with schizophrenia was present in both hemispheres and was widespread, extending from the frontal to occipital brain regions. CONCLUSIONS: Despite the small sample size, diffusion tensor imaging was powerful enough to yield significant group differences, indicating widespread alteration in brain white matter integrity but not necessarily white matter volume in schizophrenia.
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Citations
Cites
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516
Cited by
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120
Looking into the functional architecture of the brain with diffusion MRI.
Le Bihan, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1119 · Cited by 1,571
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793
A review of diffusion tensor imaging studies in schizophrenia
Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769
Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530
An investigation of functional and anatomical connectivity using magnetic resonance imaging
Koch, M. A., Norris, D. G., & Hund-Georgiadis, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1052 · Cited by 509
Diffusion MRI at 25: exploring brain tissue structure and function
Le Bihan, D., & Johansen-Berg, H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.006 · Cited by 498
Frontostriatal Microstructure Modulates Efficient Recruitment of Cognitive Control
Liston, C., Watts, R., Tottenham, N., Davidson, M. C., Niogi, S., Ulug, A. M., & Casey, B. J. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj003 · Cited by 477
Hof, P. R., Haroutunian, V., Friedrich, V. L., Byne, W., Buitron, C., Perl, D. P., & Davis, K. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00237-3 · Cited by 433
Urakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405
McDonald, C., Bullmore, E. T., Sham, P. C., Chitnis, X., Wickham, H., Bramon, E., & Murray, R. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.974 · Cited by 379
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376
Tuch, D. S., Salat, D. H., Wisco, J. J., Zaleta, A. K., Hevelone, N. D., & Rosas, H. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407259102 · Cited by 364
Eack, S. M., Hogarty, G. E., Cho, R. Y., Prasad, K. M. R., Greenwald, D. P., Hogarty, S. S., & Keshavan, M. S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.63 · Cited by 360
Karlsgodt, K. H., van Erp, T. G. M., Poldrack, R. A., Bearden, C. E., Nuechterlein, K. H., & Cannon, T. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.017 · Cited by 335
Magnetic Resonance Imaging of Myelin
Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.004 · Cited by 334
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
Burns, J., Job, D., Bastin, M. E., Whalley, H., Macgillivray, T., Johnstone, E. C., & Lawrie, S. M. (2003) · British Journal of Psychiatry · doi:10.1192/bjp.182.5.439 · Cited by 327
DTI mapping of human brain connectivity: Statistical fibre tracking and virtual dissection
Hagmann, P., Thiran, J.-P., Jonasson, L., Vandergheynst, P., Clarke, S., Maeder, P., & Meuli, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00142-3 · Cited by 326
Park, H.-J., Westin, C.-F., Kubicki, M., Maier, S. E., Niznikiewicz, M., Baer, A., Frumin, M., Kikinis, R., Jolesz, F. A., McCarley, R. W., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.04.036 · Cited by 295
Bae, J. N., MacFall, J. R., Krishnan, K. R. R., Payne, M. E., Steffens, D. C., & Taylor, W. D. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.052 · Cited by 288
Sanfilipo, M., Lafargue, T., Rusinek, H., Arena, L., Loneragan, C., Lautin, A., Feiner, D., Rotrosen, J., & Wolkin, A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.471 · Cited by 281
Schulte, T., Sullivan, E. V., Müller-Oehring, E. M., Adalsteinsson, E., & Pfefferbaum, A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi020 · Cited by 275
Self-citationFrontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD
Casey, B. J., Epstein, J. N., Buhle, J., Liston, C., Davidson, M. C., Tonev, S. T., Spicer, J., Niogi, S., Millner, A. J., Reiss, A., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101754 · Cited by 258
Neurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage
Kochunov, P., & Hong, L. E. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu070 · Cited by 236
Highley, J. R. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.11.1218 · Cited by 207
Molecular and Cellular Evidence for an Oligodendrocyte Abnormality in Schizophrenia
Hof, P. R., Haroutunian, V., Copland, C., Davis, K. L., & Buxbaum, J. D. (2002) · Neurochemical Research · doi:10.1023/a:1020981510759 · Cited by 199
Nobuhara, K. (2006) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.055129 · Cited by 191
Modeling the outcome of structural disconnection on resting-state functional connectivity
Cabral, J., Hugues, E., Kringelbach, M. L., & Deco, G. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.007 · Cited by 182
Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation
Bartzokis, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00364-0 · Cited by 179
Seok, J.-H., Park, H.-J., Chun, J.-W., Lee, S.-K., Cho, H. S., Kwon, J. S., & Kim, J.-J. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.02.002 · Cited by 168
van Amelsvoort, T., Daly, E., Henry, J., Robertson, D., Ng, V., Owen, M., Murphy, K. C., & Murphy, D. G. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1085 · Cited by 139
Impairments of social motor coordination in schizophrenia
Varlet, M., Marin, L., Raffard, S., Schmidt, R. C., Capdevielle, D., Boulenger, J.-P., Del-Monte, J., & Bardy, B. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029772 · Cited by 127
“supported by previous research showing slower reaction times in schizophrenia [41] and more specifically by anatomical correlates such as a degradation of the degree of myelination [42].”
ResultEvidence of white matter tract disruption in MRI hyperintensities
Taylor, W. D., Payne, M. E., Krishnan, K. R. R., Wagner, H. R., Provenzale, J. M., Steffens, D. C., & MacFall, J. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01160-x · Cited by 134
Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
Mori, T., Ohnishi, T., Hashimoto, R., Nemoto, K., Moriguchi, Y., Noguchi, H., Nakabayashi, T., Hori, H., Harada, S., Saitoh, O., et al. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2006.09.004 · Cited by 132
Fujiwara, H., Namiki, C., Hirao, K., Miyata, J., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T., & Murai, T. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.05.044 · Cited by 126
Functional magnetic resonance imaging: A review of methodological aspects and clinical applications
Hennig, J., Speck, O., Koch, M. A., & Weiller, C. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10330 · Cited by 100
Nobuhara, K., Okugawa, G., Minami, T., Takase, K., Yoshida, T., Yagyu, T., Tajika, A., Sugimoto, T., Tamagaki, C., Ikeda, K., et al. (2004) · Neuropsychobiology · doi:10.1159/000077941 · Cited by 94
The potential role of lamotrigine in schizophrenia
Large, C. H., Webster, E. L., & Goff, D. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0020-9 · Cited by 69
Kawashima, T., Nakamura, M., Bouix, S., Kubicki, M., Salisbury, D. F., Westin, C.-F., McCarley, R. W., & Shenton, M. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.014 · Cited by 65
Spoletini, I., Cherubini, A., Di Paola, M., Banfi, G., Rüsch, N., Martinotti, G., Bria, P., Rubino, I. A., Siracusano, A., Caltagirone, C., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.011 · Cited by 62
The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems
Fallon, J. H., Opole, I. O., & Potkin, S. G. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00022-7 · Cited by 53
Mathalon, D. H., Sullivan, E. V., Lim, K. O., & Pfefferbaum, A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.148
Self-citation
Metadata
- Authors
- Lim, K. O., Hedehus, M., Moseley, M., de Crespigny, A., Sullivan, E. V., & Pfefferbaum, A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1999-04-01
- Volume
- 56
- Issue
- 4
- Pages
- 367
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1987498894
- Cited by
- 447
- References
- 1
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- closed
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