The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Molecular principles of hair follicle induction and morphogenesis
Abstract
Hair follicle (HF) development is the result of neuroectodermal-mesodermal interactions, and can be divided into morphologically distinguishable stages (induction, organogenesis and cytodifferentiation). The spacing, polarity and differentiation patterns of HFs are driven by interacting, self-assembling gradients of inhibitors and activators, which are established jointly by the skin epithelium and mesenchyme. For HF development to occur, the dominant-negative influence of inhibitors of the HF differentiation pathway must be locally counteracted by specific antagonists and/or overriden by stimulators of hair placode formation. Once a mesenchymal condensate of inductive fibroblasts has formed, it takes over control of most subsequent steps of HF organogenesis and of epithelial stem cell differentiation into distinct lineages. In this review we introduce the morphological characteristics, major underlying principles and molecular key players that control HF development. The focus is on recent insights into the molecular interactions leading to hair follicle induction, and we close with synthesizing a corresponding working hypothesis.
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Cites
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
Cited by
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Self-citationScratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930
Epidermal Stem Cells of the Skin
Blanpain, C., & Fuchs, E. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 849
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800
Hair follicle stem cells are specified and function in early skin morphogenesis
Nowak, J. A., Polak, L., Pasolli, H. A., & Fuchs, E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.009 · Cited by 554
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties
Rendl, M., Polak, L., & Fuchs, E. (2008) · Genes & Development · doi:10.1101/gad.1614408 · Cited by 422
Review of hair follicle dermal cells
Yang, C.-C., & Cotsarelis, G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.11.005 · Cited by 418
β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
Atit, R., Sgaier, S. K., Mohamed, O. A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L., & Conlon, R. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.449 · Cited by 400
“Hair follicles develop from the epidermis but their formation depends on interactions with dermis (Schmidt-Ullrich and Paus, 2005).”
BackgroundSignaling Involved in Hair Follicle Morphogenesis and Development
Rishikaysh, P., Dev, K., Diaz, D., Qureshi, W., Filip, S., & Mokry, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 393
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.01.012 · Cited by 328
Biology of the Hair Follicle: The Basics
Krause, K., & Foitzik, K. (2006) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2006.01.002 · Cited by 269
Wnt Signaling in Skin Development, Homeostasis, and Disease
Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260
Fujimoto, A., Kimura, R., Ohashi, J., Omi, K., Yuliwulandari, R., Batubara, L., Mustofa, M. S., Samakkarn, U., Settheetham-Ishida, W., Ishida, T., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddm355 · Cited by 231
More than one way to skin . . .
Fuchs, E., & Horsley, V. (2008) · Genes & Development · doi:10.1101/gad.1645908 · Cited by 224
Generation of the primary hair follicle pattern.
Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., & Headon, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600825103 · Cited by 206
The Hair Follicle as an Estrogen Target and Source
Ohnemus, U., Uenalan, M., Inzunza, J., Gustafsson, J.-A., & Paus, R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0020 · Cited by 205
Self-citationSchmidt-Ullrich, R., Tobin, D. J., Lenhard, D., Schneider, P., Paus, R., & Scheidereit, C. (2006) · Development · doi:10.1242/dev.02278 · Cited by 171
Self-citationHierarchical patterning modes orchestrate hair follicle morphogenesis
Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., Johansson, J. A., Ford, M. J., Jahoda, C. A. B., Klika, V., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2002117 · Cited by 155
Fuchs (2016) · doi:10.1016/bs.ctdb.2015.11.033 · Cited by 152
Development and homeostasis of the sebaceous gland
Niemann, C., & Horsley, V. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.010 · Cited by 151
PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
Chen, Y., Fan, Z., Wang, X., Mo, M., Zeng, S. B., Xu, R.-H., Wang, X., & Wu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01650-6 · Cited by 130
Shimomura, Y., Wajid, M., Shapiro, L., & Christiano, A. M. (2008) · Development · doi:10.1242/dev.006718 · Cited by 122
Mou, C., Thomason, H. A., Willan, P. M., Clowes, C., Harris, W. E., Drew, C. F., Dixon, J., Dixon, M. J., & Headon, D. J. (2008) · Human Mutation · doi:10.1002/humu.20795 · Cited by 106
Richardson, G. D., Bazzi, H., Fantauzzo, K. A., Waters, J. M., Crawford, H., Hynd, P., Christiano, A. M., & Jahoda, C. A. B. (2009) · Development · doi:10.1242/dev.031427 · Cited by 103
Ectodysplasin A (EDA) – EDA receptor signalling and its pharmacological modulation
Kowalczyk-Quintas, C., & Schneider, P. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.01.004 · Cited by 97
Dynamic signals for hair follicle development and regeneration
Wang, X., Tredget, E. E., & Wu, Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0230 · Cited by 80
Jenkins, B. A., & Lumpkin, E. A. (2017) · Development · doi:10.1242/dev.120402 · Cited by 79
The expression of microRNA‐203 during human skin morphogenesis
Wei, T., Orfanidis, K., Xu, N., Janson, P., Ståhle, M., Pivarcsi, A., & Sonkoly, E. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01118.x · Cited by 60
(Neuro-)endocrinology of epithelial hair follicle stem cells
Paus, R., Arck, P., & Tiede, S. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.02.023 · Cited by 47
Self-citationBack to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
de Groot, S. C., Ulrich, M. M. W., Gho, C. G., & Huisman, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661787 · Cited by 33
LEF1 haploinsufficiency causes ectodermal dysplasia
Lévy, J., Capri, Y., Rachid, M., Dupont, C., Vermeesch, J. R., Devriendt, K., Verloes, A., Tabet, A., & Bailleul‐Forestier, I. (2020) · Clinical Genetics · doi:10.1111/cge.13714 · Cited by 25
Metadata
- Authors
- Schmidt-Ullrich, R., & Paus, R.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2005
- Volume
- 27
- Issue
- 3
- Pages
- 247-261
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1970801772
- Cited by
- 550
- References
- 14
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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