Hypoxia signaling in cancer: Implications for therapeutic interventions

Cites (468)

Items 201–400 of 466

  1. IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1
    Qin He, Mei Liu, Wenjie Huang, Xiaoping Chen, Bixiang Zhang, Tongyue Zhang, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji et al. · 2021 · Hepatology
  2. Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy
    Zuo, Huaqin, Tao, Junxian, Shi, Hua, He, Jian, Zhou, Zhengyang, Zhang, Chao · 2018 · Acta Biomaterialia
  3. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
    Xu Qian, Xinjian Li, Zhumei Shi, Xiaoming Bai, Yan Xia, Yanhua Zheng, Daqian Xu, Feng Chen, Yongping You, Jing Fang et al. · 2019 · Molecular Cell
  4. Biodegradable Calcium Phosphate Nanotheranostics with Tumor‐Specific Activatable Cascade Catalytic Reactions‐Augmented Photodynamic Therapy
    Lian‐Hua Fu, Yilin Wan, Chunying Li, Chao Qi, Ting He, Chen Yang, Yifan Zhang, Jing Lin, Peng Huang · 2021 · Advanced Functional Materials
  5. Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment
    Carolina J. García García, Yanqing Huang, Natividad Roberto Fuentes, Madeleine C. Turner, Maria E. Monberg, Daniel Lin, Nicholas D. Nguyen, Tara N. Fujimoto, Jun Zhao, Jaewon James Lee et al. · 2022 · Gastroenterology
  6. CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
    Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen · 2022 · Molecular Cancer
  7. MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway
    Qiuran Xu, Xin Liu, Zhikui Liu, Zhenyu Zhou, Yufeng Wang, Jianfeng Tu, Lijie Li, Hang-xing Bao, Liu Yang, Kangsheng Tu · 2017 · Molecular Cancer
  8. Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway
    Yang, Zhengyang, Wang, Jiafeng, Liu, Song, Li, Xianghui, Miao, Leiying, Yang, Bo, Zhang, Chenlin, He, Jian, Ai, Shichao, Guan, Wenxian · 2020 · Biomaterials
  9. Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells
    Huihui Li, Matjaž Rokavec, Longchang Jiang, David A. Horst, Heiko Hermeking · 2017 · Gastroenterology
  10. Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51
    Kaplan, Alanna R., Gueble, Susan E., Liu, Yanfeng, Oeck, Sebastian, Kim, Hoon, Yun, Zhong, Glazer, Peter M. · 2019 · Science Translational Medicine
  11. Hyperbaric oxygen therapy for late radiation tissue injury
    Michael H Bennett, John Feldmeier, Neil B. Hampson, Robert Smee, Christopher Milross · 2005 · Cochrane Database of Systematic Reviews
  12. Biomimetic Nanoemulsion for Synergistic Photodynamic‐Immunotherapy Against Hypoxic Breast Tumor
    Yifan Zhang, Yunyan Liao, Qinan Tang, Jing Lin, Peng Huang · 2021 · Angewandte Chemie International Edition
  13. Eukaryogenesis and oxygen in Earth history
    Daniel B. Mills, Richard A. Boyle, Stuart J. Daines, Erik A. Sperling, Davide Pisani, Philip C. J. Donoghue, Timothy M. Lenton · 2022 · Nature Ecology & Evolution
  14. Hyperbaric oxygen: the Medical Research Council trials and their clinical significance
    Dische, S. · 1978 · The British Journal of Radiology
  15. Sensitization of Hypoxic Tumour Cells—Clinical Experience
    Jens Overgaard · 1989 · International Journal of Radiation Biology
  16. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription
    Jaime G. Fernandez, Diego A. Rodríguez, Manuel Valenzuela, Claudia C. Calderón, Ulises Urzúa, David J. Munroe, Carlos Rosas, David Lemus A., Natalia Díaz‐Valdivia, Matthew C. Wright et al. · 2014 · Molecular Cancer
  17. Targeting HIF-1α abrogates PD-L1–mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues
    Bailey, Christopher M., Liu, Yan, Liu, Mingyue, Du, Xuexiang, Devenport, Martin, Zheng, Pan, Liu, Yang, Wang, Yin · 2022 · Journal of Clinical Investigation
  18. Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy
    Dunne, Michael, Regenold, Maximilian, Allen, Christine · 2020 · Advanced Drug Delivery Reviews
  19. Hybrid‐Membrane‐Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor‐Associated Macrophages Polarization and Hypoxia Relief
    Lin Hou, Xuan Gong, Jing Yang, Huijuan Zhang, Weijing Yang, Xiaoyuan Shawn Chen · 2022 · Advanced Materials
  20. Divergent mutational processes distinguish hypoxic and normoxic tumours
    Vinayak Bhandari, Constance H. Li, Robert Glen Bristow, Paul Christopher Boutros, Lauri A. Aaltonen, Federico Abascal, Adam A. Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal et al. · 2020 · Nature Communications
  21. Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets
    Jiang, Wei, Zhang, Zhen, Wang, Qin, Dou, Jiaxiang, Zhao, Yangyang, Ma, Yinchu, Liu, Huarong, Xu, Hangxun, Wang, Yucai · 2019 · Nano Letters
  22. Hypoxia‐Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild‐Photothermal Therapy
    Xueqing Li, Yongchun Pan, Chao Chen, Yanfeng Gao, Xinli Liu, Kaiyong Yang, Xiaowei Luan, Dongtao Zhou, Fei Zeng, Xin Han et al. · 2021 · Angewandte Chemie International Edition
  23. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects
    Dan Gabriel Duda, Tracy T. Batchelor, Christopher G. Willett, Rakesh K. Jain · 2007 · Trends in Molecular Medicine
  24. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
    Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W. et al. · 2016 · Nature Communications
  25. Transformable Honeycomb‐Like Nanoassemblies of Carbon Dots for Regulated Multisite Delivery and Enhanced Antitumor Chemoimmunotherapy
    Lin Hou, Dandan Chen, Ruiting Wang, Ruibing Wang, Huijuan Zhang, Zhenzhong Zhang, Zhihong Nie, Siyu Lu · 2020 · Angewandte Chemie International Edition
  26. Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
    Hao Sun, Qingtao Meng, Chengyu Shi, Hongbao Yang, Xiaobo Li, Shenshen Wu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xuehao Wang et al. · 2021 · Hepatology
  27. Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
    Wenguang Wang, Yuhao Cheng, Peng Yu, Haoran Wang, Yue Zhang, Haiheng Xu, Qingsong Ye, Ahu Yuan, Yiqiao Hu, Jinhui Wu · 2019 · Nature Communications
  28. Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
    Batlle, Raquel, Andrés, Eva, Gonzalez, Lorena, Llonch, Elisabet, Igea, Ana, Gutierrez-Prat, Núria, Berenguer-Llergo, Antoni, Nebreda, Angel R. · 2019 · Nature Communications
  29. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
    Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell, Adrian Erlebacher · 2019 · Journal of Clinical Investigation
  30. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS
    Min-Zu Wu, Wei‐Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O’Connor, Chia‐Lin Liu, Wen‐Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh‐Shiang Lin et al. · 2017 · Nature Cell Biology
  31. OXYGEN LIMITATION OF DIRECT TUMOR CELL KILL DURING PHOTODYNAMIC TREATMENT OF A MURINE TUMOR MODEL
    Barbara W. Henderson, Victor H. Fingar · 1989 · Photochemistry and Photobiology
  32. Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors
    Jang Hyun Park, Hyun-Jin Kim, Chae Won Kim, Hyeon Cheol Kim, Yujin Jung, Hyunsoo Lee, Yunah Lee, Young Seok Ju, Ji Eun Oh, Sung‐Hong Park et al. · 2021 · Nature Immunology
  33. Necrotic Cell Death in Response to Oxidant Stress Involves the Activation of the Apoptogenic Caspase-8/Bid Pathway
    Wang, Xue, Ryter, Stefan W., Dai, Chunsun, Tang, Zi-Lue, Watkins, Simon C., Yin, Xiao-Ming, Song, Ruiping, Choi, Augustine M.K. · 2003 · Journal of Biological Chemistry
  34. Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma
    Thomas B. Powles, Mark R. Lackner, Stéphane Marie. Oudard, Bernard J. Escudier, Christy Ralph, Janet Elizabeth Brown, Robert E. Hawkins, Daniel Castellano, Brian I. Rini, Michael D. Staehler et al. · 2016 · Journal of Clinical Oncology
  35. An ID2-dependent mechanism for VHL inactivation in cancer
    Sang Bae Lee, Veroniquè Frattini, Mukesh Bansal, Angelica M. Castano, Dan Sherman, Keino Hutchinson, Jeffrey N. Bruce, Andrea Califano, Guangchao Liu, Timothy J. Cardozo et al. · 2016 · Nature
  36. Hyperbaric Oxygen Therapy for Malignancy: A Review
    Jurstine Daruwalla, Christopher Christophi · 2006 · World Journal of Surgery
  37. K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
    Wu, Han-Tsang, Kuo, Yi-Chih, Hung, Jung-Jyh, Huang, Chi-Hung, Chen, Wei-Yi, Chou, Teh-Ying, Chen, Yeh, Chen, Yi-Ju, Chen, Yu-Ju, Cheng, Wei-Chung et al. · 2016 · Nature Communications
  38. Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶
    Chen, Qun, Huang, Zheng, Chen, Hua, Shapiro, Howard, Beckers, Jill, Hetzel, Fred W. · 2007 · Photochemistry and Photobiology
  39. Chemical modifiers of cancer treatment.
    C. Norman Coleman, Edward A. Bump, Robert A. Kramer · 1988 · Journal of Clinical Oncology
  40. Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells
    Sethumadhavan, Shalini, Silva, Murillo, Philbrook, Phaethon, Nguyen, Thao, Hatfield, Stephen M., Ohta, Akio, Sitkovsky, Michail V. · 2017 · PLOS ONE
  41. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2–3 trial
    Nicklas Oscarsson, Bernd Müller, Anders Rosén, Pär Lodding, Johan Mölne, Daniel Giglio, Karin M. Hjelle, Guro Vaagbø, Ole Hyldegaard, Michael Vangedal et al. · 2019 · The Lancet Oncology
  42. An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy
    Sidi Zhang, Zhenhua Li, Qingbing Wang, Qian Liu, Wei Yuan, Wei Feng, Fuyou Li · 2022 · Advanced Materials
  43. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia
    Yang Xu, Arindam Chaudhury, Ming Zhang, Barbara Savoldo, Leonid S. Metelitsa, John R. Rodgers, Jason Todd Yustein, Joel R. Neilson, Gianpietro Dotti · 2016 · Journal of Clinical Investigation
  44. O 2 Economizer for Inhibiting Cell Respiration To Combat the Hypoxia Obstacle in Tumor Treatments
    Wuyang Yu, Tao Liu, Mingkang Zhang, Zixu Wang, Jing‐Jie Ye, Chu‐Xin Li, Wenlong Liu, Runqing Li, Jun Xiang Feng, Xian‐Zheng Zhang · 2019 · ACS Nano
  45. Mouse Snail Is a Target Gene for HIF
    Luo, Daochun, Wang, Jinxia, Li, Jeff, Post, Martin · 2011 · Molecular Cancer Research
  46. Change of Oxygen Pressure in Glioblastoma Tissue Under Various Conditions
    Takaaki Beppu, K Kamada, Yuki Yoshida, Hiroshi Arai, Kuniaki Ogasawara, Akira Ogawa · 2002 · Journal of Neuro-Oncology
  47. Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia
    Niu, Yi, Lin, Ziyou, Wan, Arabella, Sun, Lei, Yan, Shijia, Liang, Heng, Zhan, Siyue, Chen, Dongshi, Bu, Xianzhang, Liu, Peiqing et al. · 2021 · Hepatology
  48. Bidirectional modulation of HIF-2 activity through chemical ligands
    Dalei Wu, Xiaoyu Su, Jing-Ping Lu, Sheng Li, Becky L. Hood, Stefan Vasile, Nalini Potluri, Xiaotong Diao, Youngchang Kim, Sepideh Khorasanizadeh et al. · 2019 · Nature Chemical Biology
  49. Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy
    Pengli Zheng, Miao Fan, Huifang Liu, Yinghua Zhang, Xinyue Dai, Hang Li, Xiaohan Zhou, Shiqi Hu, Xinjian Yang, Yi Jin et al. · 2020 · ACS Nano
  50. Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention
    Wei Jiang, Quan Li, Liang Xiao, Jiaxiang Dou, Yi Liu, Wenhao Yu, Yinchu Ma, Xiaoqiu Li, Ye‐Zi You, Zhuting Tong et al. · 2018 · ACS Nano
  51. Cross-talk between HIF and PD-1/PD-L1 pathways in carcinogenesis and therapy
    Shurin, Michael R., Umansky, Viktor · 2022 · Journal of Clinical Investigation
  52. Targeting Hypoxic Cells through the DNA Damage Response
    Monica M. Olcina, Philip S. Lecane, Ester M. Hammond · 2010 · Clinical Cancer Research
  53. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy
    Salman, Shaima, Meyers, David J., Wicks, Elizabeth E., Lee, Sophia N., Datan, Emmanuel, Thomas, Aline M., Anders, Nicole M., Hwang, Yousang, Lyu, Yajing, Yang, Yongkang et al. · 2022 · Journal of Clinical Investigation
  54. Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma
    Lifeng Li, Li Yang, Zhirui Fan, Wenhua Xue, Zhibo Shen, Yongliang Yuan, Xiangdong Sun, Dan Wang, Jingyao Lian, Liping Wang et al. · 2020 · Signal Transduction and Targeted Therapy
  55. Photochemotherapy in the Treatment of Cancer
    Lisa Dalla Via, Sebastiano Marciani Magno · 2001 · Current Medicinal Chemistry
  56. Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. I. Clinical and light microscopic studies.
    Kaplan Hp, Robinson Fr, Y Kapançi, E R Weibel · 1969 · PubMed
  57. High Intensity Focused Ultrasound-Responsive and Ultrastable Cerasomal Perfluorocarbon Nanodroplets for Alleviating Tumor Multidrug Resistance and Epithelial–Mesenchymal Transition
    Ma, Xiaotu, Yao, Meinan, Shi, Jiyun, Li, Xiaoda, Gao, Yu, Luo, Qi, Hou, Rui, Liang, Xiaolong, Wang, Fan · 2020 · ACS Nano
  58. Hyperbaric oxygenation for tumour sensitisation to radiotherapy
    Michael Bennett, John Feldmeier, Robert Smee, Christopher Milross · 2012 · Cochrane Database of Systematic Reviews
  59. Targeting hypoxic tumour cells to overcome metastasis
    Bennewith, Kevin L, Dedhar, Shoukat · 2011 · BMC Cancer
  60. Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer
    Misty Shuo Zhang, Jane Di Cui, Derek Lee, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi Ching Goh, Jacinth Wing‐Sum Cheu, Aki Pui‐Wah Tse, Macus Hao‐Ran Bao, Bowie Po‐Yee Wong et al. · 2022 · Nature Communications
  61. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor
    Qian Li, Dulei Li, Xian Zhang, Qingqing Wan, Wen Zhang, Mingke Zheng, Le Zou, Chris Elly, Jee H. Lee, Yun‐Cai Liu · 2018 · Immunity
  62. Current status of oxygen carriers (‘blood substitutes’): 2006
    Robert M. Winslow · 2006 · Vox Sanguinis
  63. Correlation of Magnetic Resonance and Oxygen Microelectrode Measurements of Carbogen-Induced Changes in Tumor Oxygenation
    Hania Al‐Hallaq, Jonathan N. River, Marta A. Zamora, Hirotaka Oikawa, Greg S. Karczmar · 1998 · International Journal of Radiation Oncology*Biology*Physics
  64. In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives
    Markus Rudin, Nicolau Beckmann, Róbert Pórszász, Torsten Reese, Damien Bochelen, André Sauter · 1999 · NMR in Biomedicine
  65. Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial
    Rui-Hua Xu, Yanqiao Zhang, Hongming Pan, Jifeng Feng, Tao Zhang, Tianshu Liu, Yanru Qin, Shukui Qin, Xianli Yin, Baorui Liu et al. · 2021 · The Lancet. Gastroenterology & hepatology
  66. Differential oxygen radical susceptibility of adriamycin-sensitive and -resistant MCF-7 human breast tumor cells.
    Edward G. Mimnaugh, Lata Dusre, John L. Atwell, Charles Edwin Myers · 1989 · PubMed
  67. E. coli Membrane Vesicles as a Catalase Carrier for Long-Term Tumor Hypoxia Relief to Enhance Radiotherapy
    Wenjing Zai, Lin Kang, Tiejun Dong, Haoran Wang, Lining Yin, Shaoju Gan, Wenjia Lai, Yibing Ding, Yiqiao Hu, Jinhui Wu · 2021 · ACS Nano
  68. Composition‐Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy
    Yue Hua, Jia‐Hong Huang, Zi‐Hui Shao, Xi‐Ming Luo, Zhao‐Yang Wang, Junqi Liu, Xueli Zhao, Xiaoyuan Shawn Chen, Shuang‐Quan Zang · 2022 · Advanced Materials
  69. Treatment of Cerebral Radionecrosis by Hyperbaric Oxygen Therapy
    Klaus A. Leber, Hans Georg Eder, H. Kovac, Udo Anegg, Gerhard Pendl · 1998 · Stereotactic and Functional Neurosurgery
  70. Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression
    Jun Yang, Oliver D. Staples, Luke W. Thomas, Thomas Briston, Mathew P. Robson, Evon Poon, Maria L. Simões, Ethaar El‐Emir, Francesca Meteora Buffa, Afshan Ahmed et al. · 2012 · Journal of Clinical Investigation
  71. Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins
    Budinger, G. R. Scott, Tso, May, McClintock, David S., Dean, David A., Sznajder, Jacob I., Chandel, Navdeep S. · 2002 · Journal of Biological Chemistry
  72. Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
    Kelie M. Reece, Emily D Richardson, Kristina M. Cook, Tessa J. Campbell, Stephen T. Pisle, Alesia J Holly, David J. Venzon, David J. Liewehr, Cindy H. Chau, Douglas K. Price et al. · 2014 · Molecular Cancer
  73. Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial
    Silvia Ulrich, Elisabeth Hasler, Stéphanie Saxer, Michaël Furian, Séverine Müller-Mottet, Stephan Keusch, Konrad Ernst Bloch · 2017 · European Heart Journal
  74. Metal peroxides for cancer treatment
    He, Jin, Fu, Lian-Hua, Qi, Chao, Lin, Jing, Huang, Peng · 2021 · Bioactive Materials
  75. The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
    Biao Ma, Hongcheng Cheng, Chenglong Mu, Guangfeng Geng, Tian Zhao, Qian Luo, Kaili Ma, Rui Chang, Qiangqiang Liu, Ruize Gao et al. · 2019 · Nature Communications
  76. Effects of Hyperthermia on Bladder Cancer
    R R Hall, R. O. K. Schade, John Swinney · 1974 · BMJ
  77. Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
    Yong Liang, Haidong Tang, Jingya Guo, Xiangyan Qiu, Zecheng Yang, Zhenhua Ren, Zhichen Sun, Yingjie Bian, Lily Xu, Hairong Xu et al. · 2018 · Nature Communications
  78. Relationship of hypoxia to metastatic ability in rodent tumours
    Katrien De Jaeger, M-C Kavanagh, Richard Peter Hill · 2001 · British Journal of Cancer
  79. A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models
    William G Kraybill, Thomas E. Olencki, Sharon S. Evans, Julie R. Ostberg, K. A. O'Leary, John F. Gibbs, Elizabeth A. Repasky · 2002 · International Journal of Hyperthermia
  80. An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
    Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen et al. · 2021 · Nature Communications
  81. Hyperbaric oxygen therapy for late radiation tissue injury
    Michael H Bennett, John Feldmeier, Neil B. Hampson, Robert Smee, Christopher Milross · 2012 · Cochrane Database of Systematic Reviews
  82. Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways
    Stella Sun, Derek Pok Him Lee, Amy Shuk-Wai Ho, Jenny Kan-Suen Pu, X.Q. Zhang, Nikki Pui Yue Lee, Philip J. Day, Wai‐Man Lui, C. F. Fung, Gkk Leung · 2013 · Neuro-Oncology
  83. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
    Jingwei Sim, Andrew S. Cowburn, Asís Palazón, Basetti Madhu, Petros A. Tyrakis, David Macías, David Bargiela, Sandra Pietsch, Michael Gralla, Colin E. Evans et al. · 2018 · Cell Metabolism
  84. Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells
    Xian Guo Wu, Yanhong Zhu, Wei Huang, Jingqiu Li, Bixiang Zhang, Zifu Li, Xiangliang Yang · 2018 · Advanced Science
  85. Platelet-Mimicking Biotaxis Targeting Vasculature-Disrupted Tumors for Cascade Amplification of Hypoxia-Sensitive Therapy
    Zhang, Mingkang, Ye, Jing-Jie, Xia, Yu, Wang, Zi-Yang, Li, Chu-Xin, Wang, Xiao-Shuang, Yu, Wuyang, Song, Wen, Feng, Jun, Zhang, Xian-Zheng · 2019 · ACS Nano
  86. Ramucirumab as Second-Line Treatment in Patients With Advanced Hepatocellular Carcinoma
    Andrew Xiuxuan Zhu, Ari David Baron, Peter Malfertheiner, Masatoshi Kudo, Seiji Kawazoe, Denis Pezet, Florian Weißinger, Giovanni Brandi, Carlo Antonio Barone, Takuji Okusaka et al. · 2016 · JAMA Oncology
  87. ZIF‐Based Nanoparticles Combine X‐Ray‐Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy
    Yanli Li, Teng Gong, Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng et al. · 2021 · Angewandte Chemie International Edition
  88. Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
    Lin, Ching-Wen, Wang, Lu-Kai, Wang, Shu-Ping, Chang, Yih-Leong, Wu, Yi-Ying, Chen, Hsuan-Yu, Hsiao, Tzu-Hung, Lai, Wei-Yun, Lu, Hsuan-Hsuan, Chang, Ya-Hsuan et al. · 2016 · Nature Communications
  89. Oxygen Toxicity in Critically Ill Adults
    Chad H. Hochberg, Matthew W. Semler, Roy G. Brower · 2021 · American Journal of Respiratory and Critical Care Medicine
  90. Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas
    Kiyotaka Kohshi, Yoshimasa Kinoshita, H. Imada, Naoki Kunugita, Haruhiko Abe, Hiromi Terashima, Naokimi Tokui, S Uemura · 1999 · British Journal of Cancer
  91. Biomimetic Nanocarriers Guide Extracellular ATP Homeostasis to Remodel Energy Metabolism for Activating Innate and Adaptive Immunity System
    Long Wu, Wei Xie, Yang Li, Qiankun Ni, Peter S. Timashev, Meng Lyu, Ligang Xia, Yuan Zhang, Lingrong Liu, Yufeng Yuan et al. · 2022 · Advanced Science
  92. Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
    Liu, Xin, Ye, Ningbing, Liu, Sha, Guan, Jiankun, Deng, Qingyuan, Zhang, Zhijie, Xiao, Chen, Ding, Ze‐yang, Zhang, Bi‐xiang, Chen, Xiao‐ping et al. · 2021 · Advanced Science
  93. Functional Immune Cell‐Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization
    Ma, Xiaotu, Yao, Meinan, Gao, Yu, Yue, Yale, Li, Yao, Zhang, Tianjiao, Nie, Guangjun, Zhao, Xiao, Liang, Xiaolong · 2022 · Advanced Science
  94. Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1
    Shan Xing, Zhi Tian, Wenying Zheng, Wenjuan Yang, Nan Du, Yixue Gu, Jiang Yin, Hao Liu, Xiaoting Jia, Donglan Huang et al. · 2021 · Molecular Cancer
  95. Effect of Apatinib Plus Pegylated Liposomal Doxorubicin vs Pegylated Liposomal Doxorubicin Alone on Platinum-Resistant Recurrent Ovarian Cancer
    Tiantian Wang, Jie Tang, Hongying Yang, Rutie Yin, Jingru Zhang, Qi Zhou, Ziling Liu, Lanqin Cao, Li Li, Yi Huang et al. · 2022 · JAMA Oncology
  96. Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance
    Kazuhiro Ikeda, Kuniko Horie‐Inoue, Takashi Suzuki, Rutsuko Hobo, Norie Nakasato, Satoru Takeda, Satoshi Inoue · 2019 · Nature Communications
  97. Induction of Spermidine/Spermine N1-Acetyltransferase in Human Cancer Cells in Response to Increased Production of Reactive Oxygen Species
    Shalu Chopra, Heather M. WALLACE · 1998 · Biochemical Pharmacology
  98. p53-Dependent Induction of p21Cip1/WAF1/Sdi1 Protects against Oxygen-Induced Toxicity
    Christopher E. Helt · 2001 · Toxicological Sciences
  99. Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial
    Glover, Mark, Smerdon, Gary R, Andreyev, H Jervoise, Benton, Barbara E, Bothma, Pieter, Firth, Oliver, Gothard, Lone, Harrison, John, Ignatescu, Mihaela, Laden, Gerard et al. · 2016 · The Lancet Oncology
  100. Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors
    Anette Raa, C. T. Stansberg, Vidar Martin Steen, Rolf Bjerkvig, Rolf Kåre Reed, Linda E. B. Stuhr · 2007 · BMC Cancer
  101. Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus
    Alfred Maier, Udo Anegg, Birgit Fell, Peter Rehak, Beatrix Ratzenhofer, Florian Tomaselli, Oliver Sankin, Hans Pinter, Freyja M. Smolle-J�ttner, Gerhard B. Friehs · 2000 · Lasers in Surgery and Medicine
  102. Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-β and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation
    Gordana Vlahovic, Zahid N. Rabbani, James E. Herndon, Mark W. Dewhirst, Z. Vujaskovic · 2006 · British Journal of Cancer
  103. Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
    Hao Geng, Changhui Xue, Janet Mendonca, Xiao‐Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian J. Hua, Alice P. Chen et al. · 2018 · Nature Communications
  104. Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
    Ingrid Nyhus Moen, Anne Margrete Oyan, Karl-Henning Kalland, Karl Johan Tronstad, Lars A. Akslen, Martha Chekenya, Per Øystein Sakariassen, Rolf Kåre Reed, Linda E. B. Stuhr · 2009 · PLoS ONE
  105. Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats
    Stuhr, Linda Elin Birkhaug, Raa, A., Øyan, A. M., Kalland, K. H., Sakariassen, P. O., Petersen, K., Bjerkvig, R., Reed, R. K. · 2007 · Journal of Neuro-Oncology
  106. Intrinsic Genomic Differences Between African American and White Patients With Clear Cell Renal Cell Carcinoma
    Krishnan, Bhavani, Rose, Tracy L., Kardos, Jordan, Milowsky, Matthew I., Kim, William Y. · 2016 · JAMA Oncology
  107. Synergizing Upconversion Nanophotosensitizers with Hyperbaric Oxygen to Remodel the Extracellular Matrix for Enhanced Photodynamic Cancer Therapy
    Jingqiu Li, Jinzhao Huang, Yanxiao Ao, Shiyu Li, Miao Yu, Zhongzheng Yu, Lingtao Zhu, Xiaoli Lan, Yanhong Zhu, Yan Zhang et al. · 2018 · ACS Applied Materials & Interfaces
  108. Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia
    Hildegard M. Schuller · 1990 · Lung Cancer
  109. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis
    Hui‐Huang Lai, Jie‐Ning Li, Ming-Yang Wang, Hsin‐Yi Huang, Carlo Maria Croce, Hui‐Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching‐Feng Chiu, Mien‐Chie Hung et al. · 2017 · Journal of Clinical Investigation
  110. Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia
    Chudal, Lalit, Pandey, Nil Kanatha, Phan, Jonathan, Johnson, Omar, Li, Xiuying, Chen, Wei · 2019 · Materials Science and Engineering: C
  111. Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy
    Hatfield, Stephen M., Sitkovsky, Michail V. · 2020 · Journal of Clinical Investigation
  112. CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells
    Songwen Ju, Feng Wang, Yirong Wang, Songguang Ju · 2020 · Molecular Cancer
  113. Ultrafast Tracking of Oxygen Dynamics During Proton FLASH
    Mirna El Khatib, Alexander L. Van Slyke, Anastasia P. Velalopoulou, Michele M. Kim, Khayrullo Shoniyozov, Srinivasarao Allu, Eric S. Diffenderfer, Theresa M. Busch, Rodney D. Wiersma, Cameron J. Koch et al. · 2022 · International Journal of Radiation Oncology*Biology*Physics
  114. HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes
    Erwin Ilegems, Galyna Bryzgalova, Jorge C. Correia, Burçak Yesildag, Edurne Berra, Jorge Lira Ruas, Teresa Pereira, Per‐Olof Berggren · 2022 · Science Translational Medicine
  115. Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy
    Youfang Lai, Xun Jia, Yujie Chi · 2020 · Physics in Medicine and Biology
  116. Microparticle, nanoparticle, and stem cell-based oxygen carriers as advanced blood substitutes
    Zhimin Tao, Paiman Peter Ghoroghchian · 2014 · Trends in biotechnology
  117. Enhancement of radiation response with bevacizumab
    Tien Ngoc HOANG, Shyhmin Huang, Eric A. Armstrong, Jens C. Eickhoff, Paul M. Harari · 2012 · Journal of Experimental & Clinical Cancer Research
  118. Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy
    Meng, Lingtong, Cheng, Yali, Gan, Shaoju, Zhang, Zhicheng, Tong, Xiaoning, Xu, Lei, Jiang, Xing, Zhu, Yishen, Wu, Jinhui, Yuan, Ahu et al. · 2018 · Molecular Pharmaceutics
  119. Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistry
    Xiaorong Sun, Xiao-Feng Li, James Russell, Ligang Xing, Muneyasu Urano, Gloria C. Li, John Laurence Humm, C. Clifton Ling · 2008 · Radiotherapy and Oncology
  120. A “Valve‐Closing” Starvation Strategy for Amplification of Tumor‐Specific Chemotherapy
    Xianglong Li, Cong Jiang, Qinghua Wang, Shaobo Yang, Yuanyuan Cao, Ji‐Na Hao, Dechao Niu, Yan Chen, Bo Han, Xin Jia et al. · 2022 · Advanced Science
  121. Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
    Jingyi Li, Tao Zhang, Tao Ren, Xiaoyu Liao, Yilong Hao, Je Sun Lim, Jong-Ho Lee, Mi Li, Jichun Shao, Rui R Liu · 2022 · Nature Communications
  122. Smart Tumor‐Cell‐Derived Microparticles Provide On‐Demand Photosensitizer Synthesis and Hypoxia Relief for Photodynamic Therapy
    Liping Zuo, Weidong Nie, Songmao Yu, Wan‐Ru Zhuang, Guanghao Wu, Houli Liu, Lili Huang, Danshu Shi, Xin Yuan Sui, Yongheng Li et al. · 2021 · Angewandte Chemie International Edition
  123. The Effect of Oxygen on the Response of Spontaneous Tumours in Mice to Radiotherapy
    Du Sault, Lucille A. · 1963 · The British Journal of Radiology
  124. Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
    Andrysik, Zdenek, Bender, Heather, Galbraith, Matthew D., Espinosa, Joaquin M. · 2021 · Nature Communications
  125. Mitochondrial Damage Response and Fate of Normal Cells Exposed to FLASH Irradiation with Protons
    Ziyang Guo, Manuela Buonanno, Andrew Harken, Guangming Zhou, Tom K. Hei · 2022 · Radiation Research
  126. Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging
    Yoshimasa Kinoshita, Kiyotaka Kohshi, Naoki Kunugita, Takeshi Tosaki, Akira Yokota · 2000 · British Journal of Cancer
  127. Recent Advances in Self-Exciting Photodynamic Therapy
    Nicholas Thomas Blum, Yifan Zhang, Junle Qu, Jing Lin, Peng Huang · 2020 · Frontiers in Bioengineering and Biotechnology
  128. Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC
    Li, Kun, Gong, Yihang, Qiu, Dongbo, Tang, Hui, Zhang, Jian, Yuan, Zenan, Huang, Yingqi, Qin, Yunfei, Ye, Linsen, Yang, Yang · 2022 · Journal for ImmunoTherapy of Cancer
  129. Hyperbaric oxygenation for tumour sensitisation to radiotherapy
    Michael Bennett, John Feldmeier, Robert Smee, Christopher Milross · 2018 · Cochrane Database of Systematic Reviews
  130. ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance
    Meilin Wang, Lei Guo, Qingang Wu, Taoling Zeng, Qi Lin, Yikai Qiao, Qun Wang, Mingdong Liu, Xin Zhang, Lan Ren et al. · 2014 · Nature Communications
  131. Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation.
    Eric V. Granowitz, Noriko Tonomura, Rita M. Benson, D. Katz, Vimla Band, Grace Makari‐Judson, Barbara A. Osborne · 2005 · PubMed
  132. Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters.
    Hildegard M. Schuller, M D McGavin, Michael Orloff, A. Riechert, B Porter · 1995 · PubMed
  133. The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy
    Nicholas W. Colangelo, Edouard I. Azzam · 2019 · Radiation Research
  134. Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction✩
    Maier, A., Tomaselli, F., Anegg, U., Rehak, P., Fell, B., Luznik, S., Pinter, H., Smolle-Jüttner, F.M. · 2000 · European Journal of Cardio-Thoracic Surgery
  135. Ultra-High Dose-Rate, Pulsed (FLASH) Radiotherapy with Carbon Ions: Generation of Early, Transient, Highly Oxygenated Conditions in the Tumor Environment
    Abdullah Muhammad Zakaria, Nicholas W. Colangelo, Jintana Meesungnoen, Edouard I. Azzam, M.-É. Plourde, Jean‐Paul Jay‐Gerin · 2020 · Radiation Research
  136. Oxygen Tension Measurements of Head and Neck Cancers
    Terris, D. J., Dunphy, E. P. · 1994 · Archives of Otolaryngology - Head and Neck Surgery
  137. IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion
    Chen, Xing, Zhao, Junjie, Herjan, Tomasz, Hong, Lingzi, Liao, Yun, Liu, Caini, Vasu, Kommireddy, Wang, Han, Thompson, Austin, Fox, Paul L. et al. · 2022 · Journal of Experimental Medicine
  138. Cell Type–Specific, Topoisomerase II–Dependent Inhibition of Hypoxia-Inducible Factor-1α Protein Accumulation by NSC 644221
    Mark Creighton-Gutteridge, John H. Cardellina, Andrew G. Stephen, Annamaria Rapisarda, Badarch Uranchimeg, Karen M. Hite, William Alexander Denny, Robert H. Shoemaker, Giovanni Melillo · 2007 · Clinical Cancer Research
  139. Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI
    Jingwen Yao, Ararat Chakhoyan, David A. Nathanson, William H. Yong, Noriko Salamon, Catalina Raymond, Sergey Mareninov, Albert Lai, Phioanh Leia Nghiemphu, Robert Michael Prins et al. · 2019 · Neuro-Oncology
  140. Blood Substitutes
    Andre Francis Palmer, Marcos Intaglietta · 2014 · Annual Review of Biomedical Engineering
  141. From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma
    Syed A. Hussain, Alison Jane Birtle, Simon J. Crabb, Robert Anthony Huddart, Diane Small, Maxwell Summerhayes, Robert J. Jones, Andrew S. Protheroe · 2018 · European Urology Oncology
  142. Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma
    Moen, Ingrid, Tronstad, Karl J, Kolmannskog, Odd, Salvesen, Gerd S, Reed, Rolf K, Stuhr, Linda EB · 2009 · BMC Cancer
  143. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines
    Chiarotto, J A, Hill, R P · 1999 · British Journal of Cancer
  144. Oxygenation inhibits ovarian tumor growth by down-regulating STAT3 and cyclin-D1 expressions
    Karuppaiyah Selvendiran, M. Lakshmi Kuppusamy, Shabnam Ahmed, Anna Bratasz, Guruguhan Meenakshisundaram, Brian K. Rivera, Mahmood Khan, Periannan Kuppusamy · 2010 · Cancer Biology & Therapy
  145. A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy
    Huang, Xiaoyu, Zhang, Wei, Peng, Yaowei, Gao, Lu, Wang, Fu, Wang, Lan, Wei, Xunbin · 2022 · ACS Nano
  146. Successful chemotherapy of experimental neuroendocrine lung tumors in hamsters with an antagonist of Ca2+/calmodulin.
    Hildegard M. Schuller, E Correa, Michael Orloff, G Reznik · 1990 · PubMed
  147. Hybrid Protein Nano‐Reactors Enable Simultaneous Increments of Tumor Oxygenation and Iodine‐131 Delivery for Enhanced Radionuclide Therapy
    Chen, Jiawen, Liang, Chao, Song, Xuejiao, Yi, Xuan, Yang, Kai, Feng, Liangzhu, Liu, Zhuang · 2019 · Small
  148. Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term Results
    Kazuhiko Ogawa, Shogo Ishiuchi, Osamu Inoue, Yoshihiko Yoshii, Atsushi Saitô, Takashi Watanabe, Shiro Iraha, Takafumi Toita, Yasumasa Kakinohana, Takuro Ariga et al. · 2011 · International Journal of Radiation Oncology*Biology*Physics
  149. Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide
    Stella Sun, Derek Lee, Nikki Pui Yue Lee, Jenny Kan-Suen Pu, Thian‐Sze Wong, Wai‐Man Lui, C. F. Fung, Gkk Leung · 2012 · Journal of Neuro-Oncology
  150. Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia
    Hiroshi Oikawa, Hania Al‐Hallaq, Marta Z. Lewis, Jonathan N. River, David A. Kovar, Gregory S. Karczmar · 1997 · Magnetic Resonance in Medicine
  151. Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer
    Qing Xiao Zhou, Samantha O. Perakis, Peter Ulz, Sumitra Mohan, Jakob Michael Riedl, Emina Talakić, Sigurd Lax, Martin Tötsch, Gerald Höefler, Thomas Bauernhofer et al. · 2020 · Genome Medicine
  152. Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy
    Leone, Robert D., Horton, Maureen R., Powell, Jonathan D. · 2015 · Cancer Cell
  153. Proteomic analysis of hyperoxia‐induced responses in the human choriocarcinoma cell line JEG‐3
    Henrik Vorum, Morten Østergaard, Philip Hensechke, Jan J. Enghild, Mahtab Riazati, Gregory Edward Rice · 2004 · PROTEOMICS
  154. Enhanced erythropoietin secretion in hepatoblastoma cells in response to hypoxia
    Minami Kikuchi Ueno, Ilona Seferyńska, Barbara S. Beckman, Jesse W. Brookins, Jun Nakashima, James W. Fisher · 1989 · American Journal of Physiology-Cell Physiology
  155. Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice
    Lu, Zhaohui, Ma, Jiawei, Liu, Bing, Dai, Chungang, Xie, Tao, Ma, Xiaoyu, Li, Ming, Dong, Jun, Lan, Qing, Huang, Qiang · 2016 · Cancer Medicine
  156. Clinical perspectives for the use of new hypoxic cell sensitizers
    J. Martin Brown · 1982 · International Journal of Radiation Oncology*Biology*Physics
  157. A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: A RTOG randomized study (#79-04)
    Lee, Ding-Jen, Pajak, Thomas F., Stetz, Joanne, Order, Stanley E., Weissberg, Joseph B., Fischer, James J. · 1989 · International Journal of Radiation Oncology*Biology*Physics
  158. Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia
    Sean C. Gehen, Peter F. Vitiello, Robert A. Bambara, Peter C. Keng, Michael A. O’Reilly · 2006 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  159. Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer—A clinical pilot study
    Florian Tomaselli, Alfred Maier, Oliver Sankin, Udo Anegg, Ulrike Stranzl, Hans Pinter, Karin Sigrid Kapp, Freyja Maria Smolle‐Jüttner · 2001 · Lasers in Surgery and Medicine
  160. Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo
    Wonwoo Kim, Mi‐Sook Kim, Hee-Jong Kim, Eun-Jin Lee, Jae‐Hoon Jeong, In Hwan Park, Youn Kyoung Jeong, Won Il Jang · 2017 · International Journal of Hyperthermia
  161. HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
    Pan Wang, Wenwu Wan, Shuanglong Xiong, Junwei Wang, Dewei Zou, Chuan Lan, Shuangjiang Yu, Bin Liao, Hua Feng, Nan Wu · 2017 · Scientific Reports
  162. Hemoglobin‐based oxygen carrier enhanced tumor oxygenation: A novel strategy for cancer therapy
    Sharon Irene Gundersen, Andre Francis Palmer · 2008 · Biotechnology Progress
  163. Photodynamic therapy enhanced by hyperbaric oxygen in acute endoluminal palliation of malignant bronchial stenosis (Clinical pilot study in 40 patients)
    Florian Tomaselli · 2001 · European Journal of Cardio-Thoracic Surgery
  164. Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts
    Kristine Yttersian Sletta, Maria K. Tveitarås, Ning Lü, Agnete S. T. Engelsen, Rolf Kåre Reed, Annette Garmann-Johnsen, Linda E. B. Stuhr · 2017 · PLoS ONE
  165. Does Hyperbaric Oxygen Enhance the Effect of Photodynamic Therapy in Patients with Advanced Esophageal Carcinoma? A Clinical Pilot Study
    A. Maier, Udo Anegg, Florian Tomaselli, Peter Rehak, Oliver Sankin, Birgit Fell, Heiko Renner, Hans Pinter, F.-M. Smolle-Jüttner, Gerhard B. Friehs · 2002 · Endoscopy
  166. Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumors
    Schüller, Hildegard M., Nylen, Eric, Park, Paul, Becker, Kenneth L. · 1990 · Life Sciences
  167. Inhibition of mouse lung tumor development by hyperoxia.
    Robert C. Lindenschmidt, A. Frandne Tryka, H.P. Witschi · 1986 · PubMed
  168. Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA
    Itaru Kato, Yoko Nishinaka, Masahiro Nakamura, Ayse U. Akarca, Akira Niwa, Hiroki Ozawa, Kenichi Yoshida, Makiko Mori, Dapeng Wang, Makiko Morita et al. · 2017 · Blood
  169. Respiratory hyperoxia reverses immunosuppression by regulating myeloid-derived suppressor cells and PD-L1 expression in a triple-negative breast cancer mouse model.
    Xueke Qian, Qi Zhang, Nan Shao, Zhen Shan, Tuck−Yun Cheang, Zhanqiang Zhang, Qiao Su, Shenming Wang, Ying Lin · 2019 · Europe PMC (PubMed Central)
  170. Biodegradable copper–metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H 2 O 2 accumulation
    Xiangyu Meng, Xuezhong Zhang, Yunfeng Lei, Dongwei Cao, Zhifei Wang · 2021 · Journal of Materials Chemistry B
  171. Exposure to hyperbaric oxygen induces cell cycle perturbation in prostate cancer cells
    John Kalns, Edward H. Piepmeier · 1999 · In Vitro Cellular & Developmental Biology - Animal
  172. Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia
    Oliver Thews, Debra K. Kelleher, Peter W. Vaupel · 2002 · Radiotherapy and Oncology
  173. Prognostic factors for tumour response and skin damage to combined radiotherapy and hyperthermia in superficial recurrent breast carcinomas
    C.-E. Lindholm, Elisabeth Kjellén, Per Gunnar Nilsson, Lars Weber, S. Hill · 1995 · International Journal of Hyperthermia
  174. Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway
    Xiucheng Liu, Hao Qin, Zheng Li, Yin Lv, Shoujie Feng, Wei Zhuang, Xiaoyu Quan, Chen Guo, Chang Chen, Hao Zhang · 2022 · European Respiratory Journal
  175. Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: A multisite EPR oximetry with implantable resonators
    Huagang G. Hou, Ruhong Dong, Hongbin Li, Benjamin B. Williams, Jean P. Lariviere, S. K. Hekmatyar, Risto A. Kauppinen, Nadeem Israr Khan, Harold M. Swartz · 2011 · Journal of Magnetic Resonance
  176. Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats.
    Yuri Sakaguchi, M Makino, T Kaneko, L. Clifton Stephens, Frederick R. Strebel, L Danhauser, G. N. Jenkins, J. M. C. Bull · 1994 · PubMed
  177. Muscle Oxygen Supply and Use in Type 1 Diabetes, From Ambient Air to the Mitochondrial Respiratory Chain: Is There a Limiting Step?
    Elsa Heyman, Frédéric Daussin, Valérie Wieczorek, Robert J. Caiazzo, Régis Matran, Phanélie M. Berthon, Julien Aucouturier, Serge Berthoin, Aurélien Descatoire, Erwan Leclair et al. · 2019 · Diabetes Care
  178. Hyperoxia-Induced DNA Damage Causes Decreased DNA Methylation in Human Lung Epithelial-Like A549 Cells
    Mihalis I. Panayiotidis, Raymond C. Rancourt, Corrie B. Allen, Suzette R. Riddle, Barbara K. Schneider, Shama Ahmad, Carl W. White · 2004 · Antioxidants and Redox Signaling
  179. Effects of oxygen on the antioxidant responses of normal and transformed cells
    Robert G. Allen, Arthur K. Balin · 2003 · Experimental Cell Research
  180. Treatment options for malignant gliomas, emphasizing towards new molecularly targeted therapies
    Andreas A. Argyriou, Anna G. Antonacopoulou, Gregoris Iconomou, Haralabos P. Kalofonos · 2008 · Critical Reviews in Oncology/Hematology
  181. Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia
    Thews, Oliver, Vaupel, Peter · 2015 · Strahlentherapie und Onkologie
  182. Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
    Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Haifeng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa et al. · 2022 · Nature Communications
  183. PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia
    Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian Heinrich Heidel, Tina M. Schnoeder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph Alexander Schmid, Johanna Baumgartner et al. · 2020 · Nature Cell Biology
  184. Hyperoxia Induces S-Phase Cell-Cycle Arrest and p21Cip1/Waf1-Independent Cdk2 Inhibition in Human Carcinoma T47D-H3 Cells
    Jean‐François Bilodeau, Robert L. Faure, Bruno Piedbœuf, Marc-Édouard Mirault · 2000 · Experimental Cell Research
  185. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer
    Shiro Koizume, Shin Ito, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Mitsuko Furuya, Roppei Yamada, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano, Yohei Miyagi · 2015 · Molecular Cancer
  186. Radiotherapy in combination with vascular-targeted therapies
    Ciric, Eva, Sersa, Gregor · 2010 · Radiology and Oncology
  187. Hypoxia is a key regulator in liver cancer progression
    Lichun Ma, Amanda J. Craig, Sophia Heinrich · 2021 · Journal of Hepatology
  188. A clinically acceptable strategy for sensitizing anti-PD-1 treatment by hypoxia relief
    Jiang, Mengshi, Qin, Bing, Luo, Lihua, Li, Xiang, Shi, Yingying, Zhang, Junlei, Luo, Zhenyu, Zhu, Chunqi, Guan, Guannan, Du, Yongzhong et al. · 2021 · Journal of Controlled Release
  189. ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer
    Keulers, Tom G., Koch, Alexander, van Gisbergen, Marike W., Barbeau, Lydie M.O., Zonneveld, Marijke I., de Jong, Monique C., Savelkouls, Kim G.M., Wanders, Roel G., Bussink, Johan, Melotte, Veerle et al. · 2022 · Autophagy
  190. Evaluation of hyperbaric oxygen as a chemosensitizer in the treatment of epithelial ovarian cancer in xenografts in mice
    Turgut Alagoz, Richard E. Buller, Barrie Anderson, Kristina L. Terrell, Robert C. Squatrito, Theodore H. Niemann, David J. Tatman, PETER J. R. JEBSON · 1995 · Cancer
  191. Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils
    Sandra Völs, Ronit Vogt Sionov, Zvi Granot · 2017 · Current Pharmaceutical Design
  192. Endobronchial Ultrasound Doppler Image Features Correlate with mRNA Expression of hif1-α and vegf-c in Patients with Non–Small-Cell Lung Cancer
    Takahiro Nakajima, Takashi Anayama, Terumoto Koike, Masato Shingyoji, Lianne Castle, Hideki Kimura, Ichiro Yoshino, Kazuhiro Yasufuku · 2012 · Journal of Thoracic Oncology
  193. Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial)
    Meritxell Arenas, Manuel Algara, Gabriel de Febrer, Carmen Rubio, X. Sanz, M.Á. De la Casa, Carlos Vasco, Judith Marín‐Corral, Pedro Fernandez-Letón, Judit Villar-García et al. · 2021 · Strahlentherapie und Onkologie
  194. Experimental study on cytotoxic effects of hyperbaric oxygen and photodynamic therapy on mouse transplanted tumor.
    Dong Gc, Hu Sx, Zhao Gy, S Z Gao, Wu Lr · 1987 · PubMed
  195. Radiotherapy after hyperbaric oxygenation improves radioresponse in experimental tumor models
    Naoki Kunugita, Kiyotaka Kohshi, Yoshimasa Kinoshita, Takahiko Katoh, Haruhiko Abe, Takeshi Tosaki, Toshihiro Kawamoto, Toshiyuki Norimura · 2001 · Cancer Letters
  196. Effects of hyperbaric oxygen and normobaric carbogen on the radiation response of the rat rhabdomyosarcoma R1H 1 1This work was partially financed by the German Cancer Aid and the Fonds Ophthalmopathy, AMC Amsterdam, The Netherlands.
    Karl Axel Hartmann, A. J. van der Kleij, Ulrich Martin Carl, Maarten C.C.M. Hulshof, Reinhart Willers, Peter Sminia · 2001 · International Journal of Radiation Oncology*Biology*Physics
  197. Thermal dose fractionation affects tumour physiological response
    Donald Ε. Thrall, Paolo F. Maccarini, Paul R. Stauffer, James R. MacFall, Marlene Hauck, Stacey A. Snyder, Beth C. Case, Keith E. Linder, Lan Lan, Linda Mackie McCall et al. · 2012 · International Journal of Hyperthermia
  198. Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis
    Kim, Sei Won, Kim, In Kyoung, Ha, Jick Hwan, Yeo, Chang Dong, Kang, Hyeon Hui, Kim, Jin Woo, Lee, Sang Haak · 2018 · Experimental Biology and Medicine
  199. O2/3 exposure inhibits cell progression affecting cyclin B1/cdk1 activity in SK‐N‐SH while induces apoptosis in SK‐N‐DZ neuroblastoma cells
    Annapaola Cannizzaro, Cecilia Verga Falzacappa, M. Martinelli, Silvia Misiti, E Brunetti, Barbara Bucci · 2007 · Journal of Cellular Physiology
  200. Hypoxia-activated prodrug: an appealing preclinical concept yet lost in clinical translation
    Lars Hartwin Lindner · 2017 · The Lancet Oncology