The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
The dynamic roles of TGF‐β in cancer
Abstract
The transforming growth factor‐β (TGF‐β) signalling pathway plays a critical and dual role in the progression of human cancer. During the early phase of tumour progression, TGF‐β acts as a tumour suppressor, exemplified by deletions or mutations in the core components of the TGF‐β signalling pathway. On the contrary, TGF‐β also promotes processes that support tumour progression such as tumour cell invasion, dissemination, and immune evasion. Consequently, the functional outcome of the TGF‐β response is strongly context‐dependent including cell, tissue, and cancer type. In this review, we describe the molecular signalling pathways employed by TGF‐β in cancer and how these, when perturbed, may lead to the development of cancer. Concomitantly with our increased appreciation of the molecular mechanisms that govern TGF‐β signalling, the potential to therapeutically target specific oncogenic sub‐arms of the TGF‐β pathway increases. Indeed, clinical trials with systemic TGF‐β signalling inhibitors for treatment of cancer patients have been initiated. However, considering the important role of TGF‐β in cardiovascular and many other tissues, careful screening of patients is warranted to minimize unwanted on‐target side effects. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,672
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,857
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,373
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C.-H., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,696
Self-citationGenes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Metastasis: from dissemination to organ-specific colonization
Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2622 · Cited by 2,649
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Kakonen, S. M., Cordón-Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,597
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,270
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Molecular requirements for epithelial–mesenchymal transition during tumor progression
Huber, M. A., Kraut, N., & Beug, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.001 · Cited by 1,821
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.-E., Heldin, C.-H., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,809
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,634
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1208 · Cited by 1,604
Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355
Molecular Definition of Breast Tumor Heterogeneity
Shipitsin, M., Campbell, L. L., Argani, P., Weremowicz, S., Bloushtain-Qimron, N., Yao, J., Nikolskaya, T., Serebryiskaya, T., Beroukhim, R., Hu, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.013 · Cited by 1,353
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,334
Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation
Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H., & Wrana, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00134-9 · Cited by 1,205
TGFβ signalling: a complex web in cancer progression
Ikushima, H., & Miyazono, K. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2853 · Cited by 1,173
Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
Ling, N., Ying, S.-Y., Ueno, N., Shimasaki, S., Esch, F., Hotta, M., & Guillemin, R. (1986) · Nature · doi:10.1038/321779a0 · Cited by 1,081
Kaartinen, V., Voncken, J. W., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,031
Smad6 inhibits signalling by the TGF-β superfamily
Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J.-I., Kawabata, M., & Miyazono, K. (1997) · Nature · doi:10.1038/39355 · Cited by 1,029
Transcriptional Activators of TGF-β Responses: Smads
Derynck, R., Zhang, Y., & Feng, X.-H. (1998) · Cell · doi:10.1016/s0092-8674(00)81696-7 · Cited by 1,029
Seoane, J., Le, H.-V., Shen, L., Anderson, S. A., & Massagué, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00298-3 · Cited by 1,028
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
Yang, L., Pang, Y., & Moses, H. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.002 · Cited by 1,023
Bhowmick, N. A., Ghiassi, M., Bakin, A., Aakre, M., Lundquist, C. A., Engel, M. E., Arteaga, C. L., & Moses, H. L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,004
Yin, J. J., Selander, K., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., Massagué, J., Mundy, G. R., & Guise, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3523 · Cited by 986
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
Tsukazaki, T., Chiang, T. A., Davison, A. F., Attisano, L., & Wrana, J. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81701-8 · Cited by 968
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
Padua, D., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 952
Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y., & Wang, X. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5545 · Cited by 950
Ghiringhelli, F., Ménard, C., Terme, M., Flament, C., Taieb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B., Vivier, E., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 949
The polarization of immune cells in the tumour environment by TGFβ
Flavell, R. A., Sanjabi, S., Wrzesinski, S. H., & Licona-Limón, P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2808 · Cited by 940
Miettinen, P. J., Ebner, R., Lopez, A. R., & Derynck, R. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.6.2021 · Cited by 937
Transforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908
Betaglycan presents ligand to the TGFβ signaling receptor
López-Casillas, F., Wrana, J. L., & Massagué, J. (1993) · Cell · doi:10.1016/0092-8674(93)90368-z · Cited by 901
Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity
Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H.-R., Zhang, Y., & Wrana, J. L. (2005) · Science · doi:10.1126/science.1105718 · Cited by 881
Guise, T. A., Yin, J. J., Taylor, S. D., Kumagai, Y., Dallas, M., Boyce, B. F., Yoneda, T., & Mundy, G. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118947 · Cited by 851
Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., Imamura, T., & Miyazono, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100008200 · Cited by 844
Moustakas, A., & Heldin, C. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00550.x · Cited by 804
Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine · doi:10.1038/nm1001-1118 · Cited by 770
The two faces of transforming growth factor β in carcinogenesis
Roberts, A. B., & Wakefield, L. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633291100 · Cited by 747
Parsons, R. E., Myeroff, L. L., Liu, B., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1995) · PubMed · Cited by 738
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Shim, J.-H., Xiao, C., Paschal, A. E., Bailey, S. T., Rao, P., Hayden, M. S., Lee, K.-Y., Bussey, C., Steckel, M., Tanaka, N., et al. (2005) · Genes & Development · doi:10.1101/gad.1360605 · Cited by 738
Castriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Bottino, C., Moretta, L., & Moretta, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730640100 · Cited by 726
Crystal Structure of a Smad MH1 Domain Bound to DNA
Shi, Y., Wang, Y.-F., Jayaraman, L., Yang, H., Massagué, J., & Pavletich, N. P. (1998) · Cell · doi:10.1016/s0092-8674(00)81600-1 · Cited by 725
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
Hata, A., Lagna, G., Massagué, J., & Hemmati-Brivanlou, A. (1998) · Genes & Development · doi:10.1101/gad.12.2.186 · Cited by 725
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
Cheifetz, S., Weatherbee, J. A., Tsang, M. L.-S., Anderson, J. K., Mole, J. E., Lucas, R., & Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90192-9 · Cited by 706
Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling
Goumans, M.-J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., & ten Dijke, P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00386-1 · Cited by 689
Self-citationSeoane, J., Le, H.-V., & Massagué, J. (2002) · Nature · doi:10.1038/nature01119 · Cited by 684
Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674
DPC4 gene in various tumor types.
Schutte, M. E. M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., et al. (1996) · PubMed · Cited by 672
Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition
Heldin, C.-H., Landström, M., & Moustakas, A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.021 · Cited by 634
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C.-H., & Moustakas, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0658 · Cited by 610
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., & Taketo, M. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81132-0 · Cited by 609
Giampieri, S., Manning, C., Hooper, S., Jones, L., Hill, C. S., & Sahai, E. (2009) · Nature Cell Biology · doi:10.1038/ncb1973 · Cited by 601
Repression of p15INK4b expression by Myc through association with Miz-1
Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bartek, J., Massagué, J., Hänel, F., et al. (2001) · Nature Cell Biology · doi:10.1038/35070076 · Cited by 575
TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β
Yamashita, M., Fatyol, K., Jin, C., Wang, X., Liu, Z., & Zhang, Y. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.002 · Cited by 559
Lee, J.-C., Lee, K.-M., Kim, D.-W., & Heo, D. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7335 · Cited by 549
Ikushima, H., Todo, T., Ino, Y., Takahashi, M., Miyazawa, K., & Miyazono, K. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.08.018 · Cited by 539
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
LEVY, L., & HILL, C. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.009 · Cited by 539
Super-SILAC mix for quantitative proteomics of human tumor tissue
Geiger, T., Cox, J., Ostasiewicz, P., Wisniewski, J. R., & Mann, M. (2010) · Nature Methods · doi:10.1038/nmeth.1446 · Cited by 538
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
Kang, Y., He, W., Tulley, S., Gupta, G. P., Serganova, I., Chen, C.-R., Manova-Todorova, K., Blasberg, R., Gerald, W. L., & Massagué, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506517102 · Cited by 532
The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
Tarin, D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0699 · Cited by 531
Signaling of transforming growth factor‐β family members through Smad proteins
Itoh, S., Itoh, F., Goumans, M., & ten Dijke, P. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01828.x · Cited by 529
Self-citationTGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA
Lee, M. K., Pardoux, C., Hall, M. C., Lee, P. S., Warburton, D., Qing, J., Smith, S. M., & Derynck, R. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601818 · Cited by 527
MicroRNAs as regulators of epithelial-mesenchymal transition
Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6851 · Cited by 506
FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L., Adorno, M., Martello, G., Stinchfield, M. J., Soligo, S., Morsut, L., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.051 · Cited by 494
Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein
Stroschein, S. L., Wang, W., Zhou, S., Zhou, Q., & Luo, K. (1999) · Science · doi:10.1126/science.286.5440.771 · Cited by 492
PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
Lin, X., Duan, X., Liang, Y.-Y., Su, Y., Wrighton, K. H., Long, J., Hu, M., Davis, C. M., Wang, J., Brunicardi, F. C., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.044 · Cited by 485
Kopp, H.-G., Placke, T., & Salih, H. R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2123 · Cited by 469
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
Luo, K., Stroschein, S. L., Wang, W., Chen, D., Martens, E., Zhou, S., & Zhou, Q. (1999) · Genes & Development · doi:10.1101/gad.13.17.2196 · Cited by 468
Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy
Wrzesinski, S. H., Wan, Y. Y., & Flavell, R. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1157 · Cited by 452
Regulation of cell proliferation by Smad proteins
Ten Dijke, P., Goumans, M., Itoh, F., & Itoh, S. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10066 · Cited by 450
Self-citationMyeroff, L. L., Parsons, R. E., Kim, S., Hedrick, L., Cho, K. R., Orth, K., Mathis, J. M., Kinzler, K. W., Lutterbaugh, J., & Park, K. (1995) · PubMed · Cited by 445
Molecular Biology of Bone Metastasis
Kingsley, L. A., Fournier, P. G. J., Chirgwin, J. M., & Guise, T. A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0234 · Cited by 435
Siegel, P. M., Shu, W., Cardiff, R. D., Muller, W. J., & Massagué, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932636100 · Cited by 429
Piek, E., Moustakas, A., Kurisaki, A., Heldin, C.-H., & Dijke, P. T. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4557 · Cited by 426
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215234 · Cited by 415
Uhl, M., Aulwurm, S., Wischhusen, J., Weiler, M., Ma, J. Y., Almirez, R., Mangadu, R., Liu, Y.-W., Platten, M., Herrlinger, U., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1013 · Cited by 414
Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase
Dubois, C. M., Laprise, M.-H., Blanchette, F., Gentry, L. E., & Leduc, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10618 · Cited by 405
Yang, Y.-A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z.-Y., Green, J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215333 · Cited by 404
Yang, Y.-A., Dukhanina, O. I., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z.-Y., Green, J. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15333 · Cited by 404
Torre-Amione, G., Beauchamp, R. D., Koeppen, H., Park, B. H., Schreiber, H., Moses, H. L., & Rowley, D. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1486 · Cited by 403
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Conery, A. R., Cao, Y., Thompson, E. A., Townsend, C. M., Ko, T. C., & Luo, K. (2004) · Nature Cell Biology · doi:10.1038/ncb1117 · Cited by 398
Pardali, K., Kurisaki, A., Morén, A., ten Dijke, P., Kardassis, D., & Moustakas, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909467199 · Cited by 392
Self-citationGrady, W. M., Myeroff, L. L., Swinler, S. E., Rajput, A., Thiagalingam, S., Lutterbaugh, J., Neumann, A., Brattain, M. G., Chang, J., Kim, S., et al. (1999) · PubMed · Cited by 391
Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway
He, W., Dorn, D. C., Erdjument-Bromage, H., Tempst, P., Moore, M. A. S., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.03.045 · Cited by 390
Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling
Gao, S., Alarcón, C., Sapkota, G., Rahman, S., Chen, P.-Y., Goerner, N., Macias, M. J., Erdjument-Bromage, H., Tempst, P., & Massagué, J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.043 · Cited by 389
Negative regulation of TGF-β receptor/Smad signal transduction
Itoh, S., & ten Dijke, P. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.015 · Cited by 388
Self-citationTGF-β induces apoptosis through Smad-mediated expression of DAP-kinase
Jang, C.-W., Chen, C.-H., Chen, C.-C., Chen, J.-Y., Su, Y.-H., & Chen, R.-H. (2002) · Nature Cell Biology · doi:10.1038/ncb731 · Cited by 386
Ijichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Fujitani, Y., Fujitani, S., Wright, C. V. E., & Moses, H. L. (2006) · Genes & Development · doi:10.1101/gad.1475506 · Cited by 379
Akiyoshi, S., Inoue, H., Hanai, J.-I., Kusanagi, K., Nemoto, N., Miyazono, K., & Kawabata, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35269 · Cited by 373
Deckers, M., van Dinther, M., Buijs, J., Que, I., Löwik, C., van der Pluijm, G., & ten Dijke, P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3560 · Cited by 371
Self-citationTumour budding in colorectal carcinoma
Prall, F. (2007) · Histopathology · doi:10.1111/j.1365-2559.2006.02551.x · Cited by 369
Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116871 · Cited by 359
Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members
Afrakhte, M., Morén, A., Jossan, S., Itoh, S., Sampath, K., Westermark, B., Heldin, C.-H., Heldin, N.-E., & ten Dijke, P. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9170 · Cited by 353
Self-citationBiswas, S., Guix, M., Rinehart, C., Dugger, T. C., Chytil, A., Moses, H. L., Freeman, M. L., & Arteaga, C. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30740 · Cited by 346
Ubiquitin-dependent degradation of TGF-β-activated Smad2
Lo, R. S., & Massagué, J. (1999) · Nature Cell Biology · doi:10.1038/70258 · Cited by 344
Melisi, D., Ishiyama, S., Sclabas, G. M., Fleming, J. B., Xia, Q., Tortora, G., Abbruzzese, J. L., & Chiao, P. J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0337 · Cited by 323
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
Bonni, S., Wang, H.-R., Causing, C. G., Kavsak, P., Stroschein, S. L., Luo, K., & Wrana, J. L. (2001) · Nature Cell Biology · doi:10.1038/35078562 · Cited by 310
Id proteins in cell growth and tumorigenesis
Sikder, H. A., Devlin, M. K., Dunlap, S., Ryu, B., & Alani, R. M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00141-7 · Cited by 309
Wikström, P., Stattin, P., Franck-Lissbrant, I., Damber, J.-E., & Bergh, A. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980915)37:1<19::aid-pros4>3.0.co;2-3 · Cited by 307
Friese, M. A., Wischhusen, J., Wick, W., Weiler, M., Eisele, G., Steinle, A., & Weller, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1627 · Cited by 305
Dasch, J. R., Pace, D. R., Waegell, W., Inenaga, D., & Ellingsworth, L. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.5.1536 · Cited by 293
Goggins, M., Shekher, M. C., Turnacioglu, K. K., Yeo, C. J., Hruban, R. H., & Kern, S. E. (1998) · PubMed · Cited by 288
Daly, A. C., Randall, R. A., & Hill, C. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01192-08 · Cited by 277
Nomura, T., Khan, M. M., Kaul, S. C., Dong, H.-D., Wadhwa, R., Colmenares, C., Kohno, I., & Ishii, S. (1999) · Genes & Development · doi:10.1101/gad.13.4.412 · Cited by 275
Guasch, G., Schober, M., Pasolli, H. A., Conn, E. B., Polak, L., & Fuchs, E. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.020 · Cited by 268
Cheng, N., Bhowmick, N. A., Chytil, A., Gorksa, A. E., Brown, K. A., Muraoka, R., Arteaga, C. L., Neilson, E. G., Hayward, S. W., & Moses, H. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208685 · Cited by 267
Yoo, J., Ghiassi, M., Jirmanova, L., Balliet, A. G., Hoffman, B., Fornace, A. J., Liebermann, D. A., Böttinger, E. P., & Roberts, A. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307869200 · Cited by 261
Scandura, J. M., Boccuni, P., Massagué, J., & Nimer, S. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406771101 · Cited by 254
Forrester, E., Chytil, A., Bierie, B., Aakre, M., Gorska, A. E., Sharif-Afshar, A.-R., Muller, W. J., & Moses, H. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3272 · Cited by 249
A FoxO–Smad synexpression group in human keratinocytes
Gomis, R. R., Alarcón, C., He, W., Wang, Q., Seoane, J., Lash, A., & Massagué, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605333103 · Cited by 246
Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7
Itoh, S., Landström, M., Hermansson, A., Itoh, F., Heldin, C.-H., Heldin, N.-E., & ten Dijke, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29195 · Cited by 239
Self-citationNucleocytoplasmic shuttling of Smad proteins
Hill, C. S. (2009) · Cell Research · doi:10.1038/cr.2008.325 · Cited by 234
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer
Berx, G., Raspé, E., Christofori, G., Thiery, J. P., & Sleeman, J. P. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9114-6 · Cited by 226
Hau, P., Jachimczak, P., Schlingensiepen, R., Schulmeyer, F., Jauch, T., Steinbrecher, A., Brawanski, A., Proescholdt, M., Schlaier, J., Buchroithner, J., et al. (2007) · Oligonucleotides · doi:10.1089/oli.2006.0053 · Cited by 215
Hoot, K. E., Lighthall, J., Han, G., Lu, S.-L., Li, A., Ju, W., Kulesz-Martin, M., Bottinger, E., & Wang, X.-J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33713 · Cited by 209
Dalal, B. I., Keown, P. A., & Greenberg, A. H. (1993) · PubMed · Cited by 208
Lu, S.-L., Herrington, H., Reh, D., Weber, S., Bornstein, S., Wang, D., Li, A. G., Tang, C.-F., Siddiqui, Y., Nord, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1413306 · Cited by 204
Bueno, L., de Alwis, D. P., Pitou, C., Yingling, J., Lahn, M., Glatt, S., & Trocóniz, I. F. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2007.10.008 · Cited by 201
Koinuma, D., Tsutsumi, S., Kamimura, N., Taniguchi, H., Miyazawa, K., Sunamura, M., Imamura, T., Miyazono, K., & Aburatani, H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01038-08 · Cited by 197
Hjelmeland, M. D., Hjelmeland, A. B., Sathornsumetee, S., Reese, E. D., Herbstreith, M. H., Laping, N. J., Friedman, H. S., Bigner, D. D., Wang, X.-F., & Rich, J. N. (2004) · PubMed · Cited by 192
Muraoka, R. S., Koh, Y., Roebuck, L. R., Sanders, M. E., Brantley-Sieders, D., Gorska, A. E., Moses, H. L., & Arteaga, C. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8691-8703.2003 · Cited by 191
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J. R., Tabor, V., Aichele, P., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.043 · Cited by 184
Petersen, M., Pardali, E., van der Horst, G., Cheung, H., van den Hoogen, C., van der Pluijm, G., & ten Dijke, P. (2010) · Oncogene · doi:10.1038/onc.2009.426 · Cited by 184
Self-citationFriedman, E. D., Gold, L. I., Klimstra, D., Zeng, Z., Winawer, S. J., & Cohen, A. M. (1995) · PubMed · Cited by 182
Ehata, S., Hanyu, A., Fujime, M., Katsuno, Y., Fukunaga, E., Goto, K., Ishikawa, Y., Nomura, K., Yokoo, H., Shimizu, T., et al. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2006.00357.x · Cited by 180
Hjelmeland, M. D., Hjelmeland, A. B., Sathornsumetee, S., Reese, E. D., Herbstreith, M. H., Laping, N. J., Friedman, H. S., Bigner, D. D., Wang, X.-F., & Rich, J. N. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.737.3.6 · Cited by 177
Muñoz, N. M., Upton, M., Rojas, A., Washington, M. K., Lin, L., Chytil, A., Sozmen, E. G., Madison, B. B., Pozzi, A., Moon, R. T., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0890 · Cited by 169
Induction of Smad6 mRNA by Bone Morphogenetic Proteins
Takase, M., Imamura, T., Sampath, T. K., Takeda, K., Ichijo, H., Miyazono, K., & Kawabata, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8200 · Cited by 164
Sapkota, G., Knockaert, M., Alarcón, C., Montalvo, E., Brivanlou, A. H., & Massagué, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610172200 · Cited by 163
Watanabe, Y., Itoh, S., Goto, T., Ohnishi, E., Inamitsu, M., Itoh, F., Satoh, K., Wiercinska, E., Yang, W., Shi, L., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.10.028 · Cited by 160
Self-citationTGF-β type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling
Qiu, T., Wu, X., Zhang, F., Clemens, T. L., Wan, M., & Cao, X. (2010) · Nature Cell Biology · doi:10.1038/ncb2022 · Cited by 157
Descargues, P., Sil, A. K., Sano, Y., Korchynskyi, O., Han, G., Owens, P., Wang, X., & Karin, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712044105 · Cited by 157
Ge, R., Rajeev, V., Ray, P., Lattime, E. C., Rittling, S. R., Medicherla, S., Protter, A., Murphy, A., Chakravarty, J., Dugar, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0162 · Cited by 155
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
Wisotzkey, R. G., Mehra, A., Sutherland, D. J., Dobens, L. L., Liu, X., Dohrmann, C. E., Attisano, L., & Raftery, L. A. (1998) · Development · doi:10.1242/dev.125.8.1433 · Cited by 152
Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast
Walker, R. A., & Dearing, S. J. (1992) · European Journal of Cancer · doi:10.1016/s0959-8049(05)80116-9 · Cited by 151
Chen, T., Carter, D., Garrigue‐Antar, L., & Reiss, M. (1998) · PubMed · Cited by 150
Kondo, H., Guo, J., & Bringhurst, F. R. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1667 · Cited by 147
Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., Aburatani, H., Mishima, H. K., Imamura, T., Miyazono, K., et al. (2003) · PubMed · Cited by 142
Subramanian, G., Schwarz, R. E., Higgins, L., McEnroe, G., Chakravarty, S., Dugar, S., & Reiss, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0018 · Cited by 138
Identification of phosphatases for Smad in the BMP/DPP pathwayPreprint
Chen, H. B., Shen, J., Ip, Y. T., & Xu, L. (2006) · Genes & Development · doi:10.1101/gad.1384706 · Cited by 136
Targeting transforming growth factor-β signaling in liver metastasis of colon cancer
Zhang, B., Halder, S. K., Zhang, S., & Datta, P. K. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.11.035 · Cited by 134
A Transforming Growth Factor β-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A
Zhang, L., Duan, C. J., Binkley, C. E., Li, G., Uhler, M. D., Logsdon, C. D., & Simeone, D. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2169-2180.2004 · Cited by 124
Joseph, H., Gorska, A. E., Sohn, P., et al. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1221 · Cited by 124
Modeling metastasis in the mouse
Bos, P. D., Nguyen, D. X., & Massagué, J. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.06.003 · Cited by 121
Wang, D., Kanuma, T., Mizunuma, H., Takama, F., Ibuki, Y., Wake, N., Mogi, A., Shitara, Y., & Takenoshita, S. (2000) · PubMed · Cited by 121
Protein Microarrays for Personalized Medicine
Yu, X., Schneiderhan‐Marra, N., & Joos, T. O. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2009.137158 · Cited by 111
Ohgushi, M., Kuroki, S., Fukamachi, H., O’Reilly, L. A., Kuida, K., Strasser, A., & Yonehara, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10017-10028.2005 · Cited by 109
Targeting TGF-β in prostate cancer: therapeutic possibilities during tumor progression
Jones, E., Pu, H., & Kyprianou, N. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220802705696 · Cited by 109
Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
Ohkawara, B., Shirakabe, K., Hyodo-Miura, J., Matsuo, R., Ueno, N., Matsumoto, K., & Shibuya, H. (2004) · Genes & Development · doi:10.1101/gad.1166904 · Cited by 106
Goey, H., Keller, J. R., Back, T. C., Longo, D. L., Ruscetti, F. W., & Wiltrout, R. H. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.3.877 · Cited by 103
Buck, M. B., Fritz, P., Dippon, J., Zugmaier, G., & Knabbe, C. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0320-03 · Cited by 100
Picon, A. I., Gold, L. I., Wang, J., Cohen, A. M., & Friedman, E. D. (1998) · PubMed · Cited by 100
Rowland‐Goldsmith, M., Maruyama, H., Matsuda, K., Idezawa, T., Ralli, M., Ralli, S., & Korc, M. (2002) · PubMed · Cited by 92
Shinto, O., Yashiro, M., Kawajiri, H., Shimizu, K., Shimizu, T., Miwa, A., & Hirakawa, K. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605561 · Cited by 90
Schlingensiepen, K., Fischer-Blass, B., Schmaus, S., & Ludwig, S. (2007) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-540-71279-4_16 · Cited by 89
Bandyopadhyay, A. M., Zhu, Y., Malik, S. N., Kreisberg, J. I., Brattain, M. G., Sprague, E. A., Luo, J., López‐Casillas, F., & Sun, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205439 · Cited by 87
Nam, J., Suchar, A. M., Kang, M., Stuelten, C. H., Tang, B., Michalowska, A. M., Fisher, L. W., Fedarko, N. S., Jain, A., Pinkas, J., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0068 · Cited by 86
The role of transforming growth factor Β in glioma progression
Jennings, M. T., & Pietenpol, J. A. (1998) · Journal of Neuro-Oncology · doi:10.1023/a:1005863419880 · Cited by 85
Cellular context‐dependent “colors” of transforming growth factor‐β signaling
Ikushima, H., & Miyazono, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01441.x · Cited by 82
Kim, S. G., Jong, H.-S., Kim, T.-Y., Lee, S. E., Kim, N. K., Hong, S. H., & Bang, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-04-0201 · Cited by 82
Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas
Izumoto, S., Arita, N., Ohnishi, T., Hiraga, S., Taki, T., Tomita, N., Ohue, M., & Hayakawa, T. (1997) · Cancer Letters · doi:10.1016/s0304-3835(96)04583-1 · Cited by 81
Control of microRNA biogenesis by TGFβ signaling pathway—A novel role of Smads in the nucleus
Hata, A., & Davis‐Dusenbery, B. N. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.004 · Cited by 77
Promoter‐wide analysis of Smad4 binding sites in human epithelial cells
Koinuma, D., Tsutsumi, S., Kamimura, N., Imamura, T., Aburatani, H., & Miyazono, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01299.x · Cited by 70
Biswas, S., Criswell, T. L., Wang, S. E., & Arteaga, C. L. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0952 · Cited by 69
Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines
Cerutti, J. M., Ebina, K. N., Matsuo, S. E., Martins, L., Maciel, R. M. B., & Kimura, E. T. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345213 · Cited by 61
4E‐BP1 is a target of Smad4 essential for TGFβ‐mediated inhibition of cell proliferation
Azar, R., Alard, A., Susini, C., Bousquet, C., & Pyronnet, S. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.291 · Cited by 60
Overexpression of the TGF-β antagonist Smad7 in endometrial cancer
Dowdy, S. C., Mariani, A., Reinholz, M. M., Keeney, G. L., Spelsberg, T. C., Podratz, K. C., & Janknecht, R. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.10.006 · Cited by 59
Vincent-Hubert, F., Hagiwara, K., Yang, K., Stoner, G. D., Demetrick, D. J., & Bennett, W. P. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0934 · Cited by 57
Hutchison, N., Hendry, B. M., & Sharpe, C. C. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.05.012 · Cited by 45
Dzwonek, J., Preobrazhenska, O., Cazzola, S., Conidi, A., Schellens, A., van Dinther, M., Stubbs, A., Klippel, A., Huylebroeck, D., ten Dijke, P., et al. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0558 · Cited by 32
Takenoshita, S., Mogi, A., Tani, M., Osawa, H., Sunaga, H., Kakegawa, H., Yanagita, Y., Koida, T., Kimura, M., Fujita, K. I., et al. (1998) · Oncology Reports · doi:10.3892/or.5.2.367 · Cited by 28
Diener, K. R., Woods, A. E., Manavis, J., Brown, M. P., & Hayball, J. D. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.123 · Cited by 18
Cited by
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.033 · Cited by 912
NF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 574
The Role of Cytokines in Breast Cancer Development and Progression
Esquivel-Velázquez, M., Ostoa-Saloma, P., Palacios-Arreola, M. I., Nava-Castro, K. E., Castro, J. I., & Morales-Montor, J. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0026 · Cited by 490
Tumor-induced perturbations of cytokines and immune cell networks
Burkholder, B., Huang, R.-Y., Burgess, R., Luo, S., Jones, V. S., Zhang, W., Lv, Z.-Q., Gao, C.-Y., Wang, B.-L., Zhang, Y.-M., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.01.004 · Cited by 356
Metadata
- Authors
- Meulmeester, E., & ten Dijke, P.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2010-10-18
- Volume
- 223
- Issue
- 2
- Pages
- 206-219
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2084414513
- Cited by
- 388
- References
- 185
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
