Tryptophan depletion causes a rapid lowering of mood in normal males

Cytokines and major depression

Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235

Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers Evidence for Monoaminergic Mechanisms

Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

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Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861

Neurobiological similarities in depression and drug dependence: a self-medication hypothesis

Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767

Serotoninergic regulation of emotional and behavioural control processes

Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

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The role of serotonin in human mood and social interaction

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Tryptophan depletion in normal volunteers produces selective impairments in learning and memory

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Effects of tryptophan depletion in drug-free adults with autistic disorder

McDougle, C. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830110029004 · Cited by 301

Serotonin and the Neurobiology of Depression: Effects of Tryptophan Depletion in Drug-Free Depressed Patients

Delgado, P. L. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110025005 · Cited by 289

Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour

Rogers, R. D., Blackshaw, A. J., Middleton, H. C., Matthews, K., Hawtin, K., Crowley, C., Hopwood, A., Wallace, C., Deakin, J. F. W., Sahakian, B. J., et al. (1999) · Psychopharmacology · doi:10.1007/pl00005494 · Cited by 289

Reconciling the Role of Serotonin in Behavioral Inhibition and Aversion: Acute Tryptophan Depletion Abolishes Punishment-Induced Inhibition in Humans

Crockett, M. J., Clark, L., & Robbins, T. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-09.2009 · Cited by 271

Serotonin, inhibition, and negative mood

Dayan, P., & Huys, Q. J. M. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0040004 · Cited by 263

Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation.

Riedel, W. J., Klaassen, T., Deutz, N. E. P., van Someren, A., & van Praag, H. M. (1999) · Psychopharmacology · doi:10.1007/s002130050845 · Cited by 271

Effects of tryptophan loading on human cognition, mood, and sleep

Silber, B. Y., & Schmitt, J. A. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.005 · Cited by 260

The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers

Murphy, F., Smith, K., Cowen, P., Robbins, T., & Sahakian, B. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1128-9 · Cited by 255

Toward a unified theory of serotonin dysregulation in eating and related disorders

Brewerton, T. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00001-5 · Cited by 245

Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers

Schmitt, J. A. J., Jorissen, B. L., Sobczak, S., van Boxtel, M. P. J., Hogervorst, E., Deutz, N. E. P., & Riedel, W. J. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400102 · Cited by 227

Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression.

Neumeister, A., Konstantinidis, A., Stastny, J., Schwarz, M. J., Vitouch, O., Willeit, M., Praschak-Rieder, N., Zach, J., de Zwaan, M., Bondy, B., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.613 · Cited by 223

The reciprocal interaction between serotonin and social behaviour

Kiser, D., SteemerS, B., Branchi, I., & Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.009 · Cited by 214

Serotonergic Modulation of Prefrontal Cortex during Negative Feedback in Probabilistic Reversal Learning

Evers, E. A. T., Cools, R., Clark, L., van der Veen, F. M., Jolles, J., Sahakian, B. J., & Robbins, T. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300663 · Cited by 208

Pathophysiology of seasonal affective disorder: a review.

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The serotonin transporter in psychiatric disorders: insights from PET imaging

Spies, M., Knudsen, G. M., Lanzenberger, R., & Kasper, S. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00232-1 · Cited by 177

Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity

Clark, L., Roiser, J. P., Cools, R., Rubinsztein, D. C., Sahakian, B. J., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0104-6 · Cited by 175

Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review

Mendelsohn, D., Riedel, W. J., & Sambeth, A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.006 · Cited by 175

Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

Rubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2116-z · Cited by 171

Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction

Cools, R., Robinson, O. J., & Sahakian, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301598 · Cited by 172

HPA and Immune Axes in Stress: Involvement of the Serotonergic System

Leonard, B. E. (2006) · Neuroimmunomodulation · doi:10.1159/000104854 · Cited by 169

Serotonin and decision making processes

Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.001 · Cited by 167

Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces

Cools, R., Calder, A. J., Lawrence, A. D., Clark, L., Bullmore, E., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2215-5 · Cited by 161

Is breakfast consumption related to mental distress and academic performance in adolescents?

Lien, L. (2007) · Public Health Nutrition · doi:10.1017/s1368980007258550 · Cited by 152

The chronobiology and neurobiology of winter seasonal affective disorder

Levitan, R. D. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/rlevitan · Cited by 149

Acute Tryptophan Depletion. Part I: Rationale and Methodology

Hood, S. D., Bell, C. J., & Nutt, D. J. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01627.x · Cited by 135

Effects of Acute Tryptophan Depletion on Mood and Facial Emotion Perception Related Brain Activation and Performance in Healthy Women with and without a Family History of Depression

van der Veen, F. M., Evers, E. A. T., Deutz, N. E. P., & Schmitt, J. A. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301212 · Cited by 118

The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention

Roiser, J. P., Müller, U., Clark, L., & Sahakian, B. J. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570600705x · Cited by 117

The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients

Booij, L., Van der Does, A. J. W., Haffmans, P. M. J., Riedel, W. J., Fekkes, D., & Blom, M. J. B. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105051538 · Cited by 105

Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.

Roiser, J. P., Blackwell, A. D., Cools, R., Clark, L., Rubinsztein, D. C., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301055 · Cited by 98

Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: a PET/[11C]raclopride study in healthy men

Leyton, M., Dagher, A., Boileau, I., Casey, K., Baker, G. B., Diksic, M., Gunn, R., Young, S. N., & Benkelfat, C. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300328 · Cited by 95

The role of dopamine in alcohol self-administration in humans: individual differences

Barrett, S. P., Pihl, R. O., Benkelfat, C., Brunelle, C., Young, S. N., & Leyton, M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.01.008 · Cited by 92

Acute serotonin and dopamine depletion improves attentional control: findings from the Stroop task

Scholes, K. E., Harrison, B. J., O'Neill, B. V., Leung, S., Croft, R. J., Pipingas, A., Phan, K. L., & Nathan, P. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301262 · Cited by 86

Serotonergic targets in depression.

Middlemiss, D. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00116-3 · Cited by 88

Faulty cortisol/serotonin interplay. Psychopathological and biological characterisation of a new, hypothetical depression subtype (SeCA depression)

van Praag, H. M. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02923-x · Cited by 87

Mood congruent memory bias induced by tryptophan depletion

KLAASSEN, T., RIEDEL, W. J., DEUTZ, N. E. P., & VAN PRAAG, H. M. (2002) · Psychological Medicine · doi:10.1017/s003329170100438x · Cited by 85

Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and mood

Bhatti, T., Gillin, J. C., Seifritz, E., Moore, P., Clark, C., Golshan, S., Stahl, S., Rapaport, M., & Kelsoe, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)80252-1 · Cited by 85

Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers

Murphy, S. E., Longhitano, C., Ayres, R. E., Cowen, P. J., & Harmer, C. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0401-8 · Cited by 81

Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women

Mohajeri, M. H., Wittwer, J., Vargas, K., Hogan, E., Holmes, A., Rogers, P. J., Goralczyk, R., & Gibson, E. L. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514003754 · Cited by 81

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Roiser, J. P., Levy, J., Fromm, S. J., Wang, H., Hasler, G., Sahakian, B. J., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301581 · Cited by 80

Inflammation and depression: Is there a causal connection with dementia?

E.Leonard, B., & Myint, A. (2006) · Neurotoxicity Research · doi:10.1007/bf03033243 · Cited by 76

Acute tryptophan depletion improves performance and modulates the BOLD response during a Stroop task in healthy females

Evers, E. A. T., van der Veen, F. M., Jolles, J., Deutz, N. E. P., & Schmitt, J. A. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.026 · Cited by 71

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study

Kuwano, N., Kato, T. A., Setoyama, D., Sato-Kasai, M., Shimokawa, N., Hayakawa, K., Ohgidani, M., Sagata, N., Kubo, H., Kishimoto, J., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.01.014 · Cited by 69

Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controls

Sobczak, S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00345-7 · Cited by 67

Better to give than to take? Interactive social decision-making in severe major depressive disorder

Destoop, M., Schrijvers, D., De Grave, C., Sabbe, B., & De Bruijn, E. R. A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.010 · Cited by 66

Serotonergic functioning correlates with positive and negative affect in psychiatrically healthy males

Zald, D. H., & Depue, R. A. (2001) · Personality and Individual Differences · doi:10.1016/s0191-8869(00)00011-8 · Cited by 61

Serotonergic modulation of reward and punishment: evidence from pharmacological fMRI studies

Macoveanu, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.003 · Cited by 55

Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers

Casey, K. F., Benkelfat, C., Young, S. N., & Leyton, M. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.02.002 · Cited by 54

The effects of experimentally lowered serotonin function on emotional information processing and memory in remitted depressed patients

Merens, W., Booij, L., Haffmans, P. J., & van der Does, A. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107081531 · Cited by 49

Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task

van der Veen, F. M., Evers, E. A. T., van Deursen, J. A., Deutz, N. E. P., Backes, W. H., & Schmitt, J. A. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.014 · Cited by 45

Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects

Arnulf, I. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00358-5 · Cited by 41

Acute Tryptophan Depletion Increases Translational Indices of Anxiety but not Fear: Serotonergic Modulation of the Bed Nucleus of the Stria Terminalis?

Robinson, O. J., Overstreet, C., Allen, P. S., Pine, D. S., & Grillon, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.43 · Cited by 35

Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stress

Firk, C., & Markus, C. R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1125-8 · Cited by 19

No effect of acute tryptophan depletion on verbal declarative memory in young persons with ADHD

Zepf, F. D., Landgraf, M., Biskup, C. S., Dahmen, B., Poustka, F., Wöckel, L., & Stadler, C. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12089 · Cited by 19

Selective effects of simultaneous monoamine depletion on mood and emotional responsiveness

Hughes, J.-M., Matrenza, C., Kemp, A. H., Harrison, B. J., Liley, D., & Nathan, P. J. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003845 · Cited by 16

Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants

Merino, J. J., Cabaña-Muñoz, M. E., Toledano Gasca, A., Garcimartín, A., Benedí, J., Camacho-Alonso, F., & Parmigiani-Izquierdo, J. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091368 · Cited by 12

The Neurochemical Modulation of Prefrontal Control Processes

Robbins, T. W., & Kehagia, A. A. (2017) · The Wiley Handbook of Cognitive Control · doi:10.1002/9781118920497.ch19 · Cited by 4