Cited by 199Gut microbiota and healthBirth, Development, and HealthMaternal Mental Health During Pregnancy and Postpartum

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Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease

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Codagnone, Martin G., Spichak, Simon, O’Mahony, Siobhain M., O’Leary, Olivia F., Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G., Cryan, John F.·2019·Biological Psychiatry

DOI 10.1016/j.biopsych.2018.06.014

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Abstract

It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environmental exposures is key in this regard. However, recent research has also identified another important factor in the microbiota-the trillions of microorganisms that inhabit key body niches, including the vagina and gastrointestinal tract. Because the composition of these maternal microbiome sites has been linked to maternal metabolism and is also vertically transmitted to offspring, changes in the maternal microbiota are poised to significantly affect the newborn. In fact, several lines of evidence show that the gut microbiota interacts with diet, drugs, and stress both prenatally and postnatally and that these exogenous factors could also affect the dynamic changes in the microbiota composition occurring during pregnancy. Animal models have shown great utility in illuminating how these disruptions result in behavioral and brain morphological phenotypes reminiscent of psychiatric disorders (anxiety, depression, schizophrenia, and autism spectrum disorders). Increasing evidence points to critical interactions among the microbiota, host genetics, and both the prenatal and postnatal environments to temporally program susceptibility to psychiatric disorders later in life. Sex-specific phenotypes may be programmed through the influence of the microbiota on the hypothalamic-pituitary-adrenal axis and neuroimmune system.

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“Though there exists no current research of its impa ct on the microbiota, the bacterial mimetic lipopolysaccharide can also induce behavioral pheno types for anxiety, depression, or autism spectrum disorder in offspring (109, 110); impairme nts in hippocampal development and neurogenesis (111, 112); and increased post…”
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Authors: Codagnone, M. G., Spichak, S., O’Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Teagasc - The Irish Agriculture and Food Development Authority (IE)
Corresponding author: Cryan, John F.
ORCID: Spichak, Simon
O’Mahony, Siobhain M.
O’Leary, Olivia F.
Clarke, Gerard
Stanton, Catherine
Dinan, Timothy G.
Cryan, John F.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2019-01
Volume: 85
Issue: 2
Pages: 150-163
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2018.06.014
OpenAlex: W2810733185
Cited by: 198
References: 180
Citations by year: 2026: 12 · 2025: 14 · 2024: 23 · 2023: 21 · 2022: 37 · 2021: 27 · 2020: 32 · 2019: 26
FWCI: 2.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
Funders: Science Foundation Ireland (12/RC/2273, 12/RC/)
APC Microbiome Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: microbiota, developmental origins of health and disease, maternal microbiome, gut microbiota, vertical transmission, pregnancy, intrauterine environment, postnatal environment, mental illness, anxiety, depression, schizophrenia, autism spectrum disorder, behavioral phenotypes, brain structure, sex differences, hypothalamic-pituitary-adrenal axis, neuroimmune system, host genetics, diet, stress
MeSH terms: Gastrointestinal Microbiome, Animals, Mental Disorders, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects

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