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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren·2013·Cell Reports
DOI 10.1016/j.celrep.2013.07.030PMC PMC3784301
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Crossref · 10.1016/j.celrep.2013.07.030

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  • Partial inhibition of mTORC1 in genetic mouse models can extend lifespan and healthspan in mice.

    “Even partial inhibition of mTORC1 in genetic mouse models (e.g., S6K1−/−, mTOR+/− mLST8+/−, mTORΔ/Δ, TSC1tg) can extend lifespan and healthspan in mice 13,17–19.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [18]

    The Abstract reports that mTORΔ/Δ mice had approximately 20% longer median survival and preserved function in many, but not all, organ systems. However, it says these mice had reduced activity of both mTORC1 and mTORC2; the Discussion likewise describes a balanced reduction in both. This study therefore does not establish that partial inhibition of mTORC1 alone extends lifespan and healthspan. (LLM, conf=0.86)

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Research works printed but not linked: 30

  1. Barreto, 2010, Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice, J. Neurosurg. Anesthesiol., 22, 214, 10.1097/ANA.0b013e3181d56c98 · DOI
  2. Bjedov, 2010, Mechanisms of lifespan extension by rapamycin in the fruit fly Drosophila melanogaster, Cell Metab., 11, 35, 10.1016/j.cmet.2009.11.010 · DOI · Paper page
  3. Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex, Nature, 450, 736, 10.1038/nature06322 · DOI · Paper page
  4. Gangloff, 2004, Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development, Mol. Cell. Biol., 24, 9508, 10.1128/MCB.24.21.9508-9516.2004 · DOI · Paper page
  5. Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007 · DOI
  6. Hausdorff, 2001, Gait variability and fall risk in community-living older adults: a 1-year prospective study, Arch. Phys. Med. Rehabil., 82, 1050, 10.1053/apmr.2001.24893 · DOI
  7. Kaeberlein, 2005, Regulation of yeast replicative lifespan by TOR and Sch9 in response to nutrients, Science, 310, 1193, 10.1126/science.1115535 · DOI · Paper page
  8. Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Curr. Biol., 14, 885, 10.1016/j.cub.2004.03.059 · DOI · Paper page
  9. Kastle, 2011, Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system, Curr. Pharm. Des., 17, 4007, 10.2174/138161211798764898 · DOI
  10. Kennard, 2011, Age sensitivity of behavioral tests and brain substrates of normal aging in mice, Front Aging Neurosci, 3, 9, 10.3389/fnagi.2011.00009 · DOI
  11. Kenyon, 2011, The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing, Philos. Trans. R. Soc. Lond. B Biol. Sci., 366, 9, 10.1098/rstb.2010.0276 · DOI · Paper page
  12. Lamming, 2012, Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity, Science, 335, 1638, 10.1126/science.1215135 · DOI · Paper page
  13. Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017 · DOI · Paper page
  14. Maki, 1997, Gait changes in older adults: predictors of falls or indicators of fear, J. Am. Geriatr. Soc., 45, 313, 10.1111/j.1532-5415.1997.tb00946.x · DOI
  15. Medvedik, 2007, MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae, PLoS Biol., 5, e261, 10.1371/journal.pbio.0050261 · DOI · Paper page
  16. Miller, 2011, Rapamycin, but not resveratrol or simvastatin, extends lifespan of genetically heterogeneous mice, J. Gerontol. A Biol. Sci. Med. Sci., 66, 191, 10.1093/gerona/glq178 · DOI · Paper page
  17. Murakami, 2004, mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells, Mol. Cell. Biol., 24, 6710, 10.1128/MCB.24.15.6710-6718.2004 · DOI
  18. Sarbassov, 2006, Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB, Mol. Cell, 22, 159, 10.1016/j.molcel.2006.03.029 · DOI · Paper page
  19. Schöneich, 2006, Protein modification in aging: an update, Exp. Gerontol., 41, 807, 10.1016/j.exger.2006.07.002 · DOI
  20. Shang, 2011, Ubiquitin-proteasome pathway and cellular responses to oxidative stress, Free Radic. Biol. Med., 51, 5, 10.1016/j.freeradbiomed.2011.03.031 · DOI
  21. Wang, 2004, Statistical methods for testing effects on “maximum lifespan”, Mech. Ageing Dev., 125, 629, 10.1016/j.mad.2004.07.003 · DOI · Paper page
  22. Wilkinson, 2012, Rapamycin slows aging in mice, Aging Cell, 11, 675, 10.1111/j.1474-9726.2012.00832.x · DOI · Paper page
  23. Xian, 2012, Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells, Nat. Med., 18, 1095, 10.1038/nm.2793 · DOI · Paper page
  24. Zhang, 2011, Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production, Blood, 117, 1228, 10.1182/blood-2010-05-287821 · DOI
  25. Chen, 2009, Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation, Cell Metab., 9, 548, 10.1016/j.cmet.2009.05.004 · DOI
  26. Gautam, 2006, Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency, Cell Metab., 4, 363, 10.1016/j.cmet.2006.09.008 · DOI
  27. Piesla, 2009, Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models, Brain Res., 1295, 89, 10.1016/j.brainres.2009.07.091 · DOI
  28. Ravoori, 2010, Quantification of mineralized bone response to prostate cancer by noninvasive in vivo microCT and non-destructive ex vivo microCT and DXA in a mouse model, PLoS ONE, 5, e9854, 10.1371/journal.pone.0009854 · DOI
  29. Vincelette, 2007, Gait analysis in a murine model of collagen-induced arthritis, Arthritis Res. Ther., 9, R123, 10.1186/ar2331 · DOI
  30. Wu, 2006, Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity, Cell Metab., 4, 61, 10.1016/j.cmet.2006.05.010 · DOI

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Metadata

Authors
Wu, J. J., Liu, J., Chen, E. B., Wang, J. J., Cao, L., Narayan, N., Fergusson, M. M., Rovira, I. I., Allen, M., Springer, D. A., Lago, C. U., Zhang, S., DuBois, W., Ward, T., deCabo, R., Gavrilova, O., Mock, B., & Finkel, T.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2013-09
Volume
4
Issue
5
Pages
913-920
ISSN
2211-1247
DOI
10.1016/j.celrep.2013.07.030
PMC
PMC3784301
Cited by
307
References
9
Language
en
Licence

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