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From Vaccines to Memory and Back

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Sallusto, Federica, Lanzavecchia, Antonio, Araki, Koichi, Ahmed, Rafi·2010·Immunity
DOI 10.1016/j.immuni.2010.10.008
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Abstract

Summary Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently new methods have been developed to dissect the immune response in experimental animals and humans which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells – a journey from vaccines to memory and back.

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Metadata

Authors
Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R.
Venue
Immunity
Publisher
Elsevier BV
Published
2010-10
Volume
33
Issue
4
Pages
451-463
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2010.10.008
OpenAlex
W2135360970
Cited by
637
References
27
FWCI
15.69
Type
journal article
Language
en
Open access
bronze
Licence

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