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Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines
Open accessAbstract
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL-6 family of cytokines now consists of ten members. Although some of the family members' functions are redundant as a result of the expression of gp130, there are also functional distinctions between members. The mechanisms that determine functional redundancies and distinctions are not completely understood. Yet, research has clarified the role of IL-6 family cytokines in autoimmune diseases and has led to effective therapies that target them. Here, we review the IL-6 family of cytokines in autoimmune diseases, with a particular focus on the prototypical member IL-6, from the viewpoints of their structure, signaling, and biological features and discuss possible mechanisms of their functional pleiotropy.
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In the citing paper
“Binding of IL-6 to IL-6RA and gp130 leads to activation of JAK/ STAT3 and, to a lesser extent, YAP.23”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [23]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Proper transduction of the IL-6 signal requires IL-6 receptor IL-6RA and co-receptor gp130.23”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [23]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“As IL-6/STAT3 signaling is mainly involved in the proinflammatory response, 23 it was unexpected that it controlled cell identity conversion in liver injury.”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [23]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“IL-6 is a prototypical member of the IL-6 family of cytokines, which is composed of 10 members including IL-6, IL-11, IL-27, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine factor 1 (CLCF1), IL-35 and IL-39 (33).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The IL-6R is composed of an IL-6-binding receptor molecule (IL-6Rα) and a signal transducer, gp130, which is shared among the IL-6 family of cytokines (Fig. 1A) (33).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
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In the citing paper
“IL-6 transcription is induced by a variety of stimuli, such as Toll-like receptor (TLR) ligands, IL-1, TNFα, reactive oxygen species (ROS) and zinc (Zn) and also depends on epigenetic regulation (33, 82, 84–86).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
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“Indeed, this mode plays crucial roles in chronic inflammation (33, 96).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“For IL-6 activity, the expression of both IL-6Rα and gp130 on the cell surface is required, which limits the number of target cells on which IL-6 acts to lymphocytes, myeloid cells and hepatocytes (33).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
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In the citing paper
“Furthermore, ADAM17 increases sIL-6Rα, which activates STAT3 through gp130 on a variety of non-immune cells including fibroblasts, endothelial cells and epithelial cells (33, 96).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [33]
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Citations
Cites
High-performance medicine: the convergence of human and artificial intelligence
Topol, E. J. (2019) · Nature Medicine · doi:10.1038/s41591-018-0300-7 · Cited by 10,450
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
Artificial intelligence in medicine
Hamet, P., & Tremblay, J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.011 · Cited by 2,334
Genetics of rheumatoid arthritis contributes to biology and drug discovery
the RACI consortium, Okada, Y., the GARNET consortium, Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., et al. (2014) · Nature · doi:10.1038/nature12873 · Cited by 2,310
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L., Workman, C., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R., & Vignali, D. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,152
Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Self-citationBlastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kašpar, P., Brunet, L. J., Bhatt, H., Gadi, I. K., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,033
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature · doi:10.1038/332083a0 · Cited by 1,633
Self-citationLiver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Bcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506
Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M. A., Vaisberg, E., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00324-2 · Cited by 1,462
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Self-citationIliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374
Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327
Parham, C. L., Chirica, M., Timans, J., Vaisberg, E., Travis, M. A., Cheung, J., Pflanz, S., Zhang, R. V., Singh, K. P., Vega, F., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5699 · Cited by 1,314
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
BIRAC Consortium, Stahl, E. A., YEAR Consortium, Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., Li, Y., Kurreeman, F. A. S., et al. (2010) · Nature Genetics · doi:10.1038/ng.582 · Cited by 1,253
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213
(2012) · The Lancet · doi:10.1016/s0140-6736(12)60110-x · Cited by 1,146
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079
Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., & Kishimoto, T. (1988) · Science · doi:10.1126/science.3136546 · Cited by 1,059
Self-citationShen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature · doi:10.1038/nature12979 · Cited by 1,048
Molecular cloning and expression of an IL-6 signal transducer, gp130
Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., & Kishimoto, T. (1990) · Cell · doi:10.1016/0092-8674(90)90411-7 · Cited by 1,039
Self-citationIL-23 promotes tumour incidence and growth
Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature · doi:10.1038/nature04808 · Cited by 1,018
Gearing, D. P., Comeau, M. R., Friend, D. J., Gimpel, S. D., Thut, C. J., McGourty, J., Brasher, K. K., King, J. A., Gillis, S. A., Mosley, B., et al. (1992) · Science · doi:10.1126/science.1542794 · Cited by 889
The two faces of IL-6 on Th1/Th2 differentiation
Diehl, S. A., & Rincón, M. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00210-9 · Cited by 873
IL-35-mediated induction of a potent regulatory T cell population
Collison, L. W., Chaturvedi, V., Henderson, A. L., Giacomin, P., Guy, C. S., Bankoti, J., Finkelstein, D., Forbes, K., Workman, C. J., Brown, S. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1952 · Cited by 870
Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 835
Oxford IBD Cohort Investigators, West, N. R., Hegazy, A. N., Owens, B. M. J., Bullers, S. J., Linggi, B. E., Buonocore, S. M., Coccia, M., Görtz, D., This, S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4307 · Cited by 812
Interleukin 6 and its receptor: ten years later
Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788
Self-citationExcessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology · doi:10.1002/eji.1830181122 · Cited by 784
Self-citationInterleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.
Poli, V., Balena, R. F., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G. A., & Costantini, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06368.x · Cited by 745
IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase
Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., & Kishimoto, T. (1993) · Science · doi:10.1126/science.8511589 · Cited by 724
Self-citationA functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C. Y., Gately, M. K., & Gubler, U. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14002 · Cited by 689
Damme, J. V., Opdenakker, G., Simpson, R. J., Rubira, M. R., Cayphas, S., Vink, A., Billiau, A., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.914 · Cited by 669
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
Jostock, T., Müllberg, J., Özbek, S., Atreya, R., Blinn, G., Voltz, N., Fischer, M., Neurath, M., & Rose-John, S. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01867.x · Cited by 665
Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
Boulanger, M. J., Chow, D., Brevnova, E. E., & García, K. C. (2003) · Science · doi:10.1126/science.1083901 · Cited by 658
Hirota, H., Chen, J., Betz, U. A. K., Rajewsky, K., Gu, Y., Ross, J., Müller, W., & Chien, K. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80729-1 · Cited by 654
Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., & Hirano, T. (1996) · Immunity · doi:10.1016/s1074-7613(00)80501-4 · Cited by 652
Self-citationPaul, S. R., Bennett, F., Calvetti, J., Kelleher, K. S., Wood, C. R., O'Hara, R. M., Leary, A. C., Sibley, B. S., Clark, S., & Williams, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7512 · Cited by 651
Interleukin-6: designing specific therapeutics for a complex cytokine
Garbers, C., Heink, S., Korn, T., & Rose-John, S. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.45 · Cited by 643
IL-11 is a crucial determinant of cardiovascular fibrosis
Schafer, S., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Moreno-Moral, A., DeLaughter, D. M., Ng, B., Patone, G., Chow, K., Khin, E., et al. (2017) · Nature · doi:10.1038/nature24676 · Cited by 639
Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.407 · Cited by 634
LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor
Davis, S. H., Aldrich, T. H., Stahl, N., Li, P., Taga, T., Kishimoto, T., Ip, N. Y., & Yancopoulos, G. D. (1993) · Science · doi:10.1126/science.8390097 · Cited by 634
A gp130–Src–YAP module links inflammation to epithelial regeneration
Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature · doi:10.1038/nature14228 · Cited by 633
Interleukin-6 and its receptors: a highly regulated and dynamic system
Wolf, J., Rose-John, S., & Garbers, C. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.024 · Cited by 618
Suppressors of cytokine signaling and immunity
Kubo, M., Hanada, T., & Yoshimura, A. (2003) · Nature Immunology · doi:10.1038/ni1012 · Cited by 617
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
Stöckli, K. A., Lottspeich, F., Sendtner, M., Masiakowski, P., Carroll, P., Götz, R., Lindholm, D., & Thoenen, H. (1989) · Nature · doi:10.1038/342920a0 · Cited by 616
Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E., & Stark, G. R. (2007) · Genes & Development · doi:10.1101/gad.1553707 · Cited by 611
Rare and low-frequency coding variants alter human adult height
Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., et al. (2017) · Nature · doi:10.1038/nature21039 · Cited by 610
The Receptor for Ciliary Neurotrophic Factor
Davis, S. H., Aldrich, T. H., Valenzuela, D. M., Wong, V., Furth, M. E., Squinto, S. P., & Yancopoulos, G. D. (1991) · Science · doi:10.1126/science.1648265 · Cited by 605
Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130.
Gearing, D. P., Thut, C. J., VandeBos, T., Gimpel, S. D., Delaney, P. B., King, J., Price, V. L., Cosman, D. J., & Beckmann, M. P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07833.x · Cited by 590
Ware, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S., Liggitt, D., Koblar, S. A., Gliniak, B., McKenna, H. J., Papayannopoulou, T., Thoma, B., et al. (1995) · Development · doi:10.1242/dev.121.5.1283 · Cited by 589
IgG1 plasmacytosis in interleukin 6 transgenic mice
Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7547 · Cited by 586
Self-citationLin, Z.-Q., Kondo, T., Ishida, Y., Takayasu, T., & Mukaida, N. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802397 · Cited by 585
Gearing, D. P., Gough, N. M., King, J. A., Hilton, D. J., Nicola, N. A., Simpson, R. J., Nice, E. C., Kelso, A., & Metcalf, D. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02742.x · Cited by 575
Nakajima, K., Yamanaka, Y., Nakae, K., Kojima, H., Ichiba, M., Kiuchi, N., Kitaoka, T., Fukada, T., Hibi, M., & Hirano, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00734.x · Cited by 565
Self-citationOgura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., & Hirano, T. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.018 · Cited by 564
Self-citationDisruption of the CNTF gene results in motor neuron degeneration
Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G., & Thoenen, H. (1993) · Nature · doi:10.1038/365027a0 · Cited by 558
Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.
Pennica, D., King, K. L., Shaw, K. J., Luis, E., Rullamas, J., Luoh, S.-M., Darbonne, W. C., Knutzon, D. S., Yen, R., & Chien, K. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.1142 · Cited by 553
Interleukin-6: Biology, signaling and strategies of blockade
Schaper, F., & Rose‐John, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.004 · Cited by 532
De novo design of potent and selective mimics of IL-2 and IL-15
Silva, D.-A., Yu, S., Ulge, U. Y., Spangler, J. B., Jude, K. M., Labão-Almeida, C., Ali, L. R., Quijano-Rubio, A., Ruterbusch, M., Leung, I., et al. (2019) · Nature · doi:10.1038/s41586-018-0830-7 · Cited by 531
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
Park, S.-J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S.-I., Kamimura, D., Ueda, N., Iwakura, Y., Ishihara, K., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3844 · Cited by 519
Self-citationPlasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
Cassese, G., Arce, S., Hauser, A. E., Lehnert, K., Moewes, B., Mostarac, M., Muehlinghaus, G., Szyska, M., Radbruch, A., & Manz, R. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1684 · Cited by 487
Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486
Leukemia inhibitory factor (LIF)
Nicola, N. A., & Babon, J. J. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.001 · Cited by 478
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Rebouissou, S., Amessou, M., Couchy, G., Poussin, K., Imbeaud, S., Pilati, C., Izard, T., Balabaud, C., Bioulac-Sage, P., & Zucman-Rossi, J. (2009) · Nature · doi:10.1038/nature07475 · Cited by 477
Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474
Robb, L., Li, R., Hartley, L., Nandurkar, H. H., Köentgen, F., & Begley, C. G. (1998) · Nature Medicine · doi:10.1038/nm0398-303 · Cited by 468
The composition and signaling of the IL-35 receptor are unconventional
Collison, L. W., Delgoffe, G. M., Guy, C. S., Vignali, K. M., Chaturvedi, V., Fairweather, D., Satoskar, A. R., García, K. C., Hunter, C. A., Drake, C. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2227 · Cited by 465
Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J.-G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100135197 · Cited by 456
The role of interleukin-6 in mucosal IgA antibody responses in vivo
Ramsay, A. J., Husband, A. J., Ramshaw, L. A., Bao, S., Matthaei, K. I., Koehler, G., & Kopf, M. (1994) · Science · doi:10.1126/science.8160012 · Cited by 454
van Rhee, F., Wong, R. S., Munshi, N., Rossi, J.-F., Ke, X.-Y., Fosså, A., Simpson, D., Capra, M., Liu, T., Hsieh, R. K., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70319-5 · Cited by 454
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444
Putoczki, T. L., Thiem, S., Loving, A., Busuttil, R. A., Wilson, N. J., Ziegler, P. K., Nguyen, P. M., Preaudet, A., Farid, R., Edwards, K. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.017 · Cited by 431
Molnarfi, N., Schulze‐Topphoff, U., Weber, M. S., Patarroyo, J. C., Prod’homme, T., Varrin‐Doyer, M., Shetty, A., Linington, C., Slavin, A., Hidalgo, J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130699 · Cited by 422
Structural Biology of Shared Cytokine Receptors
Wang, X., Lupardus, P. J., LaPorte, S. L., & García, K. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090616 · Cited by 417
Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., & Kishimoto, T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11349 · Cited by 408
Self-citationWSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A. C., Nishina, H., Potter, J., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00206-0 · Cited by 406
Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice
Gallucci, R. M., Simeonova, P. P., Matheson, J. M., Kommineni, C., Guriel, J. L., Sugawara, T., & Luster, M. I. (2000) · The FASEB Journal · doi:10.1096/fj.00-0073com · Cited by 405
Development of Th1-type immune responses requires the type I cytokine receptor TCCR
Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.-H., Gurney, A. L., Grewal, I. S., & de Sauvage, F. J. (2000) · Nature · doi:10.1038/35038103 · Cited by 402
Induction of rat acute‐phase proteins by interleukin 6 in vivo
Geiger, T. M., Andus, T., Klapproth, J., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180510 · Cited by 401
Self-citationLinker, R. A., Mäurer, M., Gaupp, S., Martini, R., Holtmann, B., Giess, R., Rieckmann, P., Lassmann, H., Toyka, K. V., Sendtner, M., et al. (2002) · Nature Medicine · doi:10.1038/nm0602-620 · Cited by 398
Dechiara, T., Vejsada, R., Poueymirou, W., Acheson, A., Suri, C., Conover, J., Friedman, B., Mcclain, J., Pan, L., Stahl, N., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90172-8 · Cited by 395
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
Heink, S., Yogev, N., Garbers, C., Herwerth, M., Aly, L., Gasperi, C., Husterer, V., Croxford, A. L., Möller-Hackbarth, K., Bartsch, H. S., et al. (2017) · Nature Immunology · doi:10.1038/ni.3632 · Cited by 386
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
Ferreira, M. A., Matheson, M. C., Duffy, D. L., Marks, G. B., Hui, J., Le Souëf, P., Danoy, P., Baltic, S., Nyholt, D. R., Jenkins, M., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60874-x · Cited by 381
Hu, Z., Wu, C. H., Shi, Y., Guo, H., Zhao, X., Yin, Z., Yang, L., Dai, J., Hu, L., Tan, W., et al. (2011) · Nature Genetics · doi:10.1038/ng.875 · Cited by 374
Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
Awasthi, A., Riol‐Blanco, L., Jäger, A., Korn, T., Pot, C., Galileos, G., Bettelli, E., Kuchroo, V. K., & Oukka, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900732 · Cited by 365
Escary, J.-L., Perreau, J., Dumènil, D., Ezine, S., & Brûlet, P. (1993) · Nature · doi:10.1038/363361a0 · Cited by 363
Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.228 · Cited by 351
Self-citationIL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells
Diveu, C., McGeachy, M. J., Boniface, K., Stumhofer, J. S., Sathe, M., Joyce-Shaikh, B., Chen, Y., Tato, C. M., McClanahan, T. K., Malefyt, R. D. W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801162 · Cited by 346
Sander, L. E., Sackett, S. D., Dierssen, U., Beraza, N., LINKE, R. P., Müller, M. M., Blander, J. M., Tacke, F., & Trautwein, C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091474 · Cited by 346
Somers, W. S., Stahl, M., & Seehra, J. S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.989 · Cited by 343
Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression1
Riedemann, N., Neff, T., Guo, R., Bernacki, K. D., Laudes, I. J., Sarma, J., Lambris, J. D., & Ward, P. A. (2003) · Journal of Immunology · doi:10.4049/jimmunol.170.1.503 · Cited by 340
Devergne, O., Hummel, M., Koeppen, H., Beau, M. M. L., Nathanson, E., Kieff, E. D., & Birkenbach, M. P. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.1143-1153.1996 · Cited by 338
Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts
Haegeman, G., Content, J., Volckaert, G., DERYNCK, R., Tavernier, J. H., & Fiers, W. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09931.x · Cited by 336
Essential function of LIF receptor in motor neurons
Li, M., Sendtner, M., & Smith, A. G. (1995) · Nature · doi:10.1038/378724a0 · Cited by 321
Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine · doi:10.1038/nm1282 · Cited by 308
Physics of life: The dawn of quantum biology
Ball, P. (2011) · Nature · doi:10.1038/474272a · Cited by 307
Dual Oncostatin M (OSM) Receptors
Mosley, B., Imus, C. D., Friend, D., Boiani, N., Thoma, B., Park, L., & Cosman, D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32635 · Cited by 307
Arima, Y., Harada, M., Kamimura, D., Park, J.-H., Kawano, F., Yull, F. E., Kawamoto, T., Iwakura, Y., Betz, U. A. K., Márquez, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.022 · Cited by 307
Self-citationJAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis
Fragoulis, G. E., McInnes, I. B., & Siebert, S. (2018) · Lara D. Veeken · doi:10.1093/rheumatology/key276 · Cited by 296
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Wang, Q., He, Z., Huang, M., Liu, T., Wang, Y., Xu, H., Duan, H., Ma, P., Zhang, L., Zamvil, S. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03050-0 · Cited by 293
Andus, T., Geiger, T. M., Hirano, T., Northoff, H., Ganter, U., Bauer, J., Kishimoto, T., & Heinrich, P. C. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80344-7 · Cited by 292
Self-citationHuman herpesvirus 8 encodes a homolog of interleukin-6
Neipel, F., Albrecht, J. C., Ensser, A., Huang, Y. Q., Li, J. J., Friedman‐Kien, A. E., & Fleckenstein, B. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.839-842.1997 · Cited by 291
Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., & Hirano, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4109 · Cited by 286
Self-citationOhtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80162-4 · Cited by 284
Self-citationcDNA cloning of murine interleukin-HP1: homology with human interleukin 6
Snick, J. V., Cayphas, S., Szikora, J., Renauld, J., Roost, E. V., Boon, T., & Sirnpson, R. J. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180202 · Cited by 282
Marais, A., Adams, B., Ringsmuth, A. K., Ferretti, M., Gruber, J. M., Hendrikx, R., Schuld, M., Smith, S. L., Sinayskiy, I., Krüger, T. P. J., et al. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0640 · Cited by 274
Heaney, M., & Golde, D. W. (1996) · Blood · doi:10.1182/blood.v87.3.847.bloodjournal873847 · Cited by 273
Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm045 · Cited by 268
Self-citationLIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Butzkueven, H., Zhang, J., Soilu‐Hänninen, M., Hochrein, H., Chionh, F. J. M., Shipham, K. A., Emery, B., Turnley, A. M., Petratos, S., Ernst, M., et al. (2002) · Nature Medicine · doi:10.1038/nm0602-613 · Cited by 263
Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology
Hermanns, H. M. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.006 · Cited by 263
Molecular Phylogeny within Type I Cytokines and Their Cognate Receptors
Boulay, J., O’Shea, J. J., & Paul, W. E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00211-5 · Cited by 262
Stankoff, B., Aigrot, M., Noel, F., Watilliaux, A., Zalc, B., & Lubetzki, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09221.2002 · Cited by 261
Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
Senaldi, G., Varnum, B. C., Sarmiento, U. M., Starnes, C. O., Lile, J., Scully, S. A., Guo, J., Elliott, G., McNinch, J. S., Shaklee, C. L., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11458 · Cited by 253
Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor
McFarland-Mancini, M. M., Funk, H. M., Paluch, A. M., Zhou, M., Giridhar, P. V., Mercer, C. A., Kozma, S. C., & Drew, A. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901929 · Cited by 249
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman’s disease in mice
Brandt, S. J., Bodine, D. M., Dunbar, C. E., & Nienhuis, A. W. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114749 · Cited by 248
Okuda, Y., Sakoda, S., Bernard, C. C. A., Fujimura, H., Saeki, Y., Kishimoto, T., & Yanagihara, T. (1998) · International Immunology · doi:10.1093/intimm/10.5.703 · Cited by 244
Bernad, A., Kopf, M., Kulbacki, R., Weich, N., Koehler, G., & Gutiérrez-Ramos, J. (1994) · Immunity · doi:10.1016/s1074-7613(94)80014-6 · Cited by 242
Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., et al. (1999) · Blood · doi:10.1182/blood.v93.6.1809.406k35_1809_1816 · Cited by 239
Self-citationWard, L. D., Howlett, G. J., Discolo, G., Yasukawa, K., Hammacher, A., Moritz, R. L., & Simpson, R. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31651-4 · Cited by 237
Tamm, C., Böwer, N., & Annerén, C. (2011) · Journal of Cell Science · doi:10.1242/jcs.075796 · Cited by 231
Wunderlich, F. T., Ströhle, P., Könner, A. C., Gruber, S., Tovar, S., Brönneke, H. S., Juntti-Berggren, L., Li, L.-S., van Rooijen, N., Libert, C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.011 · Cited by 229
Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice
Metcalf, D., Nicola, N. A., & Gearing, D. (1990) · Blood · doi:10.1182/blood.v76.1.50.50 · Cited by 229
Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.232 · Cited by 227
Self-citationArid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo
Masuda, K., Ripley, B., Nishimura, R., Mino, T., Takeuchi, O., Shioi, G., Kiyonari, H., & Kishimoto, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307419110 · Cited by 226
Atsumi, T., Ishihara, K., Kamimura, D., Ikushima, H., Ohtani, T., Hirota, S., Kobayashi, H., Park, S.-J., Saeki, Y., Kitamura, Y., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020619 · Cited by 225
Self-citationInterleukin-6 is required for a protective immune response to systemic Escherichia coli infection
Dalrymple, S., Slattery, R., Aud, D., Krishna, M., Lucian, L., & Murray, R. (1996) · Infection and Immunity · doi:10.1128/iai.64.8.3231-3235.1996 · Cited by 224
Betz, U. A. K., Bloch, W., van den Broek, M. F., Yoshida, K., Taga, T., Kishimoto, T., Addicks, K., Rajewsky, K., & Müller, W. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1955 · Cited by 218
Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., Richards, P. J., Slinn, S., Ernst, M., Jenkins, B. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.613 · Cited by 215
Receptor recognition by gp130 cytokines
Bravo, J., & Heath, J. K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2399 · Cited by 214
Robinson, R. C. (1994) · Cell · doi:10.1016/0092-8674(94)90449-9 · Cited by 213
Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M., & Hirano, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00500.x · Cited by 213
Self-citationThe Two-Faced Cytokine IL-6 in Host Defense and Diseases
Narazaki, M., & Kishimoto, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113528 · Cited by 211
Nguyen, H., Noss, E. H., Mizoguchi, F., Huppertz, C., Wei, K. S., Watts, G. F. M., & Brenner, M. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.004 · Cited by 210
Schwerd, T., Twigg, S. R. F., Aschenbrenner, D., Manrique, S., Miller, K. A., Taylor, I. B., Capitani, M., McGowan, S. J., Sweeney, E. A., Weber, A. P., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161810 · Cited by 209
May, L. T., HELFGOTT, D. C., & Sehgal, P. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.8957 · Cited by 206
Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.
Baumann, H., & Schendel, P. F. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54940-1 · Cited by 204
Nieminen, P., Morgan, N. V., Fenwick, A. L., Parmanen, S., Veistinen, L., Mikkola, M. L., van der Spek, P. J., Giraud, A. S., Judd, L. M., Arte, S., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.024 · Cited by 200
CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT
Watowich, S. S., Wu, H., Socolovsky, M., Klingmüller, U., Constantinescu, S. N., & Lodish, H. F. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.91 · Cited by 200
A null mutation in the human CNTF gene is not causally related to neurological diseases
Takahashi, R., Yokoji, H., Misawa, H., Hayashi, M., Hu, J., & Deguchi, T. (1994) · Nature Genetics · doi:10.1038/ng0594-79 · Cited by 199
Malik, N., Kallestad, J. C., Gunderson, N. L., Austin, S. D., Neubauer, M., Ochs, V., Marquardt, H., Zarling, J. M., SHOYAB, M., Wei, C., et al. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.7.2847 · Cited by 198
Dagoneau, N., Scheffer, D. I., Huber, C., Al-Gazali, L. I., Rocco, M. D., Godard, A., Martinovic, J., Raas‐Rothschild, A., Sigaudy, S., Unger, S., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/381715 · Cited by 189
Jones, G. W., McLoughlin, R. M., Hammond, V. J., Parker, C. R., Williams, J. D., Malhotra, R., Scheller, J., Williams, A. S., Rose-John, S., Topley, N., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901528 · Cited by 189
Liu, J., Guan, X., & Ma, X. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061440 · Cited by 188
A novel IL‐23p19/Ebi3 (IL‐39) cytokine mediates inflammation in Lupus‐like mice
Wang, X., Wei, Y., He, X., Liu, X., Zhang, Y., Han, G., Chen, G., Hou, C., Ma, N., Shen, B., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546095 · Cited by 185
Gearing, D. P., & Cosman, D. J. (1991) · Cell · doi:10.1016/0092-8674(91)90131-h · Cited by 181
Sawa, S.-I., Kamimura, D., Jin, G.-H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M., & Hirano, T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052187 · Cited by 176
Self-citationTargeted disruption of oncostatin M receptor results in altered hematopoiesis
Tanaka, M., Hirabayashi, Y., Sekiguchi, T., Inoue, T., Katsuki, M., & Miyajima, A. (2003) · Blood · doi:10.1182/blood-2003-02-0367 · Cited by 176
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Hirata, Y., Taga, T., Hibi, M., Nakano, N., Hirano, T., & Kishimoto, T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.9.2900 · Cited by 175
Self-citationDisruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice
Nieuwenhuis, E. E. S., Neurath, M. F., Corazza, N., Iijima, H., Trgovcich, J., Wirtz, S. J., Glickman, J. N., Bailey, D. T., Yoshida, M., Galle, P. R., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252648899 · Cited by 172
Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
HIRANO, T. (2010) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.86.717 · Cited by 172
Self-citationCiliary neurotrophic factor: Pharmacokinetics and acute‐phase response in rat
Dittrich, F., Theonen, H., & Sendtner, M. (1994) · Annals of Neurology · doi:10.1002/ana.410350206 · Cited by 171
Chew, E. Y., Clemons, T. E., Jaffe, G. J., Johnson, C. A., Farsiu, S., Lad, E. M., Guymer, R. H., Rosenfeld, P. J., Hubschman, J., Constable, I. J., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.09.041 · Cited by 171
The soluble interleukin 6 receptor: advanced therapeutic options in inflammation
Rose‐John, S. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.782 · Cited by 169
Cao, W., Yang, Y., Wang, Z., Liu, A., Fang, L., Wu, F., Hong, J., Shi, Y., Leung, S., Dong, C., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.011 · Cited by 168
Wu, C. Y., Wang, X., Gadina, M., O’Shea, J. J., Presky, D. H., & Magram, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6221 · Cited by 165
Mease, P. J., Gottlieb, A. B., Berman, A., Drescher, E., Xing, J. W., Wong, R. L., & Banerjee, S. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39700 · Cited by 152
Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis
Arita, K., South, A. P., Filho, G. H., Sakuma, T. H., Lai‐Cheong, J. E., Clements, S. E., Odashiro, M., Odashiro, D. N., Hans-Neto, G., Hans, N. R., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.002 · Cited by 149
Regulation of the acute phase and immune responses: interleukin-6.
Sehgal, P. B. (1989) · PubMed · Cited by 148
Skiniotis, G., Boulanger, M. J., García, K. C., & Walz, T. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb941 · Cited by 146
Cloning and Characterization of a Novel Class I Cytokine Receptor
Sprecher, C. A., Grant, F. J., Baumgartner, J. W., Presnell, S., Schrader, S. K., Yamagiwa, T., Whitmore, T. E., O’Hara, P. J., & Foster, D. F. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8576 · Cited by 143
Hasegawa, H., Mizoguchi, I., Chiba, Y., Ohashi, M., Xu, M., & Yoshimoto, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00479 · Cited by 142
Interleukin-11 Potentiates Oligodendrocyte Survival and Maturation, and Myelin Formation
Zhang, Y., Taveggia, C., Melendez‐Vasquez, C. V., Einheber, S., Raine, C. S., Salzer, J. L., Brosnan, C. F., & John, G. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2289-06.2006 · Cited by 141
Structure of the IFNγ receptor complex guides design of biased agonists
Mendoza, J. L., Escalante, N. K., Jude, K. M., Bellón, J. S., Su, L., Horton, T. M., Tsutsumi, N., Berardinelli, S. J., Haltiwanger, R. S., Piehler, J., et al. (2019) · Nature · doi:10.1038/s41586-019-0988-7 · Cited by 138
Oppenheim, R. W., Wiese, S., Prevette, D. M., Armanini, M. P., Wang, S., Houenou, L. J., Holtmann, B., Götz, R., Pennica, D., & Sendtner, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01283.2001 · Cited by 137
Suthaus, J., Stuhlmann-Laeisz, C., Tompkins, V., Rosean, T. R., Klapper, W., Tosato, G., Janz, S., Scheller, J., & Rose-John, S. (2012) · Blood · doi:10.1182/blood-2011-09-377705 · Cited by 131
IL-6: a cytokine at the crossroads of autoimmunity
Jones, B. E., Maerz, M. D., & Buckner, J. H. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.002 · Cited by 131
Lanktree, M. B., Guo, Y., Murtaza, M., Glessner, J., Bailey, S. D., Onland‐Moret, N. C., Lettre, G., Ongen, H., Rajagopalan, R., Johnson, T., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.007 · Cited by 130
Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease
Fajgenbaum, D. C. (2018) · Blood · doi:10.1182/blood-2018-05-848671 · Cited by 130
Haroon, F., Drögemüller, K., Händel, U., Brunn, A., Reinhold, D., Nishanth, G., Müller, W., Trautwein, C., Ernst, M., Deckert, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001135 · Cited by 122
Alveolar Epithelial STAT3, IL-6 Family Cytokines, and Host Defense during Escherichia coli Pneumonia
Quinton, L. J., Jones, M. R., Robson, B. E., Simms, B. T., Whitsett, J. A., & Mizgerd, J. P. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0365oc · Cited by 118
Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily
Jones, L. L., & Vignali, D. A. A. (2011) · Immunologic Research · doi:10.1007/s12026-011-8209-y · Cited by 114
Endogenous and Exogenous IL-6 Inhibit Aeroallergen-Induced Th2 Inflammation
Wang, J., Homer, R., Chen, Q., & Elias, J. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.4051 · Cited by 114
Cardiotrophin-1 Is a Key Regulator of Glucose and Lipid Metabolism
Moreno-Aliaga, M. J., Pérez-Echarri, N., Marcos‐Gómeź, B., Larequi, E., Gil-Bea, F. J., Viollet, B., Gimenez-Lopez, I., Martínez, J. A., Prìeto, J., & Bustos, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.013 · Cited by 113
Sidell, N., Taga, T., Hirano, T., Kishimoto, T., & Saxon, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.11.3809 · Cited by 113
Self-citationDisease-association analysis of an inflammation-related feedback loop
Murakami, M., Harada, M., Kamimura, D., Ogura, H., Okuyama, Y., Kumai, N., Okuyama, A., Singh, R., Jiang, J.-J., Atsumi, T., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.028 · Cited by 110
Self-citationA functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
Esparza-Gordillo, J., Schaarschmidt, H., Liang, L., Cookson, W., Bauerfeind, A., Lee-Kirsch, M.-A., Nemat, K., Henderson, J., Paternoster, L., Harper, J. I., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.057 · Cited by 107
Zimmermann, M., Bianchetto-Aguilera, F. M., Castellucci, M., Rossato, M., Costa, S. E., Lunardi, C., Ostuni, R., Girolomoni, G., Natoli, G., Bazzoni, F., et al. (2015) · Nature Communications · doi:10.1038/ncomms7061 · Cited by 105
Quintana, A., Erta, M., Ferrer, B., Comes, G., Giralt, M., & Hidalgo, J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.011 · Cited by 104
Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20100900 · Cited by 100
Self-citationHu, L., Yu, Y., Huang, H., Fan, H., Hu, L., Yin, C., Li, K., Fulton, D. J. R., & Chen, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00696 · Cited by 100
Gubernatorova, E. O., Gorshkova, E. A., Namakanova, O. A., Zvartsev, R. V., Hidalgo, J., Drutskaya, M. S., Tumanov, A. V., & Nedospasov, S. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02718 · Cited by 100
Association of a Null Mutation in the CNTF Gene With Early Onset of Multiple Sclerosis
Giess, R., Mäurer, M., Linker, R. A., Gold, R., Warmuth‐Metz, M., Toyka, K. V., Sendtner, M., & Rieckmann, P. (2002) · Archives of Neurology · doi:10.1001/archneur.59.3.407 · Cited by 98
Shahin, T., Aschenbrenner, D., Cağdaş, D. N., Bal, S. K., Conde, C. D., Garncarz, W., Medgyesi, D., Schwerd, T., Karaatmaca, B., Çetinkaya, P. G., et al. (2018) · Haematologica · doi:10.3324/haematol.2018.194233 · Cited by 96
Xu, E., Pereira, M. M. A., Karakasilioti, I., Theurich, S., Al-Maarri, M., Rappl, G., Waisman, A., Wunderlich, F. T., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms14803 · Cited by 95
StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00901-6 · Cited by 94
NEDD4 Is Involved in Inflammation Development during Keloid Formation
Fujita, M., Yamamoto, Y., Jiang, J., Atsumi, T., Tanaka, Y., Ohki, T., Murao, N., Funayama, E., Hayashi, T., Osawa, M., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.07.044 · Cited by 94
Self-citationPlun‐Favreau, H., Elson, G., Chabbert, M., Froger, J., deLapeyrière, O., Lelièvre, E., Guillet, C., Hermann, J., Gauchat, J., Gascan, H., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1692 · Cited by 92
Do, J., Kim, D., Kim, S., Valentin-Torres, A., Dvorina, N., Jang, E., Nagarajavel, V., DeSilva, T. M., Li, X., Ting, A. H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703100114 · Cited by 92
Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11
Chérel, M., Sorel, M., Lebeau, B., Dubois, S. P., Moreau, J., Bataille, R., Minvielle, S., & Jacques, Y. (1995) · Blood · doi:10.1182/blood.v86.7.2534.2534 · Cited by 88
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)
Hirano, T., Matsuda, T., Hosoi, K., Okano, A., Matsui, H., & Kishimoto, T. (1988) · Immunology Letters · doi:10.1016/0165-2478(88)90099-5 · Cited by 86
Self-citationDiscovery and characterization of olokizumab
Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A. J., Popplewell, A. G., Adams, R., BAKER, T. S., Rapecki, S., et al. (2014) · mAbs · doi:10.4161/mabs.28612 · Cited by 86
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier, P. C., May, U., Scheller, J., Rose-John, S., & Schiffelholz, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.013 · Cited by 84
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The cytokine storm and COVID-19
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IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“IL-6 is a prototypical member of the IL-6 family of cytokines, which is composed of 10 members including IL-6, IL-11, IL-27, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine factor 1 (CLCF1), IL-35 and IL-39 (33).”
BackgroundInfluentialSelf-citationCOVID-19: a new virus, but a familiar receptor and cytokine release syndrome
Hirano, T., & Murakami, M. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.003 · Cited by 772
Self-citationThe cytokine network involved in the host immune response to periodontitis
Pan, W., Wang, Q., & Chen, Q. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0064-z · Cited by 740
How COVID-19 induces cytokine storm with high mortality
Hojyo, S., Uchida, M., Tanaka, K., Hasebe, R., Tanaka, Y., Murakami, M., & Hirano, T. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00146-3 · Cited by 663
Self-citation
Metadata
- Authors
- Murakami, M., Kamimura, D., & Hirano, T.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Hirano, Toshio
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 50
- Issue
- 4
- Pages
- 812-831
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2936183454
- Cited by
- 533
- References
- 280
- Citations by year
- 2026: 52 · 2025: 70 · 2024: 76 · 2023: 69 · 2022: 90 · 2021: 98 · 2020: 63 · 2019: 15
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- JSPS-KAKENHI
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- interleukin-6, IL-6 family cytokines, gp130, cytokine signaling, functional redundancy, pleiotropy, specificity, autoimmune disease, cytokine structure, therapeutic targeting
- MeSH terms
- Interleukin-6 Inhibitors, Animals, Autoimmune Diseases, Gene Expression Regulation, Multigene Family, Inflammation, Structure-Activity Relationship, Signal Transduction, Interleukin-6, Cytokines, Receptors, Cytokine, Receptors, Interleukin-6, Protein Subunits, Mice, Genetic Pleiotropy
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