DNA damage in the oligodendrocyte lineage and its role in brain aging

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129

Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383

The handbook of aging and cognition

Mitchell, D. B. (2001) · Applied Cognitive Psychology · doi:10.1002/acp.747 · Cited by 1,898

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177

Inflammatory cortical demyelination in early multiple sclerosis.

Lucchinetti, C. F., Popescu, B. F. G., Bunyan, R. F., Moll, N. M., Roemer, S. F., Lassmann, H., Brück, W., Parisi, J. E., Scheithauer, B. W., Giannini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100648 · Cited by 1,103

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008

Untitled work

(2000) · Cited by 1,006

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961

Candidate mechanisms for chemotherapy-induced cognitive changes

Ahles, T. A., & Saykin, A. J. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2073 · Cited by 958

Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury

Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799

Senescence and aging: the critical roles of p53

Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia

Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00455.2002 · Cited by 795

The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.

Gunning-Dixon, F. M., & Raz, N. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.2.224 · Cited by 794

The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.

Gunning‐Dixon, F. M., & Raz, N. (2000) · Neuropsychology · doi:10.1037//0894-4105.14.2.224 · Cited by 790

The case for rejecting the amyloid cascade hypothesis

Herrup, K. (2015) · Nature Neuroscience · doi:10.1038/nn.4017 · Cited by 768

Oxidative damage in multiple sclerosis lesions

Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754

The MRE11 complex: starting from the ends

Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700

Prolonged myelination in human neocortical evolution

Miller, D. J., Duka, T., Stimpson, C. D., Schapiro, S. J., Baze, W. B., McArthur, M. J., Fobbs, A. J., Sousa, A. M. M., Šestan, N., Wildman, D. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117943109 · Cited by 699

Impaired adult myelination in the prefrontal cortex of socially isolated mice

Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685

Effects of age on volumes of cortex, white matter and subcortical structures

Walhovd, K. B., Fjell, A. M., Reinvang, I., Lundervold, A., Dale, A. M., Eilertsen, D. E., Quinn, B. T., Salat, D. H., Makris, N., & Fischl, B. R. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.020 · Cited by 674

Control of local protein synthesis and initial events in myelination by action potentials

Wake, H., Lee, P. R., & Fields, R. D. (2011) · Science · doi:10.1126/science.1206998 · Cited by 636

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1899 · Cited by 629

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development

Barrès, A., Lazar, M. A., & RAFF, M. C. (1994) · Development · doi:10.1242/dev.120.5.1097 · Cited by 593

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

Back, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559

Cortical Lesions and Atrophy Associated With Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis

Calabrese, M., Agosta, F., Rinaldi, F., Mattisi, I., Grossi, P., Favaretto, A., Atzori, M., Bernardi, V., Barachino, L., Rinaldi, L., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.174 · Cited by 556

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 499

Age-dependent fate and lineage restriction of single NG2 cells

Zhu, X., Hill, R. A., Dietrich, D., Komitova, M., Suzuki, R., & Nishiyama, A. (2011) · Development · doi:10.1242/dev.047951 · Cited by 464

Neuronal activity biases axon selection for myelination in vivo

Hines, J. H., Ravanelli, A. M., Schwindt, R. K., Scott, E. K., & Appel, B. (2015) · Nature Neuroscience · doi:10.1038/nn.3992 · Cited by 460

White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging

Barber, R., Scheltens, P., Gholkar, A., Ballard, C., McKeith, I., Ince, P., Perry, R., & O'Brien, J. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.1.66 · Cited by 440

White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease

Bartzokis, G., Cummings, J. L., Sultzer, D. L., Henderson, V. W., Nuechterlein, K. H., & Mintz, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.393 · Cited by 431

Astroglia in dementia and Alzheimer's disease

Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 409

Reimagining Alzheimer's Disease—An Age-Based Hypothesis

Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 408

Prefrontal white matter volume is disproportionately larger in humans than in other primates

Schoenemann, P. T., Sheehan, M. J., & Glotzer, L. D. (2005) · Nature Neuroscience · doi:10.1038/nn1394 · Cited by 406

Patterns of oligodendroglia pathology in multiple sclerosis

Ozawa, K., Suchanek, G., Breitschopf, H., Br€ck, W., Budka, H., Jellinger, K. A., & Lassmann, H. (1994) · Brain · doi:10.1093/brain/117.6.1311 · Cited by 404

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3991 · Cited by 398

Diffusion tensor imaging of post mortem multiple sclerosis brain

Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395

Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress

Thorburne, S. K., & Juurlink, B. H. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031014.x · Cited by 390

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382

Understanding White Matter Disease: Imaging-Pathological Correlations in Vascular Cognitive Impairment

Black, S., Gao, F., & Bilbao, J. (2009) · Stroke · doi:10.1161/strokeaha.108.537704 · Cited by 379

Role of myelin plasticity in oscillations and synchrony of neuronal activity

Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378

Dwarfism with retinal atrophy and deafness

Cockayne, E. A. (1936) · Archives of Disease in Childhood · doi:10.1136/adc.11.61.1 · Cited by 377

Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation

Samanta, J., & Kessler, J. A. (2004) · Development · doi:10.1242/dev.01273 · Cited by 361

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

Lee, J., Choy, M. L., Ngo, L., Foster, S. S., & Marks, P. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1008522107 · Cited by 359

TFIIH: when transcription met DNA repair

Compe, E., & Egly, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3350 · Cited by 357

Widespread Demyelination in the Cerebellar Cortex in Multiple Sclerosis

Kutzelnigg, A., Faber-Rod, J., Bauer, J., Lucchinetti, C. F., Sørensen, P. S., Laursen, H. B., Stadelmann, C., Brück, W., Rauschka, H., Schmidbauer, M., et al. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00041.x · Cited by 339

Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition

van der Horst, G. T. J., STEEG, H. V., Berg, R. J. W., van Gool, A. J., de Wit, J., Weeda, G., Morreau, H., Beems, R. B., van Kreijl, C. F., de Gruijl, F. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80223-8 · Cited by 339

Neuropathologic correlates of white matter hyperintensities

Young, V. G., Halliday, G. M., & Kril, J. J. (2008) · Neurology · doi:10.1212/01.wnl.0000319691.50117.54 · Cited by 336 · cited 2×

Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain

Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 336

Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

Lu, F., Selak, M. A., O'Connor, J. J., Croul, S. E., Lorenzana, C., Butunoi, C., & Kálmán, B. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00343-9 · Cited by 331

Oligodendrocyte development and the onset of myelination in the human fetal brain

Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323

A common brain network links development, aging, and vulnerability to disease

Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317

Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex

Salami, M., Itami, C., Tsumoto, T., & Kimura, F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937380100 · Cited by 314

Intracortical Myelin Links with Performance Variability across the Human Lifespan: Results from T1- and T2-Weighted MRI Myelin Mapping and Diffusion Tensor Imaging

Grydeland, H., Walhovd, K. B., Tamnes, C. K., Westlye, L. T., & Fjell, A. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2811-13.2013 · Cited by 308

Multiple sclerosis normal‐appearing white matter: Pathology–imaging correlations

Moll, N. M., Rietsch, A. M., Thomas, S., Ransohoff, A. J., Lee, J., Fox, R., Chang, A., Ransohoff, R. M., & Fisher, E. (2011) · Annals of Neurology · doi:10.1002/ana.22521 · Cited by 297

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

Scolding, N. J. (1998) · Brain · doi:10.1093/brain/121.12.2221 · Cited by 293

Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression

Marin‐Husstege, M., Muggironi, M., Liu, A., & Casaccia-Bonnefil, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10333.2002 · Cited by 293

Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

Gouw, A. A., Seewann, A., Vrenken, H., van der Flier, W. M., Rozemuller, J. M., Barkhof, F., Scheltens, P., & Geurts, J. J. G. (2008) · Brain · doi:10.1093/brain/awn265 · Cited by 281

Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey

Peters, A., & Sethares, C. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.10099 · Cited by 274

The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation

He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 272

Response of Schwann Cells to Action Potentials in Development

Stevens, B., & Fields, R. D. (2000) · Science · doi:10.1126/science.287.5461.2267 · Cited by 271

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

Bujalka, H., Koenning, M., Jackson, S., Perreau, V. M., Pope, B., Hay, C. M., Mitew, S., Hill, A. F., Lu, Q. R., Wegner, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001625 · Cited by 271 · cited 5×

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

Mitew, S., Hay, C. M., Peckham, H., Xiao, J., Koenning, M., & Emery, B. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.029 · Cited by 268

Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

Desai, M. K., Sudol, K. L., Janelsins, M. C., Mastrangelo, M. A., Frazer, M. E., & Bowers, W. J. (2009) · Glia · doi:10.1002/glia.20734 · Cited by 266

Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

Psachoulia, K., Jamen, F., Young, K. M., & Richardson, W. D. (2009) · Neuron Glia Biology · doi:10.1017/s1740925x09990354 · Cited by 257

Cockayne syndrome and xeroderma pigmentosum

Rapin, I., Lindenbaum, Y., Dickson, D. W., Kraemer, K. H., & Robbins, J. H. (2000) · Neurology · doi:10.1212/wnl.55.10.1442 · Cited by 255

Myelination, oligodendrocytes, and serious mental illness

Haroutunian, V. H., Katsel, P., Roussos, P., Davis, K. L., Altshuler, L. L., & Bartzokis, G. (2014) · Glia · doi:10.1002/glia.22716 · Cited by 251

Ataxia telangiectasia mutated activation by transcription‐ and topoisomerase I‐induced DNA double‐strand breaks

Sordet, O., Redon, C. E., Guirouilh‐Barbat, J., Smith, S. H., Solier, S., Douarre, C., Conti, C., Nakamura, A., Das, B. B., Nicolas, E., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.97 · Cited by 245

Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

Mattson, M. P., & Liu, D. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:215 · Cited by 242

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative‐induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

Marchesi, V. T. (2011) · The FASEB Journal · doi:10.1096/fj.11-0102ufm · Cited by 232

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

Desai, M. K., Mastrangelo, M. A., Ryan, D. A., Sudol, K. L., Narrow, W. C., & Bowers, W. J. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100087 · Cited by 232

Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS

Koenning, M., Jackson, S., Hay, C. M., Faux, C. H., Kilpatrick, T. J., Willingham, M. M., & Emery, B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1069-12.2012 · Cited by 231

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230

Neuropathologic basis of white matter hyperintensity accumulation with advanced age

Erten‐Lyons, D., Woltjer, R. L., Kaye, J. A., Mattek, N., Dodge, H. H., Green, S., Tran, H. T. D., Howieson, D. B., Wild, K. V., & Silbert, L. C. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e45 · Cited by 227

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219

Induction of oligodendrocyte differentiation by Olig2 and Sox10: Evidence for reciprocal interactions and dosage-dependent mechanisms

Liu, Z., Hu, X., Cai, J., Liu, B., Peng, X., Wegner, M., & Qiu, M. S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.007 · Cited by 217

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

Kashiyama, K., Nakazawa, Y., Pilz, D. T., Guo, C., Shimada, M., Sasaki, K., Fawcett, H., Wing, J., Lewin, S. O., Carr, L., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.007 · Cited by 212

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012) · Nature Medicine · doi:10.1038/nm.2709 · Cited by 210

Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging

Holland, C. M., Smith, E. E., Csapo, I., Gurol, M. E., Brylka, D. A., Killiany, R., Blacker, D., Albert, M., Guttmann, C. R. G., & Greenberg, S. M. (2008) · Stroke · doi:10.1161/strokeaha.107.497438 · Cited by 204

Arrested Oligodendrocyte Lineage Progression During Human Cerebral White Matter Development: Dissociation Between the Timing of Progenitor Differentiation and Myelinogenesis

Back, S. A., Luo, N. L., Borenstein, N. S., Volpe, J. J., & Kinney, H. C. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.2.197 · Cited by 196

White Matter Hyperintensities and Cerebral Amyloidosis: Necessary and Sufficient for Clinical Expression of Alzheimer Disease?

Provenzano, F. A., Muraskin, J., Tosto, G., Narkhede, A., Wasserman, B. T., Griffith, E. Y., Guzman, V. A., Meier, I. B., Zimmerman, M. E., Brickman, A. M., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1321 · Cited by 192

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

Li, J., Hart, R. P., Mallimo, E. M., Swerdel, M. R., Kusnecov, A. W., & Herrup, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3564 · Cited by 177

Genomic integrity and the ageing brain

Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4020 · Cited by 174

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169

Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

Pang, Y., Campbell, L., Zheng, B., Fan, L.-W., Cai, Z., & Rhodes, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.040 · Cited by 167

DNA damage stabilizes interaction of CSB with the transcription elongation machinery

van den Boom, V., Citterio, E., Hoogstraten, D., Zotter, A., Egly, J., van Cappellen, W. A., Hoeijmakers, J. H. J., Houtsmuller, A. B., & Vermeulen, W. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401056 · Cited by 166

Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well

Brown, W. R., Moody, D. M., Thore, C. R., Challa, V. R., & Anstrom, J. A. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.015 · Cited by 162

Molecular Analysis of Mutations in the CSB(ERCC6) Gene in Patients with Cockayne Syndrome

Mallery, D. L., Tanganelli, B., Colella, S., Steingrimsdottir, H., van Gool, A. J., Troelstra, C., Stefanini, M., & Lehmann, A. R. (1998) · The American Journal of Human Genetics · doi:10.1086/301686 · Cited by 161

Ataxia telangiectasia mutated is essential during adult neurogenesisPreprint

Allen, D. M., van Praag, H., Ray, J., Ohler, Z. W., Winrow, C. J., Carter, T. A., Braquet, R., Harrington, E. A., Ried, T., Brown, K. D., et al. (2001) · Genes & Development · doi:10.1101/gad.869001 · Cited by 159

Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain

Gururaj Joshi, A., Aluise, C. D., Cole, M. P., Rukhsana Sultana, A., Pierce, W. M. J., Vore, M. E., Clair, D. K. S., & Butterfield, D. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.021 · Cited by 159

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Katyal, S., Lee, Y., Nitiss, K. C., Downing, S. M., Li, Y., Shimada, M., Zhao, J., Russell, H. R., Petrini, J. H. J., Nitiss, J. L., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3715 · Cited by 152

The Cockayne Syndrome Group B Gene Product Is Involved in General Genome Base Excision Repair of 8-Hydroxyguanine in DNA

Tuo, J., Müftüoğlu, M., Chen, C., Jaruga, P., Selzer, R. R., Brosh, R. M., Rodriguez, H., Dizdaroğlu, M., & Bohr, V. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107888200 · Cited by 150

White matter hyperintensities predict amyloid increase in Alzheimer's disease

Grimmer, T., Faust, M., Auer, F., Alexopoulos, P., Förstl, H., Henriksen, G., Perneczky, R., Sorg, C., Yousefi, B. H., Drzezga, A. E., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.016 · Cited by 146

Differential aging of cerebral white matter in middle-aged and older adults: A seven-year follow-up

Bender, A. R., Voelkle, M. C., & Raz, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.030 · Cited by 143

Minocycline alleviates hypoxic–ischemic injury to developing oligodendrocytes in the neonatal rat brain

Cai, Z., Lin, S., Fan, L.-W., Pang, Y., & Rhodes, P. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.023 · Cited by 141

Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death

Daroui, P., Desai, S. D., Li, T., Liu, A. A., & Liu, L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311370200 · Cited by 138

Oxidative damage to DNA in plaques of MS brains

Vladimirova, O. V., O'Connor, J. J., Cahill, A., Alder, H., Butunoi, C., & Kálmán, B. (1998) · Multiple Sclerosis Journal · doi:10.1177/135245859800400503 · Cited by 138

Neurological symptoms and natural course of xeroderma pigmentosum

Anttinen, A., Koulu, L., Nikoskelainen, E., Portin, R., Kurki, T., Erkinjuntti, M., Jaspers, N. G. J., Raams, A., Green, M. H. L., Lehmann, A. R., et al. (2008) · Brain · doi:10.1093/brain/awn126 · Cited by 132

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells

Lyssiotis, C. A., Walker, J. R., Wu, C., Kondo, T., Schultz, P. G., & Wu, X. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707044104 · Cited by 132

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Stevnsner, T., Müftüoğlu, M., Aamann, M. D., & Bohr, V. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.009 · Cited by 130

A fourth type of neuroglial cell in the adult central nervous system

Peters, A. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000044195.64009.27 · Cited by 129

Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation

Liu, J., Magri, L., Zhang, F., Marsh, N. O., Albrecht, S., Huynh, J. L., Kaur, J., Kuhlmann, T., Zhang, W., Slesinger, P. A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2606-14.2015 · Cited by 129

Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism

Yang, Y. F., & Herrup, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4946-04.2005 · Cited by 129

Cockayne syndrome in adults: Review with clinical and pathologic study of a new case

Rapin, I., Weidenheim, K., Lindenbaum, Y., Rosenbaum, P., Merchant, S. N., Krishna, S., & Dickson, D. W. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210110101 · Cited by 124

Neuroimaging In Cockayne Syndrome

Koob, M., Laugel, V., Durand, M., Fothergill, H., Dalloz, C., Sauvanaud, F., Dollfus, H., Namer, I. J., & Dietemann, J. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2135 · Cited by 118

Morphometric Analysis of Arteriolar Tortuosity in Human Cerebral White Matter of Preterm, Young, and Aged Subjects

Thore, C. R., Anstrom, J. A., Moody, D. M., Challa, V. R., Marion, M. C., & Brown, W. R. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180537147 · Cited by 114

The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment

Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., Brickman, A. M., & Initiative, A. D. N. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.014 · Cited by 112

Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes

Lasiene, J., Matsui, A., Sawa, Y., Wong, F., & Horner, P. J. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00462.x · Cited by 111

Valproic acid increases white matter repair and neurogenesis after stroke

Liu, X., Chopp, M., Kassis, H., Jia, L., Hozeska‐Solgot, A., Zhang, R. L., Chen, C., Cui, Y. S., & Zhang, Z. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.012 · Cited by 111

Thyroid Hormone Regulates Oligodendrocyte Accumulation in Developing Rat Brain White Matter Tracts

Schoonover, C. M., Seibel, M. M., Jolson, D. M., Stack, M. J., Rahman, R. J., Jones, S. A., Mariash, C. N., & Anderson, G. W. (2004) · Endocrinology · doi:10.1210/en.2004-0065 · Cited by 111

Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

Thurn, K. T., Thomas, S., Raha, P., Qureshi, I., & Münster, P. N. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1242 · Cited by 108

Cholesterol synthesis rate in human hippocampus declines with aging

Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.034 · Cited by 107

Age‐Associated White Matter Lesions: The MRC C ognitive F unction and A geing S tudy

Wharton, S. B., Simpson, J. E., Brayne, C., & Ince, P. G. (2014) · Brain Pathology · doi:10.1111/bpa.12219 · Cited by 105

The Glial or Neuronal Fate Choice of Oligodendrocyte Progenitors Is Modulated by Their Ability to Acquire an Epigenetic Memory

Liu, A., Han, Y. R., Li, J., Sun, D., Ouyang, M., Plummer, M. R., & Casaccia‐Bonnefil, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1226-07.2007 · Cited by 97

NF-?B modulates lipopolysaccharide-induced microglial nerve growth factor expression

Heese, K., Fiebich, B. L., Bauer, J., & Otten, U. (1998) · Glia · doi:10.1002/(sici)1098-1136(199804)22:4 · Cited by 96

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

Compe, E., Malerba, M., Soler, L., Marescaux, J., Borrelli, E., & Egly, J. (2007) · Nature Neuroscience · doi:10.1038/nn1990 · Cited by 95

Cockayne syndrome: Unusual neuropathological findings and review of the literature

Soffer, D., Grotsky, H. W., Rapin, I., & Suzuki, K. (1979) · Annals of Neurology · doi:10.1002/ana.410060407 · Cited by 93

Epigenetic memory loss in aging oligodendrocytes in the corpus callosum

Shen, S., Liu, A., Li, J., Wolubah, C., & Casaccia‐Bonnefil, P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.026 · Cited by 92

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

Al‐Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Medical Research Council Cognitive Function and Ageing Study (2015) · Brain Pathology · doi:10.1111/bpa.12216 · Cited by 85

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

Jiang, D., Zhang, Y., Hart, R. P., Chen, J., Herrup, K., & Li, J. (2015) · Brain · doi:10.1093/brain/awv284 · Cited by 84

The entorhinal cortex: an examination of cyto- and myeloarchitectonic organization in humans

Krimer, L. S. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.8.722 · Cited by 83

Xeroderma pigmentosum/Cockayne syndrome complex: first neuropathological study and review of eight other cases

Lindenbaum, Y., Dickson, D. W., Rosenbaum, P. S., Kraemer, K. H., Robbins, J. H., & Rapin, I. (2001) · European Journal of Paediatric Neurology · doi:10.1053/ejpn.2001.0523 · Cited by 83

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Jaarsma, D., van der Pluijm, I., de Waard, M. C., Haasdijk, E. D., Brandt, R. M. C., Vermeij, M., Rijksen, Y., Maas, A., STEEG, H. V., Hoeijmakers, J. H. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002405 · Cited by 80

Age-related neuronal loss in the rat brain starts at the end of adolescence

Morterá, P., & Herculano-Houzel, S. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00045 · Cited by 79

Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH

Hashimoto, S., & Egly, J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp390 · Cited by 79

p53 is Present in Synapses Where it Mediates Mitochondrial Dysfunction and Synaptic Degeneration in Response to DNA Damage, and Oxidative and Excitotoxic Insults

Gilman, C. P., Chan, S. L., Guo, Z., Zhu, X., Greig, N. H., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:3:159 · Cited by 77

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Sordet, O., Khan, Q. A., Plo, I., Pourquier, P., Urasaki, Y., Yoshida, A., Antony, S., Kohlhagen, G., Solary, É., Saparbaev, M. K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410277200 · Cited by 72

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

Alagöz, M., Chiang, S., Sharma, A. B., & El‐Khamisy, S. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058239 · Cited by 71

E2F1 Coregulates Cell Cycle Genes and Chromatin Components during the Transition of Oligodendrocyte Progenitors from Proliferation to Differentiation

Magri, L., Swiss, V. A., Jablonska, B., Liang, L., Pedré, X., Walsh, M. J., Zhang, W., Gallo, V., Canoll, P., & Casaccia, P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2840-13.2014 · Cited by 71

Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation

Conway, G. D., O’Bara, M. A., Vedia, B. H., Pol, S. U., & Sim, F. J. (2012) · Glia · doi:10.1002/glia.22410 · Cited by 70

Normal Appearing and Diffusely Abnormal White Matter in Patients with Multiple Sclerosis Assessed with Quantitative MR

West, J., Aalto, A., Tisell, A., Leinhard, O. D., Landtblom, A., Smedby, Ö., & Lundberg, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095161 · Cited by 68

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression

Carlessi, L., Filippis, L. D., Lecis, D., Vescovi, A. L., & Delia, D. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.10 · Cited by 64

Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA

Shafirovich, V., Kropachev, K. Y., Anderson, T., Liu, Z., Kolbanovskiy, M., Martin, B. D., Sugden, K. D., Shim, Y., Chen, X., Min, J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.693218 · Cited by 64

Base excision repair in the mammalian brain: Implication for age related neurodegeneration

Sýkora, P., Wilson, D. M., & Bohr, V. A. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.005 · Cited by 59

HDACs and the senescent phenotype of WI-38 cells

Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-37 · Cited by 57

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis

Rebbaa, A., Zheng, X. S., Chu, F., & Mirkin, B. L. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401895 · Cited by 56

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

Clement, A. B., Gamerdinger, M., Tamboli, I. Y., Lütjohann, D., Walter, J., Greeve, I., Gimpl, G., & Behl, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06360.x · Cited by 55

ID2: A negative transcription factor regulating oligodendroglia differentiation

Chen, X., Zhang, Y., Cai, Q., & Yao, Z. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22826 · Cited by 54

Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors

Boda, E., Maria, S. D., Rosa, P., Taylor, V., Abbracchio, M. P., & Buffo, A. (2014) · Glia · doi:10.1002/glia.22750 · Cited by 53

The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D)

Lai, J.-P., Liu, Y.-C., Alimchandani, M., Liu, Q., Aung, P. P., Matsuda, K. M., Lee, C. R., Tsokos, M., Hewitt, S. M., Rushing, E. J., et al. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-4 · Cited by 51

White matter mapping in Alzheimer's disease: A neuropathological study.

Sjöbeck, M., Haglund, M., & Englund, E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.007 · Cited by 50

Premature aging-related peripheral neuropathy in a mouse model of progeria

Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M., Arbujas, N., Robbins, P. D., Glorioso, J. C., & Niedernhofer, L. J. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.04.010 · Cited by 46

PERIPHERAL NEUROPATHY IN XERODERMA PIGMENTOSUM

Kanda, T., Oda, M., YONEZAWA, M., Tamagawa, K., Isa, F., Hanakago, R., & Tsukagoshi, H. (1990) · Brain · doi:10.1093/brain/113.4.1025 · Cited by 46

Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy

Keeney, J. T. R., Miriyala, S., Noel, T. J., Moscow, J. A., Clair, D. K. S., & Butterfield, D. A. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.023 · Cited by 46

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage

Hernandez, M., & Casaccia, P. (2015) · Glia · doi:10.1002/glia.22818 · Cited by 42

Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1

He, Y., Sandoval, J., & Casaccia‐Bonnefil, P. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000057 · Cited by 42

Histone deacetylases in replicative senescence: evidence for a senescence‐specific form of HDAC‐2

Wagner, M., Brosch, G., Zwerschke, W., Seto, E., Loidl, P., & Jansen‐Dürr, P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02524-8 · Cited by 39

Brain damage from anticancer treatments in adults

Ricard, D., Taillia, H., & Renard, J.-L. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328330c669 · Cited by 38

The role of DNA base excision repair in brain homeostasis and disease

Akbari, M., Morevati, M., Croteau, D. L., & Bohr, V. A. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.029 · Cited by 34

MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome

Assaf, Y., Galron, R., Shapira, I., Nitzan, A., Blumenfeld‐Katzir, T., Solomon, A., Holdengreber, V., Wang, Z., Shiloh, Y., & Barzilai, A. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.021 · Cited by 33

A neurological phenotype in mice with DNA repair gene Ercc1 deficiency

Lawrence, N. J., Sacco, J. J., Brownstein, D. G., Gillingwater, T. H., & Melton, D. W. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.10.005 · Cited by 33

Trichothiodystrophy: Clinical Spectrum, Central Nervous System Imaging, and Biochemical Characterization of Two Siblings.

Chen, E., Cleaver, J. E., Weber, C. A., Packman, S., Barkovich, A. J., Koch, T., Williams, M. L. K., Golabi, M., & Price, V. H. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12399493 · Cited by 30

Cranial MRI in the Nijmegen breakage syndrome

Bekiesińska‐Figatowska, M., Chrzańowska, K., Sikorska, J., Walecki, J. M., Krajewska‐Walasek, M., wiak, S. J., & Kleijer, W. J. (2000) · Neuroradiology · doi:10.1007/s002340050011 · Cited by 28

Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells

Arter, J., & Wegner, M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.13013 · Cited by 27

Trichothiodystrophy: Clinical Spectrum, Central Nervous System Imaging, and Biochemical Characterization of Two Siblings

Cleaver, J. E., Weber, C. A., Barkovich, A. J., Koch, T., Williams, M. L. K., Price, V. H., Chen, E., Packman, S., & Golabi, M. (1994) · Journal of Investigative Dermatology · doi:10.1038/jid.1994.29 · Cited by 26

Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum

Dar, I., Yosha, G., Elfassy, R., Galron, R., Wang, Z., Shiloh, Y., & Barzilai, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204172 · Cited by 26

Identical male twins and brother with Cockayne syndrome

Houston, C. S., Zaleski, W. A., Rozdilsky, B., & Opitz, J. M. (1982) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320130212 · Cited by 25

Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome

Revet, I. M., Feeney, L., Tang, A. A., Huang, E. J., & Cleaver, J. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202621109 · Cited by 25

Reciprocally Regulated Chromatin Association of Cockayne Syndrome Protein B and p53 Protein

Lake, R. J., Basheer, A., & Fan, H.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252643 · Cited by 25

Postmortem Findings in the Nijmegen Breakage Syndrome

van de KAA, C. A., Weemaes, C. M. R., Wesseling, P., Schaafsma, H. E., Haraldsson, Á., & de Weger, R. A. (1994) · Pediatric Pathology · doi:10.3109/15513819409037676 · Cited by 24

Motor pathway degeneration in young ataxia telangiectasia patients: A diffusion tractography study

Sahama, I., Sinclair, K., Fiori, S., Doecke, J. D., Pannek, K., Reid, L. B., Lavin, M. F., & Rose, S. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.08.007 · Cited by 23

Comparison of MRI white matter changes with neuropsychologic impairment in Cockayne syndrome

Sugita, K., Takanashi, J., Ishii, M., & Niimi, H. (1992) · Pediatric Neurology · doi:10.1016/0887-8994(92)90369-a · Cited by 23

Cerebral White-Matter Changes Suggesting Leukodystrophy in Ataxia Telangiectasia

Chung, E. O., Bodensteiner, J. B., Noorani, P. A., & Schochet, S. S. (1994) · Journal of Child Neurology · doi:10.1177/088307389400900106 · Cited by 23

Xeroderma pigmentosum: Neurological, Neurophysiological and Morphological Studies

Hakamada, S., Watanabe, K., Sobue, G., Hara, K., & Miyazaki, S. (2008) · European Neurology · doi:10.1159/000115457 · Cited by 22

ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration

Carlessi, L., Poli, E., Filippis, L. D., & Delia, D. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.013 · Cited by 22

A novel mutation and novel features in Nijmegen breakage syndrome

Maraschio, P., DANESINO, C., ANTOCCIA, A., RICORDY, R., TANZARELLA, C., VARON, R., REIS, A., BESANA, D., GUALA, A., & TIEPOLO, L. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.2.113 · Cited by 21

Quantitative evaluation of brain involvement in ataxia telangiectasia by diffusion weighted MR imaging

Fırat, A. K., Karakaş, H. M., Fırat, Y., & Yakıncı, C. (2005) · European Journal of Radiology · doi:10.1016/j.ejrad.2005.04.009 · Cited by 21

Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system

Baranes, K., Raz-Prag, D., Nitzan, A., Galron, R., Ashery‐Padan, R., Rotenstreich, Y., Assaf, Y., Shiloh, Y., Wang, Z., Barzilai, A., et al. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.026 · Cited by 21

Abnormal white matter signal in ataxia telangiectasia.

Ciemins, J. J., & Horowitz, A. L. (2000) · PubMed · Cited by 21

Oxidative damage to DNA in plaques of MS brains

Vladimirova, O. O., O'Connor, J., Cahill, A., et al. (1998) · Multiple Sclerosis Journal · doi:10.1191/135245898678919456 · Cited by 21

DNA damage and oxidative injury are associated with hypomyelination in the corpus callosum of newborn Nbn CNS‐del mice

Liu, B., Chen, X., Wang, Z. Q., & Tong, W. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23313 · Cited by 19

Magnetic resonance imaging of brain abnormalities in patients with the Nijmegen breakage syndrome

Bekiesińska‐Figatowska, M., Chrzańowska, K., Jurkiewicz, E., Wakulińska, A., Rysiewski, H., Gładkowska‐Dura, M., & Walecki, J. M. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1532 · Cited by 16

Trichothiodystrophy with Dysmyelination and Central Osteosclerosis

Harreld, J. H., Smith, E. C., Prose, N. S., Puri, P. K., & Barboriak, D. P. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1665 · Cited by 16

Altered corticomotor‐cerebellar integrity in young ataxia telangiectasia patients

Sahama, I., Sinclair, K., Fiori, S., Pannek, K., Lavin, M. F., & Rose, S. (2014) · Movement Disorders · doi:10.1002/mds.25970 · Cited by 15

MR Findings of Cerebral White Matter in Cockayne Syndrome

Adachi, M., Kawanami, T., Ohshima, F., & Hosoya, T. (2006) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.5.41 · Cited by 14

Trichothiodystrophy with severe cardiac and neurological involvement in two sisters

Toelle, S. P., Valsangiacomo, E. R., & Boltshauser, E. (2001) · European Journal of Pediatrics · doi:10.1007/s004310100845 · Cited by 14

Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study

Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.461 · Cited by 14

Cerebellar and cerebral atrophy in trichothiodystrophy

Yoon, H.-K., Sargent, M. A., Prendiville, J., & Poskitt, K. J. (2005) · Pediatric Radiology · doi:10.1007/s00247-005-1495-6 · Cited by 12

Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes

Liu, B., Chen, X., Wang, Z., & Tong, W. (2013) · Glia · doi:10.1002/glia.22593 · Cited by 9

The Cerebro-Morphological Fingerprint of a Progeroid Syndrome: White Matter Changes Correlate with Neurological Symptoms in Xeroderma Pigmentosum

Kassubek, J., Sperfeld, A., Pinkhardt, E. H., Unrath, A., Müller, H., Scharffetter‐­Kochanek, K., Ludolph, A. C., & Berneburg, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030926 · Cited by 7

Absence of β-Amyloid Immunoreactivity in Mesial Temporal Lobe in Cockayne's Syndrome

Woody, R. C., Harding, B. N., Brumback, R. A., & Leech, R. W. (1991) · Journal of Child Neurology · doi:10.1177/088307389100600106 · Cited by 6

[Histological and radiobiological study on adult cases with ataxia telangiectasia].

Serizawa, M., Sakamoto, M., Hirabayashi, K., Fujiwara, Y., & Atsumi, T. (1994) · PubMed · Cited by 4

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242

White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

Nasrabady, S. E., Rizvi, B., Goldman, J. E., & Brickman, A. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0515-3 · Cited by 723

Astrocytes and Aging

Palmer, A. L., & Ousman, S. S. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00337 · Cited by 256

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D. (2016) · ALTEX · doi:10.14573/altex.1609122 · Cited by 266

Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

Spaas, J., van Veggel, L., Schepers, M., Tiane, A., van Horssen, J., Wilson, D. M., Moya, P. R., Piccart, E., Hellings, N., Eijnde, B. O., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03802-0 · Cited by 224

Oligodendrocytes and myelin in aging and disease

Sainz, A., Rojas, R., Ruiz, A., & Matute, C. (2025) · Ageing & Longevity · doi:10.47855/jal9020-2025-1-6 · Cited by 2

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia

Tse, K., Cheng, A., Ma, F., & Herrup, K. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.010 · Cited by 56

Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation

Rivera, A. D., Azim, K., & Butt, A. M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.338995 · Cited by 14

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9

DNA Damage, DNA Repair, Aging, and NeurodegenerationPreprint

Maynard, S., Fang, E. F., Scheibye‐Knudsen, M., Croteau, D. L., & Bohr, V. A. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025130 · Cited by 454