Cited by 154Muscle metabolism and nutritionMetabolism, Diabetes, and CancerExercise and Physiological Responses

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

Pilegaard, Henriette, Osada, Takuya, Andersen, Lisbeth T., Helge, Jørn W., Saltin, Bengt, Neufer, P. Darrell·2005·Metabolism

DOI 10.1016/j.metabol.2005.03.008

Open this paper in CoChat — free account

Abstract

In skeletal muscle of humans, transcription of several metabolic genes is transiently induced during recovery from exercise when no food is consumed. To determine the potential influence of substrate availability on the transcriptional regulation of metabolic genes during recovery from exercise, 9 male subjects (aged 22-27) completed 75 minutes of cycling exercise at 75% Vo2 max on 2 occasions, consuming either a high-carbohydrate (HC) or low-carbohydrate (LC) diet during the subsequent 24 hours of recovery. Nuclei were isolated and tissue frozen from vastus lateralis muscle biopsies obtained before exercise and 2, 5, 8, and 24 hours after exercise. Muscle glycogen was restored to near resting levels within 5 hours in the HC trial, but remained depressed through 24 hours in the LC trial. During the 2- to 8-hour recovery period, leg glucose uptake was 5- to 15-fold higher with HC ingestion, whereas arterial plasma free fatty acid levels were approximately 3- to 7-fold higher with LC ingestion. Exercise increased (P < .05) transcription and/or mRNA content of the pyruvate dehydrogenase kinase 4, uncoupling protein 3, lipoprotein lipase, carnitine palmitoyltransferase I, hexokinase II, peroxisome proliferator activated receptor gamma coactivator-1 alpha, and peroxisome proliferator activated receptor alpha. Providing HC during recovery reversed the activation of pyruvate dehydrogenase kinase 4, uncoupling protein 3, lipoprotein lipase, and carnitine palmitoyltransferase I within 5 to 8 hours after exercise, whereas providing LC during recovery elicited a sustained/enhanced increase in activation of these genes through 8 to 24 hours of recovery. These findings provide evidence that factors associated with substrate availability and/or cellular metabolic recovery (eg, muscle glycogen restoration) influence the transcriptional regulation of metabolic genes in skeletal muscle of humans during recovery from exercise.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2005.03.008

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089
Handbook of Physiology. Section 12. Exercise: Regulation and Integration of Multiple Systems
Coast, J. R. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199703000-00021 · Cited by 915
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885
Self-citation
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
Pilegaard, H., Ordway, G. A., Saltin, B., & Neufer, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e806 · Cited by 563
Self-citation
Effect of physical exercise on sensitivity and responsiveness to insulin in humans
Mikines, K. J., Sonne, B., Farrell, P. A., Tronier, B., & Galbo, H. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.3.e248 · Cited by 538
Regulation of gene expression by insulin
O’Brien, R. M., & Granner, D. K. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.1109 · Cited by 532
Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content
Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. D. (2001) · The FASEB Journal · doi:10.1096/fj.01-0507fje · Cited by 514
Self-citation
Prolonged increase in insulin-stimulated glucose transport in muscle after exercise
Cartee, G. D., Young, D. A., Sleeper, M. D., Zierath, J., Wallberg-Henriksson, H., & Holloszy, J. O. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.4.e494 · Cited by 342
Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans
Rådegran, G. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1383 · Cited by 296

Show all 42 references

Research works printed but not linked: 1

Bergstrom, 1962, Muscle electrolytes in man, Scand J Clin Lab Invest Suppl, 68, 1

Sorted by citations

Regulation of energy metabolism by long-chain fatty acids
Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 858
The Molecular Bases of Training Adaptation
Coffey, V. G., & Hawley, J. A. (2007) · Sports Medicine · doi:10.2165/00007256-200737090-00001 · Cited by 756
Impact of Oxidative Stress on Exercising Skeletal Muscle
Steinbacher, P., & Eckl, P. (2015) · Biomolecules · doi:10.3390/biom5020356 · Cited by 436
Four grams of glucose
Wasserman, D. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90563.2008 · Cited by 384
Coordination of metabolic plasticity in skeletal muscle
Hood, D. A., Irrcher, I., Ljubicic, V., & Joseph, A.-M. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02182 · Cited by 370
Periodized Nutrition for Athletes
Jeukendrup, A. E. (2017) · Sports Medicine · doi:10.1007/s40279-017-0694-2 · Cited by 299
Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
Regulation of Muscle Glycogen Metabolism during Exercise: Implications for Endurance Performance and Training Adaptations
Hearris, M., Hammond, K., Fell, J., & Morton, J. (2018) · Nutrients · doi:10.3390/nu10030298 · Cited by 252
Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle
Al-Khalili, L., Bouzakri, K., Glund, S., Lönnqvist, F., Koistinen, H. A., & Krook, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0490 · Cited by 250
PGC-1α-mediated adaptations in skeletal muscle
Olesen, J., Kiilerich, K., & Pilegaard, H. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0834-0 · Cited by 244
Self-citation
The Role of Milk- and Soy-Based Protein in Support of Muscle Protein Synthesis and Muscle Protein Accretion in Young and Elderly Persons
Phillips, S. M., Tang, J. E., & Moore, D. R. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718096 · Cited by 243
Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis
Impey, S. G., Hearris, M. A., Hammond, K. M., Bartlett, J. D., Louis, J., Close, G. L., & Morton, J. P. (2018) · Sports Medicine · doi:10.1007/s40279-018-0867-7 · Cited by 232
“[16] 9 active men Acute exercise 75-min cycling (75% VO2max) followed by 24 h recovery with either HIGH or LOW CHO diet.”
BackgroundMethod
Reduced physical activity and risk of chronic disease: the biology behind the consequences
Booth, F. W., Laye, M. J., Lees, S. J., Rector, R. S., & Thyfault, J. P. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0606-5 · Cited by 253
Carbohydrate availability and exercise training adaptation: Too much of a good thing?
Bartlett, J. D., Hawley, J. A., & Morton, J. P. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2014.920926 · Cited by 230
New strategies in sport nutrition to increase exercise performance
Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221
Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle
Hawley, J. A., Lundby, C., Cotter, J. D., & Burke, L. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.014 · Cited by 182
Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle
Wang, L., Mascher, H., Psilander, N., Blomstrand, E., & Sahlin, K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00086.2011 · Cited by 181
Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise
Fritzen, A. M., Lundsgaard, A.-M., & Kiens, B. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0405-1 · Cited by 180
Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging
Ljubicic, V., Joseph, A.-M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y. J., Nguyen, L. M.-D., & Hood, D. A. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.031 · Cited by 167
Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle
Mathai, A. S., Bonen, A., Benton, C. R., Robinson, D. L., & Graham, T. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00847.2007 · Cited by 158
The physiological regulation of glucose flux into musclein vivo
Wasserman, D. H., Kang, L., Ayala, J. E., Fueger, P. T., & Lee, R. S. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.048041 · Cited by 153
Intramuscular mechanisms of overtraining
Cheng, A. J., Jude, B., & Lanner, J. T. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101480 · Cited by 176
Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis
Bartlett, J. D., Louhelainen, J., Iqbal, Z., Cochran, A. J., Gibala, M. J., Gregson, W., Close, G. L., Drust, B., & Morton, J. P. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00498.2012 · Cited by 147
Fatty Acid Signaling: The New Function of Intracellular Lipases
Papáčková, Z., & Cahová, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023831 · Cited by 144
Enhanced Endurance Performance by Periodization of Carbohydrate Intake: “Sleep Low” Strategy
MARQUET, L.-A., BRISSWALTER, J., LOUIS, J., TIOLLIER, E., BURKE, L. M., HAWLEY, J. A., & HAUSSWIRTH, C. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000823 · Cited by 134
Metabolic stress‐dependent regulation of the mitochondrial biogenic molecular response to high‐intensity exercise in human skeletal muscle
Fiorenza, M., Gunnarsson, T. P., Hostrup, M., Iaia, F. M., Schena, F. F., Pilegaard, H., & Bangsbo, J. (2018) · The Journal of Physiology · doi:10.1113/jp275972 · Cited by 132
Self-citation
Toward a Common Understanding of Diet–Exercise Strategies to Manipulate Fuel Availability for Training and Competition Preparation in Endurance Sport
Burke, L. M., Hawley, J. A., Jeukendrup, A., Morton, J. P., Stellingwerff, T., & Maughan, R. J. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0289 · Cited by 132
Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis
Granata, C., Jamnick, N. A., & Bishop, D. J. (2018) · Sports Medicine · doi:10.1007/s40279-018-0894-4 · Cited by 135
A Framework for Periodized Nutrition for Athletics
Stellingwerff, T., Morton, J. P., & Burke, L. M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0305 · Cited by 135
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, V. G., Jemiolo, B., Edge, J., Garnham, A. P., Trappe, S. W., & Hawley, J. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00351.2009 · Cited by 120
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, V. G., Pilegaard, H., Garnham, A. P., O'Brien, B. J., & Hawley, J. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91221.2008 · Cited by 116
Self-citation
Carbohydrate Availability and Physical Performance: Physiological Overview and Practical Recommendations
Mata, F., Valenzuela, P. L., Gimenez, J., Tur, C., Ferreria, D., Domínguez, R., Sanchez-Oliver, A. J., & Martínez Sanz, J. M. (2019) · Nutrients · doi:10.3390/nu11051084 · Cited by 112
Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes
Impey, S. G., Hammond, K. M., Shepherd, S. O., Sharples, A. P., Stewart, C., Limb, M., Smith, K., Philp, A., Jeromson, S., Hamilton, D. L., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12803 · Cited by 109
Predictive Metabolomics Evaluation of Nutrition-Modulated Metabolic Stress Responses in Human Blood Serum During the Early Recovery Phase of Strenuous Physical Exercise
Chorell, E., Möritz, T., Branth, S., Antti, H., & Svensson, M. (2009) · Journal of Proteome Research · doi:10.1021/pr900081q · Cited by 109
Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training
Schenk, S., & Horowitz, J. F. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2006 · Cited by 108
Protein Requirements and Recommendations for Athletes: Relevance of Ivory Tower Arguments for Practical Recommendations
Tipton, K. D., & Witard, O. C. (2007) · Clinics in Sports Medicine · doi:10.1016/j.csm.2006.11.003 · Cited by 105
Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane, S. C., Camera, D. M., Lassiter, D. G., Areta, J. L., Bird, S. R., Yeo, W. K., Jeacocke, N. A., Krook, A., Zierath, J. R., Burke, L. M., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00857.2014 · Cited by 102
Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle
Psilander, N., Frank, P., Flockhart, M., & Sahlin, K. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2504-8 · Cited by 101
Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle
Burch, N., Arnold, A., Item, F., Summermatter, S., Santos, G., Christe, M., Boutellier, U., Toigo, M., & Handschin, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010970 · Cited by 99
PGC-1α-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions
Benton, C. R., Wright, D. C., & Bonen, A. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-074 · Cited by 95
Exercise, sex, menstrual cycle phase, and 17β-estradiol influence metabolism-related genes in human skeletal muscle
Fu, M.-H. H., Maher, A. C., Hamadeh, M. J., Ye, C., & Tarnopolsky, M. A. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00115.2009 · Cited by 90
Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans
Cochran, A. J. R., Little, J. P., Tarnopolsky, M. A., & Gibala, M. J. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00659.2009 · Cited by 90
Exercise and the Treatment of Diabetes and Obesity
O’Gorman, D. J., & Krook, A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.07.006 · Cited by 88
Post‐exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle
Cheng, A. J., Willis, S. J., Zinner, C., Chaillou, T., Ivarsson, N., Ørtenblad, N., Lanner, J. T., Holmberg, H., & Westerblad, H. (2017) · The Journal of Physiology · doi:10.1113/jp274870 · Cited by 81
The effect of training on the expression of mitochondrial biogenesis- and apoptosis-related proteins in skeletal muscle of patients with mtDNA defects
Adhihetty, P. J., Taivassalo, T., Haller, R. G., Walkinshaw, D. R., & Hood, D. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2007 · Cited by 75
PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise
Pilegaard, H., Birk, J. B., Sacchetti, M., Mourtzakis, M., Hardie, D. G., Stewart, G. A., Neufer, P. D., Saltin, B., van Hall, G., & Wojtaszewski, J. F. P. (2006) · Diabetes · doi:10.2337/db06-0152 · Cited by 74
Self-citation
Adaptations to skeletal muscle with endurance exercise training in the acutely fed versus overnight-fasted state
Stannard, S. R., Buckley, A. J., Edge, J. A., & Thompson, M. W. (2010) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2010.03.002 · Cited by 73
Cellular mechanisms regulating fuel metabolism in mammals: Role of adipose tissue and lipids during prolonged food deprivation
Viscarra, J. A., & Ortiz, R. M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.014 · Cited by 73
The Importance of Fatty Acids as Nutrients during Post-Exercise Recovery
Lundsgaard, A.-M., Fritzen, A. M., & Kiens, B. (2020) · Nutrients · doi:10.3390/nu12020280 · Cited by 72
“moderate-intensity exercise in trained male subjects, the mRNA contents of several exercise-responsive metabolic genes, such as PDK4, uncoupling protein 3 (UCP3), LPL, CPT1, CD36, forkhead homolog in rhabdomyosarcoma 1 (FOXO1), and peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), were increase…”
Background
Periodization of carbohydrate intake: short-term effect on performance
Marquet, L.-A., Hausswirth, C., Molle, O., Hawley, J., Burke, L., Tiollier, E., & Brisswalter, J. (2016) · Nutrients · doi:10.3390/nu8120755 · Cited by 70
PGC-1α-induced improvements in skeletal muscle metabolism and insulin sensitivityThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.
Bonen, A. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-008 · Cited by 70
Post-exercise carbohydrate and energy availability induce independent effects on Skeletal muscle cell signalling and bone turnover: implications for training adaptation
Hammond, K. M., Sale, C., Fraser, W., Tang, J., Shepherd, S. O., Strauss, J. A., Close, G. L., Cocks, M., Louis, J., Pugh, J., et al. (2019) · The Journal of Physiology · doi:10.1113/jp278209 · Cited by 68
Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein
ROWLANDS, D. S., Thomson, J. S., Timmons, B. W., Raymond, F., Fuerholz, A., Mansourian, R., Zwahlen, M.-C., Métairon, S., Glover, E. I., Stellingwerff, T., et al. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00073.2011 · Cited by 66
Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise
Psilander, N., Wang, L., Westergren, J., Tonkonogi, M., & Sahlin, K. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1544-1 · Cited by 66
Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery
Leick, L., Plomgaard, P., Grønlykke, L., Al‐Abaiji, F., Wojtaszewski, J. F. P., & Pilegaard, H. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.00988.x · Cited by 61
Self-citation
No superior adaptations to carbohydrate periodization in elite endurance athletes
GEJL, K. D., THAMS, L. B., HANSEN, M., ROKKEDAL-LAUSCH, T., PLOMGAARD, P., NYBO, L., LARSEN, F. J., CARDINALE, D. A., JENSEN, K., HOLMBERG, H.-C., et al. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001377 · Cited by 57
Metabolic Reserve of the Heart: The Forgotten Link Between Contraction and Coronary Flow
Kassiotis, C., Rajabi, M., & Taegtmeyer, H. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.11.005 · Cited by 53
Exercise twice‐a‐day potentiates markers of mitochondrial biogenesis in men
Andrade‐Souza, V. A., Ghiarone, T., Sansonio, A., Silva, K. A. S., Tomazini, F., Arcoverde, L., Fyfe, J. J., Perri, E., Saner, N. J., Kuang, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901207rr · Cited by 53
Graded reductions in preexercise muscle glycogen impair exercise capacity but do not augment skeletal muscle cell signaling: implications for CHO periodization
Hearris, M. A., Hammond, K. M., Seaborne, R. A. E., Stocks, B., Shepherd, S. O., Philp, A., Sharples, A. P., Morton, J. P., & Louis, J. B. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00913.2018 · Cited by 50
Repeated Sprints Alter Signaling Related to Mitochondrial Biogenesis in Humans
Serpiello, F. R., McKenna, M. J., Bishop, D. J., Aughey, R. J., Caldow, M. K., Cameron‐Smith, D., & Stepto, N. K. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318240067e · Cited by 48
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
Bayer, H., Lang, K., Buck, E., Higelin, J., Barteczko, L., Pasquarelli, N., Sprissler, J., Lucas, T., Holzmann, K., Demestre, M., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.11.001 · Cited by 51
Effect of intensity of resistance exercise on postprandial lipemia
Singhal, A., Trilk, J. L., Jenkins, N. T., Bigelman, K. A., & Cureton, K. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90726.2008 · Cited by 48
5′‐AMP activated protein kinase α2 controls substrate metabolism during post‐exercise recovery via regulation of pyruvate dehydrogenase kinase 4
Fritzen, A. M., Lundsgaard, A., Jeppesen, J. F., Christiansen, M. L. B., Biensø, R. S., Dyck, J. R. B., Pilegaard, H., & Kiens, B. (2015) · The Journal of Physiology · doi:10.1113/jp270821 · Cited by 47
Self-citation
Intensity-dependent gene expression after aerobic exercise in endurance-trained skeletal muscle
Викторович, П. Д., Makhnovskii, P. A., Kurochkina, N. S., Lysenko, E. A., Vepkhvadze, T. F., & Виноградова, О. Л. (2018) · Biology of Sport · doi:10.5114/biolsport.2018.77828 · Cited by 45
Protein ingestion does not impair exercise-induced AMPK signalling when in a glycogen-depleted state: implications for train-low compete-high
Taylor, C., Bartlett, J. D., van de Graaf, C. S., Louhelainen, J., Coyne, V., Iqbal, Z., MacLaren, D. P. M., Gregson, W., Close, G. L., & Morton, J. P. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2574-7 · Cited by 43
Exercising with low muscle glycogen content increases fat oxidation and decreases endogenous, but not exogenous carbohydrate oxidation
Margolis, L. M., Wilson, M. A., Whitney, C. C., Carrigan, C. T., Murphy, N. E., Hatch‐McChesney, A., Montain, S. J., & Pasiakos, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.05.003 · Cited by 43
The mRNA expression profile of metabolic genes relative to MHC isoform pattern in human skeletal muscles
Plomgaard, P., Penkowa, M., Leick, L., Pedersen, B. K., Saltin, B., & Pilegaard, H. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00183.2006 · Cited by 43
Self-citation
Exercise and the Treatment of Diabetes and Obesity
O’Gorman, D. J., & Krook, A. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.007 · Cited by 44
Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle
Kiilerich, K., Gudmundsson, M., Birk, J. B., Lundby, C., Taudorf, S., Plomgaard, P., Saltin, B., Pedersen, P. A., Wojtaszewski, J. F. P., & Pilegaard, H. (2009) · Diabetes · doi:10.2337/db09-1032 · Cited by 42
Self-citation
High-Fat Ketogenic Diets and Physical Performance: A Systematic Review
Murphy, N. E., Carrigan, C. T., & Margolis, L. M. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa101 · Cited by 46
Whole-body fat oxidation increases more by prior exercise than overnight fasting in elite endurance athletes.
Andersson Hall, U., Edin, F., Pedersen, A., & Madsen, K. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2015-0452 · Cited by 41
Insulin, Muscle Glucose Uptake, and Hexokinase: Revisiting the Road Not Taken
Wasserman, D. H. (2021) · Physiology · doi:10.1152/physiol.00034.2021 · Cited by 44
Combined speed endurance and endurance exercise amplify the exercise‐induced PGC‐1 α and PDK4 mRNA response in trained human muscle
Skovgaard, C., Brandt, N., Pilegaard, H., & Bangsbo, J. (2016) · Physiological Reports · doi:10.14814/phy2.12864 · Cited by 40
Self-citation
Carbohydrate restricted recovery from long term endurance exercise does not affect gene responses involved in mitochondrial biogenesis in highly trained athletes
Jensen, L., Gejl, K. D., Ørtenblad, N., Nielsen, J. L., Bech, R. D., Nygaard, T., Sahlin, K., & Frandsen, U. (2015) · Physiological Reports · doi:10.14814/phy2.12184 · Cited by 38
Calcium signalling in the regulation of PGC-1α, PDK4 and HKII mRNA expression
Kusuhara, K., Madsen, K., Jensen, L., Hellsten, Y., & Pilegaard, H. (2007) · Biological Chemistry · doi:10.1515/bc.2007.052 · Cited by 38
Self-citation
Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max
Bye, A., Høydal, M. A., Catalucci, D., Langaas, M., Kemi, O. J., Beisvåg, V., Koch, L. G., Britton, S. L., Ellingsen, Ø., & Wisløff, U. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90282.2008 · Cited by 38
Performance effects of periodized carbohydrate restriction in endurance trained athletes – a systematic review and meta-analysis
Gejl, K. D., & Nybo, L. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00435-3 · Cited by 33
The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exercise-Induced Slow-Twitch Muscle Fibre Transformation in Humans
Steinbacher, P., Feichtinger, R. G., Kedenko, L., Kedenko, I., Reinhardt, S., Schönauer, A.-L., Leitner, I., Sänger, A. M., Stoiber, W., Kofler, B., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123881 · Cited by 33
Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Huang, T., Linden, M. A., Fuller, S. E., Goldsmith, F., Simon, J., Batdorf, H. M., Scott, M. C., Essajee, N. M., Brown, J. M., & Noland, R. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00410.2020 · Cited by 36
Effects of Creatine and Carbohydrate Loading on Cycling Time Trial Performance
TOMCIK, K. A., CAMERA, D. M., BONE, J. L., ROSS, M. L., JEACOCKE, N. A., TACHTSIS, B., SENDEN, J., VAN LOON, L. J. C., HAWLEY, J. A., & BURKE, L. M. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001401 · Cited by 33
β-Adrenergic receptor blockade blunts postexercise skeletal muscle mitochondrial protein synthesis rates in humans
Robinson, M. M., Bell, C., Peelor, F. F., & Miller, B. F. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00160.2011 · Cited by 31
Impact of adrenaline and metabolic stress on exercise‐induced intracellular signaling and PGC‐1α mRNA response in human skeletal muscle
Brandt, N., Gunnarsson, T. P., Hostrup, M., Tybirk, J., Nybo, L., Pilegaard, H., & Bangsbo, J. (2016) · Physiological Reports · doi:10.14814/phy2.12844 · Cited by 32
Self-citation
Postexercise High-Fat Feeding Suppresses p70S6K1 Activity in Human Skeletal Muscle
HAMMOND, K. M., IMPEY, S. G., CURRELL, K., MITCHELL, N., SHEPHERD, S. O., JEROMSON, S., HAWLEY, J. A., CLOSE, G. L., HAMILTON, L. D., SHARPLES, A. P., et al. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001009 · Cited by 30
PGC-1α increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, P. A., Hardie, D. G., Wojtaszewski, J. F. P., & Pilegaard, H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00400.2010 · Cited by 31
Self-citation
Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle
Biensø, R. S., Knudsen, J. G., Brandt, N., Pedersen, P. A., & Pilegaard, H. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1399-5 · Cited by 29
Self-citation
Skeletal muscle lipid flux: running water carries no poison
Funai, K., & Semenkovich, C. F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00152.2011 · Cited by 24
Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise
Helge, J. W., Rehrer, N. J., Pilegaard, H., Manning, P. J., Lucas, S. J. E., GERRARD, D. F., & Cotter, J. D. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01709.x · Cited by 24
Self-citation
Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest
Kiilerich, K., Ringholm, S., Biensø, R. S., Fisher, J. P., Iversen, N., van Hall, G., Wojtaszewski, J. F. P., Saltin, B., Lundby, C., Calbet, J. A. L., et al. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00063.2011 · Cited by 23
Self-citation
Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle
Brandt, N., Nielsen, L., Buch, B. T., Gudiksen, A., Ringholm, S., Hellsten, Y., Bangsbo, J., & Pilegaard, H. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00082.2017 · Cited by 21
Self-citation
Achieving energy balance with a high‐fat meal does not enhance skeletal muscle adaptation and impairs glycaemic response in a sleep‐low training model
Areta, J. L., Iraki, J., Owens, D. J., Joanisse, S., Philp, A., Morton, J. P., & Hallén, J. (2020) · Experimental Physiology · doi:10.1113/ep088795 · Cited by 20
Basal and insulin‐stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise
Stephens, F. B., Norton, L., Jewell, K., Chokkalingam, K., Parr, T., & Tsintzas, K. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.051367 · Cited by 20
Ammonium Chloride Ingestion Attenuates Exercise-Induced mRNA Levels in Human Muscle
Edge, J., Mündel, T., Pilegaard, H., Hawke, E. J., Leikis, M. J., Lopez-Villalobos, N., Oliveira, R. S. F., & Bishop, D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141317 · Cited by 20
Self-citation
Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?
François, M. E., Gillen, J. B., & Little, J. P. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00049 · Cited by 20
The acute and chronic influence of exercise on mitochondrial dynamics in skeletal muscle
Ritenis, E. J., Padilha, C. S., Cooke, M. B., Stathis, C. G., Philp, A., & CAMERA, D. M. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2024 · Cited by 18
Graded reductions in pre‐exercise glycogen concentration do not augment exercise‐induced nuclear AMPK and PGC‐1α protein content in human muscle
Hearris, M. A., Owens, D. J., Strauss, J. A., Shepherd, S. O., Sharples, A. P., Morton, J. P., & Louis, J. B. (2020) · Experimental Physiology · doi:10.1113/ep088866 · Cited by 19
Nutritional Strategies to Modulate the Adaptive Response to Endurance Training
Hawley, J. A. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000345813 · Cited by 16
Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise
Smith, I. J., Huffman, K. M., Durheim, M. T., Duscha, B. D., & Kraus, W. E. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90216.2008 · Cited by 18
UCI Sports Nutrition Project: Nutritional Periodization: Strategies to Enhance Training Adaptation and Recovery
Morton, J. P., Hearris, M. A., Fell, M. J., Owens, D. J., Halson, S. L., & Trommelen, J. (2025) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2025-0073 · Cited by 22
Temporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs
Brass, E. P., Peters, M. A., Hinchcliff, K. W., He, Y. D., & Ulrich, R. G. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91347.2008 · Cited by 14
Systematic Review and Meta-Analysis of Circulating Irisin Levels Following Endurance Training: Results of Continuous and Interval Training
Cosio, P. L., Peláez, M., Cadefau, J. A., & Farrán-Codina, A. (2022) · Biological Research For Nursing · doi:10.1177/10998004221142580 · Cited by 13

Authors: Pilegaard, H., Osada, T., Andersen, L. T., Helge, J. W., Saltin, B., & Neufer, P. D.
Affiliations: University of Copenhagen (DK)
Yale University (US)
ORCID: Pilegaard, Henriette
Osada, Takuya
Helge, Jørn W.
Neufer, P. Darrell
Venue: Metabolism
Publisher: Elsevier BV
Published: 2005-08
Volume: 54
Issue: 8
Pages: 1048-1055
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2005.03.008
OpenAlex: W2130919437
Cited by: 154
References: 42
Citations by year: 2026: 1 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 4 · 2013: 6 · 2012: 3
FWCI: 3.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-45372, R01AR045372)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: post-exercise recovery, skeletal muscle, substrate availability, carbohydrate intake, muscle glycogen, glucose uptake, free fatty acids, PDK4, UCP3, lipoprotein lipase, carnitine palmitoyltransferase 1, hexokinase 2, PPARγ coactivator-1α, PPARα, vastus lateralis
MeSH terms: Forkhead Box Protein O1, Uncoupling Protein 3, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adult, Carnitine O-Palmitoyltransferase, Carrier Proteins, DNA-Binding Proteins, Energy Metabolism, Physical Exertion, Glycogen, Glycogen Synthase, Heat-Shock Proteins, Hexokinase, Humans, Ion Channels, Lipoprotein Lipase, Male, Monosaccharide Transport Proteins, Muscle Proteins, Protein Kinases, RNA, Messenger, Transcription Factors, Transcriptional Activation, Gene Expression Regulation, Enzymologic, Muscle, Skeletal, CD36 Antigens, Recovery of Function, Mitochondrial Proteins, PPAR alpha, Glucose Transporter Type 4, Forkhead Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks