The DOI matches its Crossref record; 268 of the 268 references it cites were found in a registry or an index.
Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis
Open accessAbstract
The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is generally accepted that oligodendrocytes are specifically vulnerable to cuprizone intoxication due to their high metabolic demands, a comprehensive overview of the etiology of cuprizone-induced pathology is still missing to date. In this review we extensively describe the physico-chemical mode of action of cuprizone and discuss the molecular and enzymatic mechanisms by which cuprizone induces metabolic stress, oligodendrocyte apoptosis, myelin degeneration and eventually axonal and neuronal pathology. In addition, we describe the dual effector function of the immune system which tightly controls demyelination by effective induction of oligodendrocyte apoptosis, but in contrast also paves the way for fast and efficient remyelination by the secretion of neurotrophic factors and the clearance of cellular and myelinic debris. Finally, we discuss the many clinical symptoms that can be observed following cuprizone treatment, and how these strengthened the cuprizone model as a useful tool to study human multiple sclerosis, schizophrenia and epilepsy.
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In the citing paper
“Importantly this apoptosis precedes the massive demyelination caused by cuprizone administration [18], indicating that oligodendrocyte degeneration is the main cause, as opposed to a secondary immune response.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [18]
In the citing paper
“In addition to the direct effect of cuprizone on oligodendrocytes, the involvement of the brain’s resident neuroinflammatory cells such as microglia and astrocyes is also believed to be responsible for the massive demyelination occurring at 4 weeks time point of cuprizone exposure [18].”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [18]
In the citing paper
“Nevertheless, a consensus seems to be that cuprizone selectively affects oligodendrocytes.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [18]
In the citing paper
“Astrocytes and microglia collaborate through the release of cytokines, chemokines, and other, yet to be identified factors, to drive demyelination [79, 107], preventing the release of specific cytokines or chemokines, restricting astrocyte reactivity, or ablating microglia all reduce cuprizone-induced demyelination [107, 181, 189, 243].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [107]
In the citing paper
“The cuprizone model is based on oral ingestion of the copper chelator cuprizone, causing metabolic oligodendrocyte injury.”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [183]
In the citing paper
“These include cuprizone (CUP), a chemical toxin, which when provided in the diet of adult mice results in reliable demyelination of the corpus callosum (CC). Upon removal of CUP from the diet, there is robust remyelination (Matsushima & Morrell, 2001; Praet, et al, 2014; Wergeland, Torkildsen, Myhr, Mørk, & Bø et al, 2012).”
From Activated microglia drive demyelination via CSF1R signaling (2021) · cites this paper as Praet, et al, 2014
In the citing paper
“In the following chapter we will briefly introduce the cuprizone model, a toxin-induced demyelination model [21,22].”
From The Cuprizone Model: Dos and Do Nots (2020) · cites this paper as [22]
In the citing paper
“Oral intoxication with the copper-chelator cuprizone induces oligodendrocyte apoptosis within a few days, which is closely followed by the activation of the innate immune cells in the brain, i.e., astrocytes and microglia, finally leading to demyelination of distinct white and grey matter brain areas.”
From The Cuprizone Model: Dos and Do Nots (2020) · cites this paper as [22]
In the citing paper
“Mitochondrial injury and oxidative stress are believed to be fundamental elements of CPZ induced pathology (66).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [66]
Citations
Cites
Endoplasmic reticulum stress: cell life and death decisions
Xu, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26373 · Cited by 2,291
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
Malhotra, J. D., & Kaufman, R. J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1782 · Cited by 1,588
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114
Debris clearance by microglia: an essential link between degeneration and regeneration
Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012
Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768
A regenerative approach to the treatment of multiple sclerosis
Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature · doi:10.1038/nature12647 · Cited by 531
Interleukin-1β Promotes Repair of the CNS
Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502
Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 499
The cuprizone animal model: new insights into an old story
Kipp, M., Clarner, T., Dang, J., Copray, S., & Beyer, C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0591-3 · Cited by 481
Pro‐regenerative properties of cytokine‐activated astrocytes
Liberto, C. M., Albrecht, P. J., Herx, L. M., Yong, V. W., & Levison, S. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02420.x · Cited by 464
Sun, S., Liang, H., Trinkaus, K., Cross, A. H., Armstrong, R. C., & Song, S. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20774 · Cited by 461
Remyelination protects axons from demyelination-associated axon degeneration
Irvine, K. A., & Blakemore, W. F. (2008) · Brain · doi:10.1093/brain/awn080 · Cited by 420
bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416
Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice
Hiremath, M. M., Saito, Y., Knapp, G. W., Ting, J. P.-Y., Suzuki, K., & Matsushima, G. K. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00168-4 · Cited by 412
Mitochondrial defects in acute multiple sclerosis lesions
Mahad, D., Ziabreva, I., Lassmann, H., & Turnbull, D. (2008) · Brain · doi:10.1093/brain/awn105 · Cited by 406
Differentiation and death of premyelinating oligodendrocytes in developing rodent brain
Trapp, B. D., Nishiyama, A., Cheng, D., & Macklin, W. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.2.459 · Cited by 395
Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376
Spencer, J. P. E., Jenner, P., Daniel, S. E., Lees, A. J., Marsden, D. C., & Halliwell, B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052112.x · Cited by 373
Identification of a microglia phenotype supportive of remyelination
Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358
Aboul‐Enein, F., Rauschka, H., Kornek, B., Stadelmann, C., Stefferl, A., Brück, W., Lucchinetti, C. F., Schmidbauer, M., Jellinger, K. A., & Lassmann, H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.1.25 · Cited by 336
Oligodendrocytes and Ischemic Brain Injury
Dewar, D., Underhill, S. M., & Goldberg, M. P. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000053472.41007.f9 · Cited by 335
Woodruff, R. H., Fruttiger, M., Richardson, W. D., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.014 · Cited by 335
Jha, S., Srivastava, S. Y., Brickey, W. J., Iocca, H., Toews, A., Morrison, J. P., Chen, V. S., Gris, D., Matsushima, G. K., & Ting, J. P.-Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4088-10.2010 · Cited by 310
Mi, S., Miller, R. H., Tang, W., Lee, X., Hu, B., Wu, W., Zhang, Y., Shields, C. B., Zhang, Y., Miklasz, S., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21581 · Cited by 300
(1978) · PubMed · Cited by 297
Regional differences between grey and white matter in cuprizone induced demyelination
Gudi, V., Moharregh-Khiabani, D., Skripuletz, T., Koutsoudaki, P. N., Kotsiari, A., Skuljec, J., Trebst, C., & Stangel, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.005 · Cited by 252
Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia
Farooqui, A. A., & Horrocks, L. A. (2001) · The Neuroscientist · doi:10.1177/107385840100700308 · Cited by 245
Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination
Mason, J. L., Ye, P., Suzuki, K., D'Ercole, A. J., & Matsushima, G. K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05703.2000 · Cited by 237
Microglial Recruitment, Activation, and Proliferation in Response to Primary Demyelination
Remington, L. T., Babcock, A. A., Zehntner, S. P., & Owens, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060783 · Cited by 234
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination
Patel, J. R., McCandless, E. E., Dorsey, D., & Klein, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006301107 · Cited by 231
Schregel, K., Tysiak, E., Garteiser, P., Gemeinhardt, I., Prozorovski, T., Aktaş, O., Merz, H., Petersen, D., Wuerfel, J. T., & Sinkus, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200151109 · Cited by 228
Quantifying the early stages of remyelination following cuprizone-induced demyelination
Stidworthy, M. F., Genoud, S., Suter, U., Mantei, N., & Franklin, R. J. M. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00032.x · Cited by 224
Komoly, S., Hudson, L. D., Webster, H. D., & Bondy, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1894 · Cited by 223
Lin, W., Kemper, A., Dupree, J. L., Harding, H. P., Ron, D., & Popko, B. (2006) · Brain · doi:10.1093/brain/awl044 · Cited by 222
Skripuletz, T., Gudi, V., Hackstette, D., & Stangel, M. (2011) · PubMed · doi:10.14670/hh-26.1585 · Cited by 220
Blakemore, W. F. (1972) · Journal of Neurocytology · doi:10.1007/bf01102943 · Cited by 217
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage
Kim, J. Y., Shen, S., Dietz, K., He, Y., Howell, O. W., Reynolds, R., & Casaccia, P. (2009) · Nature Neuroscience · doi:10.1038/nn.2471 · Cited by 216
Metallothionein Redox Cycle and Function
Kang, Y. J. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100903 · Cited by 215
Liu, L., Belkadi, A., Darnall, L., Hu, T., Drescher, C., Cotleur, A. C., Padovani-Claudio, D., He, T., Choi, K., Lane, T. E., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2491 · Cited by 214
Gene Expression in Brain during Cuprizone-Induced Demyelination and Remyelination
Morell, P., Barrett, C. V., Mason, J. L., Toews, A. D., Hostettler, J. D., Knapp, G. W., & Matsushima, G. K. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0715 · Cited by 213
Mason, J. L., Toews, A., Hostettler, J. D., Morell, P., Suzuki, K., Goldman, J. E., & Matsushima, G. K. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63726-1 · Cited by 212
Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone
Blakemore, W. F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90118-4 · Cited by 207
Voß, E. V., Škuljec, J., Gudi, V., Skripuletz, T., Pul, R., Trebst, C., & Stangel, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.008 · Cited by 202
Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination
Franco-Pons, N., Torrente, M., Colomina, M. T., & Vilella, E. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.01.010 · Cited by 195
Ács, P., Kipp, M., Norkutė, A., Johann, S., Clarner, T., Braun, A., Berente, Z., Komoly, S., & Beyer, C. (2008) · Glia · doi:10.1002/glia.20806 · Cited by 194
Arnett, H. A., Wang, Y., Matsushima, G. K., Suzuki, K., & Ting, J. P.-Y. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09824.2003 · Cited by 190
Megamitochondria formation ‐ physiology and pathology
Wakabayashi, T. (2002) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2002.tb00452.x · Cited by 189
The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination
Hussain, R., Ghoumari, A. M., Bielecki, B., Steibel, J., Boehm, N., Lière, P., Macklin, W. B., Kumar, N., Habert, R., Mhaouty‐Kodja, S., et al. (2013) · Brain · doi:10.1093/brain/aws284 · Cited by 189
Armstrong, R. C., Le, T. Q., Frost, E. E., Borke, R. C., & Vana, A. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08574.2002 · Cited by 178
Harsan, L. A., Steibel, J., Zaremba, A., Agin, A., Sapin, R., Poulet, P., Guignard, B., Parizel, N., Grucker, D., Boehm, N., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4453-08.2008 · Cited by 177
Pasquini, L. A., Calatayud, C. A., Bertone Uña, A. L., Millet, V., Pasquini, J. M., & Soto, E. F. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9165-0 · Cited by 176
Mason, J. L., Langaman, C., Morell, P., Suzuki, K., & Matsushima, G. K. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00301.x · Cited by 172
The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration
Dugas, J. C., Ibrahim, A., & Barres, B. A. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.03.007 · Cited by 167
LIEBETANZ, D., & MERKLER, D. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.05.032 · Cited by 166
Stidworthy, M. F. (2004) · Brain · doi:10.1093/brain/awh217 · Cited by 164
McMahon, E. J., Suzuki, K., & Matsushima, G. K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00205-9 · Cited by 161
Mitochondrial Dysfunction in Neurodegenerative Diseases Associated with Copper Imbalance
Rossi, L. C., Lombardo, M. F., Ciriolo, M. R., & Rotilio, G. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014820.99232.8a · Cited by 158
Murtie, J. C., Zhou, Y.-X., Le, T. Q., Vana, A. C., & Armstrong, R. C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.006 · Cited by 157
Noradrenaline provides long‐term protection to dopaminergic neurons by reducing oxidative stress
Troadec, J., Marien, M. R., Darios, F. D., Hartmann, A., Ruberg, M., Colpaert, F. C., & Michel, P. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00556.x · Cited by 157
Selvaraju, R., Bernasconi, L., Losberger, C., Graber, P., Kadi, L., Avellana-Adalid, V., Picard-Riera, N., Van Evercooren, A. B., Cirillo, R., Kosco-Vilbois, M., et al. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.12.014 · Cited by 156
Dutta, R., Chomyk, A. M., Chang, A., Ribaudo, M. V., Deckard, S. A., Doud, M. K., Edberg, D. D., Bai, B., Li, M., Baranzini, S. E., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23860 · Cited by 155
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
Pasquini, L. A., Millet, V, Hoyos, H. C., Giannoni, J. P., Croci, D. O., Marder, M., Liu, F. T., Rabinovich, G. A., & Pasquini, J. M. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.40 · Cited by 152
Cuprizone [Bis(Cyclohexylidenehydrazide)] is Selectively Toxic for Mature Oligodendrocytes
Bénardais, K., Kotsiari, A., Škuljec, J., Koutsoudaki, P. N., Gudi, V., Singh, V., Vulinović, F., Skripuletz, T., & Stangel, M. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9380-9 · Cited by 148
Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone
Suzuki, K. (1969) · Science · doi:10.1126/science.163.3862.81 · Cited by 148
Franco, P. G., Silvestroff, L., Soto, E. F., & Pasquini, J. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.039 · Cited by 147
Li, C., Xiao, L., Liu, X., Yang, W., Shen, W., Hu, C., Yang, G., & He, C. (2013) · Glia · doi:10.1002/glia.22469 · Cited by 144
Levels of BDNF Impact Oligodendrocyte Lineage Cells following a Cuprizone Lesion
VonDran, M. W., Singh, H., Honeywell, J. Z., & Dreyfus, C. F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6595-10.2011 · Cited by 144
Ameijeiras, Á. H. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.018 · Cited by 141
Statin Therapy Inhibits Remyelination in the Central Nervous System
Miron, V. E., Zehntner, S. P., Kuhlmann, T., Ludwin, S. K., Owens, T., Kennedy, T. E., Bedell, B. J., & Antel, J. P. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080947 · Cited by 141
Chen, M., Baidoo, K. E., Verina, T., & Guilarte, T. R. (2004) · Brain · doi:10.1093/brain/awh161 · Cited by 140
Binder, M. D., Cate, H. S., Prieto, A. L., Kemper, D., Butzkueven, H., Gresle, M. M., Cipriani, T., Jokubaitis, V. G., Carmeliet, P., & Kilpatrick, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1180-08.2008 · Cited by 138
Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
Xu, H., Yang, H.-J., Zhang, Y., Clough, R., Browning, R., & Li, X.-M. (2009) · Behavioral Neuroscience · doi:10.1037/a0014477 · Cited by 137
Klinkert, W. E. F., Kojima, K., Lesslauer, W., Rinner, W., Lassmann, H., & Wekerle, H. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00183-x · Cited by 134
Patel, J. R., Williams, J. L., Muccigrosso, M. M., Liu, L., Sun, T., Rubin, J. B., & Klein, R. S. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1034-0 · Cited by 134
Butts, B. D., Houde, C., & Mehmet, H. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.70 · Cited by 132
Endogenous cell repair of chronic demyelination
Armstrong, R. C., Le, T. Q., Flint, N. C., Vana, A. C., & Zhou, Y.-X. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000205142.08716.7e · Cited by 125
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination
Hibbits, N., Yoshino, J., Le, T. Q., & Armstrong, R. C. (2012) · ASN Neuro · doi:10.1042/an20120062 · Cited by 125
(1980) · PubMed · Cited by 125
Taylor, L. C., Gilmore, W., Ting, J. P. ‐., & Matsushima, G. K. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22215 · Cited by 123
Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus
Norkute, A., Hieble, A., Braun, A., Johann, S., Clarner, T., Baumgartner, W., Beyer, C., & Kipp, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21946 · Cited by 123
Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse
Zhang, Y., Xu, H., Jiang, W., Xiao, L., Yan, B., He, J., Wang, Y., Bi, X., Li, X., & Kong, J. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.09.013 · Cited by 121
Irvine, K.-A., & Blakemore, W. F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.002 · Cited by 117
Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment
Witherick, J., Wilkins, A., Scolding, N. J., & Kemp, K. C. (2010) · Autoimmune Diseases · doi:10.4061/2011/164608 · Cited by 116
Hibbits, N., Pannu, R., Wu, T. J., & Armstrong, R. C. (2009) · ASN Neuro · doi:10.1042/an20090032 · Cited by 111
Miwa, S., Lawless, C., & von Zglinicki, T. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00426.x · Cited by 110
Carlton, W. W. (1967) · Life Sciences · doi:10.1016/0024-3205(67)90356-6 · Cited by 108
Xu, H. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00008 · Cited by 108
Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis
Manrique‐Hoyos, N., Jürgens, T., Grønborg, M., Kreutzfeldt, M., Schedensack, M., Kuhlmann, T., Schrick, C., Brück, W., Urlaub, H., Simons, M., et al. (2012) · Annals of Neurology · doi:10.1002/ana.22681 · Cited by 107
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
Veto, S., Acs, P., Bauer, J., Lassmann, H., Berente, Z., Setalo, G., Borgulya, G., Sumegi, B., Komoly, S., Gallyas, F., et al. (2010) · Brain · doi:10.1093/brain/awp337 · Cited by 107
Raasch, J., Zeller, N., van Loo, G., Merkler, D., Mildner, A., Erny, D., Knobeloch, K.-P., Bethea, J. R., Waisman, A., Knust, M., et al. (2011) · Brain · doi:10.1093/brain/awq359 · Cited by 106
Venturini, G. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07569.x · Cited by 106
Jurevics, H., Largent, C., Hostettler, J., Sammond, D. W., K. Matsushima, G., Amber Kleindienst, Toews, A. D., & Morell, P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00954.x · Cited by 106
Neuronal nitric oxide synthase plays a key role in CNS demyelination
Liñares, D., Taconis, M., Maña, P., Correcha, M., Fordham, S., Staykova, M., & Willenborg, D. O. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0294-06.2006 · Cited by 105
Neurobiological effects of sphingosine 1‐phosphate receptor modulation in the cuprizone model
Kim, H. J., Miron, V. E., Dukala, D., Proia, R. L., Ludwin, S. K., Traka, M., Antel, J. P., & Soliven, B. C. (2011) · The FASEB Journal · doi:10.1096/fj.10-173203 · Cited by 104
Bédard, A., Tremblay, P., Chernomoretz, A., & Vallières, L. (2007) · Glia · doi:10.1002/glia.20477 · Cited by 103
Gudi, V., Škuljec, J., Yildiz, Ö., Frichert, K., Skripuletz, T., Moharregh-Khiabani, D., Voß, E., Wissel, K., Wolter, S., & Stangel, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022623 · Cited by 103
Multicontrast MRI of remyelination in the central nervous system
Merkler, D., Boretius, S., Stadelmann, C., Ernsting, T., Michaelis, T., Frahm, J., & Brück, W. (2005) · NMR in Biomedicine · doi:10.1002/nbm.972 · Cited by 102
Cuprizone-Induced Demyelination as a Tool to Study Remyelination and Axonal Protection
Zendedel, A., Beyer, C., & Kipp, M. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0026-4 · Cited by 102
Platelet-Derived Growth Factor Promotes Repair of Chronically Demyelinated White Matter
Vana, A. C., Flint, N. C., Harwood, N. E., Le, T. Q., Fruttiger, M., & Armstrong, R. C. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181587d46 · Cited by 101
Blood-brain barrier permeability during Cuprizone-induced demyelination
Bakker, D. A., & Ludwin, S. K. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90055-4 · Cited by 100
In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
Hesse, A., Wagner, M., Held, J., Brück, W., Salinas-Riester, G., Hao, Z., Waisman, A., & Kuhlmann, T. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.016 · Cited by 98
Functional recovery of callosal axons following demyelination: A critical window
Crawford, D. K., Mangiardi, M., Xia, X., López-Valdés, H. E., & Tiwari-Woodruff, S. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.069 · Cited by 97
NF-?B modulates lipopolysaccharide-induced microglial nerve growth factor expression
Heese, K., Fiebich, B. L., Bauer, J., & Otten, U. (1998) · Glia · doi:10.1002/(sici)1098-1136(199804)22:4 · Cited by 96
Role of iron in neurotoxicity: a cause for concern in the elderly?
Stankiewicz, J., & Brass, S. D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831ba07c · Cited by 94
Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice
Hoffmann, K., Lindner, M., Gröticke, I., Stangel, M., & Löscher, W. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.005 · Cited by 93
Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions
Sabo, J. K., Aumann, T. D., Merlo, D., Kilpatrick, T. J., & Cate, H. S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5859-10.2011 · Cited by 93
Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin
Adamo, A. M., Paez, P. M., Cabrera, O. E. E., Wolfson, M. L., Franco, P. G., Pasquini, J. M., & Soto, E. F. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.027 · Cited by 89
Zhang, J., Jones, M. V., McMahon, M. T., Mori, S., & Calabresi, P. A. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23032 · Cited by 88
Carlton, W. W. (1966) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(66)90062-7 · Cited by 86
Wu, Q., Yang, Q., Cate, H. S., Kemper, D., Binder, M. D., Wang, H., Fang, K., Quick, M. J., Marriott, M. P., Kilpatrick, T. J., et al. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21111 · Cited by 86
Marriott, M. P., Emery, B., Cate, H. S., Binder, M. D., Kemper, D., Wu, Q., Kolbe, S., Gordon, I. R., Wang, H., Egan, G., et al. (2008) · Glia · doi:10.1002/glia.20646 · Cited by 86
Myelin Repair Is Accelerated by Inactivating CXCR2 on Nonhematopoietic Cells
Liu, L., Darnall, L., Hu, T., Choi, K., Lane, T. E., & Ransohoff, R. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1238-10.2010 · Cited by 85
Cuprizone effect on myelination, astrogliosis and microglia attraction in the mouse basal ganglia
Pott, F., Gingele, S., Clarner, T., Dang, J., Baumgartner, W., Beyer, C., & Kipp, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.084 · Cited by 85
Acs, P., Selak, M. A., Komoly, S., & Kalman, B. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.06.012 · Cited by 84
Interferon-γ Protects against Cuprizone-Induced Demyelination
Gao, X., Gillig, T. A., Ye, P., D'Ercole, A. J., Matsushima, G. K., & Popko, B. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0883 · Cited by 84
Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment
Zatta, P., Raso, M., Zambenedetti, P., Wittkowski, W., Messori, L., Piccioli, F., Mauri, P. L., & Beltramini, M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5073-8 · Cited by 84
Kipp, M., Gingele, S., Pott, F., Clarner, T., van der Valk, P., Denecke, B., Gan, L., Siffrin, V., Zipp, F., Dreher, W., et al. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.05.003 · Cited by 83
Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury
Kim, S.-J., Steelman, A. J., Zhang, Y., Kinney, H. C., & Li, J. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00501.x · Cited by 82
Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
Hoyos, H. C., Rinaldi, M., Méndez‐Huergo, S. P., Marder, M., Rabinovich, G. A., Pasquini, J. M., & Pasquini, L. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.023 · Cited by 79
IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination
Kang, Z., Liu, L., Spangler, R., Spear, C., Wang, C., Gulen, M. F., Veenstra, M., Ouyang, W., Ransohoff, R. M., & Li, X. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0841-12.2012 · Cited by 78
Makinodan, M., Yamauchi, T., Tatsumi, K., Okuda, H., Takeda, T., Kiuchi, K., Sadamatsu, M., Wanaka, A., & Kishimoto, T. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.05.006 · Cited by 78
Emery, B., Cate, H. S., Marriott, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J.-G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602574103 · Cited by 78
Silvestroff, L., Bartucci, S. L., Pasquini, J. M., & Franco, P. G. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.02.018 · Cited by 77
MHC class II exacerbates demyelination in vivo independently of T cells
Hiremath, M. M., Chen, V. S., Suzuki, K., Ting, J. P.-Y., & Matsushima, G. K. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.034 · Cited by 77
Cate, H. S., Sabo, J. K., Merlo, D., Kemper, D., Aumann, T. D., Robinson, J., Merson, T. D., Emery, B., Perreau, V. M., & Kilpatrick, T. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06660.x · Cited by 76
Loss of Branched O-Mannosyl Glycans in Astrocytes Accelerates Remyelination
Kanekiyo, K., Inamori, K., Kitazume, S., Sato, K., Maeda, J., Higuchi, M., Kizuka, Y., Korekane, H., Matsuo, I., Honke, K., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3137-12.2013 · Cited by 76
DIVISION OF GIANT MITOCHONDRIA DURING RECOVERY FROM CUPRIZONE INTOXICATION
Tandler, B., & Hoppel, C. L. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.56.1.266 · Cited by 75
Patel, R., Moore, S. M., Crawford, D. K., Hannsun, G., Manda, S. V., Tan, K. M., Molaie, D. M., & Tiwari-Woodruff, S. K. (2013) · Brain Pathology · doi:10.1111/bpa.12029 · Cited by 75
Dupree, J. L., Mason, J. L., Marcus, J., Stull, M., Levinson, R., Matsushima, G. K., & Popko, B. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x04000304 · Cited by 75
Zaaraoui, W., Deloire, M., Merle, M., Girard, C., Raffard, G., Biran, M., Inglese, M., Petry, K. G., Gonen, O., Brochet, B., et al. (2008) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-008-0141-3 · Cited by 75
Soundarapandian, M. M., Selvaraj, V., Lo, U.-G., Golub, M. S., Feldman, D. H., Pleasure, D. E., & Deng, W. (2011) · Scientific Reports · doi:10.1038/srep00002 · Cited by 75
McMahon, E. J., Cook, D. N., Suzuki, K., & Matsushima, G. K. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2964 · Cited by 75
Cuprizone neurotoxicity, copper deficiency and neurodegeneration
Benetti, F., Ventura, M., Salmini, B., Ceola, S., Carbonera, D., Mammi, S., Zitolo, A., D’Angelo, P., Urso, E., & Maffia, M. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.05.008 · Cited by 74
Hyperphosphorylation and Aggregation of Tau in Experimental Autoimmune Encephalomyelitis
Schneider, A., Araújo, G. W., Trajković, K., Herrmann, M. M., Merkler, D., Mandelkow, E., Weissert, R., & Simons, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409954200 · Cited by 72
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model
Arnett, H. A., Hellendall, R. P., Matsushima, G. K., Suzuki, K., Laubach, V. E., Sherman, P., & Ting, J. P.-Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.427 · Cited by 71
GAS6 Enhances Repair Following Cuprizone-Induced Demyelination
Tsiperson, V., Li, X., Schwartz, G. J., Raine, C. S., & Shafit‐Zagardo, B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015748 · Cited by 71
Chen, M., & Guilarte, T. R. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj172 · Cited by 70
Binder, M. D., Xiao, J., Kemper, D., Ma, G. Z. M., Murray, S. S., & Kilpatrick, T. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017727 · Cited by 70
Geva, M., Cabilly, Y., Assaf, Y., Mindroul, N., Marom, L., Raini, G., Pinchasi, D., & Elroy‐Stein, O. (2010) · Brain · doi:10.1093/brain/awq180 · Cited by 70
Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T., & Brodkin, E. S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.025 · Cited by 69
Biancotti, J. C., Kumar, S., & de Vellis, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9792-8 · Cited by 69
Myelin copper and the cuprizone model of schizophrenia
Konradi, C. L. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s129 · Cited by 68
Unravelling the chemical nature of copper cuprizone
Messori, L., Casini, A., Gabbiani, C., Sorace, L., Muniz-Miranda, M., & Zatta, P. (2007) · Dalton Transactions · doi:10.1039/b701896g · Cited by 67
Tanaka, T., Murakami, K., Bandô, Y., & Yoshida, S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12289 · Cited by 66
Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination
Bernard, F., Moreau‐Fauvarque, C., Heitz‐Marchaland, C., Zagar, Y., Dumas, L., Fouquet, S., Lee, X., Shao, Z., Mi, S., & Chédotal, A. (2012) · Glia · doi:10.1002/glia.22378 · Cited by 65
Horiuchi, M., Wakayama, K., Itoh, A., Kawai, K., Pleasure, D., Ozato, K., & Itoh, T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-227 · Cited by 65
The neurotoxicant, cuprizone, retards the differentiation of oligodendrocytes in vitro
Cammer, W. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00181-1 · Cited by 65
Tezuka, T., Tamura, M., Kondo, M. A., Sakaue, M., Okada, K., Takemoto, K., Fukunari, A., Miwa, K., Ohzeki, H., Kano, S.-I., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.003 · Cited by 64
Iron chelation as a potential therapy for neurodegenerative disease
Hider, R. C., Ma, Y., Molina‐Holgado, F., Gaeta, A., & Roy, S. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361304 · Cited by 64
Axl−/− mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
Hoehn, H. J., Kress, Y., Sohn, A. S. W., Brosnan, C. F., Bourdon, S., & Shafit‐Zagardo, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.076 · Cited by 64
Spongiform encephalopathy induced in rats and guinea pigs by cuprizone
Carlton, W. W. (1969) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(69)90057-4 · Cited by 64
Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice
Clarner, T., Parabucki, A., Beyer, C., & Kipp, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02140.x · Cited by 63
Rapôso, C., Nunes, A. K. S., Luna, R. L. D. A., Araújo, S. M. D. R., da Cruz‐Höfling, M. A., & Peixoto, C. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/321460 · Cited by 62
Chandran, P., Upadhyay, J., Markosyan, S., Lisowski, A. R., Buck, W. R., Chin, C.-L., Fox, G. B., Luo, F. R., & Day, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.051 · Cited by 62
Goldberg, J., Daniel, M., van Heuvel, Y., Victor, M., Beyer, C., Clarner, T., & Kipp, M. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9975-y · Cited by 62
Yoshikawa, K., Palumbo, S., Toscano, C. D., & Bosetti, F. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.022 · Cited by 61
An immunohistochemical study of myelin proteins during remyelination in the central nervous system
Ludwin, S. K., & Sternberger, N. H. (1984) · Acta Neuropathologica · doi:10.1007/bf00685250 · Cited by 61
Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination
Skripuletz, T., Miller, E., Moharregh-Khiabani, D., Blank, A., Pul, R., Gudi, V., Trebst, C., & Stangel, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0202-7 · Cited by 61
Mitochondrial changes associated with demyelination: Consequences for axonal integrity
Campbell, G. R., & Mahad, D. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.007 · Cited by 60
Kumar, S., Biancotti, J. C., Yamaguchi, M., & de Vellis, J. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9208-6 · Cited by 60
17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss
Taylor, L. C., Puranam, K. L., Gilmore, W., Ting, J. P. ‐., & Matsushima, G. K. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.016 · Cited by 60
Astroglial‐derived lymphotoxin‐α exacerbates inflammation and demyelination, but not remyelination
Plant, S. R., Arnett, H. A., & Ting, J. P. (2005) · Glia · doi:10.1002/glia.20089 · Cited by 60
Hu, Y., Lee, X., Ji, B., Guckian, K. M., Apicco, D. J., Pepinsky, R. B., Miller, R. H., & Mi, S. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.06.007 · Cited by 59
Islam, M. S., Tatsumi, K., Okuda, H., Shiosaka, S., & Wanaka, A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.011 · Cited by 59
Lee, K. K., De Repentigny, Y., Saulnier, R., Rippstein, P., Macklin, W. B., & Kothary, R. (2006) · Glia · doi:10.1002/glia.20343 · Cited by 59
Petratos, S., Gonzales, M. F., Azari, M. F., Marriott, M. P., Minichiello, R. A., Shipham, K. A., Profyris, C., Nicolaou, A., Boyle, K., Cheema, S. S., et al. (2004) · Glia · doi:10.1002/glia.20056 · Cited by 57
Bagchi, B., Al-Sabi, A., Kaza, S. K., Scholz, D., O’Leary, V. B., Dolly, J. O., & Ovsepian, S. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087736 · Cited by 57
Gregg, J. R., Herring, N. R., Naydenov, A. V., Hanlin, R. P., & Konradi, C. L. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.05.023 · Cited by 57
Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss
Doan, V., Kleindienst, A. M., McMahon, E. J., Long, B. R., Matsushima, G. K., & Taylor, L. C. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23174 · Cited by 56
Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit
Wang, H., Li, C., Wang, H., Mei, F., Liu, Z., Shen, H., & Xiao, L. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1323-1 · Cited by 54
Clinical and Histological Observations on Cuprizonc Toxicity and Scrapie in Mice
Pattison, I. H., & Jebbett, J. N. (1971) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)34168-7 · Cited by 54
Cuprizone neurotoxicity in the rat: morphologic observations
Love, S. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90127-x · Cited by 54
Li, J., Ghiani, C. A., Kim, J. Y., Liu, A., Sandoval, J., deVellis, J., & Casaccia‐Bonnefil, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0184-08.2008 · Cited by 53
Jurevics, H., Hostettler, J., Muse, E. D., Sammond, D. W., Matsushima, G. K., Toews, A. D., & Morell, P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00310.x · Cited by 53
Tumor necrosis factor α and its receptors in relapsing-remitting multiple sclerosis
Martino, G., Consiglio, A., Franciotta, D. M., Corti, A., Filippi, M., Vandenbroeck, K., Sciacca, F. L., Comı, G., & Grimaldi, L. M. E. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00142-1 · Cited by 52
Zhou, Y.-X., Pannu, R., Le, T. Q., & Armstrong, R. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.004 · Cited by 51
Plant, S. R., Iocca, H. A., Wang, Y., Thrash, J. C., O'Connor, B. P., Arnett, H. A., Fu, Y.-X., Carson, M. J., & Ting, J. P.-Y. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1307-07.2007 · Cited by 51
Restoration of FcRγ/Fyn signaling repairs central nervous system demyelination
Seiwa, C., Yamamoto, M., Tanaka, K., Fukutake, M., Ueki, T., Takeda, S., Sakai, R., Ishige, A., Watanabe, K., Akita, M., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21196 · Cited by 50
Olig1 is expressed in human oligodendrocytes during maturation and regeneration
Othman, A. H., Frim, D. M., Polak, P. E., Vujicic, S., Arnason, B. G. W., & Boullerne, A. I. (2011) · Glia · doi:10.1002/glia.21163 · Cited by 50
Xu, H., Yang, H.-J., Rose, G. M., & Li, X. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00031 · Cited by 49
Lin, Y., Huang, G., Jamison, S., Li, J., Harding, H. P., Ron, D., & Lin, W. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.10.009 · Cited by 49
Bernardo, A., Greco, A., Levi, G., & Minghetti, L. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.5.509 · Cited by 49
Škuljec, J., Gudi, V., Ulrich, R., Frichert, K., Yildiz, Ö., Pul, R., Voss, E. V., Wissel, K., Baumgärtner, W., & Stangel, M. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182294fad · Cited by 49
Deleterious Role of IFNγ in a Toxic Model of Central Nervous System Demyelination
Maña, P., Liñares, D., Fordham, S., Staykova, M., & Willenborg, D. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050799 · Cited by 48
(2012) · PubMed · Cited by 47
Mattner, F., Liñares, D., Staykova, M. A., Berghofer, P., Grégoire, M. C., Ballantyne, P., Quinlivan, M., Fordham, S. A., Pham, T. Q., Willenborg, D. O., et al. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1784-2 · Cited by 46
Palumbo, S., Toscano, C. D., Parente, L., Weigert, R., & Bosetti, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07363.x · Cited by 46
Maña, P., Fordham, S. A., Staykova, M. A., Correcha, M., Silva, D., Willenborg, D. O., & Liñares, D. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.013 · Cited by 46
A New Colour Reaction on Copper and Certain Carbonyl Compounds.
Nilsson, G., Erdtman, H., Lindstedt, G., & Kinell, P.-O. (1950) · Acta Chemica Scandinavica · doi:10.3891/acta.chem.scand.04-0205 · Cited by 46
FGF2 and FGFR1 signaling regulate functional recovery following cuprizone demyelination
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Metadata
- Authors
- Praet, J., Guglielmetti, C., Berneman, Z., Van der Linden, A., & Ponsaerts, P.
- Affiliations
- University of Antwerp (BE)
- Corresponding author
- Praet, Jelle
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 47
- Pages
- 485-505
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1991883207
- Cited by
- 435
- References
- 268
- Citations by year
- 2026: 29 · 2025: 36 · 2024: 29 · 2023: 37 · 2022: 51 · 2021: 49 · 2020: 48 · 2019: 49 · 2018: 41 · 2017: 35 · 2016: 19 · 2015: 12
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Fund for Scientific Research-Flanders
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- cuprizone, multiple sclerosis, demyelination, remyelination, oligodendrocyte apoptosis, myelin degeneration, metabolic stress, neuroinflammation, neurotrophic factors, myelin debris clearance, axonal pathology, neuronal pathology, schizophrenia, epilepsy, mouse model
- MeSH terms
- Animals, Brain, Cuprizone, Disease Models, Animal, Multiple Sclerosis, Myelin Sheath, Neuroglia, Neurons, Oxidative Stress, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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