Cited by 114Heart Rate Variability and Autonomic ControlVagus Nerve Stimulation ResearchCardiac Health and Mental Health

The DOI matches its Crossref record; 220 of the 225 references it cites were found in a registry or an index.

From psychological moments to mortality: A multidisciplinary synthesis on heart rate variability spanning the continuum of time

Kemp, Andrew H., Koenig, Julian, Thayer, Julian F.·2017·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2017.09.006

Open this paper in CoChat — free account

Abstract

Heart rate variability (HRV) indexes functioning of the vagus nerve, arguably the most important nerve in the human body. The Neurovisceral Integration Model has provided a structural framework for understanding brain-body integration, highlighting the role of the vagus in adaptation to the environment. In the present paper, we emphasise a temporal framework in which HRV may be considered a missing, structural link between psychological moments and mortality, a proposal we label as Neurovisceral Integration Across a Continuum of Time (or NIACT). This new framework places neurovisceral integration on a dimension of time, highlighting implications for lifespan development and healthy aging, and helping to bridge the gap between clearly demarcated disciplines such as psychology and epidemiology. The NIACT provides a novel framework, which conceptualizes how everyday psychological moments both affect and are affected by the vagus in ways that have long-term effects on mortality risk. We further emphasize that a longitudinal approach to understanding change in vagal function over time may yield novel scientific insights and important public health outcomes.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2017.09.006

Cites

220 of 220 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Untitled work
(2013) · Cited by 44,563
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs
Lakens, D. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00863 · Cited by 10,303
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The ‘Trier Social Stress Test’—a tool for investigating psychobiological stress responses in a laboratory setting
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
The Stress of Life
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond
Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli, G. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192703 · Cited by 4,750
A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967
Heart rate variability: origins, methods, and interpretive caveats
BERNTSON, G. G., THOMAS BIGGER, J., ECKBERG, D. L., GROSSMAN, P., KAUFMANN, P. G., MALIK, M., NAGARAJA, H. N., PORGES, S. W., SAUL, J. P., STONE, P. H., et al. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02140.x · Cited by 3,962
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
The inflammatory reflex
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health
Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.009 · Cited by 3,224
The New Statistics: Why and How
Cumming, G. (2014) · Psychological Science · doi:10.1177/0956797613504966 · Cited by 3,200
Autonomic nervous system activity in emotion: a review
Kreibig, S. D. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.03.010 · Cited by 3,188 · cited 2×
“Co-activation of the parasympathetic and sympathetic nervous systems (PNS and SNS) may help mitigate the deleterious effects of increased SNS activity (Norman et al., 2011), while sympathetic-parasympathetic cardiac deactivation may reflect passive sensory intake (Kreibig, 2010).”
Background
A model of neurovisceral integration in emotion regulation and dysregulation
Thayer, J. F., & Lane, R. D. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00338-4 · Cited by 3,092
Psychological flexibility as a fundamental aspect of health
Kashdan, T. B., & Rottenberg, J. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.03.001 · Cited by 3,054 · cited 1×
“We interpret this psychophysiological marker as a structural bridge between psychological moments and future morbidity (Friedman and Thayer, 1998; Kashdan and Rottenberg, 2010; Kemp et al., 2012b), providing a physiological foundation supporting response to environmental change and challenge, that…”
Background
Enhancing well-being and alleviating depressive symptoms with positive psychology interventions: a practice-friendly meta-analysis
Sin, N. L., & Lyubomirsky, S. (2009) · Journal of Clinical Psychology · doi:10.1002/jclp.20593 · Cited by 2,955 · cited 1×
“Research has highlighted the beneficial effects of positive psychological interventions on risk for future cardiac outcomes (Boehm and Kubzansky, 2012; Dubois et al., 2012; Sin and Lyubomirsky, 2009), and these effects may persist over and above addressing chronic negative emotions.”
Background
Heart rate variability: A review
Rajendra Acharya, U., Paul Joseph, K., Kannathal, N., Lim, C. M., & Suri, J. S. (2006) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-006-0119-0 · Cited by 2,820
The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.543 · Cited by 2,276
Adverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
Risks of all-cause and suicide mortality in mental disorders: a meta-review
Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115
Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040
The James-Lange Theory of Emotions: A Critical Examination and an Alternative Theory
Cannon, W. B. (1927) · The American Journal of Psychology · doi:10.2307/1415404 · Cited by 1,899
Heart rate variability as an index of regulated emotional responding
Appelhans, B. M., & Luecken, L. J. (2006) · Review of General Psychology · doi:10.1037/1089-2680.10.3.229 · Cited by 1,893
Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872
A healthy heart is not a metronome: an integrative review of the heart’s anatomy and heart rate variability.
Shaffer, F., McCraty, R., & Zerr, C. L. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01040 · Cited by 1,866
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A Polyvagal Theory
PORGES, S. W. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01213.x · Cited by 1,624
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594 · cited 1×
“…research on emotion has increased exponentially over the last decade, the term ‘emotion’ remains ill-defined, and this situation has led to an intellectual stalemate (LeDoux, 2012) leading some to liken the situation to the Hundred Years’ War between England and France (Lindquist et al., 2013).”
Background
Positive Psychological Well-Being and Mortality: A Quantitative Review of Prospective Observational Studies
Chida, Y., & Steptoe, A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818105ba · Cited by 1,592
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · cited 2×
“…function such that vagal impairment leads to dysregulation of immune system triggering downstream artherosclerotic processes as described by Tracey and colleagues (Huston and Tracey, 2010; Tracey, 2002, 2007; Tracey and Pavlov, 2012), as well as adverse effects of the disease process itself on HRV.”
Background
A tutorial on propensity score estimation for multiple treatments using generalized boosted models
McCaffrey, D. F., Griffin, B. A., Almirall, D., Slaughter, M. E., Ramchand, R., & Burgette, L. F. (2013) · Statistics in Medicine · doi:10.1002/sim.5753 · Cited by 1,450
Selected Writings of John Hughlings Jackson
SCOTT, J. (1959) · American Journal of Psychiatry · doi:10.1176/ajp.116.5.479-a · Cited by 1,291
Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis
Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.012 · Cited by 1,286
Untitled work
(2011) · Cited by 1,181
Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176
Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution and biobehavioral functions
Grossman, P., & Taylor, E. W. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.014 · Cited by 1,133
Suppressing unwanted memories by executive control
Anderson, M. C., & Green, C. (2001) · Nature · doi:10.1038/35066572 · Cited by 1,129
A meta-analysis of alcohol consumption and the risk of 15 diseases
Corrao, G. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2003.11.027 · Cited by 1,077
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis
Chalmers, J. A., Quintana, D. S., Abbott, M. J.-A., & Kemp, A. H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00080 · Cited by 1,067 · cited 5×
“This research on major depressive disorder (MDD) (Kemp et al., 2010), anxiety disorders (Chalmers et al., 2014), schizophrenia (Clamor et al., 2016), borderline personality disorder (Koenig et al., 2016) and antidepressants (Kemp, et al., 2014a; Kemp et al., 2016) is briefly reviewed below.”
BackgroundMethodInfluential
Resting Heart Rate in Cardiovascular Disease
Fox, K., Borer, J. S., Camm, A. J., Danchin, N., Ferrari, R., Lopez Sendon, J. L., Steg, P. G., Tardif, J.-C., Tavazzi, L., & Tendera, M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.079 · Cited by 1,062
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040
Upward spirals of positive emotions counter downward spirals of negativity: Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology
Garland, E. L., Fredrickson, B., Kring, A. M., Johnson, D. P., Meyer, P. S., & Penn, D. L. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.03.002 · Cited by 1,035
The role of vagal function in the risk for cardiovascular disease and mortality
Thayer, J. F., & Lane, R. D. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.013 · Cited by 1,033
Self-citation
The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: A review with emphasis on a reanalysis of previous studies
Reyes del Paso, G. A., Langewitz, W., Mulder, L. J. M., van Roon, A., & Duschek, S. (2013) · Psychophysiology · doi:10.1111/psyp.12027 · Cited by 954
The Autonomic Brain: An Activation Likelihood Estimation Meta-Analysis for Central Processing of Autonomic Function
Beissner, F., Meissner, K., Bar, K.-J., & Napadow, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1103-13.2013 · Cited by 920
The heart's content: The association between positive psychological well-being and cardiovascular health.
Boehm, J. K., & Kubzansky, L. D. (2012) · Psychological Bulletin · doi:10.1037/a0027448 · Cited by 909
A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women
Stampfer, M. J., Colditz, G. A., Willett, W. C., Speizer, F. E., & Hennekens, C. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808043190503 · Cited by 892
Heart rate variability biofeedback: how and why does it work?
Lehrer, P. M., & Gevirtz, R. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00756 · Cited by 883
Understanding The New Statistics
Cumming, G. (2013) · Routledge eBooks · doi:10.4324/9780203807002 · Cited by 878
Heart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870
Self-citation
Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
Goldstein, D. S., Bentho, O., Park, M.-Y., & Sharabi, Y. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2010.056259 · Cited by 846
Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint
Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1991) · Psychological Review · doi:10.1037/0033-295x.98.4.459 · Cited by 819
Vagal influence on working memory and attention
Hansen, A. L., Johnsen, B. H., & Thayer, J. F. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(03)00073-4 · Cited by 759
How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone
Kok, B. E., Coffey, K. A., Cohn, M. A., Catalino, L. I., Vacharkulksemsuk, T., Algoe, S. B., Brantley, M., & Fredrickson, B. L. (2013) · Psychological Science · doi:10.1177/0956797612470827 · Cited by 755
Comorbidity of substance use disorders with mood and anxiety disorders
Merikangas, K. R., Mehta, R. L., Molnar, B. E., Walters, E. E., Swendsen, J. D., Aguilar‐Gaxiola, S., Bijl, R. V., Borges, G. L. G., Caraveo-Anduaga, J. J., DeWit, D. J., et al. (1998) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00076-8 · Cited by 747
Beyond Heart Rate Variability: Vagal Regulation of Allostatic Systems
THAYER, J. F., & STERNBERG, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.014 · Cited by 703
Central and autonomic nervous system interaction is altered by short-term meditation
Tang, Y.-Y., Ma, Y., Fan, Y., Feng, H., Wang, J., Feng, S., Lu, Q., Hu, B., Lin, Y., Li, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904031106 · Cited by 680
Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects
Groves, D. A., & Brown, V. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.004 · Cited by 677
Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies
Russ, T. C., Stamatakis, E., Hamer, M., Starr, J. M., Kivimaki, M., & Batty, G. D. (2012) · BMJ · doi:10.1136/bmj.e4933 · Cited by 637
Autoimmune Diseases and Severe Infections as Risk Factors for Schizophrenia: A 30-Year Population-Based Register Study
Benros, M. E., Nielsen, P. R., Nordentoft, M., Eaton, W. W., Dalton, S. O., & Mortensen, P. B. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030516 · Cited by 582
Emotion Recognition in Children with Autism Spectrum Disorders: Relations to Eye Gaze and Autonomic State
Bal, E., Harden, E., Lamb, D., Van Hecke, A. V., Denver, J. W., & Porges, S. W. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0884-3 · Cited by 575
Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders: A Nationwide Study
Benros, M. E., Waltoft, B. L., Nordentoft, M., Østergaard, S. D., Eaton, W. W., Krogh, J., & Mortensen, P. B. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1111 · Cited by 572
Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns
Penttilä, J., Helminen, A., Jartti, T., Kuusela, T., Huikuri, H. V., Tulppo, M. P., Coffeng, R., & Scheinin, H. (2001) · Clinical Physiology · doi:10.1046/j.1365-2281.2001.00337.x · Cited by 567
Effect of Endurance Exercise on Autonomic Control of Heart Rate
Carter, J. B., Banister, E. W., & Blaber, A. P. (2003) · Sports Medicine · doi:10.2165/00007256-200333010-00003 · Cited by 556
The relationship between mental and physical health: insights from the study of heart rate variability
Kemp, A. H., & Quintana, D. S. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.06.018 · Cited by 538
Basic emotions are associated with distinct patterns of cardiorespiratory activity
Rainville, P., Bechara, A., Naqvi, N. H., & Damásio, A. R. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.024 · Cited by 533
Respiratory sinus arrhythmia, emotion, and emotion regulation during social interaction
Butler, E. A., Wilhelm, F. H., & Gross, J. J. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00467.x · Cited by 520
Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose–response meta-regression
Hillebrand, S., Gast, K. B., de Mutsert, R., Swenne, C. A., Jukema, J. W., Middeldorp, S., Rosendaal, F. R., & Dekkers, O. M. (2013) · EP Europace · doi:10.1093/europace/eus341 · Cited by 515
Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis
Alvares, G. A., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140217 · Cited by 503
Human Baroreflexes in Health and Disease
Eckberg, D. L., & Sleight, P. (1992) · doi:10.1093/oso/9780198576938.001.0001 · Cited by 502
The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics
Allen, J. J. B., Chambers, A. S., & Towers, D. N. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.08.005 · Cited by 491
Development and validation of a scale for hypomanic personality.
Eckblad, M., & Chapman, L. J. (1986) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.95.3.214 · Cited by 479
Depression, Comorbid Anxiety Disorders, and Heart Rate Variability in Physically Healthy, Unmedicated Patients: Implications for Cardiovascular Risk
Kemp, A. H., Quintana, D. S., Felmingham, K. L., Matthews, S. T., & Jelinek, H. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030777 · Cited by 477
Upward spirals of the heart: autonomic flexibility, as indexed by vagal tone, reciprocally and prospectively predicts positive emotions and social connectedness
Kok, B. E., & Fredrickson, B. L. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.09.005 · Cited by 453
Cardiac psychophysiology and autonomic space in humans: Empirical perspectives and conceptual implications.
Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.2.296 · Cited by 430
Beat-to-beat variations of heart rate reflect modulation of cardiac autonomic outflow
Saul, J. (1990) · Physiology · doi:10.1152/physiologyonline.1990.5.1.32 · Cited by 424
Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women
Cooney, M. T., Vartiainen, E. A., Laakitainen, T., Juolevi, A., Dudina, A. L., & Graham, I. M. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.12.029 · Cited by 416
Therapeutic mechanisms of vagus nerve stimulation
Henry, T. R. (2002) · Neurology · doi:10.1212/wnl.59.6_suppl_4.s3 · Cited by 415
Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia
Shepherd, A. M., Laurens, K. R., Matheson, S. L., Carr, V. J., & Green, M. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.015 · Cited by 412
Effects of 12 Months of Vagus Nerve Stimulation in Treatment-Resistant Depression: A Naturalistic Study
Rush, A. J., Sackeïm, H. A., Marangell, L. B., George, M. S., Brannan, S. K., Thomas, S., Lavori, P., Howland, R. H., Kling, M. A., Rittberg, B. R., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.024 · Cited by 407
Anxiety and autonomic flexibility: a cardiovascular approach1Portions of this paper were presented in J.F. Thayer (Chair), New Approaches to Cardiovascular Reactivity Symposium conducted at the 33rd Annual Meeting of the Society for Psychophysiological Research, October 1993, Rottach-Egern, Germany. This study was conducted in partial fulfillment of the requirements of the doctoral dissertation of the first author.1
Friedman, B. H., & Thayer, J. F. (1998) · Biological Psychology · doi:10.1016/s0301-0511(97)00027-6 · Cited by 404
Development and validation of a scale for hypomanic personality.
Eckblad, M., & Chapman, L. J. (1986) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.95.3.214 · Cited by 399
A brain-liver circuit regulates glucose homeostasis
Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392
Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA)
Licht, C. M. M., de Geus, E. J. C., Zitman, F. G., Hoogendijk, W. J. G., van Dyck, R., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1358 · Cited by 379
Components of heart rate variability measured during healing of acute myocardial infarction
Bigger, J. T., Kleiger, R. E., Fleiss, J. L., Rolnitzky, L. M., Steinman, R. C., & Miller, J. P. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)90917-4 · Cited by 369
Association between heart rate variability and fluctuations in resting-state functional connectivity
Chang, C., Metzger, C. D., Glover, G. H., Duyn, J. H., Heinze, H., & Walter, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.038 · Cited by 368
Heart rate variability is associated with emotion recognition: Direct evidence for a relationship between the autonomic nervous system and social cognition
Quintana, D. S., Guastella, A. J., Outhred, T., Hickie, I. B., & Kemp, A. H. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.08.012 · Cited by 367
Self-citation
Heart rate variability and its relation to prefrontal cognitive function: The effects of training and detraining
Hansen, A. L., Johnsen, B. H., Sollers, J. J., Stenvik, K., & Thayer, J. F. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1208-0 · Cited by 354
Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain
Follesa, P., Biggio, F., Gorini, G., Caria, S., Talani, G., Dazzi, L., Puligheddu, M., Marrosu, F., & Biggio, G. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.045 · Cited by 352
Cardiac vagal tone and sustained attention in school‐age children
SUESS, P. E., PORGES, S. W., & PLUDE, D. J. (1994) · Psychophysiology · doi:10.1111/j.1469-8986.1994.tb01020.x · Cited by 351
Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
Agelink, M. W., Malessa, R., Baumann, B., Majewski, T., Akila, F., Zeit, T., & Ziegler, D. (2001) · Clinical Autonomic Research · doi:10.1007/bf02322053 · Cited by 349
The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy
Huston, J. M., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02321.x · Cited by 345
Short- and long-term effects of cigarette smoking on heart rate variability
Hayano, J., Yamada, M., Sakakibara, Y., Fujinami, T., Yokoyama, K., Watanabe, Y., & Takata, K. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90030-5 · Cited by 321
Cardiac vagal tone is associated with social engagement and self-regulation
Geisler, F. C. M., Kubiak, T., Siewert, K., & Weber, H. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.02.013 · Cited by 313
Untitled work
(1997) · VU Research Portal · Cited by 307
Effects of Moderate and Vigorous Physical Activity on Heart Rate Variability in a British Study of Civil Servants
Rennie, K. L. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg120 · Cited by 300
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 297
Cardiac autonomic balance versus cardiac regulatory capacity
Berntson, G. G., Norman, G. J., Hawkley, L. C., & Cacioppo, J. T. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00652.x · Cited by 290
Resting respiratory sinus arrhythmia is associated with tonic positive emotionality.
Oveis, C., Cohen, A. B., Gruber, J., Shiota, M. N., Haidt, J., & Keltner, D. J. (2009) · Emotion · doi:10.1037/a0015383 · Cited by 285
Heart Rate Variability in Risk Stratification of Cardiac Patients
Huikuri, H. V., & Stein, P. K. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.07.003 · Cited by 282
The impact of heart rate variability on subjective well-being is mediated by emotion regulation
Geisler, F. C. M., Vennewald, N., Kubiak, T., & Weber, H. (2010) · Personality and Individual Differences · doi:10.1016/j.paid.2010.06.015 · Cited by 279
Reduced heart rate variability in chronic alcohol abuse: relationship with negative mood, chronic thought suppression, and compulsive drinking
Ingjaldsson, J. T., Laberg, J. C., & Thayer, J. F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01926-1 · Cited by 275
Don’t Worry, Be Sad! On the Cognitive, Motivational, and Interpersonal Benefits of Negative Mood
Forgas, J. P. (2013) · Current Directions in Psychological Science · doi:10.1177/0963721412474458 · Cited by 264
Low Heart Rate Variability and the Effect of Depression on Post–Myocardial Infarction Mortality
Carney, R. M., Blumenthal, J. A., Freedland, K. E., Stein, P. K., Howells, W. B., Berkman, L. F., Watkins, L. L., Czajkowski, S. M., Hayano, J., Domitrovich, P. P., et al. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.13.1486 · Cited by 259
Matter Over Mind: A Randomised-Controlled Trial of Single-Session Biofeedback Training on Performance Anxiety and Heart Rate Variability in Musicians
Wells, R., Outhred, T., Heathers, J. A. J., Quintana, D. S., & Kemp, A. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046597 · Cited by 246
Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation
Manta, S., Dong, J., Debonnel, G., & Blier, P. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0936 · Cited by 246
The hundred-year emotion war: Are emotions natural kinds or psychological constructions? Comment on Lench, Flores, and Bench (2011).
Lindquist, K. A., Siegel, E. H., Quigley, K. S., & Barrett, L. F. (2013) · Psychological Bulletin · doi:10.1037/a0029038 · Cited by 245
Risk for mania and positive emotional responding: Too much of a good thing?
Gruber, J., Johnson, S. L., Oveis, C., & Keltner, D. J. (2008) · Emotion · doi:10.1037/1528-3542.8.1.23 · Cited by 242
The Promise of Heart Rate Variability Biofeedback: Evidence-Based Applications
Gevirtz, R. (2013) · Biofeedback · doi:10.5298/1081-5937-41.3.01 · Cited by 242
Relation of High Heart Rate Variability to Healthy Longevity
Zulfiqar, U., Jurivich, D. A., Gao, W., & Singer, D. H. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.12.022 · Cited by 239
Evolution and Dissolution of the Nervous System
Jackson, J. H., & Wozniak, R. H. (1998) · Medical Entomology and Zoology · Cited by 238
Targeting Plasticity with Vagus Nerve Stimulation to Treat Neurological Disease
Hays, S. A., Rennaker, R. L., & Kilgard, M. P. (2013) · Progress in brain research · doi:10.1016/b978-0-444-63327-9.00010-2 · Cited by 235
Heart rate response is longer after negative emotions than after positive emotions
Brosschot, J. F., & Thayer, J. F. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(03)00146-6 · Cited by 233
Physical Activity and Heart Rate Variability in Older Adults: The Cardiovascular Health Study
Soares-Miranda, L., Sattelmair, J., Chaves, P., Duncan, G. E., Siscovick, D. S., Stein, P. K., & Mozaffarian, D. (2014) · Circulation · doi:10.1161/circulationaha.113.005361 · Cited by 228
Longitudinal Evidence for Unfavorable Effects of Antidepressants on Heart Rate Variability
Licht, C. M. M., de Geus, E. J. C., van Dyck, R., & Penninx, B. W. J. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.032 · Cited by 225
Increased heart rate variability and executive performance after aerobic training in the elderly
Albinet, C. T., Boucard, G., Bouquet, C. A., & Audiffren, M. F. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1393-y · Cited by 222
Matters of the variable heart: Respiratory sinus arrhythmia response to marital interaction and associations with marital quality
Smith, T. W., Cribbet, M. R., Nealey-Moore, J. B., Uchino, B. N., Williams, P. G., MacKenzie, J., & Thayer, J. F. (2011) · Journal of Personality and Social Psychology · doi:10.1037/a0021136 · Cited by 213
Oxytocin increases autonomic cardiac control: Moderation by loneliness
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.006 · Cited by 211
Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus
Biggio, F., Gorini, G., Utzeri, C., Olla, P., Marrosu, F., Mocchetti, I., & Follesa, P. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000200 · Cited by 209
Ethnic Differences in Resting Heart Rate Variability
Hill, L. K., Hu, D. D., Koenig, J., Sollers, J. J., Kapuku, G. K., Wang, X., Snieder, H., & Thayer, J. F. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000133 · Cited by 203
Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
Moak, J. P., Goldstein, D. S., Eldadah, B. A., Saleem, A., Holmes, C., Pechnik, S., & Sharabi, Y. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.07.019 · Cited by 203
Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?
Vonck, K. E. J., Raedt, R., Naulaerts, J., Vogelaere, F. D., Thiery, E. W., Roost, D. V., Aldenkamp, A. P., Miatton, M., & Boon, P. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.005 · Cited by 195
Effects of Depression, Anxiety, Comorbidity, and Antidepressants on Resting-State Heart Rate and Its Variability: An ELSA-Brasil Cohort Baseline Study
Kemp, A. H., Brunoni, A. R., Santos, I. S., Nunes, M. A., Dantas, E. M., Carvalho de Figueiredo, R., Pereira, A. C., Ribeiro, A. L. P., Mill, J. G., Andreão, R. V., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121605 · Cited by 189 · cited 7×
“While it is possible that these persistent reductions in HRV relate to the impact of medications including antidepressants (Kemp et al., 2010; Kemp et al., 2014a; Licht et al., 2010) and medications with anticholinergic effects (often prescribed for hypertension and cardiovascular disease) we…”
BackgroundResultInfluential
Depression and heart rate variability in patients with coronary heart disease
Carney, R. M., & Freedland, K. E. (2009) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.76.s2.03 · Cited by 185
Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke
Elkind, M. S. V., Sciacca, R. R., Boden-Albala, B. M., Rundek, T., Paik, M. C., & Sacco, R. L. (2005) · Stroke · doi:10.1161/01.str.0000195048.86810.5b · Cited by 184
Plasma Phospholipid Trans Fatty Acids, Fatal Ischemic Heart Disease, and Sudden Cardiac Death in Older Adults
Lemaître, R. N., King, I. B., Mozaffarian, D., Sotoodehnia, N., Rea, T. D., Kuller, L. H., Tracy, R. P., & Siscovick, D. S. (2006) · Circulation · doi:10.1161/circulationaha.106.620336 · Cited by 175
Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction
Shahwan, A., Bailey, C., Maxiner, W., & Harvey, A. S. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01940.x · Cited by 173
The American Heart Association Life's Simple 7 and Incident Cognitive Impairment: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Thacker, E. L., Gillett, S. R., Wadley, V. G., Unverzagt, F. W., Judd, S. E., McClure, L. A., Howard, V. J., & Cushman, M. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000635 · Cited by 169
Cardiovascular health through young adulthood and cognitive functioning in midlife
Reis, J. P., Loria, C. M., Launer, L. J., Sidney, S., Liu, K., Jacobs, D. R., Zhu, N., Lloyd‐Jones, D. M., He, K., & Yaffe, K. (2013) · Annals of Neurology · doi:10.1002/ana.23836 · Cited by 168
Resting vagal activity in schizophrenia: Meta-analysis of heart rate variability as a potential endophenotype
Clamor, A., Lincoln, T. M., Thayer, J. F., & Koenig, J. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.160762 · Cited by 167
Sympathetic nervous system and cardiac arrhythmias
Schwartz, P. J. (1990) · Medical Entomology and Zoology · Cited by 166
Stop that! Inhibition, sensitization, and their neurovisceral concomitants
Thayer, J. F., & Friedman, B. H. (2002) · Scandinavian Journal of Psychology · doi:10.1111/1467-9450.00277 · Cited by 164
Whither vagal tone.
Berntson, G. G., Cacioppo, J. T., & Grossman, P. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.08.006 · Cited by 161
Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158
Self-citation
The influences of diet and exercise on mental health through hormesis
Gómez‐Pinilla, F. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.04.003 · Cited by 158
Effect of age on long-term heart rate variability
Yeragani, V. K., Sobolewski, E., Kay, J., Jampala, V. C., & Igel, G. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00107-7 · Cited by 156
THE IMPORTANCE OF ANXIETY IN BOTH MAJOR DEPRESSION AND BIPOLAR DISORDER: Importance of Anxiety in MDD and GAD
Goldberg, D., & Fawcett, J. (2012) · Depression and Anxiety · doi:10.1002/da.21939 · Cited by 155
When worries make you sick: a review of perseverative cognition: the default stress response and somatic health
Verkuil, B., Brosschot, J. F., Gebhardt, W. A., & Thayer, J. F. (2010) · Journal of Experimental Psychopathology · doi:10.5127/jep.009110 · Cited by 155
Dysregulation of the Autonomic Nervous System Predicts the Development of the Metabolic Syndrome
Licht, C. M. M., de Geus, E. J. C., & Penninx, B. W. J. H. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3104 · Cited by 154
Inward-attention meditation increases parasympathetic activity: a study based on heart rate variability
Wu, S.-D., & Lo, P.-C. (2008) · Biomedical Research · doi:10.2220/biomedres.29.245 · Cited by 153
Positive psychological attributes and cardiac outcomes: associations, mechanisms, and interventions
DuBois, C. M., Beach, S. R., Kashdan, T. B., Nyer, M. B., Park, E. R., Celano, C. M., & Huffman, J. C. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.04.004 · Cited by 152
Blunted Heart Rate Dip During Sleep and All-Cause Mortality
Ben‐Dov, I. Z., Kark, J. D., Ben‐Ishay, D., Mekler, J., Ben-Arie, L., & Bursztyn, M. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.19.2116 · Cited by 149
Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study
Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., Mill, J. G., Lotufo, P. A., Fregni, F., & Benseñor, I. M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000497 · Cited by 149
Heart rate variability, overnight urinary norepinephrine and C‐reactive protein: evidence for the cholinergic anti‐inflammatory pathway in healthy human adults
Thayer, J. F., & Fischer, J. E. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02023.x · Cited by 146
Resting state vagal tone in borderline personality disorder: A meta-analysis
Koenig, J., Kemp, A. H., Feeling, N. R., Thayer, J. F., & Kaess, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.07.002 · Cited by 145
When tonic cardiac vagal tone predicts changes in phasic vagal tone: the role of fear and perceptual load.
Park, G., Vasey, M. W., Van Bavel, J. J., & Thayer, J. F. (2014) · Psychophysiology · doi:10.1111/psyp.12186 · Cited by 144
Self-citation
Aerobic exercise during pregnancy influences fetal cardiac autonomic control of heart rate and heart rate variability
May, L. E., Glaros, A., Yeh, H.-W., Clapp, J. F., & Gustafson, K. M. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.03.002 · Cited by 140
The Inflammatory Reflex and the Role of Complementary and Alternative Medical Therapies
Oke, S. L., & Tracey, K. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1393.013 · Cited by 139
Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults
Hvidtfeldt, U. A., Tolstrup, J. S., Jakobsen, M. U., Heitmann, B. L., Grønbæk, M., O’Reilly, É. J., Bälter, K. A., Goldbourt, U., Hallmans, G., Knekt, P., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.887513 · Cited by 134
Protective Role of Resting Heart Rate on All-Cause and Cardiovascular Disease Mortality
Saxena, A., Minton, D. M., Lee, D.-C., Sui, X., Fayad, R., Lavie, C. J., & Blair, S. N. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.09.011 · Cited by 131
The impact of breathing on HRV measurements: Implications for the longitudinal follow‐up of athletes
Saboul, D., Pialoux, V., & Hautier, C. A. (2013) · European Journal of Sport Science · doi:10.1080/17461391.2013.767947 · Cited by 131
Mayer waves history and methodology
Peňáz, J. (1978) · Medical Entomology and Zoology · Cited by 126
Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder
Moon, E., Lee, S., Kim, D.-H., & Hwang, B. (2013) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2013.11.3.137 · Cited by 125
The effect of aerobic training and cardiac autonomic regulation in young adults.
Sloan, R., Shapiro, P., Meersman, R. D., Bagiella, E., Brondolo, E., Mckinley, P., Slavov, I., Fang, Y., & Myers, M. (2009) · American Journal of Public Health · doi:10.2105/ajph.2007.133165 · Cited by 123
Association Between Reduced Heart Rate Variability and Cognitive Impairment in Older Disabled Women in the Community: Women's Health and Aging Study I
Kim, D. H., Lipsitz, L. A., Ferrucci, L., Varadhan, R., Guralnik, J. M., Carlson, M. C., Fleisher, L. A., Fried, L. P., & Chaves, P. H. M. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00940.x · Cited by 123
Investigating the Associations of Self-Rated Health: Heart Rate Variability Is More Strongly Associated than Inflammatory and Other Frequently Used Biomarkers in a Cross Sectional Occupational Sample
Jarczok, M. N., Kleber, M. E., Koenig, J., Loerbroks, A., Herr, R. M., Hoffmann, K., Fischer, J. E., Benyamini, Y., & Thayer, J. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117196 · Cited by 121
Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature
Mazurak, N., Enck, P., Muth, E. R., Teufel, M., & Zipfel, S. (2010) · European Eating Disorders Review · doi:10.1002/erv.1081 · Cited by 119
A Meta‐Analysis on the Impact of Alcohol Dependence on Short‐Term Resting‐State Heart Rate Variability: Implications for Cardiovascular Risk
Quintana, D. S., McGregor, I. S., Guastella, A. J., Malhi, G. S., & Kemp, A. H. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01913.x · Cited by 117
Altered Emotional Perception in Alcoholics: Deficits in Affective Prosody Comprehension
Monnot, M., Nixon, S. J., Lovallo, W. R., & Ross, E. D. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02222.x · Cited by 116
Effects of Emotion Regulation Difficulties on the Tonic and Phasic Cardiac Autonomic Response
Berna, G., Ott, L., & Nandrino, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102971 · Cited by 114
Fitness and Gender-Related Differences in Heart Period Variability
Rossy, L. A., & Thayer, J. F. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199811000-00022 · Cited by 106
Coronary heart disease and stroke deaths - United States, 2006.
Keenan, N. L., & Shaw, K. M. (2011) · PubMed · Cited by 105
The Non-invasive Assessment of Autonomic Influences on the Heart Using Impedance Cardiography and Heart Rate Variability
Thayer, J. F., Hansen, A. L., & Johnsen, B. H. (2010) · Springer eBooks · doi:10.1007/978-0-387-09488-5_47 · Cited by 104
Resting high‐frequency heart rate variability is related to resting brain perfusion
Allen, B., Jennings, J. R., Gianaros, P. J., Thayer, J. F., & Manuck, S. B. (2014) · Psychophysiology · doi:10.1111/psyp.12321 · Cited by 102
What goes up can come down? A preliminary investigation of emotion reactivity and emotion recovery in bipolar disorder
Gruber, J., Harvey, A. G., & Purcell, A. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.009 · Cited by 99
Inflammation and cardiorespiratory control: the role of the vagus nerve.
Thayer, J. F., Loerbroks, A., & Sternberg, E. M. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.016 · Cited by 97
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality
Kemp, A. H., Quintana, D. S., Quinn, C. R., Hopkinson, P., & Harris, A. W. F. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01387 · Cited by 95
Heart rate variability predicts control over memory retrieval.
Gillie, B. L., Vasey, M. W., & Thayer, J. F. (2014) · Psychological Science · doi:10.1177/0956797613508789 · Cited by 95 · cited 1×
“The ability to exert control over unwanted memories is therefore an important factor maintaining psychological health (Gillie et al., 2014) (see also: G.”
Background
The Parasympathetic Nervous System in the Quest for Stroke Therapeutics
Cheyuo, C., Jacob, A., Wu, R., Zhou, M., Coppa, G. F., & Wang, P. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.24 · Cited by 94
Neural control of cardiac function.
Levy, M. N. (1997) · PubMed · Cited by 87
Decreased heart rate variability during emotion regulation in subjects at risk for psychopathology
Simplicio, M. C. D., Costoloni, G., Western, D., Hanson, B. M., Taggart, P. I., & Harmer, C. J. (2011) · Psychological Medicine · doi:10.1017/s0033291711002479 · Cited by 87
Effects of passive smoking on heart rate variability, heart rate and blood pressure: an observational study
Dietrich, D. F., Schwartz, J., Schindler, C., Gaspoz, J., Barthélemy, J., Tschopp, J., Roche, F., von Eckardstein, A., Brändli, O., Leuenberger, P., et al. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym031 · Cited by 86
Individual Differences in Heart Rate Variability Predict the Degree of Slowing during Response Inhibition and Initiation in the Presence of Emotional Stimuli
Krypotos, A., Jahfari, S., van Ast, V. A., Kindt, M., & Forstmann, B. U. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00278 · Cited by 85
Cardioventilatory Coupling in Resting Human Subjects
Tzeng, Y., Larsen, P., & Galletly, D. C. (2003) · Experimental Physiology · doi:10.1113/eph8802606 · Cited by 85
Aerobic exercise during pregnancy influences infant heart rate variability at one month of age
May, L. E., Scholtz, S. A., Suminski, R., & Gustafson, K. M. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2013.11.001 · Cited by 82
Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?
Harrison, N. A., Cooper, E., Voon, V., Miles, K., & Critchley, H. D. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.001 · Cited by 76
Aristotle on the Brain
Gross, C. G. (1995) · The Neuroscientist · doi:10.1177/107385849500100408 · Cited by 76
Lower heart rate variability predicts increased level of C‐reactive protein 4 years later in healthy, nonsmoking adults
Jarczok, M. N., Koenig, J., Mauss, D., Fischer, J. E., & Thayer, J. F. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12295 · Cited by 75
Short-term effects of fish-oil supplementation on heart rate variability in humans: a meta-analysis of randomized controlled trials
Xin, W., Wei, W., & Li, X.-Y. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.049833 · Cited by 74
Do People With Psychosis Have Specific Difficulties Regulating Emotions?
Lincoln, T. M., Hartmann, M. M., Köther, U., & Moritz, S. (2014) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.1923 · Cited by 74
Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic–pituitary–adrenal axis and the autonomic nervous system
Boschloo, L., Vogelzangs, N., Licht, C. M. M., Vreeburg, S. A., Smit, J. H., van den Brink, W., Veltman, D. J., de Geus, E. J. C., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.006 · Cited by 73
Respiratory sinus arrhythmia is associated with trait positive affect and positive emotional expressivity
Wang, Z., Lu, W. D., & Qin, R. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.12.006 · Cited by 72
Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction
Carpeggiani, C., Emdin, M., Bonaguidi, F., Landi, P., Michelassi, C., Trivella, M. G., Macerata, A., & L'Abbate, A. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi252 · Cited by 70
A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 66
Moderate alcohol intake is related to increased heart rate variability in young adults: Implications for health and well‐being
Quintana, D. S., Guastella, A. J., McGregor, I. S., Hickie, I. B., & Kemp, A. H. (2013) · Psychophysiology · doi:10.1111/psyp.12134 · Cited by 65
Respiratory sinus arrhythmia responses to induced emotional states: Effects of RSA indices, emotion induction method, age, and sex
Overbeek, T. J. M., Boxtel, A. V., & Westerink, J. H. D. M. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.05.011 · Cited by 62
Effects of Smoking Cessation on Heart Rate Variability Among Long-Term Male Smokers
Harte, C. B., & Meston, C. M. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-013-9295-0 · Cited by 61
Cardiac Arrhythmias and Risk Stratification After Myocardial Infarction:
Huikuri, H. V., Mahaux, V., Bloch-Thomsen, P.-E., & CARISMA Investigators (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00061.x · Cited by 55
A systematic review on heart rate variability in Bulimia Nervosa
Peschel, S. K. V., Feeling, N. R., Vögele, C., Kaess, M., Thayer, J. F., & Koenig, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.012 · Cited by 51
Pregnant Mothers with Resolved Anxiety Disorders and Their Offspring Have Reduced Heart Rate Variability: Implications for the Health of Children
Braeken, M. A. K. A., Kemp, A. H., Outhred, T., Otte, R. A., Monsieur, G. J. Y. J., Jones, A., & den Bergh, B. R. H. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083186 · Cited by 49
Ultra-Short-Term Heart Rate Variability for Early Risk Stratification following Acute ST-Elevation Myocardial Infarction
Karp, E., Shiyovich, A., Zahger, D., Gilutz, H., Grosbard, A., & Katz, A. (2009) · Cardiology · doi:10.1159/000235568 · Cited by 45
The wonders of the Wanderer
Clancy, J. A., Deuchars, S. A., & Deuchars, J. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.064543 · Cited by 44
Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study
Kemp, A. H., Koenig, J., Thayer, J. F., Bittencourt, M. S., Pereira, A. C., Santos, I. S., Dantas, E. M., Mill, J. G., Chor, D., Ribeiro, A. L. P., et al. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000359 · Cited by 41
Heart rate variability in patients with fully remitted major depressive disorder
Chang, H., Chang, C.-C., Chen, C.-L., Kuo, T. B. J., Lu, R., & Huang, S. (2012) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2012.00658.x · Cited by 39
Sympathovagal balance from heart rate variability: time for a second round?
Pagani, M., Lucini, D., & Porta, A. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066977 · Cited by 37

Research works printed but not linked: 2

Friedman, 1998, Anxiety and autonomic flexibility: a cardiovascular approach, Biol. Psychol., 49, 303
Park, 2014, When tonic cardiac vagal tone predicts changes in phasic vagal tone: the role of fear and perceptual load, Psychophysiology, 1

Sorted by citations

A meta-analysis of heart rate variability in major depression
Koch, C., Wilhelm, M., Salzmann, S., Rief, W., & Euteneuer, F. (2019) · Psychological Medicine · doi:10.1017/s0033291719001351 · Cited by 532
Heart-rate variability: A biomarker to study the influence of nutrition on physiological and psychological health?
Young, H. A., & Benton, D. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000383 · Cited by 249
Stress and cardiovascular disease: an update
Vaccarino, V., & Bremner, J. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01024-y · Cited by 229
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
Arias-López, J. A., Williams, C., Raghvani, R., Aghajani, M., Báez, S., Belzung, C., Booij, L., Busatto, G. F., Chiarella, J., Fu, C. H. Y., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.006 · Cited by 138
A Systematic Review and Meta-Analysis of Within-Person Changes in Cardiac Vagal Activity across the Menstrual Cycle: Implications for Female Health and Future Studies
Schmalenberger, K., Eisenlohr-Moul, T., Würth, L., Schneider, E., Thayer, J., Ditzen, B., & Jarczok, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111946 · Cited by 104

See all 114

Authors: Kemp, A. H., Koenig, J., & Thayer, J. F.
Affiliations: The University of Sydney (AU)
Heidelberg University (DE)
The Ohio State University (US)
Corresponding author: Kemp, Andrew H.
Thayer, Julian F.
ORCID: Kemp, Andrew H.
Koenig, Julian
Thayer, Julian F.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2017-12
Volume: 83
Pages: 547-567
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2017.09.006
OpenAlex: W2752326235
Cited by: 114
References: 225
Citations by year: 2026: 8 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 19 · 2019: 17 · 2018: 13
FWCI: 1.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: FAPESP (#2013/50327-6)
Brazilian research funding institution
Medical School of Heidelberg University
Post-Doctoral Fellowship provided by the Daimler and Benz Foundation
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: heart rate variability, vagus nerve, neurovisceral integration, mortality risk, lifespan development, healthy aging, temporal framework
MeSH terms: Aging, Animals, Heart Rate, Humans, Psychophysiology, Vagus Nerve, Health Behavior, Visceral Afferents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

From psychological moments to mortality: A multidisciplinary synthesis on heart rate variability spanning the continuum of time

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks