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Cited by 108Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 168 of the 172 references it cites were found in a registry or an index.

Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release

Oswald, Lynn M., Wong, Dean F., Zhou, Yun, Kumar, Anil, Brasic, James, Alexander, Mohab, Ye, Weiguo, Kuwabara, Hiroto, Hilton, John, Wand, Gary S.·2007·NeuroImage
DOI 10.1016/j.neuroimage.2007.01.055
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Abstract

A challenging question that continues to plague the field of addiction is why some individuals are more vulnerable for substance use disorders than others. Several important risk factors for substance abuse have been identified in clinical studies, including trait impulsivity and environmental stress. However, the neurobiological mechanisms that underlie the relationships remain poorly understood. The purpose of this study was to examine associations among impulsivity, stress, and striatal dopamine (DA) responses to amphetamine (AMPH) in humans. Forty healthy M, F adults, ages 18-29 years, completed self-report measures of trait impulsivity, life events stress, and perceived stress. Subjects subsequently underwent two consecutive 90-min positron emission tomography (PET) studies with high specific activity [11C]raclopride. The first scan was preceded by an intravenous injection of saline; the second was preceded by 0.3 mg/kg AMPH. Findings showed that high impulsivity was associated with blunted right ventral striatal DA release. However, effects were modified by a significant interaction with life events stress. Dopamine release was greater in low vs. high impulsivity subjects under conditions of low or moderate stress. Under conditions of high stress, both groups had low DA release. Subjects with high impulsivity reported more pleasant effects with AMPH than subjects with low impulsivity. In contrast, stress was negatively associated with pleasant drug effects. No associations were observed between impulsivity or stress and cortisol responses to AMPH. The findings are consistent with notions that blunted DA responses represent an endophenotype for substance use disorders.

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Crossref · 10.1016/j.neuroimage.2007.01.055

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Research works printed but not linked: 1

  1. Wong, 1988, In vivo measurement of dopamine receptors in human brain by positron emission tomography. Age and sex differences, Ann. N. Y. Acad. Sci., 515, 203, 10.1111/j.1749-6632.1988.tb32986.x · DOI

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Metadata

Authors
Oswald, L. M., Wong, D. F., Zhou, Y., Kumar, A., Brasic, J., Alexander, M., Ye, W., Kuwabara, H., Hilton, J., & Wand, G. S.
Affiliations
Johns Hopkins University (US)
Corresponding author
Wand, Gary S.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2007-05
Volume
36
Issue
1
Pages
153-166
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2007.01.055
OpenAlex
W2013140360
Cited by
108
References
172
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 13 · 2012: 12
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01-AA10158, R01AA010158, R01AA012839, AA12839, AA 12837, R01AA012837)
  • National Center for Research Resources (M01 RR-00052, M01RR000052)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
impulsivity, chronic stress, amphetamine, striatal dopamine release, ventral striatum, life events, perceived stress, endophenotypes, substance use disorders, dopamine receptor binding, [11C]raclopride, cortisol response
MeSH terms
Adult, Amphetamine, Central Nervous System Stimulants, Carbon Radioisotopes, Chronic Disease, Corpus Striatum, Dominance, Cerebral, Dopamine, Female, Humans, Hydrocortisone, Image Processing, Computer-Assisted, Impulsive Behavior, Individuality, Life Change Events, Male, Raclopride, Positron-Emission Tomography

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