Cited by 155Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

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Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender-specific manner

Yamamoto, Y, Cushing, B.S, Kramer, K.M, Epperson, P.D, Hoffman, G.E, Carter, C.S·2004·Neuroscience

DOI 10.1016/j.neuroscience.2004.02.028

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Abstract

Early postnatal manipulations of oxytocin have long-term behavioral and physiological consequences; the present study examined the hypothesis that oxytocin or its absence influences the subsequent expression of either oxytocin or arginine vasopressin in the CNS. On postnatal day 1 female and male prairie voles (Microtus ochrogaster) received a single i.p. injection of oxytocin (3 microg), oxytocin antagonist (0.3 microg), or 50 microl of isotonic saline or were only handled. On postnatal days 1, 8 and 21, brains were fixed, sectioned and stained for oxytocin or vasopressin immunoreactivity and analyzed as a function of age, treatment and sex. Both oxytocin and vasopressin immunoreactivity were observed on day 1 in the supraoptic and paraventricular nuclei (PVN) of the hypothalamus. Numbers of oxytocin and vasopressin neurons increased with age in both nuclei. Females treated on postnatal day 1 with oxytocin or oxytocin antagonist displayed a significant increase in oxytocin immunoreactivity on day 21 in the PVN. In contrast, males treated with antagonist tended to have decreased vasopressin immunoreactivity in the same region. These results revealed that the effects of neonatal manipulation of oxytocin are age-dependent, site-specific and sexually dimorphic. The long-lasting effects of neonatal exposure to exogenous oxytocin and oxytocin antagonist indicate a role for oxytocin in the development of the CNS during the neonatal period, affecting the development of the oxytocinergic system in females and the vasopressinergic system in males. The developmental effects observed suggest one possible mechanism by which neonatal exposure to oxytocin or neonatal inhibition of endogenous oxytocin produces long-lasting behavioral and physiological alterations and could play a role in the development of male- and female-typical behavior.

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Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
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“A sexually dimorphic response is consistent with patterns seen in adult prairie voles, where OT plays a greater role in the regulation of female behavior (Williams et al., 1994; Cushing and Carter, 2000), while AVP appears to be more important in males ( Winslow et al., 1993; Insel et al., 1998).”
Method
Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology
Watson, R. E., Wiegand, S. J., Clough, R. W., & Hoffman, G. E. (1986) · Peptides · doi:10.1016/0196-9781(86)90076-8 · Cited by 933
The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat
Sawchenko, P. E., & Swanson, L. W. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902180202 · Cited by 684
The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster)
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529
Oxytocin Administered Centrally Facilitates Formation of a Partner Preference in Female Prairie Voles (Microtus ochrogaster)
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452

Show all 50 references

Research works printed but not linked: 1

Cushing, 2001, Comparison of fixation techniques, Horm Behav, 39, 329

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Authors: Yamamoto, Y., Cushing, B. S., Kramer, K. M., Epperson, P. D., Hoffman, G. E., & Carter, C. S.
Affiliations: University of Illinois Chicago (US)
University of Maryland, Baltimore (US)
Corresponding author: Cushing, B.S
ORCID: Yamamoto, Y
Cushing, B.S
Carter, C.S
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2004-01
Volume: 125
Issue: 4
Pages: 947-955
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2004.02.028
OpenAlex: W1975654938
Cited by: 155
References: 50
Citations by year: 2025: 3 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 6 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 14 · 2013: 7 · 2012: 6
FWCI: 8.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: China Scholarship Council
National Institute of Mental Health (MH 01992, K01MH001992)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 41293, P01HD038490, HD38490, F32HD041293)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, vasopressin, paraventricular nucleus, hypothalamus, neonatal manipulation, oxytocin antagonist, sex differences, Microtus ochrogaster, supraoptic nucleus, postnatal development, social behavior
MeSH terms: Animals, Animals, Newborn, Arginine Vasopressin, Arvicolinae, Female, Image Processing, Computer-Assisted, Immunohistochemistry, Male, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Sexual Behavior, Animal, Sex Factors

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Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender-specific manner

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