Cited by 157Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchStress Responses and Cortisol

The DOI matches its Crossref record; 253 of the 256 references it cites were found in a registry or an index.

Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression

Open access

Licznerski, P., Duman, R.S.·2013·Neuroscience

DOI 10.1016/j.neuroscience.2012.09.057PMC PMC3566360

Open this paper in CoChat — free account

Abstract

Dendritic spines provide a compartment for assembly and functional organization of synaptic machinery that plays a fundamental role in neuronal communication and neuroplasticity. Studies in humans as well as in animal models have demonstrated abnormal spine architecture in several psychiatric disorders, including depression and other stress-related illnesses. The negative impact of stress on the density and organization of spines is thought to contribute to the behavioral deficits caused by stress exposure. Moreover, there is now evidence that medication-induced recovery involves changes in synaptic plasticity and dendrite morphology, including increased expression of pre- and postsynaptic plasticity-related proteins, as well as the density and function of axo-spinous synapses. Here we review the evidence from brain imaging and postmortem studies demonstrating that depression is accompanied by structural and functional alterations of cortical and limbic brain regions, including the prefrontal cortex, hippocampus and amygdala. In addition, we present more direct evidence from basic research studies that exposure to stress alters spine morphology, function and plasticity and that antidepressants, particularly new rapid acting agents, reverse these effects. Elucidation of the signaling pathways and molecular mechanisms that control spine synapse assembly and plasticity will contribute to a better understanding of the pathophysiology of depression and development of novel, more effective therapeutic agents.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2012.09.057

Cites

253 of 253 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Self-citation
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Self-citation
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241 · cited 2×
“…the exact functional correlates of altered hippocampal morphology in MDD. Neuroimaging studies have also reported disrupted functional correlates of the amygdala in MDD patients (Sheline et al., 2001; Siegle et al., 2002), including abnormally elevated glucose metabolism (Drevets et al., 2008).”
Sex and depression in the National Comorbidity Survey, I: lifetime prevalence, chronicity and recurrence
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · cited 3×
“Clinical trials show that risk of developing depression is two times higher in females compared to males (Kessler et al., 1993), a phenomenon also observed in preclinical studies (Dalla et al.”
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926
Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators
McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · cited 1×
“1), which contributes to disturbances in perception of emotional cues and associated memories (LaBar and Cabeza, 2006).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Self-citation
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1×
“Synaptic activation can lead to spine plasticity via the insertion of glutamate receptors and spine enlargement, followed by reorganization of the postsynaptic density, which in turn strengthens synaptic connections (Matsuzaki et al., 2001).”
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383 · cited 1×
“For example, depressed patients show abnormally exaggerated amygdala responses to sad words and faces (Phillips et al., 2008).”
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340
Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice
Dunkel Schetter, C., & Tanner, L. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503680 · Cited by 1,268 · cited 3×
“Please cite this article in press as: Licznerski P, Duman RS. Remodeling of axo Neuroscience (2012), http://dx.doi.org/10.1016/j.neuroscience.2012.09.057 Chronic stress and depression during pregnancy may result in preterm birth and lower body weight (Dunkel Schetter and Tanner, 2012), which in turn may lead to impair…”
Influential
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233
Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232
Self-citation
Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180
Stress- and Allostasis-Induced Brain Plasticity
McEwen, B. S., & Gianaros, P. J. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100430 · Cited by 1,171
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128
Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103
Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082
Self-citation
Pubertal hormones organize the adolescent brain and behavior
Sisk, C. L., & Zehr, J. L. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.003 · Cited by 1,082
Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044 · cited 2×
“Moreover, PNS causes a lifespan reduction in neurogenesis accompanied by impairments in hippocampal-dependent spatial tasks (Lemaire et al., 2000; Odagiri et al., 2008), with passive avoidance being especially affected in female PNS progeny (Gue et al.”
Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020
Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat
Tanapat, P., Hastings, N. B., Reeves, A. J., & Gould, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05792.1999 · Cited by 994
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993
Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting
Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968
A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945
Associations of Hormones and Menopausal Status With Depressed Mood in Women With No History of Depression
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 921
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875
Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858
Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808
Self-citation
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787
Self-citation
Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 746
A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder
McKinnon, M. C., Yucel, K., Nazarov, A., & MacQueen, G. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0905 · Cited by 742
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey, L. J., Ong, W., Patel, T. S., Kanani, M., Davis, A., Mortimer, A. M., Barnes, T., & Hirsch, S. R. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.4.446 · Cited by 719
Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695
The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
MacQueen, G., & Frodl, T. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.80 · Cited by 665
Neural plasticity to stress and antidepressant treatment
Duman, R. S., Malberg, J. E., & Thome, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00177-8 · Cited by 648
Self-citation
Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 631
Anatomical and Physiological Plasticity of Dendritic Spines
Alvarez, V. A., & Sabatini, B. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094222 · Cited by 629
Locally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615
The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · cited 1×
“Chronic administration of fluoxetine or the tricylic antidepressant imipramine is reported to rescue dendrite atrophy and spine loss in hippocampal CA3 and medial PFC layer II/III pyramidal neurons caused by chronic stress (Bessa et al., 2009).”
The New Neurobiology of Autism: Cortex, Connectivity, and Neuronal Organization
Minshew, N. J., & Williams, D. L. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.945 · Cited by 592
Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581
Rapid Resolution of Suicidal Ideation After a Single Infusion of an N -Methyl- D -Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder
DiazGranados, N., Ibrahim, L. A., Brutsche, N. E., Ameli, R., Henter, I. D., Luckenbaugh, D. A., Machado-Vieira, R., & Zarate, C. A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05327blu · Cited by 564
Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550
Neuroimaging Abnormalities in the Amygdala in Mood Disorders
DREVETS, W. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07098.x · Cited by 544
Chronic stress alters synaptic terminal structure in hippocampus
Magariños, A. M., Verdugo, J. M. G., & McEwen, B. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14002 · Cited by 543
Reduced volume of orbitofrontal cortex in major depression
Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., Staib, L. H., & Charney, D. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01336-1 · Cited by 537
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525
An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 524
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 518
Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites
Fremeau, R. T., Kam, K., Qureshi, T., Johnson, J., Copenhagen, D. R., Storm‐Mathisen, J., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2004) · Science · doi:10.1126/science.1097468 · Cited by 504
Dendritic spines and long-term plasticity
Segal, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1649 · Cited by 489
Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
Vermetten, E., Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00634-6 · Cited by 487
Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
Coe, C. L., Kramer, M., Czéh, B., Gould, E., Reeves, A. J., Kirschbaum, C., & Fuchs, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00698-x · Cited by 477
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477
Reduced specificity of autobiographical memory and depression: The role of executive control.
Dalgleish, T., Williams, J. M. G., Golden, A.-M. J., Perkins, N., Barrett, L. F., Barnard, P. J., Yeung, C. A., Murphy, V., Elward, R. L., Tchanturia, K., et al. (2007) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.136.1.23 · Cited by 475
Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473
Brief Uncontrollable Stress Causes Dendritic Retraction in Infralimbic Cortex and Resistance to Fear Extinction in Mice
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
Bueller, J. A., Aftab, M., Sen, S., Gomez‐Hassan, D. M., Burmeister, M., & Zubieta, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.022 · Cited by 458
Recovery after chronic stress fails to reverse amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior
Vyas, A., Pillai, A. G., & Chattarji, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.013 · Cited by 445
Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment
Dumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439
Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
Hickie, I., Naismith, S., Ward, P. B., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., & Parker, G. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.186.3.197 · Cited by 437 · cited 2×
“MRI studies have demonstrated that these hippocampal changes can be lateral or unilateral (Videbech and Ravnkilde, 2004; McKinnon et al., 2009; MacQueen and Frodl, 2011), and that they correlate with memory deficits in depressed patients (Hickie et al., 2005).”
GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430
A negative regulator of MAP kinase causes depressive behavior
Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A. A., Newton, S. S., & Duman, R. S. (2010) · Nature Medicine · doi:10.1038/nm.2219 · Cited by 412
Self-citation
Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406
Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex
Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.030 · Cited by 403
Self-citation
Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones
Murphy, D. D., & Segal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04059.1996 · Cited by 398
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 393
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374
Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373
Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo
Liston, C., & Gan, W.-B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110444108 · Cited by 352
Stress Burden and the Lifetime Incidence of Psychiatric Disorder inYoung Adults
Turner, R. J., & Lloyd, D. A. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.481 · Cited by 347
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 341
Self-citation
Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats
Silva-Gómez, A. B., Rojas, D., Juárez, I., & Flores, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03042-7 · Cited by 336
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.50 · Cited by 324
Brain-Derived Neurotrophic Factor Promotes Long-Term Potentiation-Related Cytoskeletal Changes in Adult Hippocampus
Rex, C. S., Lin, C.-Y., Kramár, E. A., Chen, L. Y., Gall, C. M., & Lynch, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-06.2007 · Cited by 324
Enlargement of the Amygdala in Patients with a First Episode of Major Depression
Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., Jäger, M., Leinsinger, G., Hahn, K., & Möller, H.-J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01359-2 · Cited by 316
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
Pawlak, R., Magariños, A. M., Melchor, J. P., McEwen, B. S., & Strickland, S. (2003) · Nature Neuroscience · doi:10.1038/nn998 · Cited by 305
Neurobiological and clinical effects of the antidepressant tianeptine
Kasper, S., & McEwen, B. S. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00002 · Cited by 302
Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala
Vyas, A., Jadhav, S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.003 · Cited by 299
Effects of chronic stress on dendritic arborization in the central and extended amygdala
Vyas, A., Bernal, S., & Chattarji, S. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04162-8 · Cited by 291
Activity-induced targeting of profilin and stabilization of dendritic spine morphology
Ackermann, M., & Matus, A. I. (2003) · Nature Neuroscience · doi:10.1038/nn1135 · Cited by 289
Late-Preterm Birth and Its Association With Cognitive and Socioemotional Outcomes at 6 Years of Age
Talge, N. M., Holzman, C., Wang, J., Lucia, V. C., Gardiner, J. C., & Breslau, N. (2010) · PEDIATRICS · doi:10.1542/peds.2010-1536 · Cited by 288
Gender Issues in Depression
Grigoriadis, S., & Robinson, G. E. (2007) · Annals of Clinical Psychiatry · doi:10.1080/10401230701653294 · Cited by 285
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
Groc, L., Choquet, D., & Chaouloff, F. (2008) · Nature Neuroscience · doi:10.1038/nn.2150 · Cited by 280
Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
Murmu, M. S., Salomon, S., Biala, Y., Weinstock, M., Braun, K., & Bock, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05024.x · Cited by 278
Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone
Chen, Y., Dubé, C. M., Rice, C. J., & Baram, T. Z. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0225-08.2008 · Cited by 276
Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
Vaidya, V. A., Siuciak, J. A., Du, F., & Duman, R. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00289-9 · Cited by 276
Self-citation
Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders
Lin, Y., & Koleske, A. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153204 · Cited by 255
Glucocorticoids Enhance the Excitability of Principal Basolateral Amygdala Neurons
Duvarci, S., & Paré, D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0680-07.2007 · Cited by 249
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
Hashimoto, R., Numakawa, T., Ohnishi, T., Kumamaru, E., Yagasaki, Y., Ishimoto, T., Mori, T., Nemoto, K., Adachi, N., Izumi, A., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl244 · Cited by 247
Gonadal hormone modulation of dendrites in the mammalian CNS.
Cooke, B., & Woolley, C. (2005) · Journal of Neurobiology · doi:10.1002/neu.20143 · Cited by 244
Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus
Hajszán, T., MacLusky, N. J., & Leranth, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03968.x · Cited by 239
Effect of Estrogen-Serotonin Interactions on Mood and Cognition
Amin, Z., Canli, T., & Epperson, C. N. (2005) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582305277152 · Cited by 238
The Influence of Gonadal Hormones on Neuronal Excitability, Seizures, and Epilepsy in the Female
Scharfman, H. E., & MacLusky, N. J. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00672.x · Cited by 238
Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory
Morozov, A., Muzzio, I. A., Bourtchouladze, R., Van-Strien, N., Lapidus, K. A. B., Yin, D., Winder, D. G., Adams, J. P., Sweatt, J. D., & Kandel, E. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00404-5 · Cited by 236
Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232
Enlarged amygdala volume and reduced hippocampal volume in young women with major depression
Lange, C., & Irle, E. (2004) · Psychological Medicine · doi:10.1017/s0033291703001806 · Cited by 231
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszán, T., Dow, A. L., Warner‐Schmidt, J. L., Szigeti‐Buck, K., Sallam, N. L., Párducz, Á., Leranth, C., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.031 · Cited by 222
Self-citation
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex
Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219
Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218
A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley, S. L., Kedves, A. T., Olausson, P., & Taylor, J. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.123 · Cited by 218
Structural basis for the role of inhibition in facilitating adult brain plasticity
Chen, J. L., Lin, W. C., Cha, J. W., So, P. T., Kubota, Y., & Nedivi, E. (2011) · Nature Neuroscience · doi:10.1038/nn.2799 · Cited by 214
Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
Caetano, S. C., Hatch, J. P., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.08.002 · Cited by 214
Structural changes in the hippocampus in major depressive disorder: contributions of disease and treatment
Malykhin, N. V., Carter, R., Seres, P., & Coupland, N. J. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100002 · Cited by 212
White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies
Tham, M. W., Woon, P. S., Sum, M. Y., Lee, T.-S. W., & Sim, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.013 · Cited by 206
Estrogen increases the number of spinophilin‐immunoreactive spines in the hippocampus of young and aged female rhesus monkeys
Hao, J., Janssen, W. G. M., Tang, Y. C., Roberts, J. A., McKay, H. M., Lasley, B. L., Allen, P. B., Greengard, P., Rapp, P. R., Kordower, J. H., et al. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10837 · Cited by 200
Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: A three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities
Stewart, M. G., Davies, H. A., Sandi, C., Kraev, I. V., Rogachevsky, V. V., Peddie, C. J., Rodriguez, J. J., Cordero, M. I., Donohue, H. S., Gabbott, P. L. A., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.031 · Cited by 197
Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
Salvadore, G., Nugent, A. C., Lemaître, H., Luckenbaugh, D. A., Tinsley, R., Cannon, D. M., Neumeister, A., Zarate, C. A., & Drevets, W. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.011 · Cited by 195
Estrogen Replacement Increases Spinophilin-immunoreactive Spine Number in the Prefrontal Cortex of Female Rhesus Monkeys
Tang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 195
The Mental Retardation Protein PAK3 Contributes to Synapse Formation and Plasticity in Hippocampus
Boda, B., Alberi, S., Nikonenko, I., Nodé-Langlois, R., Jourdain, P., Moosmayer, M., Jourdain, L., & Müller, D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2931-04.2004 · Cited by 195
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191
Developmental Delay in Moderately Preterm-Born Children at School Entry
Kerstjens, J. M., de Winter, A. F., Bocca-Tjeertes, I. F. A., Vergert, E. M. T., Reijneveld, S. A., & Bos, A. F. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.12.041 · Cited by 178
Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
Halbach, O. V. B. U., Zacher, C., Gass, P., & Unsicker, K. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20759 · Cited by 177
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Grossman, A. W., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-06.2006 · Cited by 177
Experience-induced changes of dendritic spine densities in the prefrontal and sensory cortex: correlation with developmental time windows
Bock, J., Gruss, M., Becker, S., & Braun, K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh181 · Cited by 175
Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies
Maciąg, D., Hughes, J., O'Dwyer, G., Pride, Y., Stockmeier, C. A., Sanacora, G., & Rajkowska, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.027 · Cited by 175
Females do not express learned helplessness like males do
Dalla, C., Edgecomb, C., Whetstone, A. S., & Shors, T. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301533 · Cited by 174
Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring
Martínez‐Téllez, R. I., Hernández‐Torres, E., Gamboa, C., & Flores, G. (2009) · Synapse · doi:10.1002/syn.20664 · Cited by 174
mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
Dwyer, J. M., Lepack, A. E., & Duman, R. S. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001702 · Cited by 169
Self-citation
Enhanced anxiety, depressive‐like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)
Tordera, R. M., Totterdell, S., Wojcik, S. M., Brose, N., Elizalde, N., Lasheras, B., & del Rı́o, J. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05259.x · Cited by 169
Altered dendritic spine density in animal models of depression and in response to antidepressant treatment
Norrholm, S. D., & Ouimet, C. C. (2001) · Synapse · doi:10.1002/syn.10006 · Cited by 169
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
Liu, Z., Chuang, D., & Smith, C. B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000520 · Cited by 168
Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest
Shansky, R., & Morrison, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.062 · Cited by 163
Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G., & Tatarelli, R. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903131571 · Cited by 161
Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
Yuan, P., Zhou, R., Wang, Y., Li, X., Li, J., Chen, G., Guitart, X., & Manji, H. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.017 · Cited by 160
Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures
McLaughlin, K. J., Baran, S. E., & Conrad, C. D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8079-7 · Cited by 158
Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression
Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157
Repeated electroconvulsive seizures increase the total number of synapses in adult male rat hippocampus
Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.12.007 · Cited by 156
Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans
Soetanto, A., Wilson, R. S., Talbot, K., Un, A., Schneider, J. A., Sobiesk, M., Kelly, J., Leurgans, S., Bennett, D. A., & Arnold, S. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.48 · Cited by 148
Through the looking glass: Examining neuroanatomical evidence for cellular alterations in major depression
Hercher, C., Turecki, G., & Mechawar, N. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.01.006 · Cited by 148
Prenatal programming of postnatal endocrine responses by glucocorticoids
Bertram, C. E., & Hanson, M. A. (2002) · Reproduction · doi:10.1530/rep.0.1240459 · Cited by 148
Prominent Reduction in Pyramidal Neurons Density in the Orbitofrontal Cortex of Elderly Depressed Patients
Rajkowska, G., Miguel-Hidalgo, J. J., Dubey, P., Stockmeier, C. A., & Krishnan, K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.013 · Cited by 147
Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator
Bennur, S., Rao, B. S. S., Pawlak, R., Strickland, S., McEwen, B. S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.075 · Cited by 145
Effect of chronic restraint stress on dendritic spines and excrescences of hippocampal CA3 pyramidal neurons—a quantitative study
Sunanda, Rao, M. S. R., & Raju, T. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00822-8 · Cited by 143
Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to prenatal restraint stress
Schmitz, C., Rhodes, M. E., Bludau, M., Kaplan, S., Ong, P., Ueffing, I., Vehoff, J., Korr, H., & Frye, C. A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001118 · Cited by 140
Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: A stereological and three-dimensional ultrastructural study
Donohue, H. S., Gabbott, P. L. A., Davies, H. A., Rodríguez, J. J., Cordero, M. I., Sandi, C., Medvedev, N. I., Popov, V. I., Colyer, F. M., Peddie, C. J., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.072 · Cited by 139
NMDA Receptor Blockade Alters Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex
Martin, K. P., & Wellman, C. L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr021 · Cited by 138
Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction
Ishiwata, H., Shiga, T., & Okado, N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.048 · Cited by 138
Neuronal and morphological bases of cognitive decline in aged rhesus monkeys
Hara, Y., Rapp, P. R., & Morrison, J. H. (2011) · AGE · doi:10.1007/s11357-011-9278-5 · Cited by 133
Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus
Thome, J., Pesold, B., Baader, M., Hu, M., Gewirtz, J. C., Duman, R. S., & Henn, F. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01229-x · Cited by 128
Self-citation
The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers
Chen, G., & Manji, H. K. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218604.63463.cd · Cited by 126
Lateral amygdaloid nucleus expansion in adult rats is associated with exposure to prenatal stress
Salm, A. K., Pavelko, M., Krouse, E. M., Webster, W., Kraszpulski, M., & Birkle, D. L. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.11.005 · Cited by 125 · cited 2×
“PNS exposure of rats leads to an enlarged amygdala volume in adulthood (Salm et al., 2004) and may also cause dysregulation in BDNF in adult rats that could contribute to alterations of dendrite and spine morphology (discussed above in a separate paragraph) (Fumagalli et al.”
1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism
Chowdhury, G. M. I., Behar, K. L., Cho, W., Thomas, M. A., Rothman, D. L., & Sanacora, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.006 · Cited by 125
Prenatal stress alters dendritic morphology and synaptic connectivity in the prefrontal cortex and hippocampus of developing offspring
Mychasiuk, R., Gibb, R. L., & Kolb, B. E. (2011) · Synapse · doi:10.1002/syn.21512 · Cited by 125
Influence of estradiol, stress, and 5-HT2A agonist treatment on Brain-Derived Neurotrophic Factor expression in female rats
Çavuş, I., & Duman, R. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00236-1 · Cited by 124
Self-citation
Vesicular Glutamate Transporter VGLUT1 Has a Role in Hippocampal Long-Term Potentiation and Spatial Reversal Learning
Balschun, D., Moechars, D., Callaerts‐Vegh, Z., Vermaercke, B., Acker, N. V., Andries, L. J., & D’Hooge, R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp133 · Cited by 123
Corticostriatal brain‐derived neurotrophic factor dysregulation in adult rats following prenatal stress
Fumagalli, F., Bedogni, F., Pérez, J., Racagni, G., & Riva, M. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03592.x · Cited by 123
Memory impairment in patients with late-onset major depression: The effect of antidepressant therapy
Gallassi, R., Di Sarro, R., Morreale, A., & Amore, M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.018 · Cited by 118
Serum levels of androgens are higher in women with premenstrual irritability and dysphoria than in controls
Eriksson, E., Sundblad, C., Lisjo, P. I., Modigh, K., & Andersch, B. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90058-f · Cited by 118
Sex differences in learning deficits induced by prenatal stress in juvenile rats
Gué, M., Bravard, A., Meunier, J., Veyrier, R., Gaillet, S., Récasens, M., & Maurice, T. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00250-x · Cited by 116
Hippocampal volumetrics in depression: The importance of the posterior tail
Maller, J. J., Daskalakis, Z. J., & Fitzgerald, P. B. (2007) · Hippocampus · doi:10.1002/hipo.20339 · Cited by 115
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
Koike, H., Iijima, M., & Chaki, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.034 · Cited by 114
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik, L. G., Fredericks, C. A., Papademetris, X., Spencer, L., Lacadie, C., Wang, F., Pittman, B. P., Duncan, J. S., Staib, L. H., Duman, R. S., et al. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.107 · Cited by 112
Self-citation
Sexually dimorphic aging of dendritic morphology in CA1 of hippocampus
Markham, J. A., McKian, K. P., Stroup, T. S., & Juraska, J. M. (2004) · Hippocampus · doi:10.1002/hipo.20034 · Cited by 112
Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization
Muhammad, A., & Kolb, B. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.015 · Cited by 110
Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication
Savitz, J. B., Nugent, A. C., Bogers, W., Liu, A., Sills, R., Luckenbaugh, D. A., Bain, E., Price, J. L., Zarate, C. A., Manji, H. K., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.025 · Cited by 109
Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala
Poeggel, G., Helmeke, C., Abraham, A., Schwabe, T., Friedrich, P., & Braun, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434663100 · Cited by 107
NMDA Receptor-Dependent Regulation of Axonal and Dendritic Branching
Lee, L., Lo, F., & Erzurumlu, R. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4902-04.2005 · Cited by 106
Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression
Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · Hippocampus · doi:10.1002/hipo.20718 · Cited by 105
Neonatal Fluoxetine Exposure Affects the Neuronal Structure in the Somatosensory Cortex and Somatosensory-Related Behaviors in Adolescent Rats
Lee, L. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9022-4 · Cited by 103
Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice
Gilabert‐Juan, J., Castillo-Gómez, E., Pérez-Rando, M., Moltó, M. D., & Nácher, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.07.009 · Cited by 102
Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: Role of ERK kinase 1 (MEK1)
Dwivedi, Y., Rizavi, H. S., Zhang, H., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990575 · Cited by 101
Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex
Michelsen, K. A., van den Hove, D. L., Schmitz, C., Segers, O., Prickaerts, J., & Steinbusch, H. W. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-107 · Cited by 100
Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis
Hajek, T., Kopecek, M., & Höschl, C. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.580005 · Cited by 99

Flagged first, then by citations

3 of the 256 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Dwyer, 2011, mTOR activation is required for the antidepressant effects of mGluR2/3 blockade, Int J Neuropsychopharmacol, 1

Sorted by citations

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750
Self-citation
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752
Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 471
Neuroplasticity Underlying the Comorbidity of Pain and Depression
Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 304

See all 157

Authors: Licznerski, P., & Duman, R. S.
Affiliations: Yale University (US)
Corresponding author: Duman, R.S.
ORCID: Licznerski, P.
Duman, R.S.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2013-10
Volume: 251
Pages: 33-50
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2012.09.057
PMC: PMC3566360
OpenAlex: W2065851490
Cited by: 157
References: 256
Citations by year: 2026: 1 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 21 · 2014: 7 · 2013: 2
FWCI: 1.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH093897, R37MH045481)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, dendritic spines, synaptic plasticity, stress, antidepressants, rapid-acting antidepressants, prefrontal cortex, hippocampus, amygdala, limbic system, neuroplasticity, dendritic spine morphology
MeSH terms: Animals, Brain, Depression, Humans, Neuronal Plasticity, Neurons, Stress, Physiological, Synapses, Brain-Derived Neurotrophic Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks