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Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected
Abstract
Previous studies have shown that oxytocin improves the encoding and recognition of facial expressions, which has been proposed to be mediated by an increased exploration of the eye region during face processing. In the present study, we used eye tracking to assess visual attention to the eye region while participants performed a dynamic facial emotion recognition task. In a double-blind, placebo-controlled between-subjects design participants received 24 IU intranasal oxytocin (n = 23) or a placebo (n = 24). Although oxytocin administration had no effect on participants' visual scanning of emotional faces, it generally enhanced recognition performance, as the oxytocin group recognized emotional expressions at lower intensity levels. These findings suggest that oxytocin-induced improvement of facial emotion recognition is independent of modulations in overt visual attention.
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“others suggesting that improvements in facial emotion recognition are unaffected by eye-gaze (Hubble et al., 2016;Lischke et al., 2012; )”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Lischke et al., 2012
In the citing paper
“These results contrast with those reported by Lischke et al. (2012), who found no evidence that OXT altered eye-gaze in healthy participants.”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Lischke et al. (2012)
In the citing paper
“others indicate that OT enhances the identification of emotions regardless of valence [14], relative to placebo.”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [14]
In the citing paper
“findings from studies using lower level tasks administered after OT ingestion (RTs to emotion stimuli and emotion recognition tasks, for example) tend to be mixed and sometimes inconsistent [13], [10], [14], [11], [12].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [14]
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“…& Dadds, 2008), enhanced the ability of subjects to discriminate facial expressions in others (Domes, Heinrichs, Michel, Berger, & Herpertz, 2007; Lischke et al., 2012), promoted trust (Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005), and improved socially reinforced learning (Hurlemann et…”
BackgroundLischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx134 · Cited by 29
Le, J., Kou, J., Zhao, W., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00803 · Cited by 29
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Grainger, S. A., Henry, J. D., Steinvik, H. R., Vanman, E. J., Rendell, P. G., & Labuschagne, I. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.01.009 · Cited by 27
Horta, M., Ziaei, M., Lin, T., Porges, E. C., Fischer, H., Feifel, D., Spreng, R. N., & Ebner, N. C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.016 · Cited by 26
Le, J., Kou, J., Zhao, W., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0830-x · Cited by 29
Koenig, J., Lischke, A., Bardtke, K. F., Heinze, A.-L., Kröller, F., Pahnke, R., & Kaess, M. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01496-4 · Cited by 28
Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Aust, S., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3631-1 · Cited by 29
Woods, R., Bedard, M., McQuaid, R. J., Matheson, K., & Anisman, H. (2017) · Social Neuroscience · doi:10.1080/17470919.2017.1327458 · Cited by 27
Schaschl, H., Huber, S., Schæfer, K., Windhager, S., Wallner, B., & Fieder, M. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0372-7 · Cited by 28
Metadata
- Authors
- Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G.
- Affiliations
- Heidelberg University (DE)
- University of Rostock (DE)
- Freie Universität Berlin (DE)
- University of Freiburg (DE)
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 37
- Issue
- 4
- Pages
- 475-481
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2128782393
- Cited by
- 221
- References
- 31
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 12 · 2018: 19 · 2017: 22 · 2016: 16 · 2015: 19 · 2014: 13 · 2013: 25 · 2012: 10
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, facial emotion recognition, dynamic facial expressions, gaze, visual attention, emotional intensity, social cognition
- MeSH terms
- Administration, Intranasal, Adult, Attention, Double-Blind Method, Emotions, Eye Movements, Facial Expression, Humans, Male, Oxytocin, Photic Stimulation, Recognition, Psychology
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