Chitosan: A review on properties, biological activities and recent progress in biomedical applications

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Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing

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Recent Advances in Chitosan-Based Carriers for Gene Delivery

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Modification of Chitosan for the Generation of Functional Derivatives

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Crustacean Waste-Derived Chitosan: Antioxidant Properties and Future Perspective

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Assessment of chitosan derivatives as buccal and vaginal penetration enhancers

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Chemical Characteristics and Functional Properties of Chitosan

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Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems

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Rifampicin loaded chitosan nanoparticle dry powder presents an improved therapeutic approach for alveolar tuberculosis

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Efficacy and Mechanism of Action of Chitosan Nanocapsules for Oral Peptide Delivery

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The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells

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Carbopol/Chitosan Based pH Triggered In Situ Gelling System for Ocular Delivery of Timolol Maleate

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Nanoparticles Incorporated in pH-Sensitive Hydrogels as Amoxicillin Delivery for Eradication of Helicobacter pylori

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Copper metal–organic frameworks loaded on chitosan film for the efficient inhibition of bacteria and local infection therapy

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Thiomers — From bench to market

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Mucoadhesive Microspheres for Gastroretentive Delivery of Acyclovir: In Vitro and In Vivo Evaluation

Dhaliwal, S., Jain, S. K., Singh, H. P., & Tiwary, A. K. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9039-2 · Cited by 124

Chitosan and sodium alginate—Based bioadhesive vaginal tablets

El-Kamel, A. H., Sokar, M. S., Naggar, V. F., et al. (2002) · AAPS PharmSci · doi:10.1208/ps040444 · Cited by 124

The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs

Trapani, A., Sitterberg, J., Bakowsky, U., & Kissel, T. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.03.041 · Cited by 124

Potency and Cytotoxicity of a Novel Gallium-Containing Mesoporous Bioactive Glass/Chitosan Composite Scaffold as Hemostatic Agents

Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Gargiulo, N., Jindal, H. M., Naveen, S. V., Sekaran, S. D., Kamarul, T., & Towler, M. R. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b07769 · Cited by 124

Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells

Santos-Carballal, B., Aaldering, L. J., Ritzefeld, M., Pereira, S., Sewald, N., Moerschbacher, B. M., Götte, M., & Goycoolea, F. M. (2015) · Scientific Reports · doi:10.1038/srep13567 · Cited by 121

Bioactive Peptides/Chitosan Nanoparticles Enhance Cellular Antioxidant Activity of (−)-Epigallocatechin-3-gallate

Hu, B., Ting, Y., Zeng, X., & Huang, Q. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304821k · Cited by 120

Synthesis and characterization of a chitosan-N-acetyl cysteine conjugate

Schmitz, T., Grabovac, V., Palmberger, T. F., Hoffer, M. H., & Bernkop‐Schnürch, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.040 · Cited by 119

Mucoadhesive Films Containing Chitosan‐Coated Nanoparticles: A New Strategy for Buccal Curcumin Release

Mazzarino, L., Borsali, R., & Lemos‐Senna, E. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24142 · Cited by 119

Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization

Shahnaz, G., Vetter, A., Barthelmes, J., Rahmat, D., Laffleur, F., Iqbal, J., Perera, G., Schlocker, W., Dünnhaput, S., Augustijns, P., et al. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.02.044 · Cited by 116

Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide

Debnath, S. K., Saisivam, S., Debanth, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190976 · Cited by 115

Positively Charged Gelatin Microspheres as Gastric Mucoadhesive Drug Delivery System for Eradication ofH. pylori

Wang, Y. (2000) · Drug Delivery · doi:10.1080/107175400455173 · Cited by 110

In situ gelling properties of chitosan-thioglycolic acid conjugate in the presence of oxidizing agents

Sakloetsakun, D., Hombach, J., & Bernkop‐Schnürch, A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.060 · Cited by 109

Photodynamic therapy in wound healing in vivo: a systematic review

Oyama, J., Milaré, Á. C. F. H. R., Lera‐Nonose, D. S. S. L., dos Reis, V. N., Demarchi, I. G., Aristides, S. M. A., Teixeira, J. J. V., Silveira, T. G. V., & Lonardoni, M. V. C. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101682 · Cited by 107

Development of chitosan-based nanoparticles for pulmonary delivery of itraconazole as dry powder formulation

Jafarinejad, S., Gilani, K., Moazeni, E., Ghazi‐Khansari, M., Najafabadi, A. R., & Mohajel, N. (2012) · Powder Technology · doi:10.1016/j.powtec.2012.01.045 · Cited by 106

Chitosan-thioglycolic acid conjugate: a new scaffold material for tissue engineering?

Kast, C. E., Frick, W., Losert, U. M., & Bernkop‐Schnürch, A. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00076-0 · Cited by 105

Synthesis and Characterization of New Thiolated Chitosan Nanoparticles Obtained by Ionic Gelation Method

Esquivel, R., Juárez, J., Almada, M., Ibarra, J., & Valdez, M. A. (2015) · International Journal of Polymer Science · doi:10.1155/2015/502058 · Cited by 104

Water-soluble N-carboxymethylchitosan derivatives: Preparation, characteristics and its application

An, N. T., Thiện, Đ. T., Dong, N. T. K., et al. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.08.017 · Cited by 100

Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability

Hasanovic, A., Zehl, M., Reznicek, G., & Valenta, C. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.12.0004 · Cited by 98

β-Glycerol phosphate/genipin chitosan hydrogels: A comparative study of their properties and diclofenac delivery

Maiz–Fernández, S., Guaresti, O., Pérez‐Álvarez, L., Ruiz‐Rubio, L., Gabilondo, N., Vilas‐Vilela, J. L., & Lanceros-Méndez, S. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116811 · Cited by 95

A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats

Yao, H., Huang, S.-Y., & Chiang, M. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.12.012 · Cited by 93

Progress and prospects in chitosan derivatives: Modification strategies and medical applications

Ding, S., Wang, Y., Li, J., & Chen, S. (2021) · Journal of Materials Science & Technology · doi:10.1016/j.jmst.2020.12.008 · Cited by 92

Safety Aspects and Cholesterol-Lowering Efficacy of Chitosan Tablets

Tapola, N. S., Lyyra, M. L., Kolehmainen, R. M., Sarkkinen, E. S., & Schauss, A. G. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719671 · Cited by 88

Effect of Chitosan Chain Architecture on Gene Delivery: Comparison of Self-Branched and Linear Chitosans

Malmo, J., Vårum, K. M., & Strand, S. P. (2011) · Biomacromolecules · doi:10.1021/bm1013525 · Cited by 87

Human Buccal Mucosa as an Innovative Site of Drug Delivery

Campisi, G., Paderni, C., Saccone, R., Fede, O. D., Wolff, Ä., & Giannola, L. I. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883778 · Cited by 86

Folate Receptor-Mediated Cancer Cell Specific Gene Delivery Using Folic Acid-Conjugated Oligochitosans

Lee, D., Lockey, R. F., & Mohapatra, S. S. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.465 · Cited by 85

Wound healing and antibacterial chitosan-genipin hydrogels with controlled drug delivery for synergistic anti-inflammatory activity

del Olmo, J. A., Pérez‐Álvarez, L., Sáez‐Martínez, V., Cid, S. B., Ruiz‐Rubio, L., Pérez-González, R., Vilas‐Vilela, J. L., & Alonso, J. M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.193 · Cited by 81

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

Sharifianjazi, F., Khaksar, S., Esmaeilkhanian, A., et al. (2022) · Biomolecules · doi:10.3390/biom12020155 · Cited by 78

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang, H., Wu, F., Li, Y., Yang, X., Huang, J., Lv, T., Zhang, Y., Chen, J., Chen, H., Gao, Y., et al. (2016) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.7.178 · Cited by 77

Controlled-release biodegradable nanoparticles: From preparation to vaginal applications

Martínez‐Pérez, B., Quintanar‐Guerrero, D., Tapia-Tapia, M., Tamayo, R. C., Zambrano‐Zaragoza, M. L., Alcalá-Alcalá, S., Mendoza‐Muñoz, N., & Piñón‐Segundo, E. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.11.029 · Cited by 76

Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements

Shen, J.-M., Xu, L., Lu, Y., Cao, H.-M., Xu, Z.-G., Chen, T., & Zhang, H.-X. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.01.059 · Cited by 75

Acrylated chitosan for mucoadhesive drug delivery systems

Shitrit, Y., & Bianco‐Peled, H. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.023 · Cited by 74

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Bhise, K., Dhumal, R. S., Paradkar, A. R., & Kadam, S. S. (2007) · AAPS PharmSciTech · doi:10.1208/s12249-007-9001-0 · Cited by 73

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

Karava, A., Lazaridou, M., Nanaki, S. G., Michailidou, G., Christodoulou, E., Kostoglou, M., Iatrou, H., & Bikiaris, D. Ν. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060594 · Cited by 73

Evaluation of a Non‐Woven Fabric Coated with a Chitosan Bi‐Layer Composite for Wound Dressing

Liu, B., Yao, C., & Fang, S. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200700211 · Cited by 71

PEGylation of PLA nanoparticles to improve mucus-penetration and colloidal stability for oral delivery systems

Palacio, J., Agudelo, N. A., & López, B. L. (2015) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2015.11.006 · Cited by 70

Augmented anticancer activity of curcumin loaded fungal chitosan nanoparticles

Almutairi, F. M., Rabey, H. A. E., Tayel, A. A., Alalawy, A. I., Al-Duais, M. A., Sakran, M., & Zidan, N. S. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.207 · Cited by 70

Development of Novel Octanoyl Chitosan Nanoparticles for Improved Rifampicin Pulmonary Delivery: Optimization by Factorial Design

Petkar, K. C., Chavhan, S. S., Kunda, N. K., Saleem, I. Y., Somavarapu, S., Taylor, K. M. G., & Sawant, K. K. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-0972-9 · Cited by 69

Antibacterial and Antifouling Hybrid Ionic–Covalent Hydrogels with Tunable Mechanical Properties

Zhang, J., Shen, B., Chen, L., Chen, L., Mo, J., & Feng, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b08870 · Cited by 69

Fabrication of novel chitosan nanofiber/gold nanoparticles composite towards improved performance for a cholesterol sensor

Gomathi, P., Dhanusuraman, R., Choi, J. H., Yeum, J. H., Lee, S. C., Kim, J. C., Lee, S. H., & Ghim, H. D. (2010) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2010.10.005 · Cited by 68

Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery

Marciello, M., Rossi, S., Caramella, C. M., & Remuñán‐López, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.051 · Cited by 68

O-acylation of chitosan nanofibers by short-chain and long-chain fatty acids

Zhang, Z., Jin, F., Wu, Z., Jin, J., Li, F., Wang, Y., Wang, Z., Tang, S., Wu, C., & Wang, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.08.132 · Cited by 67

Chitosan nanoparticles loaded hydrogels promote skin wound healing through the modulation of reactive oxygen species

Wang, T., Zheng, Y., Shen, Y., Shi, Y., Li, F., Su, C., & Zhao, L. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1415212 · Cited by 67

Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

Lin, F., Jia, H., & Wu, F. (2019) · Molecules · doi:10.3390/molecules24234371 · Cited by 67

Ex vivo permeation of tamoxifen and its 4-OH metabolite through rat intestine from lecithin/chitosan nanoparticles

Barbieri, S., Buttini, F., Rossi, A., Bettini, R., Colombo, P., Ponchel, G., Sonvico, F., & Colombo, G. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.06.021 · Cited by 66

Pb(II) determination in natural water using a carbon nanotubes paste electrode modified with crosslinked chitosan

Vicentini, F. C., Silva, T. A., Pellatieri, A., Janegitz, B. C., Fatibello‐Filho, O., & Faria, R. C. (2014) · Microchemical Journal · doi:10.1016/j.microc.2014.05.008 · Cited by 66

Preparation and characterization of N-benzoyl-O-acetyl-chitosan

Cai, J., Dang, Q., Liu, C., Fan, B., Yan, J., Xu, Y., & Li, J. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.007 · Cited by 60

Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin

Wei, W., Ma, G., Wang, L.-Y., Wu, J., & Su, Z. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.06.005 · Cited by 58

Mucoadhesive properties of low molecular weight chitosan- or glycol chitosan- and corresponding thiomer-coated poly(isobutylcyanoacrylate) core-shell nanoparticles

Palazzo, C., Trapani, G., Ponchel, G., Trapani, A., & Vauthier, C. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.04.020 · Cited by 56

Chitosan Loaded into a Hydrogel Delivery System as a Strategy to Treat Vaginal Co-Infection

Perinelli, D. R., Campana, R., Σκούρας, Α., Bonacucina, G., Cespi, M., Mastrotto, F., Baffone, W., & Casettari, L. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010023 · Cited by 54

Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro

Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101738 · Cited by 54

Colon-specific delivery of mesalazine chitosan microspheres

Varshosaz, J., Jafarian‐Dehkordi, A., & Golafshan, S. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600612405 · Cited by 52

Preparation, characterization, and cellular uptake of resveratrol-loaded trimethyl chitosan nanoparticles

Min, J. B., Kim, E. S., Lee, J.-S., & Lee, H. G. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0272-2 · Cited by 52

Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance

Iglesias, N., Galbis, E., Valencia, C., Díaz, M. J., Lacroix, B., & de‐Paz, M. ‐. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.006 · Cited by 51

Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model.

Soni, J., Sardoiwala, M. N., Choudhury, S., Sharma, S., & Karmakar, S. (2021) · Materials Science and Engineering C: Materials for Biological Applications · doi:10.1016/j.msec.2021.112038 · Cited by 49

Manufacture and characterization of chitosan/PLGA nanoparticles nanocomposite buccal films.

dos Santos, T. D., Rescignano, N., Boff, L., Reginatto, F., Simões, C., de Campos, A. D., & Mijangos, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.06.014 · Cited by 48

Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells

Ciro, Y., Rojas, J., Virgilio, A. L. D., Alhajj, M. J., Carabali, G. A., & Salamanca, C. H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116436 · Cited by 48

Ability of Chitosan Gels to Disrupt Bacterial Biofilms and Their Applications in the Treatment of Bacterial Vaginosis

Kandimalla, K. K., Borden, E., Omtri, R. S., Boyapati, S. P., Smith, M., Lebby, K., Mulpuru, M., & Gadde, M. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23571 · Cited by 47

Biocompatible biodegradable polymeric antibacterial nanoparticles for enhancing the effects of a third-generation cephalosporin against resistant bacteria

Mushtaq, S., Khan, J. A., Rabbani, F., et al. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000445 · Cited by 46

Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles

Hu, F.-Q., Ww, C., Zhao, M.-D., Yuan, H., & Du, Y.-Z. (2012) · Gene Therapy · doi:10.1038/gt.2012.72 · Cited by 45

Docetaxel –Chitosan nanoparticles for breast cancer treatment: cell viability and gene expression study

Mirzaie, Z. H., Irani, S., Mirfakhraie, R., Atyabi, S. M., Dinarvand, M., Dinarvand, R., Varshochian, R., & Atyabi, F. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12814 · Cited by 43

Rebamipide-loaded chitosan nanoparticles accelerate prostatic wound healing by inhibiting M1 macrophage-mediated inflammation via the NF-κB signaling pathway

Sun, M., Deng, Z. H., Shi, F., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm01512d · Cited by 40

Synthesis of cationic alkylated chitosans and an investigation of their rheological properties and interaction with anionic surfactant

Burr, S. J., Williams, P. A., & Ratcliffe, I. C. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.105 · Cited by 34

Anti-Inflammatory Properties of Statin-Loaded Biodegradable Lecithin/Chitosan Nanoparticles: A Step Toward Nose-to-Brain Treatment of Neurodegenerative Diseases

Clementino, A., Marchi, C., Pozzoli, M., Bernini, F., Zimetti, F., & Sonvico, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716380 · Cited by 31

Porous chitosan scaffold cross-linked by chemical and natural procedure applied to investigate cell regeneration

Yao, C.-K., Liao, J., Chung, C.-W., Sung, W.-I., & Chang, N.-J. (2012) · Applied Surface Science · doi:10.1016/j.apsusc.2012.05.128 · Cited by 30

O,N-(2-sulfoethyl)chitosan: Synthesis and properties of solutions and films

Petrova, V. A., Chernyakov, D. D., Moskalenko, Y. E., Gasilova, E. R., Strelina, I. A., Okatova, O. V., Baklagina, Y. G., Vlasova, E. N., & Skorik, Y. А. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.10.058 · Cited by 27

In-vitro Characterization of Chitosan Nanoparticles of Fluconazole as a Carrier for Sustained Ocular Delivery

Santhi, K., Muralidharan, S., Yee, Y. H., Min, F. M., Ting, C. Z., & Devi, D. (2017) · Nanoscience & Nanotechnology-Asia · doi:10.2174/2210681206666160402003316 · Cited by 19